{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T22:10:18Z","timestamp":1760825418046,"version":"build-2065373602"},"reference-count":17,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thekneejournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Knee"],"published-print":{"date-parts":[[2022,12]]},"DOI":"10.1016\/j.knee.2022.08.005","type":"journal-article","created":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T12:30:28Z","timestamp":1664368228000},"page":"100-105","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Ghrelin level as a biomarker for knee osteoarthritis severity and appearance in HIV\u00a0+\u00a0patients"],"prefix":"10.1016","volume":"39","author":[{"given":"Jorge I.","family":"Arce-Rosas","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luz A.","family":"Gonz\u00e1lez-Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodolfo I.","family":"Cabrera-Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monserrat","family":"Alvarez-Zavala","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karina","family":"S\u00e1nchez-Reyes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gustavo A.","family":"Tafoya Arregu\u00edn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jose de Jes\u00fas","family":"Martinez Ru\u00edz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo","family":"Cerda de la Torre","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mois\u00e9s","family":"Ramos-Solano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime F.","family":"Andrade-Villanueva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.knee.2022.08.005_b0005","doi-asserted-by":"crossref","DOI":"10.1186\/s12891-019-2573-5","article-title":"Is treated HIV infection associated with knee cartilage degeneration and structural changes? A longitudinal study using data from the osteoarthritis initiative","volume":"20","author":"Liu","year":"2019","journal-title":"BMC Musculoskelet Disord"},{"key":"10.1016\/j.knee.2022.08.005_b0010","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1097\/00003086-200209000-00004","article-title":"Articular cartilage injuries","volume":"402","author":"Buckwalter","year":"2002","journal-title":"Clin Orthop Relat Res"},{"issue":"4","key":"10.1016\/j.knee.2022.08.005_b0015","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1089\/met.2009.0110","article-title":"Osteoarthritis: Another component of metabolic syndrome?","volume":"8","author":"Velasquez","year":"2010","journal-title":"Metab Syndr Relat Disord"},{"issue":"4","key":"10.1016\/j.knee.2022.08.005_b0020","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.joca.2011.01.022","article-title":"Osteoarthritis year 2010 in review: Pathomechanisms","volume":"19","author":"van den Berg","year":"2011","journal-title":"Osteoarthr Cartil"},{"issue":"1","key":"10.1016\/j.knee.2022.08.005_b0025","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.joca.2009.08.010","article-title":"Risk factors for onset of osteoarthritis of the knee in older adults: A systematic review and meta-analysis","volume":"18","author":"Blagojevic","year":"2010","journal-title":"Osteoarthr Cartil"},{"issue":"11","key":"10.1016\/j.knee.2022.08.005_b0030","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/j.joca.2012.06.006","article-title":"Accumulation of metabolic risk factors such as overweight, hypertension, dyslipidaemia, and impaired glucose tolerance raises the risk of occurrence and progression of knee osteoarthritis: A 3-year follow-up of the ROAD study","volume":"20","author":"Yoshimura","year":"2012","journal-title":"Osteoarthritis Cartilage"},{"issue":"8","key":"10.1016\/j.knee.2022.08.005_b0035","doi-asserted-by":"crossref","first-page":"515","DOI":"10.2519\/jospt.2013.4796","article-title":"Are joint injury, sport activity, physical activity, obesity, or occupational activities predictors for osteoarthritis? A systematic review","volume":"43","author":"Richmond","year":"2013","journal-title":"J Orthop Sports Phys Ther"},{"key":"10.1016\/j.knee.2022.08.005_b0040","first-page":"489","article-title":"Osteoarticular infection associated with the human immunodeficiency virus","volume":"9","author":"Mu\u00f1oz Fernandez","year":"1991","journal-title":"Clin Exp Rheumatol"},{"issue":"1","key":"10.1016\/j.knee.2022.08.005_b0045","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.mce.2011.04.019","article-title":"The effects of ghrelin on inflammation and the immune system","volume":"340","author":"Baatar","year":"2011","journal-title":"Mol Cell Endocrinol"},{"issue":"6","key":"10.1016\/j.knee.2022.08.005_b0050","first-page":"619","article-title":"Ghrelin: Much more than a hunger hormone","volume":"16","author":"Pradhan","year":"2013","journal-title":"Curr Opin Clin Nutr Metab Care"},{"issue":"3","key":"10.1016\/j.knee.2022.08.005_b0055","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.neuropharm.2006.04.009","article-title":"Ghrelin inhibits inflammatory pain in rats: Involvement of the opioid system","volume":"51","author":"Sibilia","year":"2006","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.knee.2022.08.005_b0060","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1210\/en.2007-0828","article-title":"Ghrelin prevents cisplatin-induced mechanical hyperalgesia and cachexia","volume":"149","author":"Garcia","year":"2008","journal-title":"Endocrinology"},{"key":"10.1016\/j.knee.2022.08.005_b0065","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.cca.2017.04.014","article-title":"Decreased synovial fluid ghrelin levels are linked with disease severity in primary knee osteoarthritis patients and are increased following laser therapy","volume":"470","author":"Zou","year":"2017","journal-title":"Clin Chim Acta"},{"issue":"2","key":"10.1016\/j.knee.2022.08.005_b0070","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1096\/fj.201700265R","article-title":"Ghrelin protects against osteoarthritis through interplay with Akt and NF-\u03baB signaling pathways","volume":"32","author":"Qu","year":"2018","journal-title":"FASEB J"},{"issue":"1","key":"10.1016\/j.knee.2022.08.005_b0075","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.endinu.2018.05.016","article-title":"Serum ghrelin and obestatin levels in HIV-infected patients: Effect of 36 weeks of antiretroviral treatment","volume":"66","author":"Rivera-Leon","year":"2019","journal-title":"Endocrinol Diabetes y Nutr"},{"key":"10.1016\/j.knee.2022.08.005_b0080","doi-asserted-by":"crossref","first-page":"2191","DOI":"10.1001\/jama.2013.281053","article-title":"World Medical Association Declaration of Helsinki","volume":"310","author":"World Medical Association","year":"2013","journal-title":"JAMA"},{"issue":"1","key":"10.1016\/j.knee.2022.08.005_b0085","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1111\/imr.12066","article-title":"CD4 + T-cell depletion in HIV infection: mechanisms of immunological failure","volume":"254","author":"Okoye","year":"2013","journal-title":"Immunol Rev"}],"container-title":["The Knee"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968016022001296?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968016022001296?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,18]],"date-time":"2025-10-18T21:53:41Z","timestamp":1760824421000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968016022001296"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,12]]},"references-count":17,"alternative-id":["S0968016022001296"],"URL":"https:\/\/doi.org\/10.1016\/j.knee.2022.08.005","relation":{},"ISSN":["0968-0160"],"issn-type":[{"type":"print","value":"0968-0160"}],"subject":[],"published":{"date-parts":[[2022,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ghrelin level as a biomarker for knee osteoarthritis severity and appearance in HIV\u00a0+\u00a0patients","name":"articletitle","label":"Article Title"},{"value":"The Knee","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.knee.2022.08.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 Elsevier B.V. All rights reserved.","name":"copyright","label":"Copyright"}]}}