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A rat model of chronic unpredictable mild stress (CUMS) was established. In total, 48 rats were randomized into control (normal rats), CUMS (CUMS modeled rats) and CUMS\u2009+\u2009IGF\u20101 (injection of IGF\u20101 before CUMS modeling) groups. Body weight, horizontal (number of horizontal crossing) and vertical activity (rearing times), and sucrose consumption were identified one day before and after the open\u2010field test. The mRNA and protein expression of PI3K, Akt, FoxO3a and Bim in the hippocampus was measured by RT\u2010qPCR and Western blotting, respectively. Compared with the control group, a lower body weight, a decreased number of horizontal crossings, reduced rearing times and lower sucrose consumption were observed in the CUMS and CUMS\u2009+\u2009IGF\u20101 groups after the test. However, a higher body weight, number of horizontal crossings, rearing times and sucrose consumption were found in the CUMS\u2009+\u2009IGF\u20101 group than those in the CUMS group. Compared with the control group, mRNA and protein expression of PI3K, Akt and FoxO3a was decreased, and Bim mRNA and protein expression was increased in the CUMS\u2009+\u2009IGF\u20101 and CUMS groups. Meanwhile, in comparison to the CUMS group, mRNA and protein expression of PI3K, Akt and FoxO3a was elevated, and Bim mRNA and protein expression was reduced in the CUMS\u2009+\u2009IGF\u20101 group. The results suggested that IGF\u20101 exerted an antidepressant\u2010like effect on chronic\u2010stress induced depression through the PI3K\/Akt\/FoxO3a pathway.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1016\/j.kjms.2018.02.004","type":"journal-article","created":{"date-parts":[[2018,3,6]],"date-time":"2018-03-06T00:54:19Z","timestamp":1520297659000},"page":"370-376","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["IGF\u20101 defends against chronic\u2010stress induced depression in rat models of chronic unpredictable mild stress through the PI3K\/Akt\/FoxO3a 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