{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T11:51:47Z","timestamp":1784548307789,"version":"3.55.0"},"reference-count":74,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,7,25]],"date-time":"2023-07-25T00:00:00Z","timestamp":1690243200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003669","name":"Korea Centers for Disease Control and Prevention","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003669","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003710","name":"KHIDI","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003710","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017051","name":"Seoul National University College of Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017051","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["2021-ER1001-01"],"award-info":[{"award-number":["2021-ER1001-01"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Ministry of Health and Welfare","doi-asserted-by":"publisher","award":["HI14C1277"],"award-info":[{"award-number":["HI14C1277"]}],"id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["li.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Laboratory Investigation"],"published-print":{"date-parts":[[2023,8]]},"DOI":"10.1016\/j.labinv.2023.100159","type":"journal-article","created":{"date-parts":[[2023,4,22]],"date-time":"2023-04-22T19:52:50Z","timestamp":1682193170000},"page":"100159","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"title":["Epigenetic Alteration of H3K27me3 as a Possible Oncogenic Mechanism of Central Neurocytoma"],"prefix":"10.1016","volume":"103","author":[{"given":"Hyunhee","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kwanghoon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu-Mi","family":"Shim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric Eunshik","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung-Ki","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji Hoon","family":"Phi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chul-Kee","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seung Hong","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8681-1597","authenticated-orcid":false,"given":"Sung-Hye","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.labinv.2023.100159_bib1","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s10143-006-0041-9","article-title":"Central neurocytoma: two case reports and review of the literature","volume":"29","author":"De Tommasi","year":"2006","journal-title":"Neurosurg Rev"},{"issue":"2","key":"10.1016\/j.labinv.2023.100159_bib2","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1007\/BF00690587","article-title":"Central neurocytoma. An electron-microscopic study of two cases","volume":"56","author":"Hassoun","year":"1982","journal-title":"Acta Neuropathol"},{"issue":"6","key":"10.1016\/j.labinv.2023.100159_bib3","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1055\/s-0040-1718693","article-title":"Differential diagnosis of central neurocytoma: two cases","volume":"82","author":"Steinsiepe","year":"2021","journal-title":"J\u00a0Neurol Surg A Cent Eur Neurosurg"},{"issue":"4","key":"10.1016\/j.labinv.2023.100159_bib4","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1017\/S0317167100003814","article-title":"Fourth ventricular neurocytoma: case report and review of the literature","volume":"31","author":"Cook","year":"2004","journal-title":"Can J Neurol Sci"},{"issue":"2","key":"10.1016\/j.labinv.2023.100159_bib5","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1097\/PAS.0b013e31823b8232","article-title":"Prognostic factors in central neurocytomas: a multicenter study of 71 cases","volume":"36","author":"Vasiljevic","year":"2012","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.labinv.2023.100159_bib6","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.ijscr.2020.02.042","article-title":"Endoscopic approach and stereotactic radiosurgery for a posterior third ventricular central neurocytoma - case report and literature review","volume":"68","author":"Khoo","year":"2020","journal-title":"Int J Surg Case Rep"},{"issue":"50","key":"10.1016\/j.labinv.2023.100159_bib7","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000013657","article-title":"Tumor control of third ventricular central neurocytoma after gamma knife radiosurgery in an elderly patient: a case report and literature review","volume":"97","author":"Park","year":"2018","journal-title":"Medicine (Baltimore)"},{"issue":"3","key":"10.1016\/j.labinv.2023.100159_bib8","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1111\/j.1750-3639.1993.tb00756.x","article-title":"Central neurocytoma: a synopsis of clinical and histological features","volume":"3","author":"Hassoun","year":"1993","journal-title":"Brain Pathol"},{"issue":"2","key":"10.1016\/j.labinv.2023.100159_bib9","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1097\/00000478-199202000-00001","article-title":"Central neurocytomas. Critical evaluation of a small-cell neuronal tumor","volume":"16","author":"Figarella-Branger","year":"1992","journal-title":"Am J Surg Pathol"},{"issue":"11","key":"10.1016\/j.labinv.2023.100159_bib10","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1097\/00000478-199211000-00001","article-title":"Cytoskeletal immunohistochemistry of central neurocytomas","volume":"16","author":"Hessler","year":"1992","journal-title":"Am J Surg Pathol"},{"issue":"2","key":"10.1016\/j.labinv.2023.100159_bib11","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1007\/s004010050416","article-title":"Human central neurocytoma cells show neuronal physiological properties in\u00a0vitro","volume":"91","author":"Patt","year":"1996","journal-title":"Acta Neuropathol"},{"issue":"3","key":"10.1016\/j.labinv.2023.100159_bib12","doi-asserted-by":"crossref","first-page":"233","DOI":"10.3109\/01913129809033474","article-title":"Ultrastructural characterization of central neurocytomas using collagen gel culture","volume":"22","author":"Tsuchida","year":"1998","journal-title":"Ultrastruct Pathol"},{"issue":"11","key":"10.1016\/j.labinv.2023.100159_bib13","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1023\/A:1006903430869","article-title":"Tissue culture of human neurocytomas induces the expression of glial fibrilary acidic protein","volume":"27","author":"Westphal","year":"1998","journal-title":"J\u00a0Neurocytol"},{"issue":"7","key":"10.1016\/j.labinv.2023.100159_bib14","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1078\/0344-0338-00446","article-title":"Neuronal nuclear antigen (NeuN): a new tool in the diagnosis of central neurocytoma","volume":"199","author":"Soylemezoglu","year":"2003","journal-title":"Pathol Res Pract"},{"issue":"3","key":"10.1016\/j.labinv.2023.100159_bib15","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/modpathol.2016.205","article-title":"Thyroid transcription factor-1 distinguishes subependymal giant cell astrocytoma from its mimics and supports its cell origin from the progenitor cells in the medial ganglionic eminence","volume":"30","author":"Hang","year":"2017","journal-title":"Mod Pathol"},{"issue":"1","key":"10.1016\/j.labinv.2023.100159_bib16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11060-004-2354-2","article-title":"Immunohistochemical study of central neurocytoma, subependymoma, and subependymal giant cell astrocytoma","volume":"74","author":"You","year":"2005","journal-title":"J\u00a0Neurooncol"},{"issue":"4","key":"10.1016\/j.labinv.2023.100159_bib17","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1038\/35067582","article-title":"A\u00a0unified hypothesis on the lineage of neural stem cells","volume":"2","author":"Alvarez-Buylla","year":"2001","journal-title":"Nat Rev Neurosci"},{"issue":"4","key":"10.1016\/j.labinv.2023.100159_bib18","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1227\/01.NEU.0000137891.99542.43","article-title":"Possible oncogenicity of subventricular zone neural stem cells: case report","volume":"55","author":"Uchida","year":"2004","journal-title":"Neurosurgery"},{"issue":"5","key":"10.1016\/j.labinv.2023.100159_bib19","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1093\/bioinformatics\/btp698","article-title":"Fast and accurate long-read alignment with Burrows-Wheeler transform","volume":"26","author":"Li","year":"2010","journal-title":"Bioinformatics"},{"issue":"1110","key":"10.1016\/j.labinv.2023.100159_bib20","first-page":"11","article-title":"From FastQ data to high confidence variant calls: the Genome Analysis Toolkit best practices pipeline","volume":"43","author":"Van der Auwera","year":"2013","journal-title":"Curr Protoc Bioinformatics"},{"issue":"19","key":"10.1016\/j.labinv.2023.100159_bib21","doi-asserted-by":"crossref","first-page":"e132","DOI":"10.1093\/nar\/gkr599","article-title":"SNVer: a statistical tool for variant calling in analysis of pooled or individual next-generation sequencing data","volume":"39","author":"Wei","year":"2011","journal-title":"Nucleic Acids Res"},{"issue":"22","key":"10.1016\/j.labinv.2023.100159_bib22","doi-asserted-by":"crossref","first-page":"11189","DOI":"10.1093\/nar\/gks918","article-title":"LoFreq: a sequence-quality aware, ultra-sensitive variant caller for uncovering cell-population heterogeneity from high-throughput sequencing datasets","volume":"40","author":"Wilm","year":"2012","journal-title":"Nucleic Acids Res"},{"issue":"4","key":"10.1016\/j.labinv.2023.100159_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1004873","article-title":"CNVkit: genome-wide copy number detection and visualization from targeted DNA sequencing","volume":"12","author":"Talevich","year":"2016","journal-title":"PLoS Comput Biol"},{"issue":"2","key":"10.1016\/j.labinv.2023.100159_bib24","doi-asserted-by":"crossref","first-page":"80","DOI":"10.4161\/fly.19695","article-title":"A\u00a0program for annotating and predicting the effects of single nucleotide polymorphisms, SnpEff: SNPs in the genome of Drosophila melanogaster strain w1118; iso-2; iso-3","volume":"6","author":"Cingolani","year":"2012","journal-title":"Fly (Austin)"},{"issue":"16","key":"10.1016\/j.labinv.2023.100159_bib25","doi-asserted-by":"crossref","first-page":"e164","DOI":"10.1093\/nar\/gkq603","article-title":"ANNOVAR: functional annotation of genetic variants from high-throughput sequencing data","volume":"38","author":"Wang","year":"2010","journal-title":"Nucleic Acids Res"},{"issue":"1","key":"10.1016\/j.labinv.2023.100159_bib26","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s13073-020-00791-w","article-title":"Best practices for variant calling in clinical sequencing","volume":"12","author":"Koboldt","year":"2020","journal-title":"Genome Med"},{"issue":"7809","key":"10.1016\/j.labinv.2023.100159_bib27","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/s41586-020-2308-7","article-title":"The mutational constraint spectrum quantified from variation in 141,456 humans","volume":"581","author":"Karczewski","year":"2020","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.labinv.2023.100159_bib28","doi-asserted-by":"crossref","first-page":"4287","DOI":"10.1038\/s41598-017-04642-4","article-title":"Korean Variant Archive (KOVA): a reference database of genetic variations in the Korean population","volume":"7","author":"Lee","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.labinv.2023.100159_bib29","doi-asserted-by":"crossref","DOI":"10.1093\/database\/baaa030","article-title":"KRGDB: the large-scale variant database of 1722 Koreans based on whole genome sequencing","volume":"2020","author":"Jung","year":"2020","journal-title":"Database (Oxford)"},{"issue":"21","key":"10.1016\/j.labinv.2023.100159_bib30","doi-asserted-by":"crossref","DOI":"10.3390\/cells11213376","article-title":"H3K27me3 in diffuse midline glioma and epithelial ovarian cancer: opposing epigenetic changes leading to the same poor outcomes","volume":"11","author":"Day","year":"2022","journal-title":"Cells"},{"key":"10.1016\/j.labinv.2023.100159_bib31","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/978-981-15-8104-5_6","article-title":"Epigenetic-targeted treatments for H3K27M-mutant midline gliomas","volume":"1283","author":"Lu","year":"2021","journal-title":"Adv Exp Med Biol"},{"issue":"1","key":"10.1016\/j.labinv.2023.100159_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10014-021-00417-y","article-title":"Molecular subtyping of ependymoma and prognostic impact of Ki-67","volume":"39","author":"Lim","year":"2022","journal-title":"Brain Tumor Pathol"},{"issue":"1","key":"10.1016\/j.labinv.2023.100159_bib33","doi-asserted-by":"crossref","first-page":"2146","DOI":"10.1038\/s41467-019-09981-6","article-title":"PFA ependymoma-associated protein EZHIP inhibits PRC2 activity through a H3 K27M-like mechanism","volume":"10","author":"Jain","year":"2019","journal-title":"Nat Commun"},{"issue":"5","key":"10.1016\/j.labinv.2023.100159_bib34","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1007\/s00428-021-03134-1","article-title":"H3K27me3 immunostaining is diagnostic and prognostic in diffuse gliomas with oligodendroglial or mixed oligoastrocytic morphology","volume":"479","author":"Ammendola","year":"2021","journal-title":"Virchows Arch"},{"issue":"7","key":"10.1016\/j.labinv.2023.100159_bib35","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14071718","article-title":"The immunohistochemical loss of H3K27me3 in intracranial meningiomas predicts shorter progression-free survival after stereotactic radiosurgery","volume":"14","author":"Ammendola","year":"2022","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.labinv.2023.100159_bib36","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.humpath.2021.06.005","article-title":"The substantial loss of H3K27me3 can stratify risk in grade 2, but not in grade 3 meningioma","volume":"115","author":"Jung","year":"2021","journal-title":"Hum Pathol"},{"key":"10.1016\/j.labinv.2023.100159_bib37","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/j.wneu.2022.04.048","article-title":"The emerging relevance of H3K27 trimethylation loss in meningioma: a systematic review of recurrence and overall survival with meta-analysis","volume":"163","author":"Lu","year":"2022","journal-title":"World Neurosurg"},{"issue":"1","key":"10.1016\/j.labinv.2023.100159_bib38","doi-asserted-by":"crossref","first-page":"1262","DOI":"10.1038\/s41467-019-09140-x","article-title":"H3K27M induces defective chromatin spread of PRC2-mediated repressive H3K27me2\/me3 and is essential for glioma tumorigenesis","volume":"10","author":"Harutyunyan","year":"2019","journal-title":"Nat Commun"},{"issue":"1","key":"10.1016\/j.labinv.2023.100159_bib39","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1007\/s10014-020-00378-8","article-title":"H3 G34-mutant high-grade glioma","volume":"38","author":"Lim","year":"2021","journal-title":"Brain Tumor Pathol"},{"issue":"2","key":"10.1016\/j.labinv.2023.100159_bib40","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1007\/s00381-020-04852-8","article-title":"Evaluating H3F3A K27M and G34R\/V somatic mutations in a cohort of pediatric brain tumors of different and rare histologies","volume":"37","author":"Oliveira","year":"2021","journal-title":"Childs Nerv Syst"},{"issue":"1","key":"10.1016\/j.labinv.2023.100159_bib41","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.molcel.2004.06.020","article-title":"SUZ12 is required for both the histone methyltransferase activity and the silencing function of the EED-EZH2 complex","volume":"15","author":"Cao","year":"2004","journal-title":"Mol cell"},{"issue":"18","key":"10.1016\/j.labinv.2023.100159_bib42","doi-asserted-by":"crossref","first-page":"4078","DOI":"10.1038\/sj.emboj.7601837","article-title":"Pcl-PRC2 is needed to generate high levels of H3-K27 trimethylation at Polycomb target genes","volume":"26","author":"Nekrasov","year":"2007","journal-title":"EMBO J"},{"issue":"1","key":"10.1016\/j.labinv.2023.100159_bib43","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/s13072-020-00369-1","article-title":"Post-translational modifications of PRC2: signals directing its activity","volume":"13","author":"Yang","year":"2020","journal-title":"Epigenetics Chromatin"},{"issue":"1","key":"10.1016\/j.labinv.2023.100159_bib44","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-15183-1","article-title":"The genomic landscape of malignant peripheral nerve sheath tumors: diverse drivers of Ras pathway activation","volume":"7","author":"Brohl","year":"2017","journal-title":"Sci Rep"},{"issue":"1","key":"10.1016\/j.labinv.2023.100159_bib45","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s40478-021-01194-7","article-title":"Loss of H3K27 trimethylation is frequent in IDH1-R132H but not in non-canonical IDH1\/2 mutated and 1p\/19q codeleted oligodendroglioma: a Japanese cohort study","volume":"9","author":"Habiba","year":"2021","journal-title":"Acta Neuropathol Commun"},{"key":"10.1016\/j.labinv.2023.100159_bib46","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/9957209","article-title":"Thyroid transcription factor-1: structure, expression, function and its relationship with disease","volume":"2021","author":"Guan","year":"2021","journal-title":"Biomed Res Int"},{"issue":"1","key":"10.1016\/j.labinv.2023.100159_bib47","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1006\/mcne.2000.0933","article-title":"TTF-1, a homeodomain gene required for diencephalic morphogenesis, is postnatally expressed in the neuroendocrine brain in a developmentally regulated and cell-specific fashion","volume":"17","author":"Lee","year":"2001","journal-title":"Mol Cell Neurosci"},{"issue":"5","key":"10.1016\/j.labinv.2023.100159_bib48","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.neuron.2008.08.017","article-title":"A\u00a0time and a place for nkx2-1 in interneuron specification and migration","volume":"59","author":"Elias","year":"2008","journal-title":"Neuron"},{"issue":"7-8","key":"10.1016\/j.labinv.2023.100159_bib49","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1007\/s00381-003-0765-6","article-title":"Features of the developing brain","volume":"19","author":"Encha-Razavi","year":"2003","journal-title":"Childs Nerv Syst"},{"issue":"2","key":"10.1016\/j.labinv.2023.100159_bib50","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.ydbio.2015.09.008","article-title":"Embryonic Nkx2.1-expressing neural precursor cells contribute to the regional heterogeneity of adult V-SVZ neural stem cells","volume":"407","author":"Delgado","year":"2015","journal-title":"Dev Biol"},{"issue":"48","key":"10.1016\/j.labinv.2023.100159_bib51","doi-asserted-by":"crossref","first-page":"12544","DOI":"10.1523\/JNEUROSCI.0829-06.2006","article-title":"Neurocytoma is a tumor of adult neuronal progenitor cells","volume":"26","author":"Sim","year":"2006","journal-title":"J\u00a0Neurosci"},{"issue":"12","key":"10.1016\/j.labinv.2023.100159_bib52","doi-asserted-by":"crossref","DOI":"10.3390\/cancers12123825","article-title":"Role of fibroblast growth factors receptors (FGFRs) in brain tumors, focus on astrocytoma and glioblastoma","volume":"12","author":"Ardizzone","year":"2020","journal-title":"Cancers (Basel)"},{"issue":"23","key":"10.1016\/j.labinv.2023.100159_bib53","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13236100","article-title":"Cell-of-origin and genetic, epigenetic, and microenvironmental factors contribute to the intra-tumoral heterogeneity of pediatric intracranial ependymoma","volume":"13","author":"Servidei","year":"2021","journal-title":"Cancers (Basel)"},{"issue":"6","key":"10.1016\/j.labinv.2023.100159_bib54","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/S0896-6273(04)00140-0","article-title":"Radial glia serve as neuronal progenitors in all regions of the central nervous system","volume":"41","author":"Anthony","year":"2004","journal-title":"Neuron"},{"issue":"8","key":"10.1016\/j.labinv.2023.100159_bib55","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1002\/glia.22827","article-title":"Coevolution of radial glial cells and the cerebral cortex","volume":"63","author":"De Juan Romero","year":"2015","journal-title":"Glia"},{"issue":"6","key":"10.1016\/j.labinv.2023.100159_bib56","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/j.neuron.2020.06.035","article-title":"Neural stem cells direct axon guidance via their radial fiber scaffold","volume":"107","author":"Kaur","year":"2020","journal-title":"Neuron"},{"issue":"2","key":"10.1016\/j.labinv.2023.100159_bib57","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.devcel.2018.10.028","article-title":"Adhesive L1CAM-Robo signaling aligns growth cone F-actin dynamics to promote axon-dendrite fasciculation in C. elegans","volume":"48","author":"Chen","year":"2019","journal-title":"Dev Cell"},{"issue":"2","key":"10.1016\/j.labinv.2023.100159_bib58","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1245\/s10434-013-3246-5","article-title":"Overexpression of L1CAM is associated with tumor progression and prognosis via ERK signaling in gastric cancer","volume":"21","author":"Ito","year":"2014","journal-title":"Ann Surg Oncol"},{"issue":"16","key":"10.1016\/j.labinv.2023.100159_bib59","doi-asserted-by":"crossref","first-page":"3982","DOI":"10.3390\/ijms20163982","article-title":"Exosomal L1CAM Stimulates Glioblastoma Cell Motility, Proliferation, and Invasiveness","volume":"20","author":"Pace","year":"2019","journal-title":"Int J Mol Sci"},{"issue":"5","key":"10.1016\/j.labinv.2023.100159_bib60","first-page":"1502","article-title":"Different shades of L1CAM in the pathophysiology of cancer stem cells","volume":"9","author":"Giordano","year":"2020","journal-title":"J\u00a0Clin Med"},{"issue":"2","key":"10.1016\/j.labinv.2023.100159_bib61","doi-asserted-by":"crossref","first-page":"120","DOI":"10.5607\/en21004","article-title":"Tumor spheroids of an aggressive form of central neurocytoma have transit-amplifying progenitor characteristics with enhanced EGFR and tumor stem cell signaling","volume":"30","author":"Shin","year":"2021","journal-title":"Exp Neurobiol"},{"key":"10.1016\/j.labinv.2023.100159_bib62","series-title":"Brain Tumor","article-title":"Expression of L1CAM in Brain Tumors: Immunohistochemical Study Using Anti-L1CAM Antibodies","author":"Izumoto","year":"1996"},{"key":"10.1016\/j.labinv.2023.100159_bib63","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.trsl.2023.01.002","article-title":"Genetically engineered human pituitary corticotroph tumor organoids exhibit divergent responses to glucocorticoid receptor modulators","volume":"256","author":"Mallick","year":"2023","journal-title":"Transl Res"},{"issue":"8","key":"10.1016\/j.labinv.2023.100159_bib64","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1007\/s11912-020-00937-4","article-title":"Advances in molecular classification and therapeutic opportunities in meningiomas","volume":"22","author":"Cordova","year":"2020","journal-title":"Curr Oncol Rep"},{"issue":"3","key":"10.1016\/j.labinv.2023.100159_bib65","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1007\/s11154-020-09607-z","article-title":"Epigenetic regulation of somatostatin and somatostatin receptors in neuroendocrine tumors and other types of cancer","volume":"22","author":"Klomp","year":"2021","journal-title":"Rev Endocr Metab Disord"},{"issue":"6","key":"10.1016\/j.labinv.2023.100159_bib66","doi-asserted-by":"crossref","first-page":"3137","DOI":"10.1210\/en.2007-1525","article-title":"Identification of an upstream promoter of the human somatostatin receptor, hSSTR2, which is controlled by epigenetic modifications","volume":"149","author":"Torrisani","year":"2008","journal-title":"Endocrinology"},{"issue":"10","key":"10.1016\/j.labinv.2023.100159_bib67","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1136\/jcp.2004.017467","article-title":"Expression of thyroid transcription factor 1 in primary brain tumours","volume":"57","author":"Zamecnik","year":"2004","journal-title":"J\u00a0Clin Pathol"},{"issue":"2","key":"10.1016\/j.labinv.2023.100159_bib68","first-page":"379","article-title":"Somatostatin analogues inhibit cancer cell proliferation in an SSTR2-dependent manner via both cytostatic and cytotoxic pathways","volume":"21","author":"Zou","year":"2009","journal-title":"Oncol Rep"},{"issue":"4","key":"10.1016\/j.labinv.2023.100159_bib69","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1097\/DAD.0000000000000983","article-title":"Vascular tumors in infants: case report and review of clinical, histopathologic, and immunohistochemical characteristics of infantile hemangioma, pyogenic granuloma, noninvoluting congenital hemangioma, tufted angioma, and kaposiform hemangioendothelioma","volume":"40","author":"Johnson","year":"2018","journal-title":"Am J Dermatopathol"},{"issue":"1","key":"10.1016\/j.labinv.2023.100159_bib70","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/his.12366","article-title":"Comparative study of soft tissue perineurioma and meningioma using a five-marker immunohistochemical panel","volume":"65","author":"Agaimy","year":"2014","journal-title":"Histopathology"},{"issue":"16","key":"10.1016\/j.labinv.2023.100159_bib71","doi-asserted-by":"crossref","first-page":"4184","DOI":"10.3390\/cancers13164184","article-title":"Glucose transporters as a target for anticancer therapy","volume":"13","author":"Pliszka","year":"2021","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.labinv.2023.100159_bib72","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.676562","article-title":"Aberrant metabolism as inductor of epigenetic changes in breast cancer: therapeutic opportunities","volume":"11","author":"Coronel-Hernandez","year":"2021","journal-title":"Front Oncol"},{"issue":"7","key":"10.1016\/j.labinv.2023.100159_bib73","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1111\/cas.12691","article-title":"Nestin as a marker of cancer stem cells","volume":"106","author":"Neradil","year":"2015","journal-title":"Cancer Sci"},{"issue":"1-2","key":"10.1016\/j.labinv.2023.100159_bib74","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.neulet.2006.02.034","article-title":"Nestin expression in neuroepithelial tumors","volume":"400","author":"Schiffer","year":"2006","journal-title":"Neurosci Lett"}],"container-title":["Laboratory Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683723001022?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683723001022?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T19:57:53Z","timestamp":1758398273000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0023683723001022"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":74,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2023,8]]}},"alternative-id":["S0023683723001022"],"URL":"https:\/\/doi.org\/10.1016\/j.labinv.2023.100159","relation":{},"ISSN":["0023-6837"],"issn-type":[{"value":"0023-6837","type":"print"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Epigenetic Alteration of H3K27me3 as a Possible Oncogenic Mechanism of Central Neurocytoma","name":"articletitle","label":"Article Title"},{"value":"Laboratory Investigation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.labinv.2023.100159","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 THE AUTHORS. Published by Elsevier Inc. on behalf of the United States & Canadian Academy of Pathology.","name":"copyright","label":"Copyright"}],"article-number":"100159"}}