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So, this study was aimed to investigate the rate of aminoglycoside resistance and the frequency of aminoglycoside resistance mediated genes of\n                      <jats:italic>aac(Ia)\u20102<\/jats:italic>\n                      ,\n                      <jats:italic>aph(3)\u2010IIIa<\/jats:italic>\n                      and\n                      <jats:italic>ant(4\u2032)\u2010Ia<\/jats:italic>\n                      among MRSA strains. A total of 467 staphylococci isolates were collected from various clinical samples.\n                      <jats:italic>S. aureus<\/jats:italic>\n                      strains were identified by standard culture and identification criteria and investigating of presence of\n                      <jats:italic>16S rRNA<\/jats:italic>\n                      and\n                      <jats:italic>nuc<\/jats:italic>\n                      genes. Cefoxitin disk diffusion, and oxacillin\u2010salt agar screening methods were used to detect the MRSA strains with subsequent molecular identification for the presence of\n                      <jats:italic>mecA<\/jats:italic>\n                      gene. Antibiotic susceptibility of MRSA strains against aminoglycoside antibiotics was evaluated by using agar disk diffusion method. Multiplex PCR for the presence of\n                      <jats:italic>aac(Ia)\u20102<\/jats:italic>\n                      ,\n                      <jats:italic>aph(3)\u2010IIIa<\/jats:italic>\n                      and\n                      <jats:italic>ant(4\u2032)\u2010Ia<\/jats:italic>\n                      encoding genes for aminoglycosides were performed for MRSA strains. From total staphylococci tested isolates, 262 (56.1%) were identified as\n                      <jats:italic>S. aureus<\/jats:italic>\n                      , of which 161 (61.45%) were detected as MRSA and all comprised\n                      <jats:italic>mecA<\/jats:italic>\n                      gene. The resistance pattern of MRSA strains to aminoglycoside antibiotics were: gentamicin 136 (84.5%); amikacin 125 (77.6%); kanamycin 139 (86.3%); tobramycin 132 (82%); and neomycin 155 (96.3%). The frequency of\n                      <jats:italic>aac(Ia)\u20102<\/jats:italic>\n                      ,\n                      <jats:italic>aph(3)\u2010IIIa<\/jats:italic>\n                      , and\n                      <jats:italic>ant(4\u2032)\u2010Ia<\/jats:italic>\n                      genes among MRSA strains, were 64%, 42% and 11.8% respectively. In conclusion, as MRSA strains are of great concern in human infections, the results of present study could provide a useful resource for health sectors for choosing appropriate antibiotics for the effective treatment of infections due to MRSA strains.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.kjms.2017.08.001","type":"journal-article","created":{"date-parts":[[2017,8,26]],"date-time":"2017-08-26T09:00:28Z","timestamp":1503738028000},"page":"587-593","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":61,"title":["Distribution of genes encoding resistance to aminoglycoside modifying enzymes in methicillin\u2010resistant\n                    <i>Staphylococcus aureus<\/i>\n                    (MRSA) strains"],"prefix":"10.1002","volume":"33","author":[{"given":"Azar 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