{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:55:54Z","timestamp":1772988954521,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,12,6]],"date-time":"2017-12-06T00:00:00Z","timestamp":1512518400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2017,12,6]],"date-time":"2017-12-06T00:00:00Z","timestamp":1512518400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2017,12,6]],"date-time":"2017-12-06T00:00:00Z","timestamp":1512518400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2017,11,10]],"date-time":"2017-11-10T00:00:00Z","timestamp":1510272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan, R.O.C.","doi-asserted-by":"crossref","award":["105-2320-B-037-006-MY2"],"award-info":[{"award-number":["105-2320-B-037-006-MY2"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["kjms-online.com","clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Kaohsiung J of Med Scie"],"published-print":{"date-parts":[[2018,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      <jats:italic>Artemisia capillaris (A. capillaris)<\/jats:italic>\n                      is a common herbal drug used for thousands years in ancient China.\n                      <jats:italic>A. capillaris<\/jats:italic>\n                      has been empirically used to manage hand\u2010foot\u2010mouth disease (HFMD), which is commonly caused by enterovirus 71 (EV71). EV71 can cause meningoencephalitis with mortality and neurologic sequelae without effective management. It is presently unknown whether\n                      <jats:italic>A. capillaris<\/jats:italic>\n                      is effective against EV71 infection. To test the hypothesis that it could protect cells from EV71\u2010induced injury, a hot water extract of\n                      <jats:italic>A. capillaris<\/jats:italic>\n                      was tested in human foreskin fibroblast cells (CCFS\u20101\/KMC) and human rhabdomyosarcoma cells (RD cells) by plaque reduction assay and flow cytometry. Inhibition of viral replication was examined by reverse quantitative RT\u2010PCR (qRT\u2010PCR). Its effect on translations of viral proteins (VP0, VP1, VP2, protease 2B and 3AB), and apoptotic proteins were examined by western blot.\n                      <jats:italic>A. capillaris<\/jats:italic>\n                      was dose\u2010dependently effective against EV71 infection in both CCFS\u20101\/KMC cells and RD cells by inhibiting viral internalization. However,\n                      <jats:italic>A. capillaris<\/jats:italic>\n                      was minimally effective on viral attachment, VP2 translation, and inhibition of virus\u2010induced apoptosis. Further isolation of effective molecules is needed. In conclusion,\n                      <jats:italic>A. capillaris<\/jats:italic>\n                      has anti\u2010EV71 activity mainly by inhibiting viral internalization.\n                      <jats:italic>A. capillaris<\/jats:italic>\n                      would be better to manage EV71 infection in combination with other agents.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.kjms.2017.11.005","type":"journal-article","created":{"date-parts":[[2017,12,6]],"date-time":"2017-12-06T02:41:37Z","timestamp":1512528097000},"page":"150-159","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Artemisia capillaris inhibited enterovirus 71\u2010induced cell injury by preventing viral 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Jung","family":"Hsieh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lien\u2010Chai","family":"Chiang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung\u2010San","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,12,6]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"574","article-title":"A review of Chinese traditional prescriptions used in treatment and prevention of hand, foot and mouth disease","volume":"22","author":"Zhang G.L.","year":"2010","journal-title":"J Tradit Chin Med"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/srep45630"},{"key":"e_1_2_6_4_2","volume-title":"Harrison's principles of internal medicine","author":"Cohen 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