{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:44:13Z","timestamp":1772988253890,"version":"3.50.1"},"reference-count":13,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2015,8,21]],"date-time":"2015-08-21T00:00:00Z","timestamp":1440115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2015,8,21]],"date-time":"2015-08-21T00:00:00Z","timestamp":1440115200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2015,8,21]],"date-time":"2015-08-21T00:00:00Z","timestamp":1440115200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100007729","name":"Ministerie van Buitenlandse Zaken","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007729","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["kjms-online.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Kaohsiung J of Med Scie"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Human immunodeficiency virus (HIV)\u20101 epidemics in Asian countries are driven by varying exposures. The epidemiology of the regional pandemic has been changing with the spread of HIV\u20101 to lower\u2010risk populations through sexual transmission. Common HIV\u20101 genotypes include subtype B and circulating recombinant form (CRF) 01_AE. Our objective was to use HIV\u20101 genotypic data to better quantify local epidemics. TASER\u2010M is a multicenter prospective cohort of HIV\u2010infected patients. Associations between HIV exposure, patient sex, country of sample origin and HIV\u20101 genotype were evaluated by multivariate logistic regression. Phylogenetic methods were used on genotypic data to investigate transmission relationships. A total of 1086 patients from Thailand, Hong Kong, Malaysia and the Philippines were included in analyses. Proportions of male patients within countries varied (Thailand: 55.6%, Hong Kong: 86.1%, Malaysia: 81.4%, Philippines: 93.8%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) as did HIV exposures (heterosexual contact: Thailand: 85.7%, Hong Kong, 46.2%, Malaysia: 47.8%, Philippines: 25.0%;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). After adjustment, we found increased subtype B infection among men who have sex with men, relative to heterosexual\u2010reported exposures (odds ratio\u2009=\u20092.4,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001). We further describe four transmission clusters of eight to 15 treatment na\u00efve, predominantly symptomatic patients (two each for subtype B and CRF01_AE). Risk\u2010group subpopulations differed with respect to the infecting HIV\u20101 genotype. Homosexual exposure patients had higher odds of being infected with subtype B. Where HIV\u20101 genotypes circulate within countries or patient risk\u2010groups, local monitoring of genotype\u2010specific transmissions may play a role in focusing public health prevention strategies. Phylogenetic evaluations provide complementary information for surveillance and monitoring of viruses with high mutation rates such as HIV\u20101 and Ebola.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.kjms.2015.07.002","type":"journal-article","created":{"date-parts":[[2015,8,21]],"date-time":"2015-08-21T14:00:53Z","timestamp":1440165653000},"page":"445-453","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Risk group characteristics and viral transmission clusters in South\u2010East Asian patients infected with human immunodeficiency virus\u20101 (HIV\u20101) circulating recombinant form (CRF) 01_AE and subtype B"],"prefix":"10.1002","volume":"31","author":[{"given":"Rebecca 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C.K.","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pacharee","family":"Kantipong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Praphan","family":"Phanuphak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris K.C.","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adeeba","family":"Kamarulzaman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rossana","family":"Ditangco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Szu\u2010Wei","family":"Huang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annette 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