{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T19:14:50Z","timestamp":1788808490581,"version":"build-2803163510"},"reference-count":48,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T00:00:00Z","timestamp":1747094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thekneejournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Knee"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.knee.2025.05.011","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T08:01:22Z","timestamp":1747814482000},"page":"52-65","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Developing and validating a machine learning model to predict chronic pain following total knee arthroplasty"],"prefix":"10.1016","volume":"56","author":[{"given":"Ziliang","family":"Cheng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingjing","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weishan","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiguang","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangpeng","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.knee.2025.05.011_b0005","doi-asserted-by":"crossref","first-page":"e508","DOI":"10.1016\/S2665-9913(23)00163-7","article-title":"Global, regional, and national burden of osteoarthritis, 1990\u20132020 and projections to 2050: a systematic analysis for the Global Burden of Disease Study 2021","volume":"5","author":"Steinmetz","year":"2023","journal-title":"Lancet Rheumatol"},{"key":"10.1016\/j.knee.2025.05.011_b0010","doi-asserted-by":"crossref","first-page":"2449","DOI":"10.1016\/j.arth.2018.03.068","article-title":"Patient factors associated with prolonged postoperative opioid use after total knee arthroplasty","volume":"33","author":"Namba","year":"2018","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.knee.2025.05.011_b0015","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1186\/s13741-024-00466-9","article-title":"Chronic post-surgical pain after total knee arthroplasty: a narrative review","volume":"13","author":"Luo","year":"2024","journal-title":"Perioper Med (Lond)"},{"key":"10.1016\/j.knee.2025.05.011_b0020","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.jos.2020.04.010","article-title":"A clinical prediction rule for predicting a delay in quality of life recovery at 1 month after total knee arthroplasty: a decision tree model","volume":"26","author":"Tanaka","year":"2021","journal-title":"Orthop Sci"},{"key":"10.1016\/j.knee.2025.05.011_b0025","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.knee.2023.04.015","article-title":"Derivation of a clinical prediction rule for chronic post-surgical pain after total knee arthroplasty considering biopsychosocial factors: a prospective cohort study","volume":"42","author":"Nishimoto","year":"2023","journal-title":"Knee"},{"key":"10.1016\/j.knee.2025.05.011_b0030","doi-asserted-by":"crossref","DOI":"10.1093\/bjsopen\/zrad113","article-title":"Machine learning models to predict surgical case duration compared to current industry standards: scoping review","volume":"7","author":"Spence","year":"2023","journal-title":"BJS Open"},{"key":"10.1016\/j.knee.2025.05.011_b0035","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.comcom.2023.11.002","article-title":"A review of Machine Learning (ML)-based IoT security in healthcare: a dataset perspective","volume":"213","author":"Neto","year":"2024","journal-title":"Comput Commun"},{"key":"10.1016\/j.knee.2025.05.011_b0040","article-title":"Moderating effects of preoperative knee pain and pain catastrophizing on the relation between COMT rs4680 genotypes and chronic postsurgical pain in total knee arthroplasty patients","volume":"43","author":"Li","year":"2024","journal-title":"Anaesth Crit Care Pain Med"},{"key":"10.1016\/j.knee.2025.05.011_b0045","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.pmn.2023.04.008","article-title":"Construction and validation of machine learning algorithms to predict chronic post-surgical pain among patients undergoing total knee arthroplasty","volume":"24","author":"Yan","year":"2023","journal-title":"Pain Manag Nurs"},{"key":"10.1016\/j.knee.2025.05.011_b0050","first-page":"105","article-title":"Complications and safety of simultaneous bilateral total knee arthroplasty: a patient characteristic and comorbidity-matched analysis","author":"Richardson","year":"2023","journal-title":"JBJS"},{"key":"10.1016\/j.knee.2025.05.011_b0055","unstructured":"Analysis of Early Postoperative Pain in the First and Second Knee in Staged Bilateral Total Knee Arthroplasty: A Retrospective Controlled Study - PubMed n.d. https:\/\/pubmed.ncbi.nlm.nih.gov\/26068371\/ (Accessed 17 January 2025)."},{"key":"10.1016\/j.knee.2025.05.011_b0060","article-title":"Calculating the sample size required for developing a clinical prediction model","volume":"368","author":"Riley","year":"2020","journal-title":"BMJ"},{"key":"10.1016\/j.knee.2025.05.011_b0065","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1016\/S0140-6736(06)68700-X","article-title":"Persistent postsurgical pain: risk factors and prevention","volume":"367","author":"Kehlet","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.knee.2025.05.011_b0070","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1093\/bja\/aeu012","article-title":"Defining persistent post-surgical pain: is an update required?","volume":"113","author":"Werner","year":"2014","journal-title":"Br J Anaesth"},{"key":"10.1016\/j.knee.2025.05.011_b0075","series-title":"Fundamentals of Clinical Data Science","article-title":"Prediction modeling methodology","author":"Dankers","year":"2019"},{"key":"10.1016\/j.knee.2025.05.011_b0080","first-page":"1","article-title":"An efficient explanation of individual classifications using game theory","volume":"11","author":"Strumbelj","year":"2010","journal-title":"J Mach Learn Res"},{"key":"10.1016\/j.knee.2025.05.011_b0085","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1302\/0301-620X.106B6.BJJ-2023-0889.R1","article-title":"Prevalence and patterns of neuropathic pain in people with chronic post-surgical pain after total knee arthroplasty","volume":"106-B","author":"Bertram","year":"2024","journal-title":"Bone Joint J"},{"key":"10.1016\/j.knee.2025.05.011_b0090","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1097\/ALN.0000000000002130","article-title":"Neuroinflammation and central sensitization in chronic and widespread pain","volume":"129","author":"Ji","year":"2018","journal-title":"Anesthesiology"},{"key":"10.1016\/j.knee.2025.05.011_b0095","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.ibneur.2022.12.007","article-title":"Research progress on the mechanism of chronic neuropathic pain","volume":"14","author":"Cui","year":"2023","journal-title":"IBRO Neurosci Rep"},{"key":"10.1016\/j.knee.2025.05.011_b0100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41572-023-00484-9","article-title":"Central neuropathic pain","volume":"9","author":"Rosner","year":"2023","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.knee.2025.05.011_b0105","doi-asserted-by":"crossref","first-page":"2457","DOI":"10.1097\/j.pain.0000000000002653","article-title":"Rethinking the definition of chronic postsurgical pain: composites of patient-reported pain-related outcomes vs pain intensities alone","volume":"163","author":"Hofer","year":"2022","journal-title":"Pain"},{"key":"10.1016\/j.knee.2025.05.011_b0110","doi-asserted-by":"crossref","DOI":"10.1136\/rapm-2018-100036","article-title":"Acute postoperative pain is an independent predictor of chronic postsurgical pain following total knee arthroplasty at 6 months: a prospective cohort study","volume":"44","author":"Buvanendran","year":"2019","journal-title":"Reg Anesth Pain Med"},{"key":"10.1016\/j.knee.2025.05.011_b0115","doi-asserted-by":"crossref","first-page":"17627","DOI":"10.3390\/ijms242417627","article-title":"Single-nucleotide polymorphisms of the PAR2 and IL-17A genes are significantly associated with chronic pain","volume":"24","author":"Soeda","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.knee.2025.05.011_b0120","doi-asserted-by":"crossref","DOI":"10.1155\/2023\/5851450","article-title":"The relationship between pain catastrophizing and cognitive function in chronic musculoskeletal pain: a scoping review","volume":"2023","author":"Alcon","year":"2023","journal-title":"Pain Res Manag"},{"key":"10.1016\/j.knee.2025.05.011_b0125","article-title":"The mechanisms and management of persistent postsurgical pain","volume":"4","author":"Fuller","year":"2023","journal-title":"Front Pain Res (Lausanne)"},{"key":"10.1016\/j.knee.2025.05.011_b0130","doi-asserted-by":"crossref","first-page":"e588","DOI":"10.1097\/PR9.0000000000000588","article-title":"Postoperative pain-from mechanisms to treatment","volume":"2","author":"Pogatzki-Zahn","year":"2017","journal-title":"Pain Rep"},{"key":"10.1016\/j.knee.2025.05.011_b0135","doi-asserted-by":"crossref","DOI":"10.1155\/2015\/657809","article-title":"Acupuncture-point stimulation for postoperative pain control: a systematic review and meta-analysis of randomized controlled trials","volume":"2015","author":"Liu","year":"2015","journal-title":"Evid Based Complement Alternat Med"},{"key":"10.1016\/j.knee.2025.05.011_b0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.ctim.2024.103068","article-title":"Recent trends in Tuina for chronic pain management: a bibliometric analysis and literature review","volume":"84","author":"Xu","year":"2024","journal-title":"Complement Ther Med"},{"key":"10.1016\/j.knee.2025.05.011_b0145","doi-asserted-by":"crossref","first-page":"3959","DOI":"10.2147\/JPR.S387756","article-title":"Effectiveness and safety of acupuncture-related therapies for chronic musculoskeletal pain: a protocol for systematic review and network meta-analysis","volume":"15","author":"Zhou","year":"2022","journal-title":"J Pain Res"},{"key":"10.1016\/j.knee.2025.05.011_b0150","first-page":"53","article-title":"Longer length of stay is associated with more early complications after total knee arthroplasty","volume":"42","author":"DeMik","year":"2022","journal-title":"Iowa Orthop J"},{"key":"10.1016\/j.knee.2025.05.011_b0155","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.3390\/jcm11082114","article-title":"Length of hospital stay after total knee arthroplasty: a correlation study on 1200 patients","volume":"11","author":"Papalia","year":"2022","journal-title":"J Clin Med"},{"key":"10.1016\/j.knee.2025.05.011_b0160","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000026768","article-title":"Pain control and related factors in hospitalized patients","volume":"100","author":"Lin","year":"2021","journal-title":"Medicine"},{"key":"10.1016\/j.knee.2025.05.011_b0165","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.knee.2016.09.022","article-title":"Length of stay and short-term functional outcomes after total knee arthroplasty: can we predict them?","volume":"24","author":"Emanuele","year":"2017","journal-title":"Knee"},{"key":"10.1016\/j.knee.2025.05.011_b0170","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1111\/aas.14278","article-title":"Levels of preoperative cerebrospinal fluid pro-inflammatory mediators and chronic pain after total knee arthroplasty surgery","volume":"67","author":"Kato","year":"2023","journal-title":"Acta Anaesthesiol Scand"},{"key":"10.1016\/j.knee.2025.05.011_b0175","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1016\/j.joca.2017.03.008","article-title":"Inflammation and post-operative recovery in patients undergoing total knee arthroplasty-secondary analysis of a randomized controlled trial","volume":"25","author":"Langkilde","year":"2017","journal-title":"Osteoarthr Cartil"},{"key":"10.1016\/j.knee.2025.05.011_b0180","doi-asserted-by":"crossref","first-page":"1598","DOI":"10.1016\/j.arth.2019.03.063","article-title":"Psychological distress independently predicts prolonged hospitalization after primary total hip and knee arthroplasty","volume":"34","author":"Halawi","year":"2019","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.knee.2025.05.011_b0185","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1097\/AJP.0b013e3182385392","article-title":"Fear-avoidance model of chronic pain: the next generation","volume":"28","author":"Crombez","year":"2012","journal-title":"Clin J Pain"},{"key":"10.1016\/j.knee.2025.05.011_b0190","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.ijbiomac.2021.06.140","article-title":"Serum albumin levels and inflammation","volume":"184","author":"Sheinenzon","year":"2021","journal-title":"Int J Biol Macromol"},{"key":"10.1016\/j.knee.2025.05.011_b0195","doi-asserted-by":"crossref","DOI":"10.1177\/00368504241274023","article-title":"The role of serum albumin in critical illness, predicting poor outcomes, and exploring the therapeutic potential of albumin supplementation","volume":"107","author":"Rabi","year":"2024","journal-title":"Sci Prog"},{"key":"10.1016\/j.knee.2025.05.011_b0200","doi-asserted-by":"crossref","first-page":"2937","DOI":"10.2147\/JPR.S469229","article-title":"Chronic pain and bone-related pathologies: a narrative review","volume":"17","author":"Pickering","year":"2024","journal-title":"J Pain Res"},{"key":"10.1016\/j.knee.2025.05.011_b0205","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1007\/s40266-017-0492-4","article-title":"Pain in osteoporosis: from pathophysiology to therapeutic approach","volume":"34","author":"Catalano","year":"2017","journal-title":"Drugs Aging"},{"key":"10.1016\/j.knee.2025.05.011_b0210","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1007\/s43465-023-01047-6","article-title":"Pain management in osteoporosis","volume":"57","author":"Rajnish","year":"2023","journal-title":"JOIO"},{"key":"10.1016\/j.knee.2025.05.011_b0215","doi-asserted-by":"crossref","first-page":"S255","DOI":"10.21037\/atm.2019.08.15","article-title":"Rehabilitation protocols following total knee arthroplasty: a review of study designs and outcome measures","volume":"7","author":"D\u00e1vila Castrodad","year":"2019","journal-title":"Ann Transl Med"},{"key":"10.1016\/j.knee.2025.05.011_b0220","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1186\/s12891-019-2900-x","article-title":"Technology-assisted rehabilitation following total knee or hip replacement for people with osteoarthritis: a systematic review and meta-analysis","volume":"20","author":"Wang","year":"2019","journal-title":"BMC Musculoskelet Disord"},{"key":"10.1016\/j.knee.2025.05.011_b0225","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000030852","article-title":"Robot-assisted rehabilitation for total knee or hip replacement surgery patients: a systematic review and meta-analysis","volume":"101","author":"Yoo","year":"2022","journal-title":"Medicine (Baltimore)"},{"key":"10.1016\/j.knee.2025.05.011_b0230","doi-asserted-by":"crossref","first-page":"1603","DOI":"10.1093\/ptj\/pzaa099","article-title":"Physical therapist management of total knee arthroplasty","volume":"100","author":"Jette","year":"2020","journal-title":"Phys Ther"},{"key":"10.1016\/j.knee.2025.05.011_b0235","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.arth.2022.10.009","article-title":"A home-based, remote-clinician-controlled, physical therapy device leads to superior outcomes when compared to standard physical therapy for rehabilitation after total knee arthroplasty","volume":"38","author":"Summers","year":"2023","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.knee.2025.05.011_b0240","doi-asserted-by":"crossref","first-page":"101","DOI":"10.2106\/JBJS.19.00695","article-title":"Effects of virtual exercise rehabilitation in-home therapy compared with traditional care after total knee arthroplasty: VERITAS, a randomized controlled trial","volume":"102","author":"Prvu Bettger","year":"2020","journal-title":"J Bone Joint Surg Am"}],"container-title":["The Knee"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968016025001176?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968016025001176?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,25]],"date-time":"2025-10-25T12:26:37Z","timestamp":1761395197000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968016025001176"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":48,"alternative-id":["S0968016025001176"],"URL":"https:\/\/doi.org\/10.1016\/j.knee.2025.05.011","relation":{},"ISSN":["0968-0160"],"issn-type":[{"value":"0968-0160","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Developing and validating a machine learning model to predict chronic pain following total knee arthroplasty","name":"articletitle","label":"Article Title"},{"value":"The Knee","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.knee.2025.05.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier B.V.","name":"copyright","label":"Copyright"}]}}