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Such properties suggest that they might have an impact on chronic inflammatory airway diseases, including nasal polyposis. The aim of this study was to understand the role of vitamin D in chronic rhinosinusitis with nasal polyps (CRSwNP) by investigating its effect on the secretion of matrix metalloproteinase\u20102 (MMP\u20102) and MMP\u20109 in nasal polyp\u2010derived fibroblasts. Two primary fibroblast cultures were established from nasal polyp tissues obtained during surgery. The nasal polyp\u2010derived fibroblasts were stimulated with tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1; 10\u2009ng\/mL) for 24 hours, followed by replacement with media alone or with vitamin D derivatives (calcitriol or tacalcitol; 10\u03bcM) and incubated for another 24 hours. After the treatments, the levels of MMP\u20102 and MMP\u20109 secreted were evaluated by both enzyme\u2010linked immunosorbent assay (ELISA) and Western blot analysis. ELISA results revealed that TNF\u2010\u03b1 could substantially stimulate the secretion of MMP\u20102 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.01) and MMP\u20109 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) in nasal polyp\u2010derived fibroblasts. More importantly, such stimulatory effect was significantly suppressed by adding calcitriol (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009\u2264\u20090.01 for MMP\u20102 and\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001 for MMP\u20109) or tacalcitol (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.005 for both MMP\u20102 and MMP\u20109). The ELISA results were also confirmed by Western blot analysis. The inhibitory effect of vitamin D derivatives on MMP\u20102 and MMP\u20109 secretion could potentiate their application in pharmacotherapy of Taiwanese CRSwNP patients.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.kjms.2015.02.001","type":"journal-article","created":{"date-parts":[[2015,3,6]],"date-time":"2015-03-06T08:51:20Z","timestamp":1425631880000},"page":"235-240","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"title":["Vitamin D decreases the secretion of matrix metalloproteinase\u20102 and matrix metalloproteinase\u20109 in fibroblasts derived from Taiwanese patients with chronic rhinosinusitis with nasal polyposis"],"prefix":"10.1002","volume":"31","author":[{"given":"Ling\u2010Feng","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih\u2010Feng","family":"Tai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen\u2010Yu","family":"Chien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng\u2010Yu","family":"Chiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeff Yi\u2010Fu","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,3,6]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1472-9725.2003.00061.x"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2005.02403.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1067\/mai.2001.119024"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2003.01828.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1164\/ajrccm.159.4.9708080"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1165\/ajrcmb.16.3.9070604"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-6749(98)70018-1"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2006.01255.x"},{"key":"e_1_2_6_10_2","doi-asserted-by":"crossref","first-page":"e69","DOI":"10.2500\/ajra.2013.27.3908","article-title":"Differential expression of remodeling markers by tissue structure in nasal polyposis","volume":"27","author":"Borja Callejas F.","year":"2013","journal-title":"Am J Rhinol Allergy"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2012.26.3724"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2010.03.008"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/85.3.853"},{"key":"e_1_2_6_14_2","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1007\/s11882-010-0144-9","article-title":"Vitamin D insufficiency and risk of severe asthma exacerbations","volume":"10","author":"Ciaccio C.E.","year":"2010","journal-title":"Curr Allergy Asthma Rep"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2009.12.033"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200808-1361OC"},{"key":"e_1_2_6_17_2","doi-asserted-by":"crossref","first-page":"370","DOI":"10.2500\/aap.2013.34.3656","article-title":"Serum 25\u2010hydroxyvitamin D concentrations and waning pneumococcal antibody titers among individuals with atopy","volume":"34","author":"Ryoo E.","year":"2013","journal-title":"Allergy Asthma Proc"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2009.03234.x"},{"key":"e_1_2_6_19_2","doi-asserted-by":"crossref","first-page":"235","DOI":"10.18388\/abp.2009_2454","article-title":"Influence of vitamin D3 analogues in combination with budesonid R on proliferation of nasal polyp fibroblasts","volume":"56","author":"Rostkowska\u2010Nadolska B.","year":"2009","journal-title":"Acta Biochim Pol"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0701988"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.22004"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/alr.21274"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1177\/0194599812448852"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2013.27.3948"},{"key":"e_1_2_6_25_2","first-page":"97","article-title":"European Position Paper on Rhinosinusitis and Nasal Polyps Group. 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A summary for otorhinolaryngologists","volume":"45","author":"Fokkens W.","year":"2007","journal-title":"Rhinology"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1159\/000107673"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1433"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.2478\/v10039-010-0012-9"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.10.7312"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.10289"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni773"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.03-1412fje"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1177\/0194599813513880"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1097\/MLG.0b013e318159cc0b"}],"container-title":["The Kaohsiung Journal of Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1607551X1500039X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1607551X1500039X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.kjms.2015.02.001","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.kjms.2015.02.001","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.kjms.2015.02.001","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T11:10:41Z","timestamp":1772968241000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1016\/j.kjms.2015.02.001"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,3,6]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2015,5]]}},"alternative-id":["10.1016\/j.kjms.2015.02.001"],"URL":"https:\/\/doi.org\/10.1016\/j.kjms.2015.02.001","archive":["Portico"],"relation":{},"ISSN":["1607-551X","2410-8650"],"issn-type":[{"value":"1607-551X","type":"print"},{"value":"2410-8650","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,3,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Vitamin D decreases the secretion of matrix metalloproteinase-2 and matrix metalloproteinase-9 in fibroblasts derived from Taiwanese patients with chronic rhinosinusitis with nasal polyposis","name":"articletitle","label":"Article Title"},{"value":"The Kaohsiung Journal of Medical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.kjms.2015.02.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}