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In this study, our aim was to demonstrate possible early glaucomatous alterations in young first\u2010 and second\u2010degree relatives of POAG patients by spectral\u2010domain optical coherence tomography. A total of 104 participants (52 relatives of POAG patients and 52 healthy individuals) were recruited in this cross\u2010sectional study. All the participants were between 17 years and 45 years of age. All eyes underwent testing with spectral\u2010domain optical coherence tomography. Peripapillary retinal nerve fiber layer thickness, hemifield macular thickness, macular ganglion cell complex thickness, posterior pole asymmetry analysis, and retinal arteriolar caliber measurements were taken for comparison between the study and control groups. The mean peripapillary retinal nerve fiber layer thickness was 104.9\u2009\u00b1\u20098.8\u2009\u03bcm in the study group and 105.6\u2009\u00b1\u20097.4\u2009\u03bcm in the control group (<jats:italic>p<\/jats:italic>\u2009=\u20090.68). Although whole macular thickness measurements were higher in the control group when compared with the study group (<jats:italic>p<\/jats:italic>\u2009=\u20090.008), the macular ganglion cell complex thickness was similar in both groups (<jats:italic>p<\/jats:italic>\u2009=\u20090.87). The posterior pole asymmetry analysis revealed no statistically significant difference between the groups in the aspect of consecutive black squares (<jats:italic>p<\/jats:italic>\u2009=\u20090.79). The mean retinal arteriolar caliber was 85.9\u2009\u00b1\u20094.8\u2009\u03bcm in the study group and 86.0\u2009\u00b1\u20095.0\u2009\u03bcm in the control group (<jats:italic>p<\/jats:italic>\u2009=\u20090.90). In conclusion, young relatives of POAG patients do not show characteristic glaucomatous damage when compared with the controls.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.kjms.2015.06.001","type":"journal-article","created":{"date-parts":[[2015,7,2]],"date-time":"2015-07-02T19:29:30Z","timestamp":1435865370000},"page":"420-425","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Posterior pole asymmetry analysis and retinal thickness measurements in young relatives of glaucoma 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