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However, the impact of DM on the development of gastroesophageal variceal bleeding (GEVB) remains unclear. We aimed to elucidate whether DM is an independent risk factor for GEVB among cirrhotic patients. A total of 146 consecutive patients with liver cirrhosis (Child\u2010Pugh Class A, <jats:italic>n<\/jats:italic>\u2009=\u200975; Class B, <jats:italic>n<\/jats:italic>\u2009=\u200940; and Class C, <jats:italic>n<\/jats:italic>\u2009=\u200931) were prospectively enrolled. Data on clinical and biochemical characteristics and history of ascites, GEVB, hepatic encephalopathy, and spontaneous bacterial peritonitis were retrospectively reviewed. Of these 146 patients, 37 (25%) had DM. Patients with DM had significantly higher ratio of Child\u2010Pugh Class B\/C (<jats:italic>p<\/jats:italic>\u2009=\u20090.043), renal insufficiency (<jats:italic>p<\/jats:italic>\u2009=\u20090.002), and history of GEVB (<jats:italic>p<\/jats:italic>\u2009=\u20090.006) compared with non\u2010DM patients. GEVB was associated with Child\u2010Pugh Class B\/C (<jats:italic>p<\/jats:italic>\u2009=\u20090.001), ascites (<jats:italic>p<\/jats:italic>\u2009=\u20090.002), hepatic encephalopathy (<jats:italic>p<\/jats:italic>\u2009=\u20090.023), and low platelet counts (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Based on stepwise multiple logistic regression analysis, Child\u2010Pugh class B\/C [odds ratio (OR)\u2009=\u20094.90, <jats:italic>p<\/jats:italic>\u2009=\u20090.003] and DM (OR\u2009=\u20092.99, <jats:italic>p<\/jats:italic>\u2009=\u20090.022) were identified as independent predictors of GEVB. In the subgroup analysis, DM significantly correlated with GEVB in patients with Child\u2010Pugh Class A (<jats:italic>p<\/jats:italic>\u2009=\u20090.042), but not in patients with Child\u2010Pugh Class B\/C (<jats:italic>p<\/jats:italic>\u2009=\u20090.128). DM is independently associated with GEVB in cirrhotic patients, especially in those with Child\u2010Pugh Class A.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.kjms.2014.06.002","type":"journal-article","created":{"date-parts":[[2014,7,22]],"date-time":"2014-07-22T20:16:34Z","timestamp":1406060194000},"page":"515-520","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["Diabetes mellitus is associated with gastroesophageal variceal bleeding in cirrhotic patients"],"prefix":"10.1002","volume":"30","author":[{"given":"Chun\u2010Hsun","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi\u2010Chun","family":"Chiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih\u2010Hung","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien\u2010Hung","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming\u2010Chao","family":"Tsai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seng\u2010Kee","family":"Chuah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih\u2010Hsiung","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsung\u2010Hui","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao\u2010Hung","family":"Hung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,7,22]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2005.10.013"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01320309"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2005.05.009"},{"key":"e_1_2_7_5_2","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1038\/ajg.2009.191","article-title":"Members of Veterans Affairs Hepatitis C Resource Center Program. 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