{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T22:21:22Z","timestamp":1790288482763,"version":"4.1.0"},"reference-count":52,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/100020595","name":"Taiwan Ministry of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019503","name":"Kaohsiung Municipal Ta-Tung Hospital","doi-asserted-by":"publisher","award":["KMTTH-109-R010"],"award-info":[{"award-number":["KMTTH-109-R010"]}],"id":[{"id":"10.13039\/100019503","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019503","name":"Kaohsiung Municipal Ta-Tung Hospital","doi-asserted-by":"publisher","award":["KMTTH-107-015"],"award-info":[{"award-number":["KMTTH-107-015"]}],"id":[{"id":"10.13039\/100019503","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019503","name":"Kaohsiung Municipal Ta-Tung Hospital","doi-asserted-by":"publisher","award":["KMTTH-110-005"],"award-info":[{"award-number":["KMTTH-110-005"]}],"id":[{"id":"10.13039\/100019503","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019503","name":"Kaohsiung Municipal Ta-Tung Hospital","doi-asserted-by":"publisher","award":["KMTTH-107-016"],"award-info":[{"award-number":["KMTTH-107-016"]}],"id":[{"id":"10.13039\/100019503","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019503","name":"Kaohsiung Municipal Ta-Tung Hospital","doi-asserted-by":"publisher","award":["KMTTH-108-052"],"award-info":[{"award-number":["KMTTH-108-052"]}],"id":[{"id":"10.13039\/100019503","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019503","name":"Kaohsiung Municipal Ta-Tung Hospital","doi-asserted-by":"publisher","award":["KMTTH-106-014"],"award-info":[{"award-number":["KMTTH-106-014"]}],"id":[{"id":"10.13039\/100019503","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019503","name":"Kaohsiung Municipal Ta-Tung Hospital","doi-asserted-by":"publisher","award":["KMTTH-109-R008"],"award-info":[{"award-number":["KMTTH-109-R008"]}],"id":[{"id":"10.13039\/100019503","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019503","name":"Kaohsiung Municipal Ta-Tung Hospital","doi-asserted-by":"publisher","award":["KMTTH-105-054"],"award-info":[{"award-number":["KMTTH-105-054"]}],"id":[{"id":"10.13039\/100019503","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019503","name":"Kaohsiung Municipal Ta-Tung Hospital","doi-asserted-by":"publisher","award":["KMTTH-108-007"],"award-info":[{"award-number":["KMTTH-108-007"]}],"id":[{"id":"10.13039\/100019503","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004694","name":"Kaohsiung Medical University","doi-asserted-by":"publisher","award":["KMUH105-5R16"],"award-info":[{"award-number":["KMUH105-5R16"]}],"id":[{"id":"10.13039\/501100004694","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST-107-2314-B-037-071"],"award-info":[{"award-number":["MOST-107-2314-B-037-071"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["110-2314-B-037-068-MY3"],"award-info":[{"award-number":["110-2314-B-037-068-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["109-2314-B-037-094-"],"award-info":[{"award-number":["109-2314-B-037-094-"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["109-2314-B-037-092-"],"award-info":[{"award-number":["109-2314-B-037-092-"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004663","name":"Ministry of Science and Technology, Taiwan","doi-asserted-by":"publisher","award":["MOST 110-2314-B-037-068-MY3"],"award-info":[{"award-number":["MOST 110-2314-B-037-068-MY3"]}],"id":[{"id":"10.13039\/501100004663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012553","name":"Chang Gung Memorial Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012553","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011645","name":"Kaohsiung Medical University Chung-Ho Memorial Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011645","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007750","name":"National Cheng Kung University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007750","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["li.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Laboratory Investigation"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.labinv.2023.100156","type":"journal-article","created":{"date-parts":[[2023,4,27]],"date-time":"2023-04-27T20:37:40Z","timestamp":1682627860000},"page":"100156","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"title":["Proteins Secreted by Lung Cancer Cells Induce the Onset of Proteinuria via Focal Adhesion Kinase Signaling in Mice"],"prefix":"10.1016","volume":"103","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9355-6686","authenticated-orcid":false,"given":"Sheng-Wen","family":"Niu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chien-Hsing","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hung-Chun","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chih-Jen","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jer-Ming","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eddy Essen","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiang-Hao","family":"Chuang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-Wen","family":"Chiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yen-Yi","family":"Zhen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi-Chih","family":"Hung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9404-3305","authenticated-orcid":false,"given":"Shang-Jyh","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.labinv.2023.100156_bib1","doi-asserted-by":"crossref","first-page":"2611","DOI":"10.1097\/01.ASN.0000139478.03463.D9","article-title":"Podocytes are firmly attached to glomerular basement membrane in kidneys with heavy proteinuria","volume":"15","author":"Lahdenkari","year":"2004","journal-title":"J\u00a0Am Soc Nephrol"},{"issue":"13","key":"10.1016\/j.labinv.2023.100156_bib2","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.137249","article-title":"Role of ultrastructural determinants of glomerular permeability in ultrafiltration function loss","volume":"5","author":"Remuzzi","year":"2020","journal-title":"JCI Insight"},{"issue":"2","key":"10.1016\/j.labinv.2023.100156_bib3","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1038\/s41581-020-0329-y","article-title":"Complexities of the glomerular basement membrane","volume":"17","author":"Naylor","year":"2021","journal-title":"Nat Rev Nephrol"},{"issue":"3","key":"10.1016\/j.labinv.2023.100156_bib4","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1681\/ASN.2005070737","article-title":"Thin basement membrane nephropathy","volume":"17","author":"Tryggvason","year":"2006","journal-title":"J\u00a0Am Soc Nephrol"},{"issue":"5","key":"10.1016\/j.labinv.2023.100156_bib5","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/s42255-020-0204-y","article-title":"A\u00a0molecular mechanism explaining albuminuria in kidney disease","volume":"2","author":"Butt","year":"2020","journal-title":"Nat Metab"},{"issue":"2","key":"10.1016\/j.labinv.2023.100156_bib6","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/S2213-8587(18)30313-9","article-title":"Change in albuminuria and subsequent risk of end-stage kidney disease: an individual participant-level consortium meta-analysis of observational studies","volume":"7","author":"Coresh","year":"2019","journal-title":"Lancet Diabetes Endocrinol"},{"issue":"5","key":"10.1016\/j.labinv.2023.100156_bib7","first-page":"478","article-title":"Insights into glomerular filtration and albuminuria","volume":"385","author":"Edwards","year":"2021","journal-title":"N\u00a0Engl J Med"},{"issue":"15","key":"10.1016\/j.labinv.2023.100156_bib8","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1056\/NEJMra1808786","article-title":"Insights into glomerular filtration and albuminuria","volume":"384","author":"Benzing","year":"2021","journal-title":"N\u00a0Engl J Med"},{"issue":"12","key":"10.1016\/j.labinv.2023.100156_bib9","doi-asserted-by":"crossref","first-page":"1674","DOI":"10.1038\/labinvest.2012.133","article-title":"Impairment of podocyte function by diphtheria toxin\u2014a new reversible proteinuria model in mice","volume":"92","author":"Goldwich","year":"2012","journal-title":"Lab Invest"},{"issue":"6","key":"10.1016\/j.labinv.2023.100156_bib10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0099083","article-title":"Laminin alpha2-mediated focal adhesion kinase activation triggers Alport glomerular pathogenesis","volume":"9","author":"Delimont","year":"2014","journal-title":"PLOS ONE"},{"issue":"6","key":"10.1016\/j.labinv.2023.100156_bib11","doi-asserted-by":"crossref","first-page":"F647","DOI":"10.1152\/ajprenal.00090.2011","article-title":"Beyond proteinuria: VDR activation reduces renal inflammation in experimental diabetic nephropathy","volume":"302","author":"Sanchez-Ni\u00f1o","year":"2012","journal-title":"Am J Physiol Renal Physiol"},{"issue":"7","key":"10.1016\/j.labinv.2023.100156_bib12","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1073\/pnas.1717870115","article-title":"Disease-causing mutation in alpha-actinin-4 promotes podocyte detachment through maladaptation to periodic stretch","volume":"115","author":"Feng","year":"2018","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"2","key":"10.1016\/j.labinv.2023.100156_bib13","first-page":"143","article-title":"Glomerular diseases and cancer: evaluation of underlying malignancy","volume":"29","author":"Pani","year":"2016","journal-title":"J\u00a0Nephrol"},{"issue":"9","key":"10.1016\/j.labinv.2023.100156_bib14","article-title":"Complete resolution of paraneoplastic membranous nephropathy following curative therapy of triple-negative breast cancer","volume":"13","author":"Khan","year":"2021","journal-title":"Cureus"},{"issue":"1","key":"10.1016\/j.labinv.2023.100156_bib15","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1186\/s12882-018-1034-y","article-title":"Paraneoplastic immunoglobulin A nephropathy and associated focal segmental glomerulosclerosis in asymptomatic low volume B-cell lymphoma\u2014a case report","volume":"19","author":"Ng","year":"2018","journal-title":"BMC Nephrol"},{"issue":"4","key":"10.1016\/j.labinv.2023.100156_bib16","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1016\/j.ekir.2021.01.026","article-title":"Paraneoplastic REG1alpha cast nephropathy associated with mixed acinar-neuroendocrine carcinoma","volume":"6","author":"Nasr","year":"2021","journal-title":"Kidney Int Rep"},{"issue":"10","key":"10.1016\/j.labinv.2023.100156_bib17","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.2215\/CJN.03770412","article-title":"Onco-nephrology: glomerular diseases with cancer","volume":"7","author":"Cambier","year":"2012","journal-title":"Clin J Am Soc Nephrol"},{"issue":"6","key":"10.1016\/j.labinv.2023.100156_bib18","doi-asserted-by":"crossref","first-page":"3218","DOI":"10.4049\/jimmunol.1003451","article-title":"Nephrotic syndrome and subepithelial deposits in a mouse model of immune-mediated anti-podocyte glomerulonephritis","volume":"187","author":"Meyer-Schwesinger","year":"2011","journal-title":"J\u00a0Immunol"},{"issue":"1","key":"10.1016\/j.labinv.2023.100156_bib19","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s10157-012-0660-0","article-title":"Clinical significance of IgG deposition in the glomerular mesangial area in patients with IgA nephropathy","volume":"17","author":"Wada","year":"2013","journal-title":"Clin Exp Nephrol"},{"issue":"4","key":"10.1016\/j.labinv.2023.100156_bib20","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1038\/nrneph.2017.32","article-title":"Glomerular disease: crescentic glomerulonephritis: beyond the immune system","volume":"13","author":"Webster","year":"2017","journal-title":"Nat Rev Nephrol"},{"issue":"2","key":"10.1016\/j.labinv.2023.100156_bib21","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1002\/path.5508","article-title":"Podocytes present antigen to activate specific T cell immune responses in inflammatory renal disease","volume":"252","author":"Li","year":"2020","journal-title":"J\u00a0Pathol"},{"issue":"2","key":"10.1016\/j.labinv.2023.100156_bib22","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1002\/path.5658","article-title":"Renal deposition and clearance of recombinant poly-IgA complexes in a model of IgA nephropathy","volume":"254","author":"Xie","year":"2021","journal-title":"J\u00a0Pathol"},{"issue":"13","key":"10.1016\/j.labinv.2023.100156_bib23","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2022722118","article-title":"Gain-of-function factor H-related 5 protein impairs glomerular complement regulation resulting in kidney damage","volume":"118","author":"Malik","year":"2021","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"10.1016\/j.labinv.2023.100156_bib24","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/pin.12024","article-title":"Proliferative glomerulonephritis with discrete deposition of monoclonal immunoglobulin \u03b31 CH2 heavy chain and \u03ba light chain: a new variant of monoclonal immunoglobulin deposition disease","volume":"63","author":"Komatsuda","year":"2013","journal-title":"Pathol Int"},{"issue":"7","key":"10.1016\/j.labinv.2023.100156_bib25","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1038\/labinvest.2011.61","article-title":"c-fms blockade reverses glomerular macrophage infiltration and halts development of crescentic anti-GBM glomerulonephritis in the rat","volume":"91","author":"Han","year":"2011","journal-title":"Lab Invest"},{"issue":"5","key":"10.1016\/j.labinv.2023.100156_bib26","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1111\/j.1523-1755.2005.00664.x","article-title":"Renal macrophage activation and Th2 polarization precedes the development of nephrotic syndrome in Buffalo\/Mna rats","volume":"68","author":"Le Berre","year":"2005","journal-title":"Kidney Int"},{"issue":"6","key":"10.1016\/j.labinv.2023.100156_bib27","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.2353\/ajpath.2007.070398","article-title":"The monocyte chemoattractant protein-1\/cognate CC chemokine receptor 2 system affects cell motility in cultured human podocytes","volume":"171","author":"Burt","year":"2007","journal-title":"Am J Pathol"},{"issue":"4","key":"10.1016\/j.labinv.2023.100156_bib28","doi-asserted-by":"crossref","first-page":"1474","DOI":"10.1083\/jcb.98.4.1474","article-title":"Laminin and fibronectin promote the haptotactic migration of B16 mouse melanoma cells in\u00a0vitro","volume":"98","author":"McCarthy","year":"1984","journal-title":"J\u00a0Cell Biol"},{"issue":"20","key":"10.1016\/j.labinv.2023.100156_bib29","doi-asserted-by":"crossref","first-page":"3085","DOI":"10.1091\/mbc.e16-04-0212","article-title":"MenaINV mediates synergistic cross-talk between signaling pathways driving chemotaxis and haptotaxis","volume":"27","author":"Oudin","year":"2016","journal-title":"Mol Biol Cell"},{"issue":"11","key":"10.1016\/j.labinv.2023.100156_bib30","doi-asserted-by":"crossref","first-page":"5549","DOI":"10.4049\/jimmunol.1500148","article-title":"A\u00a0haptotaxis assay for leukocytes based on surface-bound chemokine gradients","volume":"194","author":"Rink","year":"2015","journal-title":"J\u00a0Immunol"},{"issue":"10","key":"10.1016\/j.labinv.2023.100156_bib31","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1038\/sj.onc.1210770","article-title":"Distinct FAK-Src activation events promote alpha5beta1 and alpha4beta1 integrin-stimulated neuroblastoma cell motility","volume":"27","author":"Wu","year":"2008","journal-title":"Oncogene"},{"issue":"12","key":"10.1016\/j.labinv.2023.100156_bib32","doi-asserted-by":"crossref","first-page":"2329","DOI":"10.1242\/jcs.184507","article-title":"Lamellipodia are crucial for haptotactic sensing and response","volume":"129","author":"King","year":"2016","journal-title":"J\u00a0Cell Sci"},{"issue":"6","key":"10.1016\/j.labinv.2023.100156_bib33","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1016\/j.kint.2016.12.006","article-title":"Circulating fibronectin contributes to mesangial expansion in a murine model of type 1 diabetes","volume":"91","author":"Klemis","year":"2017","journal-title":"Kidney Int"},{"issue":"5","key":"10.1016\/j.labinv.2023.100156_bib34","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1093\/ckj\/sft097","article-title":"Fibronectin glomerulopathy","volume":"6","author":"Ishimoto","year":"2013","journal-title":"Clin Kidney J"},{"issue":"7","key":"10.1016\/j.labinv.2023.100156_bib35","doi-asserted-by":"crossref","first-page":"2538","DOI":"10.1073\/pnas.0707730105","article-title":"Mutations in FN1 cause glomerulopathy with fibronectin deposits","volume":"105","author":"Castelletti","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"8","key":"10.1016\/j.labinv.2023.100156_bib36","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0183896","article-title":"Integrative analysis for the discovery of lung cancer serological markers and validation by MRM-MS","volume":"12","author":"Shin","year":"2017","journal-title":"PLOS ONE"},{"issue":"12","key":"10.1016\/j.labinv.2023.100156_bib37","doi-asserted-by":"crossref","first-page":"3651","DOI":"10.3390\/cancers12123561","article-title":"Lung cancer cell-derived secretome mediates paraneoplastic inflammation and fibrosis in kidney in mice","volume":"12","author":"Hung","year":"2020","journal-title":"Cancers (Basel)"},{"issue":"6","key":"10.1016\/j.labinv.2023.100156_bib38","doi-asserted-by":"crossref","first-page":"1100","DOI":"10.1074\/mcp.M900398-MCP200","article-title":"Candidate serological biomarkers for cancer identified from the secretomes of 23 cancer cell lines and the human protein atlas","volume":"9","author":"Wu","year":"2010","journal-title":"Mol Cell Proteomics"},{"issue":"1","key":"10.1016\/j.labinv.2023.100156_bib39","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1083\/jcb.152.1.97","article-title":"Targeting Pyk2 to beta 1-integrin-containing focal contacts rescues fibronectin-stimulated signaling and haptotactic motility defects of focal adhesion kinase-null cells","volume":"152","author":"Klingbeil","year":"2001","journal-title":"J\u00a0Cell Biol"},{"issue":"7","key":"10.1016\/j.labinv.2023.100156_bib40","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1681\/ASN.2009090991","article-title":"Inhibition of podocyte FAK protects against proteinuria and foot process effacement","volume":"21","author":"Ma","year":"2010","journal-title":"J\u00a0Am Soc Nephrol"},{"issue":"8","key":"10.1016\/j.labinv.2023.100156_bib41","doi-asserted-by":"crossref","first-page":"2211","DOI":"10.1016\/j.ajpath.2014.05.005","article-title":"Protein tyrosine phosphatase 1B inhibition protects against podocyte injury and proteinuria","volume":"184","author":"Kumagai","year":"2014","journal-title":"Am J Pathol"},{"key":"10.1016\/j.labinv.2023.100156_bib42","doi-asserted-by":"crossref","first-page":"221","DOI":"10.3389\/fmed.2018.00221","article-title":"Proteinuric kidney diseases: a podocyte\u2019s slit diaphragm and cytoskeleton approach","volume":"5","author":"Yu","year":"2018","journal-title":"Front Med (Lausanne)"},{"issue":"9","key":"10.1016\/j.labinv.2023.100156_bib43","doi-asserted-by":"crossref","first-page":"931","DOI":"10.1038\/nm.1857","article-title":"The actin cytoskeleton of kidney podocytes is a direct target of the antiproteinuric effect of cyclosporine A","volume":"14","author":"Faul","year":"2008","journal-title":"Nat Med"},{"issue":"5","key":"10.1016\/j.labinv.2023.100156_bib44","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1172\/JCI200523371","article-title":"Synaptopodin regulates the actin-bundling activity of alpha-actinin in an isoform-specific manner","volume":"115","author":"Asanuma","year":"2005","journal-title":"J\u00a0Clin Invest"},{"issue":"6","key":"10.1016\/j.labinv.2023.100156_bib45","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1038\/sj.ki.5002751","article-title":"Mice with altered alpha-actinin-4 expression have distinct morphologic patterns of glomerular disease","volume":"73","author":"Henderson","year":"2008","journal-title":"Kidney Int"},{"issue":"1","key":"10.1016\/j.labinv.2023.100156_bib46","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1074\/jbc.M605024200","article-title":"Alpha-actinin-4 is required for normal podocyte adhesion","volume":"282","author":"Dandapani","year":"2007","journal-title":"J\u00a0Biol Chem"},{"issue":"1","key":"10.1016\/j.labinv.2023.100156_bib47","doi-asserted-by":"crossref","first-page":"6693","DOI":"10.1038\/s41598-019-42328-1","article-title":"FHL2 mediates podocyte Rac1 activation and foot process effacement in hypertensive nephropathy","volume":"9","author":"Li","year":"2019","journal-title":"Sci Rep"},{"issue":"5","key":"10.1016\/j.labinv.2023.100156_bib48","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1158\/2159-8290.CD-15-1183","article-title":"Tumor cell-driven extracellular matrix remodeling drives haptotaxis during metastatic progression","volume":"6","author":"Oudin","year":"2016","journal-title":"Cancer Discov"},{"issue":"2","key":"10.1016\/j.labinv.2023.100156_bib49","doi-asserted-by":"crossref","first-page":"415","DOI":"10.2353\/ajpath.2007.070075","article-title":"Synaptopodin protects against proteinuria by disrupting Cdc42:IRSp53:Mena signaling complexes in kidney podocytes","volume":"171","author":"Yanagida-Asanuma","year":"2007","journal-title":"Am J Pathol"},{"issue":"6","key":"10.1016\/j.labinv.2023.100156_bib50","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.2215\/CJN.01730506","article-title":"Immunoglobulin light (heavy)-chain deposition disease: from molecular medicine to pathophysiology-driven therapy","volume":"1","author":"Ronco","year":"2006","journal-title":"Clin J Am Soc Nephrol"},{"issue":"5","key":"10.1016\/j.labinv.2023.100156_bib51","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1016\/S0002-9440(10)62350-4","article-title":"In response to protein load podocytes reorganize cytoskeleton and modulate endothelin-1 gene: implication for permselective dysfunction of chronic nephropathies","volume":"166","author":"Morigi","year":"2005","journal-title":"Am J Pathol"},{"issue":"3","key":"10.1016\/j.labinv.2023.100156_bib52","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1681\/ASN.2016040414","article-title":"Synaptopodin is a coincidence detector of tyrosine versus serine\/threonine phosphorylation for the modulation of rho protein crosstalk in podocytes","volume":"28","author":"Buvall","year":"2017","journal-title":"J\u00a0Am Soc Nephrol"}],"container-title":["Laboratory Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683723000995?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683723000995?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:41:43Z","timestamp":1777423303000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0023683723000995"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":52,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["S0023683723000995"],"URL":"https:\/\/doi.org\/10.1016\/j.labinv.2023.100156","relation":{},"ISSN":["0023-6837"],"issn-type":[{"value":"0023-6837","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Proteins Secreted by Lung Cancer Cells Induce the Onset of Proteinuria via Focal Adhesion Kinase Signaling in Mice","name":"articletitle","label":"Article Title"},{"value":"Laboratory Investigation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.labinv.2023.100156","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 United States & Canadian Academy of Pathology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100156"}}