{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T16:43:41Z","timestamp":1772988221023,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2018,3,3]],"date-time":"2018-03-03T00:00:00Z","timestamp":1520035200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2018,3,3]],"date-time":"2018-03-03T00:00:00Z","timestamp":1520035200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"},{"start":{"date-parts":[[2018,3,3]],"date-time":"2018-03-03T00:00:00Z","timestamp":1520035200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2018,1,12]],"date-time":"2018-01-12T00:00:00Z","timestamp":1515715200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7122183"],"award-info":[{"award-number":["7122183"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7152146"],"award-info":[{"award-number":["7152146"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Peking University Health Science Center"},{"DOI":"10.13039\/501100007647","name":"National Taiwan University the College of Medicine","doi-asserted-by":"publisher","award":["BMU20120318"],"award-info":[{"award-number":["BMU20120318"]}],"id":[{"id":"10.13039\/501100007647","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing","doi-asserted-by":"publisher","award":["7122183"],"award-info":[{"award-number":["7122183"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing","doi-asserted-by":"publisher","award":["7152146"],"award-info":[{"award-number":["7152146"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"name":"clinical features research of\u00a0Capital","award":["Z151100004015173"],"award-info":[{"award-number":["Z151100004015173"]}]},{"name":"capital health research and development","award":["2016-1-4077"],"award-info":[{"award-number":["2016-1-4077"]}]},{"name":"Fund for Fostering Young Scholars of Peking University Health Science Center","award":["BMU2017PY009"],"award-info":[{"award-number":["BMU2017PY009"]}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Kaohsiung J of Med Scie"],"published-print":{"date-parts":[[2018,9]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:label\/>\n                    <jats:p>This paper is to elucidate the correlation between different symptoms of UTUC and the clinicopathological characteristics and prognosis. The clinicopathological data of 700 consecutive patients with UTUC who were treated with radical nephroureterectomy were reviewed, and symptoms were categorized into three groups: S1\u2010no direct symptoms, S2\u2010local symptoms (including hematuria and flank pain) and S3\u2010systemic symptoms. We found that the distributions of patients in the S1, S2 and S3 groups were 96 (13.7%), 601 (85.9%) and 3 (0.4%), respectively, and most patients in S1 were incidentally found to have abnormal findings on ultrasound during regular health examination. Altogether, 534 patients (76.3%) presented with gross hematuria, and 111 (15.9%) presented with flank pain. Patients in S1 had a higher rate of hydronephrosis (p\u2009&lt;\u20090.001), ureteral tumors (p\u2009&lt;\u20090.001), worse pre\u2010operative renal function (p\u2009=\u20090.020) and lower tumor stage (p\u2009=\u20090.038). The presence of hematuria was significantly related with renal pelvic tumors (p\u2009&lt;\u20090.001), higher pre\u2010operative eGFR (p\u2009=\u20090.047), papillary tumor architecture (p\u2009=\u20090.005) and less hydronephrosis (p\u2009&lt;\u20090.001); and the presentation of flank pain was correlated with older age (p\u2009=\u20090.008), ureteral location (p\u2009&lt;\u20090.001), hydronephrosis (p\u2009&lt;\u20090.001), sessile architecture (p\u2009&lt;\u20090.001) and higher tumor grade (p\u2009=\u20090.003). The presence of hematuria or flank pain also failed to reach significance as an independent prognostic factor. In conclusion, asymptomatic UTUC patients are featured for more hydronephrosis and lower tumor stage, while patients who presented with flank pain had a higher risk of sessile architecture and higher tumor grade. Regular health examinations might play a useful role in the early detection of UTUC patients with no symptoms.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.kjms.2018.01.003","type":"journal-article","created":{"date-parts":[[2018,3,2]],"date-time":"2018-03-02T19:42:21Z","timestamp":1520019741000},"page":"511-521","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["The significance of the initial symptom in Chinese patients with upper tract urothelial carcinoma: Regular health examination is still underutilized"],"prefix":"10.1002","volume":"34","author":[{"given":"Dong","family":"Fang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan\u2010Qing","family":"Gong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nirmish","family":"Singla","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun\u2010Lin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Geng\u2010Yan","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xue\u2010Song","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li\u2010Qun","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,3,3]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(05)67019-X"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.3322\/canjclin.48.1.6"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0094-0143(21)00144-0"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24135"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2012.32"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra051091"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0090-4295(98)00295-7"},{"key":"e_1_2_7_9_2","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0094-0143(21)00491-2","article-title":"Pathology and staging of urothelial tumors of the kidney and ureter","volume":"20","author":"Melamed M.R.","year":"1993","journal-title":"Urol Clin North Am"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2015.06.044"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2009.11.007"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0302-2838(03)00216-1"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2006040368"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.carj.2013.08.001"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.purol.2014.07.009"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2010.03.030"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2010.12.035"},{"key":"e_1_2_7_18_2","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1016\/j.urolonc.2011.07.011","article-title":"Multi\u2010institutional validation of the ability of preoperative hydronephrosis to predict advanced pathologic tumor stage in upper\u2010tract urothelial carcinoma","volume":"31","author":"Messer J.C.","year":"2011","journal-title":"Urol Oncol"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2008.10.023"},{"key":"e_1_2_7_20_2","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2015.3653"},{"key":"e_1_2_7_21_2","article-title":"Concurrent preoperative presence of hydronephrosis and flank pain independently predicts worse outcome of upper tract urothelial carcinoma","volume":"10","author":"Yeh H.C.","year":"2015","journal-title":"PLoS One"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11255-005-3151-3"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.24339"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jfma.2013.04.001"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/bju.12238"}],"container-title":["The Kaohsiung Journal of Medical Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1607551X17305879?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S1607551X17305879?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.kjms.2018.01.003","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1016\/j.kjms.2018.01.003","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1016\/j.kjms.2018.01.003","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T11:22:29Z","timestamp":1772968949000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1016\/j.kjms.2018.01.003"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,3]]},"references-count":24,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2018,9]]}},"alternative-id":["10.1016\/j.kjms.2018.01.003"],"URL":"https:\/\/doi.org\/10.1016\/j.kjms.2018.01.003","archive":["Portico"],"relation":{},"ISSN":["1607-551X","2410-8650"],"issn-type":[{"value":"1607-551X","type":"print"},{"value":"2410-8650","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The significance of the initial symptom in Chinese patients with upper tract urothelial carcinoma: Regular health examination is still underutilized","name":"articletitle","label":"Article Title"},{"value":"The Kaohsiung Journal of Medical Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.kjms.2018.01.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Kaohsiung Medical University. Published by Elsevier Taiwan LLC.","name":"copyright","label":"Copyright"}]}}