{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,9]],"date-time":"2026-06-09T12:06:00Z","timestamp":1781006760308,"version":"3.54.1"},"reference-count":22,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,1,16]],"date-time":"2016-01-16T00:00:00Z","timestamp":1452902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2016,1,16]],"date-time":"2016-01-16T00:00:00Z","timestamp":1452902400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,1,2]],"date-time":"2016-01-02T00:00:00Z","timestamp":1451692800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["kjms-online.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Kaohsiung J of Med Scie"],"published-print":{"date-parts":[[2016,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Angiogenesis is an important factor in the development and progression of prostate cancer (PCA). We aimed to investigate the values of vascular\u2010endothelial\u2010growth\u2010factor (VEGF) expression level and microvessel density (MVD) in the prediction of PCA diagnosis at repeated prostate biopsy (re\u2010PBx). We retrospectively evaluated 167 patients with re\u2010PBx according to elevated prostate\u2010specific antigen levels, suspicious digital rectal examination, and the presence of premalignant lesions. Patients with PCA on re\u2010PBx were included in the cancer group (<jats:italic>n<\/jats:italic>\u2009=\u200917). Patients with benign prostatic hyperplasia or normal tissues on re\u2010PBx were included in the control group (<jats:italic>n<\/jats:italic>\u2009=\u200921). The groups were compared according to the expression level of VEGF and MVD in initial prostate biopsy. There was no statistically significant difference between groups according to age and serum prostate\u2010specific\u2010antigen values. The mean VEGF scores of the cancer and control groups were 232.64\u2009\u00b1\u200911.14 and 183.09\u2009\u00b1\u200914.56, respectively (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). The mean MVD of the biopsy samples in the cancer and control groups were 246.47\u2009\u00b1\u200917.59\u2009<jats:italic>n<\/jats:italic>\/mm<jats:sup>2<\/jats:sup> and 197.33\u2009\u00b1\u200916.26\u2009<jats:italic>n<\/jats:italic>\/mm<jats:sup>2<\/jats:sup>, respectively (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). The cutoff values of VEGF scores and MVD were set as 200 and 215, respectively, for PCA detection in our study. Our results showed that the expression level of VEGF and MVD significantly increased in the initial prostate\u2010biopsy samples of patients with PCA diagnosed with re\u2010PBx. The evaluation of VEGF expression level and MVD might have an important value in the prediction of PCA at re\u2010PBx. The expression level of VEGF and MVD should be kept in mind as PCA\u2010related histopathological changes that indicate the increased angiogenesis in prostatic tissue.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.kjms.2015.12.001","type":"journal-article","created":{"date-parts":[[2016,1,16]],"date-time":"2016-01-16T14:01:12Z","timestamp":1452952872000},"page":"74-79","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Predictive values of vascular endothelial growth factor and microvessel\u2010density levels in initial biopsy for prostate 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Zeynep","family":"Coskun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hakan","family":"Ozkardes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2016,1,16]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0959-8049(01)00350-1"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2010.11.063"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.06.081"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1206813"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2005.05.016"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-006-9144-z"},{"key":"e_1_2_5_8_2","first-page":"857","article-title":"Study of microvessel density and the expression of the angiogenic factors VEGF, bFGF and the 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