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Sanyuansan is a compound recipe composed of ginseng total saponins,\u2009fish oil, and valeriana. The aims of this study were to validate whether Sanyuansan has antidepressant\u2010like effects through acute behavioral tests including the forced swimming test (FST), tail suspension test (TST), locomotor activity test, and chronic mild stress (CMS) mice model of depression. C57BL\/6 mice were given oral administration of 30\u2009mg\/kg imipramine, Sanyuansan, and saline, respectively. The acute behavioral tests including the TST, FST, and locomotor activity test were done after the administration of drugs for consecutively three times (24 hours, 1 hour, and 0.5 hour prior to the tests). Furthermore, the sucrose\u2009preference and the serum corticosterone level of mice in the CMS model were examined. Sanyuansan only at 900\u2009mg\/kg markedly reduced immobility time in the TST compared with the saline\u2010treated group of mice. Sanyuansan at doses of 225\u2009mg\/kg, 450\u2009mg\/kg, and 900\u2009mg\/kg significantly reduced immobility time of mice in the FST. Sanyuansan reversed the CMS\u2010induced anhedonia and hyperactivation of the hypothalamus\u2013pituitary\u2013adrenal axis. In addition, our results showed that neither imipramine nor Sanyuansan at any dosage increased spontaneous motor activity. These results suggested that Sanyuansan induced significant antidepressant\u2010like effects in mice in both acute and chronic animal models, which seemed unlikely to be attributed to an increase in locomotor activities of mice, and had no sedative\u2010like effects.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.kjms.2015.10.009","type":"journal-article","created":{"date-parts":[[2015,11,27]],"date-time":"2015-11-27T14:16:02Z","timestamp":1448633762000},"page":"605-612","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":23,"title":["Antidepressant\u2010like effects of Sanyuansan in the mouse forced swim test, tail suspension test, and chronic mild stress 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