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Male C57BL\/6 mice weighing 22\u201330\u2009g and aged 8\u201310\u2009weeks were randomly assigned to three groups: Sham group, CLP group, or CLP plus ORI group. In the CLP group and ORI group, CLP was induced, and intraperitoneal injection of normal saline and oridonin (100\u2009\u03bcg\/kg) was conducted, respectively. The survival rate was determined within the following 7\u2009days. The blood, liver, and lung were collected at 24\u2009hours after injury. Hematoxylin\u2013eosin staining of the lung, detection of lung wet\u2010to\u2010dry ratio, and serum cytokines (tumor necrosis factor [TNF]\u2010\u03b1 and interleukin [IL]\u20106), and examination of intraperitoneal and blood bacterial clearance were conducted to evaluate the therapeutic efficacy. Results showed that ORI treatment significantly reduced the lung wet\u2010to\u2010dry ratio, decreased serum TNF\u2010\u03b1 and IL\u20106, and improved liver pathology compared with the CLP group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Moreover, the intraperitoneal and blood bacterial clearance increased markedly after ORI treatment (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). The 7\u2010day survival rate in the ORI group was also dramatically higher than in the CLP group (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). Our findings indicate that ORI can attenuate liver and lung injuries and elevate bacterial clearance to increase the survival rate of sepsis mice.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.kjms.2016.07.013","type":"journal-article","created":{"date-parts":[[2016,8,31]],"date-time":"2016-08-31T05:19:21Z","timestamp":1472620761000},"page":"452-457","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":20,"title":["Protective effects of oridonin on the sepsis 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