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We defined a retrospective cohort of 394 progressive tubal ectopic pregnancy patients treated with methotrexate. A single\u2010dose methotrexate protocol using 50\u2009mg\/m<jats:sup>2<\/jats:sup> was administered to patients with progressive tubal ectopic pregnancy. Surgery was performed in patients who exhibited signs of acute abdomen due to tubal rupture. Of 394 patients that received methotrexate treatment, 335 (84.6%) responded to medical treatment, while the remaining 59 (15.36%) underwent surgery due to treatment failure. \u03b2\u2010hCG levels in the failure group were significantly higher as compared with the success group at Day 1, Day 4, and Day 7 (2116 \u00b1 3157 vs. 4178 \u00b1 3422, 2062 \u00b1 3551 vs. 4935 \u00b1 4103, and 1532 \u00b1 3007 vs. 3900 \u00b1 4783, respectively). The receiver operating characteristics curve for \u03b2\u2010hCG levels at Day 1 was 0.738, with a cutoff value of 1418\u2009mIU\/mL, while sensitivity and specificity values reached the optimum for treatment success (83.1% and 59.4%, respectively). Medical treatment with methotrexate achieved an 85.02% success rate for the treatment of progressive tubal ectopic pregnancy, while success rates for medical treatment decreased significantly when initial \u03b2\u2010hCG levels were &gt;1418\u2009mIU\/mL.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.kjms.2016.05.004","type":"journal-article","created":{"date-parts":[[2016,5,31]],"date-time":"2016-05-31T16:52:01Z","timestamp":1464713521000},"page":"317-322","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["Methotrexate treatment in progressive tubal ectopic pregnancies and hCG\u2010related clinicosurgical 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