{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T22:16:58Z","timestamp":1789165018376,"version":"build-2803163510"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,12,1]],"date-time":"2026-12-01T00:00:00Z","timestamp":1796083200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thekneejournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Knee"],"published-print":{"date-parts":[[2026,12]]},"DOI":"10.1016\/j.knee.2026.104639","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T21:13:27Z","timestamp":1789161207000},"page":"104639","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Postoperative outcomes after total knee arthroplasty in type 2 diabetes mellitus patients receiving semaglutide versus tirzepatide: a propensity score-matched national research network analysis"],"prefix":"10.1016","volume":"63","author":[{"given":"Kevin A.","family":"Wu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankit","family":"Choudhury","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua A.","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devika A.","family":"Shenoy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junho","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"Mai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suraj","family":"Dhanjani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Shatkin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel S.","family":"Wellman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorsten M.","family":"Seyler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Calin S.","family":"Moucha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brett L.","family":"Hayden","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"17","key":"10.1016\/j.knee.2026.104639_b0005","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1056\/NEJMoa1505467","article-title":"A randomized, controlled trial of total knee replacement","volume":"373","author":"Skou","year":"2015","journal-title":"N Engl J Med"},{"issue":"9","key":"10.1016\/j.knee.2026.104639_b0010","doi-asserted-by":"crossref","first-page":"3218","DOI":"10.1002\/ksa.12675","article-title":"Wearable health technology finds improvements in daily physical activity levels following total knee arthroplasty: a prospective study","volume":"33","author":"Wu","year":"2025","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"issue":"1","key":"10.1016\/j.knee.2026.104639_b0015","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.arth.2016.06.009","article-title":"Predictors of patient-reported pain and functional outcomes over 10 years after primary total knee arthroplasty: a prospective cohort study","volume":"32","author":"Jiang","year":"2017","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.knee.2026.104639_b0020","article-title":"Impact of obesity on daily activity following total knee arthroplasty","author":"Wu","year":"2025","journal-title":"J Arthroplasty"},{"issue":"5","key":"10.1016\/j.knee.2026.104639_b0025","doi-asserted-by":"crossref","first-page":"1204","DOI":"10.1016\/j.arth.2024.10.064","article-title":"Obesity and primary total knee arthroplasty: the absolute versus relative risk of periprosthetic joint infection at 15 years","volume":"40","author":"Carender","year":"2025","journal-title":"J Arthroplasty"},{"issue":"6","key":"10.1016\/j.knee.2026.104639_b0030","doi-asserted-by":"crossref","first-page":"500","DOI":"10.2106\/JBJS.L.01631","article-title":"Many diabetic total joint arthroplasty candidates are unable to achieve a preoperative hemoglobin A1c goal of 7% or less","volume":"96","author":"Giori","year":"2014","journal-title":"J Bone Joint Surg Am"},{"issue":"7","key":"10.1016\/j.knee.2026.104639_b0035","doi-asserted-by":"crossref","first-page":"S76","DOI":"10.1016\/j.arth.2018.02.071","article-title":"Preoperative glycemic control predicts perioperative serum glucose levels in patients undergoing total joint arthroplasty","volume":"33","author":"Godshaw","year":"2018","journal-title":"J Arthroplasty"},{"issue":"1","key":"10.1016\/j.knee.2026.104639_b0040","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/s41392-024-01931-z","article-title":"Glucagon-like peptide-1 receptor: mechanisms and advances in therapy","volume":"9","author":"Zheng","year":"2024","journal-title":"Signal Transduct Target Ther"},{"issue":"3","key":"10.1016\/j.knee.2026.104639_b0045","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1038\/s41591-024-03412-w","article-title":"Mapping the effectiveness and risks of GLP-1 receptor agonists","volume":"31","author":"Xie","year":"2025","journal-title":"Nat Med"},{"issue":"16","key":"10.1016\/j.knee.2026.104639_b0050","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.2106\/JBJS.24.01287","article-title":"GLP-1 receptor agonists in orthopaedic surgery: implications for perioperative care and outcomes: an orthopaedic surgeon's perspective","volume":"107","author":"Ramanathan","year":"2025","journal-title":"J Bone Joint Surg Am"},{"key":"10.1016\/j.knee.2026.104639_b0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.arth.2025.07.015","article-title":"Impact of glucagon-like peptide-1 receptor agonists on postoperative outcomes in arthroplasty: a systematic review","author":"Lee","year":"2025","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.knee.2026.104639_b0060","doi-asserted-by":"crossref","DOI":"10.1016\/j.arth.2025.06.083","article-title":"The association between glucagon-like peptide-1 receptor agonists and postoperative complications after arthroplasty: a systematic review and meta-analysis","author":"Chan","year":"2025","journal-title":"J Arthroplasty"},{"issue":"2","key":"10.1016\/j.knee.2026.104639_b0065","doi-asserted-by":"crossref","first-page":"99959","DOI":"10.5662\/wjm.v15.i2.99959","article-title":"Surgical site soft tissue thickness as a predictor of complications following arthroplasty","volume":"15","author":"Wu","year":"2025","journal-title":"World J Methodol"},{"issue":"11","key":"10.1016\/j.knee.2026.104639_b0070","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1056\/NEJMoa2032183","article-title":"Once-weekly semaglutide in adults with overweight or obesity","volume":"384","author":"Wilding","year":"2021","journal-title":"N Engl J Med"},{"issue":"1","key":"10.1016\/j.knee.2026.104639_b0075","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1056\/NEJMoa2416394","article-title":"Tirzepatide as compared with semaglutide for the treatment of obesity","volume":"393","author":"Aronne","year":"2025","journal-title":"N Engl J Med"},{"issue":"9","key":"10.1016\/j.knee.2026.104639_b0080","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1001\/jamainternmed.2024.2525","article-title":"Semaglutide vs tirzepatide for weight loss in adults with overweight or obesity","volume":"184","author":"Rodriguez","year":"2024","journal-title":"JAMA Intern Med"},{"issue":"6","key":"10.1016\/j.knee.2026.104639_b0085","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1056\/NEJMoa2107519","article-title":"Tirzepatide versus semaglutide once weekly in patients with type 2 diabetes","volume":"385","author":"Fr\u00edas","year":"2021","journal-title":"N Engl J Med"},{"key":"10.1016\/j.knee.2026.104639_b0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.artd.2024.101506","article-title":"Glucagon-like peptide-1 receptor agonist use is not associated with increased complications after total knee arthroplasty in patients with type-2 diabetes","volume":"30","author":"Heo","year":"2024","journal-title":"Arthroplast Today"},{"issue":"12","key":"10.1016\/j.knee.2026.104639_b0095","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1016\/j.arth.2024.05.079","article-title":"Decreased risk of readmission and complications with preoperative GLP-1 analog use in patients undergoing primary total joint arthroplasty","volume":"39","author":"Buddhiraju","year":"2024","journal-title":"J Arthroplasty"},{"key":"10.1016\/j.knee.2026.104639_b0100","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.knee.2025.08.007","article-title":"GLP-1 agonists are protective against postoperative complications following total knee arthroplasty","volume":"57","author":"Ranson","year":"2025","journal-title":"Knee"},{"issue":"21","key":"10.1016\/j.knee.2026.104639_b0105","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.5435\/JAAOS-D-24-01284","article-title":"The effects of glucagon-like peptide-1 agonist therapy on risk of infection, fracture, and early revision in primary total joint arthroplasty","volume":"33","author":"Levidy","year":"2025","journal-title":"J Am Acad Orthop Surg"},{"issue":"5","key":"10.1016\/j.knee.2026.104639_b0110","doi-asserted-by":"crossref","first-page":"2213","DOI":"10.1007\/s00402-023-05136-x","article-title":"What's important for recovery after a total knee replacement? A systematic review of mixed methods studies","volume":"144","author":"Khatri","year":"2024","journal-title":"Arch Orthop Trauma Surg"},{"issue":"2","key":"10.1016\/j.knee.2026.104639_b0115","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/j.ocl.2024.05.003","article-title":"Fall prevention after hip and knee arthroplasty","volume":"56","author":"Wu","year":"2025","journal-title":"Orthop Clin North Am"},{"issue":"2","key":"10.1016\/j.knee.2026.104639_b0120","doi-asserted-by":"crossref","first-page":"292","DOI":"10.2337\/dc24-1678","article-title":"Efficacy of GLP-1 receptor agonists on weight loss, BMI, and waist circumference for patients with obesity or overweight: a systematic review, meta-analysis, and meta-regression of 47 randomized controlled trials","volume":"48","author":"Wong","year":"2025","journal-title":"Diabetes Care"},{"key":"10.1016\/j.knee.2026.104639_b0125","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1007\/5584_2020_496","article-title":"Effects of GLP-1 and its analogs on gastric physiology in diabetes mellitus and obesity","volume":"1307","author":"Maselli","year":"2021","journal-title":"Adv Exp Med Biol"},{"key":"10.1016\/j.knee.2026.104639_b0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2025.103408","article-title":"Evaluation of safety of preoperative GLP-1 receptor agonists in patients undergoing elective surgery: a systematic review, meta-analysis and meta-regression","volume":"87","author":"Kamarajah","year":"2025","journal-title":"eClinicalMedicine"}],"container-title":["The Knee"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968016026003212?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0968016026003212?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T21:45:03Z","timestamp":1789163103000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0968016026003212"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,12]]},"references-count":26,"alternative-id":["S0968016026003212"],"URL":"https:\/\/doi.org\/10.1016\/j.knee.2026.104639","relation":{},"ISSN":["0968-0160"],"issn-type":[{"value":"0968-0160","type":"print"}],"subject":[],"published":{"date-parts":[[2026,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Postoperative outcomes after total knee arthroplasty in type 2 diabetes mellitus patients receiving semaglutide versus tirzepatide: a propensity score-matched national research network analysis","name":"articletitle","label":"Article Title"},{"value":"The Knee","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.knee.2026.104639","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier B.V. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"104639"}}