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Knowledge of the neurobiological mechanisms behind the deafferentation of stomatognathic systems has also expanded greatly in recent decades. In particular, current studies reveal that the peripheral deafferentations of stomatognathic systems may be projected globally into the central nervous system (CNS) and become an associated critical factor in triggering and aggravating neurodegenerative diseases.<\/jats:p>\n                    <jats:p>This review explores basic neurobiological mechanisms associated with the deafferentation of stomatognathic systems. Further included is a discussion on tooth loss and other dental deafferentation (DD) mechanisms, with a focus on dental and masticatory apparatuses associated with brain functions and which may underlie the changes observed in the aging brain. A new hypothesis is presented where DD and changes in the functionality of teeth and the masticatory apparatus may cause brain damage as a result of altered cerebral circulation and dysfunctional homeostasis. Furthermore, multiple recurrent reorganizations of the brain may be a triggering or contributing risk factor in the onset and progression of neurodegenerative conditions such as Alzheimer's disease (AD). A growing understanding of the association between DD and brain aging may lead to solutions in treating and preventing cognitive decline and neurodegenerative diseases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.kjms.2018.01.013","type":"journal-article","created":{"date-parts":[[2018,2,8]],"date-time":"2018-02-08T00:40:41Z","timestamp":1518050441000},"page":"231-237","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"title":["Dental deafferentation and brain damage: A\u2009review and a hypothesis"],"prefix":"10.1002","volume":"34","author":[{"given":"Yi\u2010Tai","family":"Jou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,2,8]]},"reference":[{"key":"e_1_2_16_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.20511"},{"key":"e_1_2_16_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.22261"},{"key":"e_1_2_16_4_2","doi-asserted-by":"publisher","DOI":"10.1177\/0022034515602478"},{"key":"e_1_2_16_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/cne.23793"},{"key":"e_1_2_16_6_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0759-12.2012"},{"key":"e_1_2_16_7_2","doi-asserted-by":"publisher","DOI":"10.1177\/1073858414531657"},{"key":"e_1_2_16_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1754-4505.2001.tb00242.x"},{"key":"e_1_2_16_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0722.2006.00401.x"},{"key":"e_1_2_16_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.archger.2011.05.022"},{"key":"e_1_2_16_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2014.07.018"},{"key":"e_1_2_16_12_2","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0097309"},{"key":"e_1_2_16_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1741-2358.2003.00003.x"},{"key":"e_1_2_16_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-051X.2009.01426.x"},{"key":"e_1_2_16_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2010.02788.x"},{"key":"e_1_2_16_16_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1532-5415.2012.04154.x"},{"key":"e_1_2_16_17_2","article-title":"Association 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