{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T19:20:06Z","timestamp":1788808806138,"version":"build-2803163510"},"reference-count":31,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thekneejournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Knee"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.knee.2019.12.010","type":"journal-article","created":{"date-parts":[[2020,1,9]],"date-time":"2020-01-09T01:14:49Z","timestamp":1578532489000},"page":"580-586","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":29,"title":["Denosumab prevents periprosthetic bone mineral density loss in the tibial metaphysis in total knee arthroplasty"],"prefix":"10.1016","volume":"27","author":[{"given":"Yasutaka","family":"Murahashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Teramoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunsuke","family":"Jimbo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yohei","family":"Okada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomoaki","family":"Kamiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Imamura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroyuki","family":"Takashima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kota","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoshi","family":"Nagoya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiko","family":"Yamashita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.knee.2019.12.010_bb0005","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1080\/17453670610045902","article-title":"Aseptic loosening, not only a question of wear: a review of different theories","volume":"77","author":"Sundfeldt","year":"2006","journal-title":"Acta Orthop"},{"key":"10.1016\/j.knee.2019.12.010_bb0010","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1016\/j.arth.2017.02.032","article-title":"Low preoperative BMD is related to high migration of tibia components in uncemented TKA-92 patients in a combined DEXA and RSA study with 2-year follow-up","volume":"32","author":"Andersen","year":"2017","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.knee.2019.12.010_bb0015","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0883-5403(99)90206-1","article-title":"Preoperative bone mineral density of the proximal tibia and migration of the tibial component after uncemented total knee arthroplasty","volume":"14","author":"Petersen","year":"1999","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.knee.2019.12.010_bb0020","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1054\/arth.2000.6617","article-title":"The effect of the preoperative bone quality on the fixation of the tibial component in total knee arthroplasty","volume":"15","author":"Li","year":"2000","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.knee.2019.12.010_bb0025","doi-asserted-by":"crossref","first-page":"268","DOI":"10.3109\/17453674.2016.1173982","article-title":"Periprosthetic tibial bone mineral density changes after total knee arthroplasty","volume":"87","author":"Jaroma","year":"2016","journal-title":"Acta Orthop"},{"key":"10.1016\/j.knee.2019.12.010_bb0030","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1007\/s00223-002-1022-9","article-title":"Effect of alendronate on periprosthetic bone loss after total knee arthroplasty: a one-year, randomized, controlled trial of 19 patients","volume":"71","author":"Soininvaara","year":"2002","journal-title":"Calcif Tissue Int"},{"key":"10.1016\/j.knee.2019.12.010_bb0035","doi-asserted-by":"crossref","first-page":"267","DOI":"10.2106\/00004623-200602000-00003","article-title":"Three-year changes in bone mineral density around the knee after a six-month course of oral alendronate following total knee arthroplasty. A prospective, randomized study","volume":"88","author":"Wang","year":"2006","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.knee.2019.12.010_bb0040","doi-asserted-by":"crossref","first-page":"3233","DOI":"10.1002\/art.38789","article-title":"Oral bisphosphonate use and total knee\/hip implant survival: validation of results in an external population-based cohort","volume":"6","author":"Prieto-Alhambra","year":"2014","journal-title":"Arthritis Rheumatol"},{"key":"10.1016\/j.knee.2019.12.010_bb0045","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.arth.2015.09.005","article-title":"Lower total knee arthroplasty revision risk associated with bisphosphonate use, even in patients with normal bone density","volume":"31","author":"Namba","year":"2016","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.knee.2019.12.010_bb0050","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1302\/0301-620X.97B3.33643","article-title":"Effect of one-year post-operative alendronate treatment on periprosthetic bone after total knee arthroplasty. A seven-year randomised controlled trial of 26 patients","volume":"97-B","author":"Jaroma","year":"2015","journal-title":"Bone Joint J"},{"key":"10.1016\/j.knee.2019.12.010_bb0055","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1080\/17453670610013213","article-title":"Postoperative clodronate decreases prosthetic migration: 4-year follow-up of a randomized radiostereometric study of 50 total knee patients","volume":"77","author":"Hilding","year":"2006","journal-title":"Acta Orthop"},{"key":"10.1016\/j.knee.2019.12.010_bb0060","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1016\/j.injury.2015.02.011","article-title":"Anti-RANKL treatment improves screw fixation in cancellous bone in rats","volume":"46","author":"Bernhardsson","year":"2015","journal-title":"Injury"},{"key":"10.1016\/j.knee.2019.12.010_bb0065","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1007\/s00590-018-2223-x","article-title":"Restoration of proximal periprosthetic bone loss by denosumab in cementless total hip arthroplasty","volume":"28","author":"Nagoya","year":"2018","journal-title":"Eur J Orthop Surg Traumatol"},{"key":"10.1016\/j.knee.2019.12.010_bb0070","doi-asserted-by":"crossref","first-page":"1595","DOI":"10.1007\/s00402-012-1601-9","article-title":"Osteodensitometry measurements of periprosthetic bone using dual energy X-ray absorptiometry following total knee arthroplasty","volume":"132","author":"Windisch","year":"2012","journal-title":"Arch Orthop Trauma Surg"},{"key":"10.1016\/j.knee.2019.12.010_bb0075","doi-asserted-by":"crossref","first-page":"1503","DOI":"10.1302\/0301-620X.96B11.33465","article-title":"Trabecular bone density of the proximal tibia as it relates to failure of a total knee replacement","volume":"9","author":"Ritter","year":"2014","journal-title":"Bone Joint J"},{"key":"10.1016\/j.knee.2019.12.010_bb0080","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1302\/0301-620X.95B7.30537","article-title":"Changes in tibial bone density measured from standard radiographs in cemented and uncemented total knee replacements after ten years' follow-up","volume":"95","author":"Small","year":"2013","journal-title":"Bone Joint J"},{"key":"10.1016\/j.knee.2019.12.010_bb0085","doi-asserted-by":"crossref","first-page":"745","DOI":"10.2106\/00004623-198769050-00016","article-title":"Radiographic analysis of the axial alignment of the lower extremity","volume":"69","author":"Moreland","year":"1987","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.knee.2019.12.010_bb0090","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1136\/ard.16.4.494","article-title":"Radiological assessment of osteo-arthrosis","volume":"16","author":"Kellgren","year":"1957","journal-title":"Ann Rheum Dis"},{"key":"10.1016\/j.knee.2019.12.010_bb0095","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1359\/jbmr.090716","article-title":"Effects of denosumab on bone mineral density and bone turnover in postmenopausal women transitioning from alendronate therapy","volume":"25","author":"Kendler","year":"2010","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.knee.2019.12.010_bb0100","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.jocd.2012.02.006","article-title":"Denosumab significantly increases DXA BMD at both trabecular and cortical sites: results from the FREEDOM study","volume":"16","author":"Bolognese","year":"2013","journal-title":"J Clin Densitom"},{"key":"10.1016\/j.knee.2019.12.010_bb0105","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1056\/NEJMoa044459","article-title":"Denosumab in postmenopausal women with low bone mineral density","volume":"354","author":"McClung","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.knee.2019.12.010_bb0110","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1359\/jbmr.0809010","article-title":"Comparison of the effect of denosumab and alendronate on BMD and biochemical markers of bone turnover in postmenopausal women with low bone mass: a randomized, blinded, phase 3 trial","volume":"24","author":"Brown","year":"2009","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.knee.2019.12.010_bb0115","doi-asserted-by":"crossref","first-page":"3163","DOI":"10.1210\/jc.2016-1801","article-title":"Denosumab or zoledronic acid in postmenopausal women with osteoporosis previously treated with oral bisphosphonates","volume":"101","author":"Miller","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.knee.2019.12.010_bb0120","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1080\/17453674.2017.1300746","article-title":"Denosumab reduces early migration in total knee replacement","volume":"88","author":"Ledin","year":"2017","journal-title":"Acta Orthop"},{"key":"10.1016\/j.knee.2019.12.010_bb0125","doi-asserted-by":"crossref","first-page":"614","DOI":"10.3109\/17453674.2012.747052","article-title":"Early migration of tibial components is associated with late revision: a systematic review and meta-analysis of 21,000 knee arthroplasties","volume":"83","author":"Pijls","year":"2012","journal-title":"Acta Orthop"},{"key":"10.1016\/j.knee.2019.12.010_bb0130","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1210\/jc.2016-3170","article-title":"Severe rebound-associated vertebral fractures after denosumab discontinuation: 9 clinical cases report","volume":"102","author":"Lamy","year":"2017","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.knee.2019.12.010_bb0135","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1002\/jbmr.3110","article-title":"Clinical features of 24 patients with rebound-associated vertebral fractures after denosumab discontinuation: systematic review and additional cases","volume":"32","author":"Anastasilakis","year":"2017","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.knee.2019.12.010_bb0140","doi-asserted-by":"crossref","first-page":"1917","DOI":"10.1007\/s00198-015-3458-6","article-title":"Rebound-associated vertebral fractures after discontinuation of denosumab-from clinic and biomechanics","volume":"27","author":"Popp","year":"2016","journal-title":"Osteoporos Int"},{"key":"10.1016\/j.knee.2019.12.010_bb0145","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1002\/jbmr.3337","article-title":"Vertebral fractures after discontinuation of denosumab: a post hoc analysis of the randomized placebo-controlled FREEDOM trial and its extension","volume":"33","author":"Cummings","year":"2018","journal-title":"J Bone Miner Res"},{"key":"10.1016\/j.knee.2019.12.010_bb0150","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1093\/rheumatology\/35.9.813","article-title":"Inverse relationship osteoarthritis-osteoporosis: what is the evidence? What are the consequences?","volume":"35","author":"Dequeker","year":"1996","journal-title":"Br J Rheumatol"},{"key":"10.1016\/j.knee.2019.12.010_bb0155","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0883-5403(06)80174-9","article-title":"Evaluation of micromotion in cemented vs uncemented knee arthroplasty in osteoarthrosis and rheumatoid arthritis. Randomized study using roentgen stereophotogrammetric analysis","volume":"6","author":"Nilsson","year":"1991","journal-title":"J Arthroplasty"}],"container-title":["The Knee"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968016019303217?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968016019303217?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T21:49:03Z","timestamp":1760824143000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968016019303217"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":31,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["S0968016019303217"],"URL":"https:\/\/doi.org\/10.1016\/j.knee.2019.12.010","relation":{},"ISSN":["0968-0160"],"issn-type":[{"value":"0968-0160","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Denosumab prevents periprosthetic bone mineral density loss in the tibial metaphysis in total knee arthroplasty","name":"articletitle","label":"Article Title"},{"value":"The Knee","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.knee.2019.12.010","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}