{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:00:20Z","timestamp":1773792020098,"version":"3.50.1"},"reference-count":77,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2014,6,26]],"date-time":"2014-06-26T00:00:00Z","timestamp":1403740800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2014,6,26]],"date-time":"2014-06-26T00:00:00Z","timestamp":1403740800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,1,27]],"date-time":"2016-01-27T00:00:00Z","timestamp":1453852800000},"content-version":"vor","delay-in-days":580,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["kjms-online.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Kaohsiung J of Med Scie"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>To select cytogenetically normal embryos, preimplantation genetic diagnosis (PGD) aneuploidy screening (AS) is used in numerous centers around the world. Chromosomal abnormalities lead to developmental problems, implantation failure, and early abortion of embryos. The usefulness of PGD in identifying single\u2010gene diseases, human leukocyte antigen typing, X\u2010linked diseases, and specific genetic diseases is well\u2010known. In this review, preimplantation embryo genetics, PGD research studies, and the European Society of Human Reproduction and Embryology PGD Consortium studies and reports are examined. In addition, criteria for embryo selection, technical aspects of PGD\u2010AS, and potential noninvasive embryo selection methods are described. Indications for PGD and possible causes of discordant PGD results between the centers are discussed. The limitations of fluorescence <jats:italic>in situ<\/jats:italic> hybridization, and the advantages of the array comparative genomic hybridization are included in this review. Although PGD\u2010AS for patients of advanced maternal age has been shown to improve <jats:italic>in\u2009vitro<\/jats:italic> fertilization outcomes in some studies, to our knowledge, there is not sufficient evidence to use advanced maternal age as the sole indication for PGD\u2010AS. PGD\u2010AS might be harmful and may not increase the success rates of <jats:italic>in\u2009vitro<\/jats:italic> fertilization. At the same time PGD, is not recommended for recurrent implantation failure and unexplained recurrent pregnancy loss.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.kjms.2014.05.008","type":"journal-article","created":{"date-parts":[[2014,6,26]],"date-time":"2014-06-26T21:00:55Z","timestamp":1403816455000},"page":"491-498","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Is preimplantation genetic diagnosis the ideal embryo selection method in aneuploidy screening?"],"prefix":"10.1002","volume":"30","author":[{"given":"Levent","family":"Sahin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Murat","family":"Bozkurt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilal","family":"Sahin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aykut","family":"G\u00fcrel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayse Ender","family":"Yumru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,6,26]]},"reference":[{"key":"e_1_2_16_2_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/der004"},{"key":"e_1_2_16_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2013.06.031"},{"key":"e_1_2_16_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmg021"},{"key":"e_1_2_16_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deg269"},{"key":"e_1_2_16_6_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/del358"},{"key":"e_1_2_16_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/HUMREP\/11.3.595"},{"key":"e_1_2_16_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/13.12.3431"},{"key":"e_1_2_16_9_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0967199400002707"},{"key":"e_1_2_16_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh258"},{"key":"e_1_2_16_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2005.02.009"},{"key":"e_1_2_16_12_2","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/j.fertnstert.2012.05.041","article-title":"An embryo cleavage pattern based on the relative blastomere size as a function of cell number for predicting implantation outcome","volume":"98","author":"Sela R.","year":"2012","journal-title":"Fertil Steril"},{"key":"e_1_2_16_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/13.4.1003"},{"key":"e_1_2_16_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/14.5.1318"},{"key":"e_1_2_16_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/15.11.2394"},{"key":"e_1_2_16_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2009.11.003"},{"key":"e_1_2_16_17_2","first-page":"CD002118","article-title":"Cleavage stage versus blastocyst stage embryo transfer in assisted conception","volume":"19","author":"Blake D.","year":"2005","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_16_18_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/det079"},{"key":"e_1_2_16_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2012.10.021"},{"key":"e_1_2_16_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1439-0272.2001.tb01493.x"},{"key":"e_1_2_16_21_2","doi-asserted-by":"publisher","DOI":"10.1159\/000101741"},{"key":"e_1_2_16_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/ng1296-400"},{"key":"e_1_2_16_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.tig.2006.02.007"},{"key":"e_1_2_16_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(02)03271-5"},{"key":"e_1_2_16_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(10)60866-8"},{"key":"e_1_2_16_26_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deq231"},{"key":"e_1_2_16_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)91723-6"},{"key":"e_1_2_16_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2006.07.1512"},{"key":"e_1_2_16_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(10)61057-7"},{"key":"e_1_2_16_30_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/16.9.1954"},{"key":"e_1_2_16_31_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deq344"},{"key":"e_1_2_16_32_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a138001"},{"key":"e_1_2_16_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(10)61146-7"},{"key":"e_1_2_16_34_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/15.9.2003"},{"key":"e_1_2_16_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(10)61715-4"},{"key":"e_1_2_16_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(10)61671-9"},{"key":"e_1_2_16_37_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/14.9.2191"},{"key":"e_1_2_16_38_2","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-12-22"},{"key":"e_1_2_16_39_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/dei259"},{"key":"e_1_2_16_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2004.06.071"},{"key":"e_1_2_16_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2004.02.108"},{"key":"e_1_2_16_42_2","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1093\/humrep\/deh293","article-title":"ART in recurrent miscarriage: preimplantation genetic diagnosis\/screening or surrogacy?","volume":"19","author":"Carp H.J.","year":"2004","journal-title":"Hum Reprod"},{"key":"e_1_2_16_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(99)00495-1"},{"key":"e_1_2_16_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.07.2002"},{"key":"e_1_2_16_45_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a136027"},{"key":"e_1_2_16_46_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.humrep.a136207"},{"key":"e_1_2_16_47_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/12.8.1762"},{"key":"e_1_2_16_48_2","first-page":"CD005291","article-title":"Preimplantation genetic screening for abnormal number of chromosomes (aneuploidies) in in\u2009vitro fertilisation or intracytoplasmic sperm injection","volume":"25","author":"Twisk M.","year":"2006","journal-title":"Cochrane Database Syst Rev"},{"key":"e_1_2_16_49_2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmr052"},{"key":"e_1_2_16_50_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2009.05.002"},{"key":"e_1_2_16_51_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/den129"},{"key":"e_1_2_16_52_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(10)60961-3"},{"key":"e_1_2_16_53_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16209-0"},{"key":"e_1_2_16_54_2","doi-asserted-by":"publisher","DOI":"10.1369\/jhc.4B6395.2005"},{"key":"e_1_2_16_55_2","doi-asserted-by":"publisher","DOI":"10.1002\/pd.388"},{"key":"e_1_2_16_56_2","doi-asserted-by":"publisher","DOI":"10.1002\/pd.1623"},{"key":"e_1_2_16_57_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh094"},{"key":"e_1_2_16_58_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh536"},{"key":"e_1_2_16_59_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-0033-1363552"},{"key":"e_1_2_16_60_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa067744"},{"key":"e_1_2_16_61_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-006-9073-x"},{"key":"e_1_2_16_62_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2006.08.108"},{"key":"e_1_2_16_63_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2012.11.041"},{"key":"e_1_2_16_64_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2008.10.072"},{"key":"e_1_2_16_65_2","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1097\/AOG.0b013e31819e9f05","article-title":"Preimplantation genetic screening for aneuploidy","volume":"113","author":"American College of Obstetricians and Gynecologists. ACOG Committee Opinion No. 430","year":"2009","journal-title":"Obstet Gynecol"},{"key":"e_1_2_16_66_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2013.08.051"},{"key":"e_1_2_16_67_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/den488"},{"key":"e_1_2_16_68_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1472-6483(10)61714-2"},{"key":"e_1_2_16_69_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004390051030"},{"key":"e_1_2_16_70_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4914(00)01867-0"},{"key":"e_1_2_16_71_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/der082"},{"key":"e_1_2_16_72_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2010.04.064"},{"key":"e_1_2_16_73_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/der068"},{"key":"e_1_2_16_74_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/der295"},{"key":"e_1_2_16_75_2","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmh050"},{"key":"e_1_2_16_76_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2011.04.052"},{"key":"e_1_2_16_77_2","doi-asserted-by":"crossref","unstructured":"E.C.Lau M.M.Janson C.B.Ball M.R.Roesler P.VanTuinen D.P.Bick et al.Preimplantation genetic testing: current status and future prospects.S.FriedlerIn\u2009vitrofertilization\u2014Innovative clinical and laboratory aspects. InTech.2012 ISBN 978\u2010953\u201051\u20100503\u20109","DOI":"10.5772\/36856"},{"key":"e_1_2_16_78_2","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/det271"}],"container-title":["The Kaohsiung Journal of Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1607551X14001405?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1607551X14001405?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.kjms.2014.05.008","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,14]],"date-time":"2023-09-14T04:34:59Z","timestamp":1694666099000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1016\/j.kjms.2014.05.008"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,26]]},"references-count":77,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["10.1016\/j.kjms.2014.05.008"],"URL":"https:\/\/doi.org\/10.1016\/j.kjms.2014.05.008","archive":["Portico"],"relation":{},"ISSN":["1607-551X","2410-8650"],"issn-type":[{"value":"1607-551X","type":"print"},{"value":"2410-8650","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,26]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Is preimplantation genetic diagnosis the ideal embryo selection method in aneuploidy screening?","name":"articletitle","label":"Article Title"},{"value":"The Kaohsiung Journal of Medical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.kjms.2014.05.008","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}