{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T06:31:23Z","timestamp":1791268283513,"version":"4.1.0"},"reference-count":38,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thekneejournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Knee"],"published-print":{"date-parts":[[2021,1]]},"DOI":"10.1016\/j.knee.2020.12.024","type":"journal-article","created":{"date-parts":[[2021,1,23]],"date-time":"2021-01-23T07:34:46Z","timestamp":1611387286000},"page":"417-421","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":71,"special_numbering":"C","title":["Revision knee replacement for prosthetic joint infection: Epidemiology, clinical outcomes and health-economic considerations"],"prefix":"10.1016","volume":"28","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2401-1372","authenticated-orcid":false,"given":"Shiraz A.","family":"Sabah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6069-978X","authenticated-orcid":false,"given":"Abtin","family":"Alvand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4258-5866","authenticated-orcid":false,"given":"Andrew J.","family":"Price","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.knee.2020.12.024_b0005","unstructured":"National Joint Registry for England Wales Northern Ireland and the Isle of Man. NJR 17th Annual Report 2020."},{"key":"10.1016\/j.knee.2020.12.024_b0010","doi-asserted-by":"crossref","DOI":"10.1302\/0301-620X.97B8.35170","article-title":"The epidemiology of revision total knee and hip arthroplasty in England and Wales: A comparative analysis with projections for the United States. a study using the national joint registry dataset","author":"Patel","year":"2015","journal-title":"Bone Jt J"},{"key":"10.1016\/j.knee.2020.12.024_b0015","doi-asserted-by":"crossref","first-page":"780","DOI":"10.2106\/00004623-200704000-00012","article-title":"Projections of Primary and Revision Hip and Knee Arthroplasty in the United States from 2005 to 2030","volume":"89","author":"Kurtz","year":"2007","journal-title":"J Bone Jt Surg"},{"key":"10.1016\/j.knee.2020.12.024_b0020","article-title":"The projected volume of primary and revision total knee arthroplasty will place an immense burden on future heath care systems over the next 30 years","author":"Klug","year":"2020","journal-title":"Knee Surgery, Sport Traumatol Arthrosc"},{"key":"10.1016\/j.knee.2020.12.024_b0025","doi-asserted-by":"crossref","first-page":"2194","DOI":"10.1007\/s11999-017-5396-4","article-title":"Periprosthetic Joint Infection Is the Main Cause of Failure for Modern Knee Arthroplasty: An Analysis of 11,134 Knees","volume":"475","author":"Koh","year":"2017","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.knee.2020.12.024_b0030","unstructured":"Robertsson O, Sundberg M, Lidgren L, W-Dahl A. The Swedish Knee Arthroplasty Register - Annual Report 2016 n.d. https:\/\/www.researchgate.net\/publication\/311439835_Annual_report_2016_-_The_Swedish_Knee_Arthroplasty_Register (accessed October 21, 2020)."},{"key":"10.1016\/j.knee.2020.12.024_b0035","unstructured":"Rothwell A, Hobbs T, Frampton C, Taylor J, Muir D, Mohammed K. THE NEW ZEALAND JOINT REGISTRY - Annual Report 2017 n.d. https:\/\/nzoa.org.nz\/system\/files\/DH7827_NZJR_2017_Report_v4_26Oct17.pdf (accessed October 21, 2020)."},{"key":"10.1016\/j.knee.2020.12.024_b0040","unstructured":"Graves S, de Steiger RN, Lewis P, Harris I. The Australian National Joint Replacement Registry - 2017 Annual Report n.d. https:\/\/aoanjrr.sahmri.com\/annual-reports-2017 (accessed October 21, 2020)."},{"key":"10.1016\/j.knee.2020.12.024_b0045","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/S1473-3099(18)30755-2","article-title":"Risk factors associated with revision for prosthetic joint infection following knee replacement: an observational cohort study from England and Wales","volume":"19","author":"Lenguerrand","year":"2019","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.knee.2020.12.024_b0050","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2016-014056","article-title":"Description of the rates, trends and surgical burden associated with revision for prosthetic joint infection following primary and revision knee replacements in England and Wales: An analysis of the National Joint Registry for England, Wales, Northern Ire","volume":"7","author":"Lenguerrand","year":"2017","journal-title":"BMJ Open"},{"key":"10.1016\/j.knee.2020.12.024_b0055","doi-asserted-by":"crossref","DOI":"10.2106\/JBJS.RVW.18.00084","article-title":"Outcome of Revision Surgery for Infection after Total Knee Arthroplasty: Results of 3 Surgical Strategies","volume":"7","author":"Leta","year":"2019","journal-title":"JBJS Rev"},{"key":"10.1016\/j.knee.2020.12.024_b0060","unstructured":"National Joint Registry for England Wales Northern Ireland and the Isle of Man. NJR 16th Annual Report 2019."},{"key":"10.1016\/j.knee.2020.12.024_b0065","doi-asserted-by":"crossref","first-page":"108","DOI":"10.7150\/jbji.24285","article-title":"Treatment of Prosthetic Joint Infection with Debridement, Antibiotics and Irrigation with Implant Retention - a Narrative Review","volume":"3","author":"Sousa","year":"2018","journal-title":"J Bone Jt Infect"},{"key":"10.1016\/j.knee.2020.12.024_b0070","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2017-018673","article-title":"LEAK study: design of a nationwide randomised controlled trial to find the best way to treat wound leakage after primary hip and knee arthroplasty","volume":"7","author":"Lowik","year":"2017","journal-title":"BMJ Open"},{"key":"10.1016\/j.knee.2020.12.024_b0075","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.2106\/JBJS.17.00249","article-title":"Mortality after total knee arthroplasty: A systematic review of incidence, temporal trends, and risk factors","volume":"100","author":"Berstock","year":"2018","journal-title":"J Bone Jt Surg - Am"},{"issue":"948\u2013952","key":"10.1016\/j.knee.2020.12.024_b0080","article-title":"In-Hospital Mortality in Patients With Periprosthetic Joint Infection","volume":"32","author":"Shahi","year":"2017","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.knee.2020.12.024_b0085","doi-asserted-by":"crossref","first-page":"2177","DOI":"10.2106\/JBJS.L.00789","article-title":"Periprosthetic joint infection increases the risk of one-year mortality","volume":"95","author":"Zmistowski","year":"2013","journal-title":"J Bone Jt Surg - Am"},{"key":"10.1016\/j.knee.2020.12.024_b0090","unstructured":"Survival Rates for Soft Tissue Sarcoma n.d. https:\/\/www.cancer.org\/cancer\/soft-tissue-sarcoma\/detection-diagnosis-staging\/survival-rates.html (accessed June 10, 2020)."},{"key":"10.1016\/j.knee.2020.12.024_b0095","unstructured":"Cancer survival in England - Office for National Statistics n.d. https:\/\/www.ons.gov.uk\/peoplepopulationandcommunity\/healthandsocialcare\/conditionsanddiseases\/bulletins\/cancersurvivalinengland\/nationalestimatesforpatientsfollowedupto2017 (accessed June 10, 2020)."},{"key":"10.1016\/j.knee.2020.12.024_b0100","doi-asserted-by":"crossref","DOI":"10.1302\/0301-620X.102B3.BJJ-2020-0067","article-title":"Networks in orthopaedics","author":"Ahmed","year":"2020","journal-title":"Bone Joint J"},{"key":"10.1016\/j.knee.2020.12.024_b0105","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/j.arth.2014.03.009","article-title":"Definition of periprosthetic joint infection","volume":"29","author":"Parvizi","year":"2014","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.knee.2020.12.024_b0110","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1016\/j.arth.2016.11.016","article-title":"Outcome of Total Hip and Total Knee Revision Arthroplasty With Minor Infection Criteria: A Retrospective Matched-Pair Analysis","volume":"32","author":"Staats","year":"2017","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.knee.2020.12.024_b0115","doi-asserted-by":"crossref","first-page":"239","DOI":"10.2106\/JBJS.18.00356","article-title":"Two-stage exchange protocol for periprosthetic joint infection following total knee arthroplasty in 245 knees without prior treatment for infection","volume":"101","author":"Petis","year":"2019","journal-title":"J Bone Jt Surg - Am"},{"key":"10.1016\/j.knee.2020.12.024_b0120","doi-asserted-by":"crossref","unstructured":"Kunutsor SK, Whitehouse MR, Lenguerrand E, Blom AW, Beswick AD, Team I. Re-Infection Outcomes Following One- And Two-Stage Surgical Revision of Infected Knee Prosthesis: A Systematic Review and Meta-Analysis. PLoS ONE [Electronic Resour 2016;11:e0151537. https:\/\/doi.org\/https:\/\/dx.doi.org\/10.1371\/journal.pone.0151537.","DOI":"10.1371\/journal.pone.0151537"},{"key":"10.1016\/j.knee.2020.12.024_b0125","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.arth.2017.09.021","article-title":"Revision Total Knee Arthroplasty for Periprosthetic Joint Infection Is Associated With Increased Postoperative Morbidity and Mortality Relative to Noninfectious Revisions","volume":"33","author":"Boddapati","year":"2018","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.knee.2020.12.024_b0130","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.1007\/s11999-012-2278-7","article-title":"Reason for revision influences early patient outcomes after aseptic knee revision","volume":"470","author":"Baker","year":"2012","journal-title":"Clin Orthop Relat Res"},{"key":"10.1016\/j.knee.2020.12.024_b0135","doi-asserted-by":"crossref","first-page":"2582140","DOI":"10.1155\/2018\/2582140","article-title":"Periprosthetic Joint Infection Does Not Preclude Good Outcomes after a Revision Total Knee Arthroplasty: A 7-Year Follow-Up Study of 144 Retrospective Cases","volume":"2018","author":"Ro","year":"2018","journal-title":"Biomed Res Int"},{"key":"10.1016\/j.knee.2020.12.024_b0140","doi-asserted-by":"crossref","first-page":"2713","DOI":"10.1007\/s00167-012-2090-7","article-title":"Patient reported outcome measures after revision of the infected TKR: comparison of single versus two-stage revision","volume":"21","author":"Baker","year":"2013","journal-title":"Knee Surgery, Sport Traumatol Arthrosc"},{"key":"10.1016\/j.knee.2020.12.024_b0145","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1302\/2058-5241.4.190003","article-title":"Outcome of single-stage versus two-stage exchange for revision knee arthroplasty for chronic periprosthetic infection","volume":"4","author":"Pangaud","year":"2019","journal-title":"EFORT Open Rev"},{"key":"10.1016\/j.knee.2020.12.024_b0150","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1007\/s00167-012-1885-x","article-title":"Two-stage revision of septic knee prosthesis with articulating knee spacers yields better infection eradication rate than one-stage or two-stage revision with static spacers Knee Surgery","volume":"20","author":"Roman\u00f2","year":"2012","journal-title":"Sport Traumatol Arthrosc"},{"key":"10.1016\/j.knee.2020.12.024_b0155","first-page":"20","article-title":"A Randomized Trial of Static and Articulating Spacers for the Treatment of Infection Following Total Knee Arthroplasty","volume":"2020","author":"Nahhas","year":"2020","journal-title":"J Bone Jt Surg Am"},{"key":"10.1016\/j.knee.2020.12.024_b0160","doi-asserted-by":"crossref","unstructured":"Lavernia C, Lee DJ, Hernandez VH. The increasing financial burden of knee revision surgery in the United States. Clin. Orthop. Relat. Res., vol. 446, Lippincott Williams and Wilkins; 2006, p. 221\u20136. https:\/\/doi.org\/10.1097\/01.blo.0000214424.67453.9a.","DOI":"10.1097\/01.blo.0000214424.67453.9a"},{"key":"10.1016\/j.knee.2020.12.024_b0165","doi-asserted-by":"crossref","DOI":"10.1302\/0301-620X.97B2.33707","article-title":"Financial analysis of revision knee surgery based on NHS tariffs and hospital costs","author":"Kallala","year":"2015","journal-title":"Bone Joint J"},{"key":"10.1016\/j.knee.2020.12.024_b0170","unstructured":"WHO | Cost-effectiveness analysis for health interventions. WHO 2010."},{"key":"10.1016\/j.knee.2020.12.024_b0175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1136\/bmjopen-2017-019477","article-title":"Associations between preoperative Oxford hip and knee scores and costs and quality of life of patients undergoing primary total joint replacement in the NHS England: An observational study","volume":"8","author":"Eibich","year":"2018","journal-title":"BMJ Open"},{"key":"10.1016\/j.knee.2020.12.024_b0180","doi-asserted-by":"crossref","DOI":"10.3310\/hta18190","article-title":"a randomised controlled trial of the clinical effectiveness and costeffectiveness of different knee prostheses the knee arthroplasty trial kat","volume":"18","author":"Murray","year":"2014","journal-title":"Health Technol Assess"},{"key":"10.1016\/j.knee.2020.12.024_b0185","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/pgfar05120","article-title":"Lower limb arthroplasty: can we produce a tool to predict outcome and failure, and is it cost-effective? An epidemiological study","volume":"5","author":"Arden","year":"2017","journal-title":"Program Grants Appl Res"},{"key":"10.1016\/j.knee.2020.12.024_b0190","unstructured":"NHS Digital. Patient Reported Outcome Measures (PROMs) n.d. https:\/\/digital.nhs.uk\/data-and-information\/data-tools-and-services\/data-services\/patient-reported-outcome-measures-proms (accessed April 16, 2020)."}],"container-title":["The Knee"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968016020304208?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968016020304208?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T21:53:50Z","timestamp":1760824430000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968016020304208"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,1]]},"references-count":38,"alternative-id":["S0968016020304208"],"URL":"https:\/\/doi.org\/10.1016\/j.knee.2020.12.024","relation":{},"ISSN":["0968-0160"],"issn-type":[{"value":"0968-0160","type":"print"}],"subject":[],"published":{"date-parts":[[2021,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Revision knee replacement for prosthetic joint infection: Epidemiology, clinical outcomes and health-economic considerations","name":"articletitle","label":"Article Title"},{"value":"The Knee","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.knee.2020.12.024","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}