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Six\u2010week\u2010old Sprague\u2013Dawley rats were randomly divided into three groups: (1) RD group, normal rats fed a regular diet (RD), (2) DM group, T2DM rats fed a high\u2010fat diet, and (3) Eu\u2010A group, T2DM rats fed a high fat diet plus oral Eu\u2010A (5\u2009mg\/kg\/day). After 30 days, the DM group had higher body weight, higher blood glucose and lower insulin levels than the RD group. The DM group also had increased protein expression of glycogen synthase kinase (GSK) in liver and skeletal muscle and decreased protein expression of insulin receptor (IR), insulin receptor substrate\u20101 (IRS\u20101), IRS\u20102, AMP\u2010activated protein kinase (AMPK), glucose transporter\u20104 (GLUT\u20104), glucokinase (GCK), and peroxisome proliferator\u2010activated receptor \u03b3 (PPAR\u2010\u03b3). STZ\/nicotinamide\u2010induced T2DM increased the expression of mitogen\u2010activated protein kinases (MAPKs: p38, ERK, JNK) and inflammatory p65 protein. In the Eu\u2010A treated T2DM rats, however, blood glucose was attenuated and the insulin concentration stimulated. Changes in IR, IRS\u20101 and IRS\u20102 proteins as well as AMPK, GLUT\u20104, GCK, GSK, PPAR\u2010\u03b3, MAPKs, and inflammatory p65 proteins were ameliorated. These results suggested that Eu\u2010A alleviates STZ\/nicotinamide\u2010induced hyperglycemia by improving insulin levels and glucose metabolism, and inhibiting the MAPKs\u2010 and p65\u2010mediated inflammatory pathway.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.kjms.2017.11.003","type":"journal-article","created":{"date-parts":[[2017,11,29]],"date-time":"2017-11-29T12:15:36Z","timestamp":1511957736000},"page":"142-149","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["Eugenosedin\u2010A improves glucose metabolism and inhibits MAPKs expression in streptozotocin\/nicotinamide\u2010induced diabetic 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