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The aim of this study is to assess the relevance of serum pentraxin 3 (PTX3) and interleukin\u20106 (IL\u20106) concentrations in PD. The study enrolled 40 patients with PD in the acute phase and 40 healthy controls. Plasma PTX3 and IL\u20106 concentrations were evaluated in 40 patients in the acute phase of PD and 40 healthy controls by enzyme\u2010linked immunosorbent assay. Serum concentrations of both PTX3 and IL\u20106 were significantly higher in the PD patients than in the control group (<jats:italic>p<\/jats:italic> = 0.001 and <jats:italic>p<\/jats:italic> = 0.001, respectively). There was a significant correlation between concentration of PTX3 and painful erections. IL\u20106 concentrations were significantly higher in patients with erectile dysfunction. IL\u20106 and PTX3 levels showed no correlation with age, serum C\u2010reactive protein, degree of curvature, and disease duration. IL\u20106 trans\u2010signaling and PTX3 amplification at the site of inflammation could have a role in pathophysiological mechanisms of PD. Biological drugs may be used for treatment during the acute phase of the disease based on this mechanism.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.kjms.2017.01.007","type":"journal-article","created":{"date-parts":[[2017,3,1]],"date-time":"2017-03-01T03:16:37Z","timestamp":1488338197000},"page":"195-200","update-policy":"http:\/\/dx.doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Role of interleukin\u20106 and pentraxin 3 as an early marker in Peyronie's 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