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The purpose of this study was to evaluate the effects of transcatheter renal sympathetic denervation (RSD) on the development of pulmonary arterial hypertension and cardiac dysfunction in dogs using two\u2010dimensional speckle tracking imaging. Twenty\u2010two dogs were randomly divided into three groups: control group (<jats:italic>n<\/jats:italic>\u2009=\u20097), PAH group (<jats:italic>n<\/jats:italic>\u2009=\u20098), and PAH\u2009+\u2009RSD group (<jats:italic>n<\/jats:italic>\u2009=\u20097). All dogs were assessed using two\u2010dimensional speckle tracking imaging. The ventricular strain, ventricular synchrony, left ventricular (LV) twist, and torsion rate were analyzed to evaluate cardiac function. After 8 weeks, the right ventricular lateral longitudinal strain and the septum longitudinal strain were reduced in the PAH group compared with the control group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). However, these values were significantly restored in the PAH\u2009+\u2009RSD group compared with the PAH group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). The degree of LV and RV dyssynchrony was significantly higher in the PAH group compared with the control group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), but the degree of LV and RV dyssynchrony was significantly lower in the PAH\u2009+\u2009RSD group compared to the PAH group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). The LV twist was significantly restored in the PAH\u2009+\u2009RSD group compared to the PAH group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). Similarly, the rotation rate was markedly decreased in the PAH group, and strikingly improved in the PAH\u2009+\u2009RSD group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01). These results indicate that RSD prevents the development of PAH and cardiac dysfunction in dogs.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.kjms.2015.05.006","type":"journal-article","created":{"date-parts":[[2015,7,4]],"date-time":"2015-07-04T19:01:32Z","timestamp":1436036492000},"page":"405-412","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Renal sympathetic denervation prevents the development of pulmonary arterial hypertension and cardiac dysfunction in 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