{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T19:44:46Z","timestamp":1791143086543,"version":"4.1.0"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,12,16]],"date-time":"2014-12-16T00:00:00Z","timestamp":1418688000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2014,12,16]],"date-time":"2014-12-16T00:00:00Z","timestamp":1418688000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2014,12,16]],"date-time":"2014-12-16T00:00:00Z","timestamp":1418688000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,2,1]],"date-time":"2016-02-01T00:00:00Z","timestamp":1454284800000},"content-version":"vor","delay-in-days":412,"URL":"https:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"name":"National Nature Science Foundation of the People's Republic of China","award":["30760072"],"award-info":[{"award-number":["30760072"]}]}],"content-domain":{"domain":["kjms-online.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Kaohsiung J of Med Scie"],"published-print":{"date-parts":[[2015,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Emerging evidence suggests that activation of the Notch1 signaling pathway inducing epithelial to mesenchymal transition (EMT) mediated by Snail\/Slug promotes invasion and metastasis of breast cancer cells\n                      <jats:italic>in\u2009vitro<\/jats:italic>\n                      . However, the implication of the Notch1\u2010Snail\/Slug\u2010EMT axis in breast cancer patients remains unclear. A total of 200 formalin\u2010fixed paraffin\u2010embedded samples of invasive ductal carcinoma (IDC), and 37 adjacent non\u2010neoplastic tissue (ANNT) samples from patients who had not been treated with neoadjuvant therapy were examined. Expression of Notch1, Slug, Snail, E\u2010cadherin, N\u2010cadherin, and vimentin was determined by immunohistochemistry on tissue microarrays (TMAs). The correlation between protein expression and clinicopathological characteristics of breast cancer patients was also evaluated. Results showed that a significantly high percentage of cases with high expression of Notch1 (74%, 148\/200), Slug (36%, 72\/200), Snail (62%, 124\/200), and N\u2010cadherin (77%, 153\/200) and a low percentage of cases with high expression of E\u2010cadherin (27%, 54\/200) were observed in IDC compared to those in ANNTs. High Notch1, Slug, Snail, and N\u2010cadherin expression and low E\u2010cadherin expression in patients with IDC were significantly correlated with lymph node metastasis. In addition, correlation analysis results revealed that high Notch1 expression was significantly associated with high Slug, Snail, and N\u2010cadherin expression and low E\u2010cadherin expression in IDC. Furthermore, a high Snail expression was significantly associated with low E\u2010cadherin expression, and a high Slug expression was found to be significantly associated with increased N\u2010cadherin expression in patients with IDC. Hence, our study suggested that the Notch1\u2010Snail\/Slug\u2010EMT axis may be implicated in the lymph node metastasis affecting patients with IDC.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.kjms.2014.11.008","type":"journal-article","created":{"date-parts":[[2014,12,16]],"date-time":"2014-12-16T08:49:34Z","timestamp":1418719774000},"page":"70-76","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":27,"title":["Implications of the Notch1\u2010Snail\/Slug\u2010epithelial to mesenchymal transition axis for lymph node metastasis in infiltrating ductal carcinoma"],"prefix":"10.1002","volume":"31","author":[{"given":"Yu\u2010Wen","family":"Cao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guo\u2010Xing","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian\u2010Ping","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Bin","family":"Cui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian\u2010Ming","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei\u2010Hua","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu\u2010Qin","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Qin","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,12,16]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2003.10.006"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2012.01.021"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2131"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1186\/1479-5876-10-226"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI38019"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1245\/ASO.2005.04.010"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2005.07.009"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2009.11.007"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1745-7270.2008.00443.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm754"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1101\/gad.276304"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20071082"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10585-011-9412-x"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6605486"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s12032-012-0260-6"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2407-9-325"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1177\/1066896911427035"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1743-7563.2011.01433.x"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.biocel.2010.03.016"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1210\/me.2007-0512"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-2926"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.2254"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1186\/bcr578"},{"key":"e_1_2_6_25_2","first-page":"2389","article-title":"Expression 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