{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T20:30:42Z","timestamp":1789504242471,"version":"build-2803163510"},"reference-count":47,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thekneejournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Knee"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.knee.2019.12.007","type":"journal-article","created":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T01:14:49Z","timestamp":1578532489000},"page":"51-60","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":49,"title":["Osteoarthritis-related biomarkers profile in chronic anterior cruciate ligament injured knee"],"prefix":"10.1016","volume":"27","author":[{"given":"Berta","family":"Alonso","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Bravo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lidia","family":"Mediavilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arancha R.","family":"Gortazar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Forriol","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier","family":"Vaquero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Concepcion","family":"Guisasola","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.knee.2019.12.007_bb0005","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1093\/rheumatology\/ket346","article-title":"Defining and mapping the person with osteoarthritis for population studies and public health","volume":"53","author":"Thomas","year":"2014","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.knee.2019.12.007_bb0010","first-page":"81","article-title":"Inflammatory mediators in osteoarthritis: a critical review of the state-of-the-art, current prospects","volume":"85","author":"Rahmati","year":"2016","journal-title":"and future challenges Bone"},{"key":"10.1016\/j.knee.2019.12.007_bb0015","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.bone.2012.02.012","article-title":"The role of synovitis in osteoarthritis pathogenesis","volume":"51","author":"Scanzello","year":"2012","journal-title":"Bone"},{"key":"10.1016\/j.knee.2019.12.007_bb0020","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/bs.pmbts.2017.03.003","article-title":"Matrix metalloproteinases and synovial joint pathology","volume":"148","author":"Malemud","year":"2017","journal-title":"Prog Mol Biol Transl Sci"},{"issue":"45","key":"10.1016\/j.knee.2019.12.007_bb0025","article-title":"Innate immune responses and osteoarthritis","volume":"19","author":"Kalaitzoglou","year":"2017","journal-title":"Curr Rheumatol Rep"},{"key":"10.1016\/j.knee.2019.12.007_bb0030","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1080\/03008207.2016.1177036","article-title":"Recent advances in the understanding of molecular mechanisms of cartilage degeneration, synovitis and subchondral bone changes in osteoarthritis","volume":"57","author":"Wei","year":"2016","journal-title":"Connect Tissue Res"},{"key":"10.1016\/j.knee.2019.12.007_bb0035","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1007\/s12192-010-0201-2","article-title":"Extracellular heat shock protein 70 (HSPA1A) and classical vascular risk factors in a general population","volume":"15","author":"Dulin","year":"2010","journal-title":"Cell Stress Chaperones"},{"key":"10.1016\/j.knee.2019.12.007_bb0040","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1080\/02656730902902001","article-title":"Activation of natural killer cells by heat shock protein 70. 2002","volume":"25","author":"Multhoff","year":"2009","journal-title":"Int J Hyperthermia"},{"key":"10.1016\/j.knee.2019.12.007_bb0045","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1002\/jor.22208","article-title":"Acute and late changes in intraarticular cytokine levels following anterior cruciate ligament injury","volume":"31","author":"Bigoni","year":"2013","journal-title":"J Orthop Res"},{"key":"10.1016\/j.knee.2019.12.007_bb0050","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.joca.2014.09.004","article-title":"Osteoarthritis-related biomarkers following anterior cruciate ligament injury and reconstruction: a systematic review","volume":"23","author":"Harkey","year":"2015","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.knee.2019.12.007_bb0055","doi-asserted-by":"crossref","first-page":"1296","DOI":"10.1016\/j.arthro.2010.02.011","article-title":"Cytokine profiling in acute anterior cruciate ligament injury","volume":"26","author":"Cuellar","year":"2010","journal-title":"Arthroscopy"},{"key":"10.1016\/j.knee.2019.12.007_bb0060","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1002\/jor.23272","article-title":"Characterization of synovial fluid cytokine profiles in chronic meniscal tear of the knee","volume":"35","author":"Bigoni","year":"2017","journal-title":"J Orthop Res"},{"key":"10.1016\/j.knee.2019.12.007_bb0065","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1002\/jor.23341","article-title":"Review of current understanding of post-traumatic osteoarthritis resulting from sports injuries","volume":"35","author":"Carbone","year":"2017","journal-title":"J Orthop Res"},{"key":"10.1016\/j.knee.2019.12.007_bb0070","doi-asserted-by":"crossref","first-page":"752","DOI":"10.1302\/0301-620X.43B4.752","article-title":"The etiology of chondromalacia patellae","volume":"43","author":"Outerbridge","year":"1961","journal-title":"J Bone Joint Surg Br"},{"key":"10.1016\/j.knee.2019.12.007_bb0075","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1016\/j.arthro.2009.12.018","article-title":"The expression of proinflammatory cytokines and matrix metalloproteinases in the synovial membranes of patients with osteoarthritis compared with traumatic knee disorders","volume":"26","author":"Wassilew","year":"2010","journal-title":"Arthroscopy"},{"issue":"2","key":"10.1016\/j.knee.2019.12.007_bb0080","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1177\/0363546514562168","article-title":"Factors predictive of concomitant injuries among children and adolescents undergoing anterior cruciate ligament surgery","volume":"43","author":"Newman","year":"2015","journal-title":"Am J Sports Med"},{"key":"10.1016\/j.knee.2019.12.007_bb0085","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1177\/0363546514559912","article-title":"Correlation of meniscal and articular cartilage injuries in children and adolescents with timing of anterior cruciate ligament reconstruction","volume":"43","author":"Anderson","year":"2015","journal-title":"Am J Sports Med"},{"key":"10.1016\/j.knee.2019.12.007_bb0090","doi-asserted-by":"crossref","DOI":"10.4414\/smw.2012.13583","article-title":"Biomechanics and pathomechanisms of osteoarthritis","volume":"142","author":"Egloff","year":"2012","journal-title":"Swiss Med Wkly"},{"key":"10.1016\/j.knee.2019.12.007_bb0095","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/j.aott.2015.11.003","article-title":"Serum and knee sinovial fluid matrix metalloproteinase-13 and tumor necrosis factor-alpha levels in patients with late-stage osteoarthritis","volume":"50","author":"\u00d6zler","year":"2016","journal-title":"Acta Orthop Traumatol Turc"},{"key":"10.1016\/j.knee.2019.12.007_bb0100","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1002\/jcp.21258","article-title":"Osteoarthritis","volume":"213","author":"Goldring","year":"2007","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.knee.2019.12.007_bb0105","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1055\/s-0036-1583269","article-title":"Comparison of synovial fluid cytokine levels between traumatic knee injury and end-stage osteoarthritis","volume":"30","author":"Siqueira","year":"2017","journal-title":"J Knee Surg"},{"key":"10.1016\/j.knee.2019.12.007_bb0110","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.joca.2013.04.002","article-title":"An explorative study comparing levels of soluble mediators in control and osteoarthritic synovial fluid","volume":"21","author":"Beekhuizen","year":"2013","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.knee.2019.12.007_bb0115","doi-asserted-by":"crossref","first-page":"R124","DOI":"10.1186\/ar2013","article-title":"Expression profiling of metalloproteinases and their inhibitors in synovium and cartilage","volume":"8","author":"Davidson","year":"2006","journal-title":"Arthritis Res Ther"},{"key":"10.1016\/j.knee.2019.12.007_bb0120","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1016\/j.joca.2016.09.008","article-title":"Concentrations of synovial fluid biomarkers and the prediction of knee osteoarthritis 16 years after anterior cruciate ligament injury","volume":"25","author":"Neuman","year":"2017","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.knee.2019.12.007_bb0125","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1016\/j.joca.2010.08.016","article-title":"Circulating levels of IL-6 and TNF-\u03b1 are associated with knee radiographic osteoarthritis and knee cartilage in older adults","volume":"18","author":"Stannus","year":"2010","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.knee.2019.12.007_bb0130","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s00281-017-0619-z","article-title":"Selected cytokine pathways in rheumatoid arthritis","volume":"39","author":"Noack","year":"2017","journal-title":"Semin Immunopathol"},{"key":"10.1016\/j.knee.2019.12.007_bb0135","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1002\/art.39146","volume":"67","author":"Struglics","year":"2015","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.knee.2019.12.007_bb0140","first-page":"1143","article-title":"Interleukin-6 from subchondral bone mesenchymal stem cells contributes to the pathological phenotypes of experimental osteoarthritis","volume":"10","author":"Wu","year":"2018","journal-title":"Am J Transl Res"},{"key":"10.1016\/j.knee.2019.12.007_bb0145","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1002\/art.30137","article-title":"Synovial inflammation in patients undergoing arthroscopic meniscectomy: molecular characterization and relationship to symptoms","volume":"63","author":"Scanzello","year":"2011","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.knee.2019.12.007_bb0150","doi-asserted-by":"crossref","first-page":"1218","DOI":"10.1016\/j.clinbiochem.2011.07.010","article-title":"Association of plasma and synovial fluid interferon-\u03b3 inducible protein-10 with radiographic severity in knee osteoarthritis","volume":"44","author":"Tantavisut","year":"2011","journal-title":"Clin Biochem"},{"key":"10.1016\/j.knee.2019.12.007_bb0155","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/s00005-011-0115-4","article-title":"CXCL8 and CCL5 expression in synovial fluid and blood serum in patients with osteoarthritis of the knee","volume":"59","author":"Pierzchala","year":"2011","journal-title":"Arch Immunol Ther Exp (Warsz)"},{"key":"10.1016\/j.knee.2019.12.007_bb0160","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.arthro.2015.08.033","article-title":"Correlation of synovial fluid biomarkers with cartilage pathology and associated outcomes in knee","volume":"32","author":"Cu\u00e9llar","year":"2016","journal-title":"Arthroscopy"},{"key":"10.1016\/j.knee.2019.12.007_bb0165","doi-asserted-by":"crossref","first-page":"1458","DOI":"10.1016\/j.joca.2010.08.003","article-title":"Chemokine profile of synovial fluid from normal, osteoarthritis and rheumatoid arthritis patients: CCL25, CXCL10 and XCL1 recruit human subchondral mesenchymal progenitor cells","volume":"18","author":"Endres","year":"2010","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.knee.2019.12.007_bb0170","doi-asserted-by":"crossref","first-page":"20658","DOI":"10.3390\/ijms141020658","article-title":"Absolute quantification of selected proteins in the human osteoarthritic secretome","volume":"14","author":"Peffers","year":"2013","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.knee.2019.12.007_bb0175","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/j.arthro.2016.11.019","article-title":"Biomarker changes in anterior cruciate ligament-deficient knees compared with healthy controls","volume":"33","author":"Kaplan","year":"2017","journal-title":"Arthroscopy"},{"key":"10.1016\/j.knee.2019.12.007_bb0180","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1186\/1471-2474-13-126","article-title":"Matrix metalloproteinase protein expression profiles cannot distinguish between normal and early osteoarthritic synovial fluid","volume":"13","author":"Heard","year":"2012","journal-title":"BMC Musculoskelet Disord"},{"key":"10.1016\/j.knee.2019.12.007_bb0185","doi-asserted-by":"crossref","first-page":"388","DOI":"10.11622\/smedj.2014092","article-title":"Production of a polyclonal antibody against osteogenic protein-1, and its role in the diagnosis of osteoarthritis","volume":"55","author":"Bhutia","year":"2014","journal-title":"Singapore Med J"},{"key":"10.1016\/j.knee.2019.12.007_bb0190","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1186\/1471-2474-11-232","article-title":"Phase 1 safety and tolerability study of BMP-7 in symptomatic knee osteoarthritis","volume":"11","author":"Hunter","year":"2010","journal-title":"BMC Musculoskelet Disord"},{"key":"10.1016\/j.knee.2019.12.007_bb0195","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.cytogfr.2011.08.001","article-title":"Bone morphogenetic protein 7: a broad-spectrum growth factor with multiple target therapeutic potency","volume":"22","author":"Boon","year":"2011","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.knee.2019.12.007_bb0200","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1080\/09553000600643516","article-title":"Peripheral leukocyte response to oncological radiotherapy: expression of heat shock proteins","volume":"82","author":"Guisasola","year":"2006","journal-title":"Int J Radiat Biol"},{"key":"10.1016\/j.knee.2019.12.007_bb0205","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/s12192-017-0859-9","article-title":"An overview of cytokines and heat shock response in polytraumatized patients","volume":"23","author":"Guisasola","year":"2018","journal-title":"Cell Stress Chaperones"},{"key":"10.1016\/j.knee.2019.12.007_bb0210","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1097\/BOR.0b013e328349c2b1","article-title":"Inflammation in osteoarthritis","volume":"23","author":"Goldring","year":"2011","journal-title":"Curr Opin Rheumatol"},{"key":"10.1016\/j.knee.2019.12.007_bb0215","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.jbspin.2016.06.010","article-title":"Alarmins firing arthritis: helpful diagnostic tools and promising therapeutic targets","volume":"84","author":"Lavric","year":"2017","journal-title":"Joint Bone Spine"},{"key":"10.1016\/j.knee.2019.12.007_bb0220","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1615\/JLongTermEffMedImplants.2014011295","article-title":"Role of innate immune sensors, TLRs, and NALP3 in rheumatoid arthritis and osteoarthritis","volume":"24","author":"Takakubo","year":"2014","journal-title":"J Long Term Eff Med Implants"},{"key":"10.1016\/j.knee.2019.12.007_bb0225","article-title":"Circulating and synovial fluid heat shock protein 70 are correlated with severity in knee osteoarthritis","volume":"1","author":"Ngarmukos","year":"2018","journal-title":"Cartilage"},{"key":"10.1016\/j.knee.2019.12.007_bb0230","doi-asserted-by":"crossref","first-page":"868","DOI":"10.2174\/1389200218666170728115606","article-title":"Translational shift of HSP90 as a novel therapeutic target from cancer to neurodegenerative disorders: an emerging trend in the cure of Alzheimer's and Parkinson's diseases","volume":"18","author":"Alam","year":"2017","journal-title":"Curr Drug Metab"},{"key":"10.1016\/j.knee.2019.12.007_bb0235","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1007\/s10522-015-9607-7","article-title":"The role of Hsp70 in oxi-inflamm-aging and its use as a potential biomarker of lifespan","volume":"16","author":"Mart\u00ednez de Toda","year":"2015","journal-title":"Biogerontology"}],"container-title":["The Knee"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968016019303187?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968016019303187?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T21:50:22Z","timestamp":1760824222000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968016019303187"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":47,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2020,1]]}},"alternative-id":["S0968016019303187"],"URL":"https:\/\/doi.org\/10.1016\/j.knee.2019.12.007","relation":{},"ISSN":["0968-0160"],"issn-type":[{"value":"0968-0160","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Osteoarthritis-related biomarkers profile in chronic anterior cruciate ligament injured knee","name":"articletitle","label":"Article Title"},{"value":"The Knee","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.knee.2019.12.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}