{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T14:02:00Z","timestamp":1776261720603,"version":"3.50.1"},"reference-count":32,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Laboratory and Clinical Medicine"],"published-print":{"date-parts":[[2005,1]]},"DOI":"10.1016\/j.lab.2004.11.016","type":"journal-article","created":{"date-parts":[[2005,1,25]],"date-time":"2005-01-25T13:14:04Z","timestamp":1106658844000},"page":"12-16","source":"Crossref","is-referenced-by-count":3,"title":["The 50th anniversary of the identification of primary aldosteronism: A retrospective of the work of Jerome W. Conn"],"prefix":"10.1016","volume":"145","author":[{"given":"David E.","family":"Schteingart","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.lab.2004.11.016_bib1","first-page":"3","article-title":"Part I. Painting background. Part II. Primary aldosteronism, a new clinical syndrome","volume":"45","author":"Conn","year":"1955","journal-title":"J Lab Clin Med"},{"key":"10.1016\/j.lab.2004.11.016_bib2","first-page":"373","article-title":"The mechanism of acclimatization to heat","volume":"3","author":"Conn","year":"1949","journal-title":"Adv Intern Med"},{"key":"10.1016\/j.lab.2004.11.016_bib3","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1210\/jcem-10-1-12","article-title":"Production of endogenous salt-active corticoids as reflected in the concentrations of sodium and chloride of thermal sweat","volume":"10","author":"Conn","year":"1950","journal-title":"J Clin Endocrinol"},{"key":"10.1016\/j.lab.2004.11.016_bib4","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/S0140-6736(52)91551-1","article-title":"Secretion of a salt retaining hormone by the adrenal cortex","volume":"263","author":"Simpson","year":"1952","journal-title":"Lancet"},{"key":"10.1016\/j.lab.2004.11.016_bib5","doi-asserted-by":"crossref","first-page":"171","DOI":"10.3181\/00379727-73-17614","article-title":"Bioassay of desoxycorticosterone-like material in urine","volume":"73","author":"Deming","year":"1950","journal-title":"Exp Biol Med"},{"key":"10.1016\/j.lab.2004.11.016_bib6","first-page":"560","article-title":"The mechanism of sodium retention in cirrohsis of the liver [abstract]","volume":"32","author":"Chart","year":"1953","journal-title":"J Clin Invest"},{"key":"10.1016\/j.lab.2004.11.016_bib7","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1210\/endo-52-6-623","article-title":"Method of assay of a sodium retaining factor in human urine","volume":"52","author":"Singer","year":"1953","journal-title":"Endocrinology"},{"key":"10.1016\/j.lab.2004.11.016_bib8","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1172\/JCI102896","article-title":"Chromatographic separation of the sodium- retaining corticoid from the urine of children with nephrosis compared with observations in normal children","volume":"33","author":"Luetscher","year":"1954","journal-title":"J Clin Invest"},{"key":"10.1016\/j.lab.2004.11.016_bib9","doi-asserted-by":"crossref","first-page":"3438","DOI":"10.1210\/jcem.80.12.8530580","article-title":"Primary aldosteronism (Conn\u2019s syndrome)","volume":"80","author":"Gitler","year":"1995","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.lab.2004.11.016_bib10","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1001\/jama.1964.03070160037008","article-title":"Suppression of plasma renin activity in primary aldosteronism. Distinguishing primary from secondary aldosteronism in hypertensive disease","volume":"190","author":"Conn","year":"1964","journal-title":"JAMA"},{"key":"10.1016\/j.lab.2004.11.016_bib11","first-page":"403","article-title":"Angiotensin, aldosterone and human arterial hypertension","volume":"84","author":"Genest","year":"1961","journal-title":"Can Med Assoc J"},{"key":"10.1016\/j.lab.2004.11.016_bib12","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1161\/01.CIR.25.1.203","article-title":"Interrelationship between angiotensin, norepinephrine, epinephrine, aldosterone secretion and electrolyte metabolism in man","volume":"25","author":"Laragh","year":"1962","journal-title":"Circulation"},{"key":"10.1016\/j.lab.2004.11.016_bib13","first-page":"160","article-title":"Sodium, renal arterial distension and juxtaglomerular apparatus","volume":"90","author":"Tobian","year":"1964","journal-title":"Canad Med Assoc J"},{"key":"10.1016\/j.lab.2004.11.016_bib14","first-page":"272","article-title":"Relationship of angiotensin to renal hypertension","volume":"90","author":"Morris","year":"1964","journal-title":"Canad Med Assoc J"},{"key":"10.1016\/j.lab.2004.11.016_bib15","first-page":"99","article-title":"Hypertension and renal loss of potassium","volume":"73","author":"Laidlaw","year":"1961","journal-title":"Trans Am Clin Climat Assoc"},{"key":"10.1016\/j.lab.2004.11.016_bib16","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1172\/JCI105543","article-title":"Postural augmentation of plasma renin activity and aldosterone excretion in normal people","volume":"46","author":"Cohen","year":"1967","journal-title":"Clin Invest"},{"key":"10.1016\/j.lab.2004.11.016_bib17","doi-asserted-by":"crossref","first-page":"1135","DOI":"10.1056\/NEJM196511182732106","article-title":"Hypertension, the potassium ion and impaired carbohydrate tolerance","volume":"273","author":"Conn","year":"1965","journal-title":"N Engl J Med"},{"key":"10.1016\/j.lab.2004.11.016_bib18","first-page":"257","article-title":"The evolution of primary aldosteronism:1954\u20131967","volume":"62","author":"Conn","year":"1966","journal-title":"Harvey Lectures"},{"issue":"Suppl 2","key":"10.1016\/j.lab.2004.11.016_bib19","first-page":"5148","article-title":"Prevelance of primary aldosteronism (PA) in newly diagnosed hypertensive patients","volume":"22","author":"Rossi","year":"2004","journal-title":"J Hypertension"},{"key":"10.1016\/j.lab.2004.11.016_bib20","first-page":"1025","article-title":"Accurate and rapid measurement of plasma renin activity by radioimmunoassay. Results in normal and hypertensive people","volume":"77","author":"Cohen","year":"1971","journal-title":"J Lab Clin Med"},{"key":"10.1016\/j.lab.2004.11.016_bib21","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/0005-2795(70)90225-4","article-title":"Studies on the partial isolation of human renin","volume":"221","author":"Waldhausl","year":"1970","journal-title":"Biochimia et Biophysica Acta"},{"key":"10.1016\/j.lab.2004.11.016_bib22","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/S0022-5347(17)61996-7","article-title":"Preoperative tumor localization by adrenal venography in patients with primary aldosteronism","volume":"103","author":"Cerny","year":"1970","journal-title":"J Urol"},{"key":"10.1016\/j.lab.2004.11.016_bib23","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1210\/jcem-33-4-713","article-title":"Primary aldosteronism","volume":"33","author":"Conn","year":"1971","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.lab.2004.11.016_bib24","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/S0022-5347(17)60331-8","article-title":"Localization of adrenal tumors by photoscanning","volume":"109","author":"Herwig","year":"1973","journal-title":"J Urol"},{"key":"10.1016\/j.lab.2004.11.016_bib25","first-page":"841","article-title":"The dexamethasone-modified adrenal scintiscan in hyporeninemic aldosteronism (tumor versus hyperplasia). A comparison with adrenal venography and adrenal venous aldosterone","volume":"88","author":"Conn","year":"1976","journal-title":"J Lab Clin Med"},{"key":"10.1016\/j.lab.2004.11.016_bib26","first-page":"137","article-title":"Primary aldosteronism","volume":"7","author":"Conn","year":"1977","journal-title":"Adv Nephrol Necker Hosp"},{"key":"10.1016\/j.lab.2004.11.016_bib27","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S0022-5347(17)60423-3","article-title":"The syndrome of hypertension, hyperreninemia and secondary aldosteronism associated with renal juxtaglomerular cell tumor (primary reninism)","volume":"109","author":"Conn","year":"1973","journal-title":"J Urol"},{"key":"10.1016\/j.lab.2004.11.016_bib28","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1001\/archinte.1972.03650050016004","article-title":"Primary reninism. Hypertension, hyperreninemia, and secondary aldosteronism due to renin-producing juxtaglomerular cell tumors","volume":"130","author":"Conn","year":"1972","journal-title":"Arch Intern Med"},{"key":"10.1016\/j.lab.2004.11.016_bib29","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1001\/jama.1968.03140330034006","article-title":"Licorice-induced pseudoaldosteronism. Hypertension, hypokalemia, aldosteronopenia, and suppressed plasma renin activity","volume":"205","author":"Conn","year":"1968","journal-title":"JAMA"},{"key":"10.1016\/j.lab.2004.11.016_bib30","doi-asserted-by":"crossref","first-page":"2384","DOI":"10.1210\/jc.2003-030138","article-title":"Hypertension and the cortisol-cortisone shuttle","volume":"88","author":"Quinkler","year":"2003","journal-title":"J Endocrinol Metab"},{"key":"10.1016\/j.lab.2004.11.016_bib31","first-page":"116","article-title":"Aldosteronism in hypertensive disease","volume":"98","author":"Conn","year":"1970","journal-title":"Med Times"},{"key":"10.1016\/j.lab.2004.11.016_bib32","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1530\/acta.0.0900490","article-title":"17 alpha-Hydroxylase deficiency. A combination of hydroxylation defect and reversible blockade in aldosterone biosynthesis","volume":"90","author":"Rovner","year":"1979","journal-title":"Acta Endocrinol"}],"container-title":["Journal of Laboratory and Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022214304003300?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022214304003300?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,29]],"date-time":"2019-01-29T23:57:33Z","timestamp":1548806253000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022214304003300"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,1]]},"references-count":32,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2005,1]]}},"alternative-id":["S0022214304003300"],"URL":"https:\/\/doi.org\/10.1016\/j.lab.2004.11.016","relation":{},"ISSN":["0022-2143"],"issn-type":[{"value":"0022-2143","type":"print"}],"subject":[],"published":{"date-parts":[[2005,1]]}}}