{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T04:51:25Z","timestamp":1761540685986},"reference-count":23,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2006,5,1]],"date-time":"2006-05-01T00:00:00Z","timestamp":1146441600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Journal of Laboratory and Clinical Medicine"],"published-print":{"date-parts":[[2006,5]]},"DOI":"10.1016\/j.lab.2005.12.005","type":"journal-article","created":{"date-parts":[[2006,5,13]],"date-time":"2006-05-13T14:21:38Z","timestamp":1147530098000},"page":"220-227","source":"Crossref","is-referenced-by-count":14,"title":["Aspirin therapy for inhibition of platelet reactivity in the presence of erythrocytes in patients with vascular disease"],"prefix":"10.1016","volume":"147","author":[{"given":"M. Teresa","family":"Santos","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juana","family":"Vall\u00e9s","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Justo","family":"Aznar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aida","family":"Lago","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Sanchez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Cosin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio","family":"Moscard\u00f3","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Pi\u00f1\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. Johan","family":"Broekman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron J.","family":"Marcus","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.lab.2005.12.005_bib1","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1136\/bmj.324.7329.71","article-title":"Collaborative meta-analysis of randomized trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients","volume":"324","year":"2002","journal-title":"Br Med J"},{"key":"10.1016\/j.lab.2005.12.005_bib2","doi-asserted-by":"crossref","first-page":"2497","DOI":"10.1111\/j.1538-7836.2003.00479.x","article-title":"Heterologous cell-cell interactions. thromboregulation, cerebroprotection and cardioprotection by CD39 (NTPDase-1)","volume":"1","author":"Marcus","year":"2003","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.lab.2005.12.005_bib3","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1172\/JCI115032","article-title":"Enhancement of platelet reactivity and modulation of eicosanoid production by intact erythrocytes","volume":"87","author":"Santos","year":"1991","journal-title":"J Clin Invest"},{"key":"10.1016\/j.lab.2005.12.005_bib4","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1161\/01.CIR.102.16.1924","article-title":"Participation of tyrosine phosphorylation in cytoskeletal reorganization,\u03b1IIb\u03b23 integrin receptor activation and aspirin-insensitive mechanisms of thrombin-stimulated human platelets","volume":"102","author":"Santos","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.lab.2005.12.005_bib5","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1161\/01.CIR.0000013777.21160.07","article-title":"Aspirin-resistant thromboxane biosynthesis and the risk of myocardial infarction, stroke, or cardiovascular death in patients at high risk for cardiovascular events","volume":"105","author":"Eikelboom","year":"2002","journal-title":"Circulation"},{"key":"10.1016\/j.lab.2005.12.005_bib6","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1172\/JCI116709","article-title":"Down-regulation of human platelet reactivity by neutrophils. Participation of lipoxygenase derivatives and adhesive proteins","volume":"92","author":"Valles","year":"1993","journal-title":"J Clin Invest"},{"key":"10.1016\/j.lab.2005.12.005_bib7","doi-asserted-by":"crossref","first-page":"2080","DOI":"10.1161\/01.CIR.91.7.2080","article-title":"Effects of aspirin on platelet-neutrophil interactions","volume":"91","author":"Lopez-Farre","year":"1995","journal-title":"Circulation"},{"key":"10.1016\/j.lab.2005.12.005_bib8","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1182\/blood.V78.1.154.154","article-title":"Erythrocytes metabolically enhance collagen-induced platelet responsiveness via increased thromboxane production, ADP release, and recruitment","volume":"78","author":"Valles","year":"1991","journal-title":"Blood"},{"key":"10.1016\/j.lab.2005.12.005_bib9","doi-asserted-by":"crossref","first-page":"3978","DOI":"10.1182\/blood.V99.11.3978","article-title":"Platelet-erythrocyte interactions enhance \u03b1IIb\u03b23integrin receptor activation and P-selectin expression during platelet recruitment","volume":"99","author":"Valles","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.lab.2005.12.005_bib10","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1161\/01.CIR.95.1.63","article-title":"Prothrombotic effects of erythrocytes on platelet reactivity","volume":"95","author":"Santos","year":"1997","journal-title":"Circulation"},{"key":"10.1016\/j.lab.2005.12.005_bib11","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1161\/01.CIR.97.4.350","article-title":"Erythrocyte promotion of platelet reactivity decreases the effectiveness of aspirin as an antithrombotic therapeutic modality","volume":"97","author":"Valles","year":"1998","journal-title":"Circulation"},{"key":"10.1016\/j.lab.2005.12.005_bib12","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1097\/00062752-199704050-00006","article-title":"Platelet kinetics","volume":"4","author":"Dale","year":"1997","journal-title":"Curr Opin Hematol"},{"key":"10.1016\/j.lab.2005.12.005_bib13","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/0049-3848(80)90334-5","article-title":"Possible significance of small numbers of functional platelets in a population of aspirin-treated platelets in vitro and in vivo","volume":"18","author":"Cerskus","year":"1980","journal-title":"Thromb Res"},{"key":"10.1016\/j.lab.2005.12.005_bib14","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1182\/blood.V61.6.1081.1081","article-title":"Monitoring the entry of new platelets into the circulation after ingestion of aspirin","volume":"61","author":"Di Minno","year":"1983","journal-title":"Blood"},{"key":"10.1016\/j.lab.2005.12.005_bib15","doi-asserted-by":"crossref","first-page":"1206","DOI":"10.1161\/01.CIR.101.10.1206","article-title":"Aspirin","volume":"101","author":"Awtry","year":"2000","journal-title":"Circulation"},{"key":"10.1016\/j.lab.2005.12.005_bib16","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1161\/hc3801.097475","volume":"104","author":"Smith","year":"2001","journal-title":"Circulation"},{"key":"10.1016\/j.lab.2005.12.005_bib17","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1161\/01.STR.0000028456.18614.93","article-title":"Anticoagulants and antiplatelet agents in acute ischemic stroke","volume":"33","author":"Coull","year":"2002","journal-title":"Stroke"},{"key":"10.1016\/j.lab.2005.12.005_bib18","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1161\/01.ATV.17.11.2309","article-title":"Isoprostanes","volume":"17","author":"Patrono","year":"1997","journal-title":"Arterioscler Thromb Vasc Biol"},{"key":"10.1016\/j.lab.2005.12.005_bib19","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/nrd985","article-title":"Scientific and therapeutic advances in antiplatelet therapy","volume":"2","author":"Bhatt","year":"2003","journal-title":"Nat Rev Drug Discov"},{"key":"10.1016\/j.lab.2005.12.005_bib20","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1161\/01.CIR.90.4.1908","article-title":"Platelet-induced vascular smooth muscle cell proliferation is modulated by the growth amplification factors serotonin and adenosine diphosphate","volume":"90","author":"Crowley","year":"1994","journal-title":"Circulation"},{"key":"10.1016\/j.lab.2005.12.005_bib21","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1161\/01.CIR.0000088843.52678.8A","article-title":"Genetic and acquired determinants of individual variability of response to antiplatelet drugs","volume":"108","author":"Schafer","year":"2003","journal-title":"Circulation"},{"key":"10.1016\/j.lab.2005.12.005_bib22","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1016\/S0735-1097(02)03014-0","article-title":"A prospective, blinded determination of the natural history of aspirin resistance among stable patients with cardiovascular disease","volume":"41","author":"Gum","year":"2003","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.lab.2005.12.005_bib23","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/0049-3848(93)90164-J","article-title":"Two-year follow-up of aspirin responder and aspirin non responder. A pilot-study including 180 post-stroke patients","volume":"71","author":"Grotemeyer","year":"1993","journal-title":"Thromb Res"}],"container-title":["Journal of Laboratory and Clinical Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022214305004178?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0022214305004178?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,14]],"date-time":"2020-04-14T21:05:14Z","timestamp":1586898314000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0022214305004178"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,5]]}},"alternative-id":["S0022214305004178"],"URL":"https:\/\/doi.org\/10.1016\/j.lab.2005.12.005","relation":{},"ISSN":["0022-2143"],"issn-type":[{"value":"0022-2143","type":"print"}],"subject":[],"published":{"date-parts":[[2006,5]]}}}