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However, the underlying molecular mechanisms of NPC radioresistance remain poorly understood. The present study aimed to investigate the potential role and mechanism of miR\u2010206 in NPC radioresistance. We observed that miR\u2010206 was down\u2010regulated in radioresistant NPC cells. Furthermore, restoration of miR\u2010206 in CNE2\u2010IR cells suppressed enhanced radiosensitivity of NPC cells. In contrast, inhibition of miR\u2010206 in CNE2 cells reduced the radiosensitivity. We also found that miR\u2010206 directly targeted IGF1 and inhibited the PI3K\/AKT pathway. Our data demonstrate that miR\u2010206 sensitizes NPC cell to irradiation by targeting IGF1, highlighting the therapeutic potential of miR\u2010206 in NPC radiosensitization.<\/jats:p><\/jats:sec>","DOI":"10.1016\/j.kjms.2017.05.015","type":"journal-article","created":{"date-parts":[[2017,7,10]],"date-time":"2017-07-10T03:30:16Z","timestamp":1499657416000},"page":"427-432","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":25,"title":["miR\u2010206 enhances nasopharyngeal carcinoma radiosensitivity by targeting 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