{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T13:22:40Z","timestamp":1789132960328,"version":"build-2803163510"},"reference-count":30,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2016,7,25]],"date-time":"2016-07-25T00:00:00Z","timestamp":1469404800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2016,7,25]],"date-time":"2016-07-25T00:00:00Z","timestamp":1469404800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2016,7,2]],"date-time":"2016-07-02T00:00:00Z","timestamp":1467417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["kjms-online.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Kaohsiung J of Med Scie"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:label\/><jats:p>Hashimoto's thyroiditis (HT) is the most common endocrine disorder leading to hypothyroidism. HT is characterized by the presence of elevated circulating antibodies, especially anti\u2010thyroid peroxidase (anti\u2010TPO) and anti\u2010thyroglobulin (anti\u2010Tg). In our study, we aimed to reveal the effects of autoimmunity on health\u2010related quality of life of euthyroid HT patients. Patients who were admitted to the Adnan Menderes University Outpatient Clinic were enrolled. The medical records of the patients were surveyed and their demographical data were collected. By using communication data, the patients were invited to our clinic, to inform them about our study and to fill out the health\u2010related quality of life questionnaire. A total of 84 euthyroid HT patients older than 18\u2009years who completed the short form\u201036 questionnaire, were enrolled. As all patients were euthyroid, there was a significant negative correlation between each domain score and the antibody levels, individually. Patients who had higher anti\u2010TPO and anti\u2010Tg levels had significantly lower quality of life domain scores (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). There was statistically no significant correlation between the antibody levels and thyroid function tests (<jats:italic>p<\/jats:italic>\u2009&gt;\u20090.05). Additionally, all dimension scores were significantly higher both in the anti\u2010Tg and anti\u2010TPO negative groups, indicating a better quality of life than that in the antibody positive groups. Our study revealed that higher thyroid antibody levels were negatively correlated with life quality scores. Thus, patients who had higher anti\u2010TPO and anti\u2010Tg levels had significantly lower quality of life domain scores. We believe that apart from hypothyroidism, a high antibody level was one of the contributing factors for the development of HT\u2010associated symptoms, leading to a lower quality of life. Other probable contributing factors such as selenium deficiency, thyroid hormone fluctuation, and disease awareness should keep in mind.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.kjms.2016.06.006","type":"journal-article","created":{"date-parts":[[2016,7,27]],"date-time":"2016-07-27T05:28:46Z","timestamp":1469597326000},"page":"427-433","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"title":["Autoimmunity affects health\u2010related quality of\u2009life in patients with Hashimoto's thyroiditis"],"prefix":"10.1002","volume":"32","author":[{"given":"Hilal","family":"Bektas 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