{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T16:48:27Z","timestamp":1761238107000},"reference-count":36,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2014,6,25]],"date-time":"2014-06-25T00:00:00Z","timestamp":1403654400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2014,6,25]],"date-time":"2014-06-25T00:00:00Z","timestamp":1403654400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,1,27]],"date-time":"2016-01-27T00:00:00Z","timestamp":1453852800000},"content-version":"vor","delay-in-days":581,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["kjms-online.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Kaohsiung J of Med Scie"],"published-print":{"date-parts":[[2014,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label \/><jats:p>Although understanding the relation between psychotic behavior and immune abnormalities has been the focus of research for many years, it remains to be elucidated whether the changes in cytokine levels are part of etiology or a result of the stress associated with the disorder. In accordance with previous studies on changes in cytokine levels due to metabolic changes and psychosis, we hypothesized that fatty liver may potentiate apomorphine\u2010induced stereotypy in a rodent model and that a synthetic glucagon\u2010like peptide\u20101 analog <jats:italic>exenatide<\/jats:italic> would ameliorate this effect. In this study, 18 male Sprague Dawley albino mature rats were used. We induced hepatosteatosis in these rats by feeding them with 30% fructose dissolved in drinking water for 8 weeks. The animals were divided into three groups, namely, the normal group, the intracerebroventricular (ICV) exenatide group, and the ICV NaCl group. Apomorphine\u2010induced stereotypic behavior test was performed in all groups and the liver was removed for histopathological examination after all the rats were euthanized. In the nonalcoholic fatty liver (NAFL) group, stereotypy scores were significantly increased compared with the control group rats (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.00001). A significant decrease in stereotypy scores were observed in the ICV exenatide group with NAFL when compared with the ICV saline group with NAFL (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.005). In addition, brain malondialdehyde and tumor necrosis factor\u2010\u03b1 levels decreased in the ICV exenatide group. The results of this study showed that fatty liver enhances the effect of apomorphine on stereotypy, which was reversed by exenatide possibly by antioxidant and anti\u2010inflammatory effects.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.kjms.2014.05.007","type":"journal-article","created":{"date-parts":[[2014,6,25]],"date-time":"2014-06-25T10:19:00Z","timestamp":1403691540000},"page":"447-452","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Fatty liver\u2010induced changes in stereotypic behavior in rats and effects of glucagon\u2010like peptide\u20101 analog on stereotypy"],"prefix":"10.1002","volume":"30","author":[{"given":"Oytun","family":"Erba\u015f","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00fcseyin Serdar","family":"Akseki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Volkan","family":"Solmaz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00fcseyin","family":"Aktu\u011f","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dilek","family":"Ta\u015fk\u0131ran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,6,25]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(99)70506-8"},{"key":"e_1_2_5_3_2","first-page":"17","article-title":"Diabetes mellitus, obesity, and hepatic steatosis","volume":"13","author":"Youssef W.","year":"2002","journal-title":"Semin Gastrointest Dis"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.2337\/dc06-1539"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-013-0087-8"},{"key":"e_1_2_5_6_2","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1016\/S0168-8278(98)80073-1","article-title":"Non\u2010alcoholic steatohepatitis (NASH): a disease of emerging identity and importance","volume":"29","author":"Oliver F.W.J.","year":"1998","journal-title":"J Hepatol"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v18.i8.727"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1210\/jc.83.8.2907"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117936"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm1166"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2006.02.011"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200011163432007"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-9964(00)00094-3"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02922260"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.111.190702"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2012.06.026"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2013.08.001"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(98)00904-4"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(02)02740-3"},{"key":"e_1_2_5_20_2","first-page":"114","article-title":"Antipsychotic\u2010like effect of GLP\u20101 agonist liraglutide but not DPP\u2010IV inhibitor sitagliptin in mouse model for psychosis","volume":"10","author":"Dixit T.S.","year":"2013","journal-title":"Physiol Behav"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2012.03.014"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.4196\/kjpp.2009.13.2.71"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0702350"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(00)00638-X"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(76)90527-3"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1986.tb05175.x"},{"key":"e_1_2_5_27_2","doi-asserted-by":"crossref","first-page":"64473","DOI":"10.1371\/journal.pone.0064473","article-title":"Short and long term sseffects of interleukin\u20102 treatment on the sensitivity of periadolescent female mice to interleukin\u20102 and dopamine uptake inhibitor","volume":"24","author":"Rankin J.S.","year":"2013","journal-title":"PLoS One"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2006.08.005"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.108.052605"},{"key":"e_1_2_5_30_2","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1001\/archpsyc.1989.01810030098018","article-title":"Increased serum interleukin 2 receptor concentration in schizophrenic and brain\u2010damaged subjects","volume":"46","author":"Anguli R.","year":"1989","journal-title":"Arch Gen Psychiatry"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-9964(99)00171-1"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0920-9964(00)00007-4"},{"key":"e_1_2_5_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.neures.2006.06.002"},{"key":"e_1_2_5_34_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1819.2010.02094.x"},{"key":"e_1_2_5_35_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.48.2.206"},{"key":"e_1_2_5_36_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.6.2557"},{"key":"e_1_2_5_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2012.11.009"}],"container-title":["The Kaohsiung Journal of Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1607551X14001399?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1607551X14001399?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.kjms.2014.05.007","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T16:55:50Z","timestamp":1694710550000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1016\/j.kjms.2014.05.007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,25]]},"references-count":36,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2014,9]]}},"alternative-id":["10.1016\/j.kjms.2014.05.007"],"URL":"https:\/\/doi.org\/10.1016\/j.kjms.2014.05.007","archive":["Portico"],"relation":{},"ISSN":["1607-551X","2410-8650"],"issn-type":[{"value":"1607-551X","type":"print"},{"value":"2410-8650","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,25]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Fatty liver-induced changes in stereotypic behavior in rats and effects of glucagon-like peptide-1 analog on stereotypy","name":"articletitle","label":"Article Title"},{"value":"The Kaohsiung Journal of Medical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.kjms.2014.05.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}