{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T00:08:30Z","timestamp":1775693310883,"version":"3.50.1"},"reference-count":38,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,2,1]],"date-time":"2024-02-01T00:00:00Z","timestamp":1706745600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"vor","delay-in-days":366,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100003977","name":"Israel Science Foundation","doi-asserted-by":"publisher","award":["1745\/19"],"award-info":[{"award-number":["1745\/19"]}],"id":[{"id":"10.13039\/501100003977","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["li.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Laboratory Investigation"],"published-print":{"date-parts":[[2024,2]]},"DOI":"10.1016\/j.labinv.2023.100308","type":"journal-article","created":{"date-parts":[[2023,12,20]],"date-time":"2023-12-20T02:46:41Z","timestamp":1703040401000},"page":"100308","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["NLRP3 Deficiency in Nonimmune Cells Averts Obesity-Induced Fatty Liver Disease"],"prefix":"10.1016","volume":"104","author":[{"given":"Lilah","family":"Margalit Grigg","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bander","family":"Abu Shrkihe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irina","family":"Efimova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inna","family":"Solodeev","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuval","family":"Shteingard","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nir","family":"Shani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel","family":"Zvibel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4222-5323","authenticated-orcid":false,"given":"Chen","family":"Varol","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.labinv.2023.100308_bib1","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1056\/NEJMoa1614362","article-title":"Health effects of overweight and obesity in 195 countries over 25 years","volume":"377","author":"Collaborators","year":"2017","journal-title":"N\u00a0Engl J Med"},{"issue":"11","key":"10.1016\/j.labinv.2023.100308_bib2","doi-asserted-by":"crossref","first-page":"633","DOI":"10.1038\/nrendo.2017.90","article-title":"Adapting to obesity with adipose tissue inflammation","volume":"13","author":"Reilly","year":"2017","journal-title":"Nat Rev Endocrinol"},{"issue":"6","key":"10.1016\/j.labinv.2023.100308_bib3","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1042\/BCJ20190472","article-title":"The NLRP3 inflammasome regulates adipose tissue metabolism","volume":"477","author":"Barra","year":"2020","journal-title":"Biochem J"},{"issue":"4","key":"10.1016\/j.labinv.2023.100308_bib4","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1530\/EJE-07-0206","article-title":"Interleukin-18 in plasma and adipose tissue: effects of obesity, insulin resistance, and weight loss","volume":"157","author":"Bruun","year":"2007","journal-title":"Eur J Endocrinol"},{"issue":"10","key":"10.1016\/j.labinv.2023.100308_bib5","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/j.tem.2015.08.001","article-title":"The IL-1 pathway in type 2 diabetes and cardiovascular complications","volume":"26","author":"Herder","year":"2015","journal-title":"Trends Endocrinol Metab"},{"issue":"2","key":"10.1016\/j.labinv.2023.100308_bib6","doi-asserted-by":"crossref","first-page":"422","DOI":"10.1016\/j.atherosclerosis.2009.12.017","article-title":"Caspase-1 recognizes extended cleavage sites in its natural substrates","volume":"210","author":"Shen","year":"2010","journal-title":"Atherosclerosis"},{"issue":"7674","key":"10.1016\/j.labinv.2023.100308_bib7","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1038\/nature24022","article-title":"Inflammasome-driven catecholamine catabolism in macrophages blunts lipolysis during ageing","volume":"550","author":"Camell","year":"2017","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.labinv.2023.100308_bib8","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/j.cmet.2019.10.006","article-title":"Aging induces an Nlrp3 inflammasome-dependent expansion of adipose B cells that impairs metabolic homeostasis","volume":"30","author":"Camell","year":"2019","journal-title":"Cell Metab"},{"issue":"2","key":"10.1016\/j.labinv.2023.100308_bib9","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nm.2279","article-title":"The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance","volume":"17","author":"Vandanmagsar","year":"2011","journal-title":"Nat Med"},{"issue":"5","key":"10.1016\/j.labinv.2023.100308_bib10","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1038\/ni.2022","article-title":"Fatty acid-induced NLRP3-ASC inflammasome activation interferes with insulin signaling","volume":"12","author":"Wen","year":"2011","journal-title":"Nature immunology"},{"issue":"5","key":"10.1016\/j.labinv.2023.100308_bib11","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/j.cmet.2014.03.029","article-title":"Adipose tissue macrophages promote myelopoiesis and monocytosis in obesity","volume":"19","author":"Nagareddy","year":"2014","journal-title":"Cell Metab"},{"issue":"6","key":"10.1016\/j.labinv.2023.100308_bib12","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/j.cmet.2010.11.011","article-title":"The inflammasome-mediated caspase-1 activation controls adipocyte differentiation and insulin sensitivity","volume":"12","author":"Stienstra","year":"2010","journal-title":"Cell Metab"},{"issue":"9","key":"10.1016\/j.labinv.2023.100308_bib13","doi-asserted-by":"crossref","first-page":"2423","DOI":"10.1194\/jlr.M038638","article-title":"Obese adipocytes show ultrastructural features of stressed cells and die of pyroptosis","volume":"54","author":"Giordano","year":"2013","journal-title":"J\u00a0Lipid Res"},{"key":"10.1016\/j.labinv.2023.100308_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.metabol.2023.155527","article-title":"TNFalpha-induced NLRP3 inflammasome mediates adipocyte dysfunction and activates macrophages through adipocyte-derived lipocalin 2","volume":"142","author":"Javaid","year":"2023","journal-title":"Metabolism"},{"key":"10.1016\/j.labinv.2023.100308_bib15","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1016\/j.lfs.2017.03.012","article-title":"Palmitic acid elicits hepatic stellate cell activation through inflammasomes and hedgehog signaling","volume":"176","author":"Duan","year":"2017","journal-title":"Life Sci"},{"issue":"37","key":"10.1016\/j.labinv.2023.100308_bib16","doi-asserted-by":"crossref","first-page":"15324","DOI":"10.1073\/pnas.1100255108","article-title":"Inflammasome is a central player in the induction of obesity and insulin resistance","volume":"108","author":"Stienstra","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"issue":"5","key":"10.1016\/j.labinv.2023.100308_bib17","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.jhep.2017.01.022","article-title":"NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice","volume":"66","author":"Mridha","year":"2017","journal-title":"J\u00a0Hepatol"},{"key":"10.1016\/j.labinv.2023.100308_bib18","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2021.715765","article-title":"The specific NLRP3 antagonist IFM-514 decreases fibrosis and inflammation in experimental murine non-alcoholic steatohepatitis","volume":"8","author":"Torres","year":"2021","journal-title":"Front Mol Biosci"},{"issue":"10","key":"10.1016\/j.labinv.2023.100308_bib19","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.1007\/s00109-014-1170-1","article-title":"NLRP3 inflammasome activation is required for fibrosis development in NAFLD","volume":"92","author":"Wree","year":"2014","journal-title":"J\u00a0Mol Med (Berl)"},{"issue":"9","key":"10.1016\/j.labinv.2023.100308_bib20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0161939","article-title":"Loss of Nlrp3 does not protect mice from western diet-induced adipose tissue inflammation and glucose intolerance","volume":"11","author":"Ringling","year":"2016","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.labinv.2023.100308_bib21","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1038\/s41374-021-00535-3","article-title":"NLRP3 deficiency did not attenuate NASH development under high fat calorie diet plus high fructose and glucose in drinking water","volume":"101","author":"Zhu","year":"2021","journal-title":"Lab Invest"},{"issue":"7384","key":"10.1016\/j.labinv.2023.100308_bib22","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1038\/nature10809","article-title":"Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesity","volume":"482","author":"Henao-Mejia","year":"2012","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.labinv.2023.100308_bib23","article-title":"Lack of NLRP3-inflammasome leads to gut-liver axis derangement, gut dysbiosis and a worsened phenotype in a mouse model of NAFLD","volume":"7","author":"Pierantonelli","year":"2017","journal-title":"Sci Rep"},{"issue":"7903","key":"10.1016\/j.labinv.2023.100308_bib24","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1038\/s41586-022-04518-2","article-title":"A\u00a0single-cell atlas of human and mouse white adipose tissue","volume":"603","author":"Emont","year":"2022","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.labinv.2023.100308_bib25","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1016\/j.cell.2021.12.018","article-title":"Spatial proteogenomics reveals distinct and evolutionarily conserved hepatic macrophage niches","volume":"185","author":"Guilliams","year":"2022","journal-title":"Cell"},{"issue":"10","key":"10.1016\/j.labinv.2023.100308_bib26","doi-asserted-by":"crossref","first-page":"2559","DOI":"10.1002\/stem.2429","article-title":"Obesity and type 2 diabetes alters the immune properties of human adipose derived stem cells","volume":"34","author":"Serena","year":"2016","journal-title":"Stem Cells"},{"issue":"5","key":"10.1016\/j.labinv.2023.100308_bib27","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1007\/s12015-020-10005-w","article-title":"Nlrp3 inflammasome signaling regulates the homing and engraftment of hematopoietic stem cells (HSPCs) by enhancing incorporation of CXCR4 receptor into membrane lipid rafts","volume":"16","author":"Adamiak","year":"2020","journal-title":"Stem Cell Rev Rep"},{"issue":"6","key":"10.1016\/j.labinv.2023.100308_bib28","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1053\/j.gastro.2007.03.059","article-title":"Obesity, inflammation, and insulin resistance","volume":"132","author":"Shoelson","year":"2007","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.labinv.2023.100308_bib29","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-33486-9","article-title":"NLRP3 Inflammasome modulates post-burn lipolysis and hepatic fat infiltration via fatty acid synthase","volume":"8","author":"Vinaik","year":"2018","journal-title":"Sci Rep"},{"issue":"3","key":"10.1016\/j.labinv.2023.100308_bib30","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.cell.2019.05.054","article-title":"Lipid-associated macrophages control metabolic homeostasis in a trem2-dependent manner","volume":"178","author":"Jaitin","year":"2019","journal-title":"Cell"},{"issue":"5","key":"10.1016\/j.labinv.2023.100308_bib31","doi-asserted-by":"crossref","first-page":"E515","DOI":"10.1152\/ajpendo.00097.2017","article-title":"Adaptive facultative diet-induced thermogenesis in wild-type but not in UCP1-ablated mice","volume":"313","author":"von Essen","year":"2017","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"3","key":"10.1016\/j.labinv.2023.100308_bib32","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.jhep.2012.03.035","article-title":"Inflammasomes in liver diseases","volume":"57","author":"Szabo","year":"2012","journal-title":"J\u00a0Hepatol"},{"issue":"4","key":"10.1016\/j.labinv.2023.100308_bib33","doi-asserted-by":"crossref","DOI":"10.1038\/cddis.2015.84","article-title":"NOX1-induced accumulation of reactive oxygen species in abdominal fat-derived mesenchymal stromal cells impinges on long-term proliferation","volume":"6","author":"Sela","year":"2015","journal-title":"Cell Death Dis"},{"issue":"1","key":"10.1016\/j.labinv.2023.100308_bib34","article-title":"Author correction: lack of NLRP3-inflammasome leads to gut-liver axis derangement, gut dysbiosis and a worsened phenotype in a mouse model of NAFLD","volume":"7","author":"Pierantonelli","year":"2017","journal-title":"Sci Rep"},{"issue":"4","key":"10.1016\/j.labinv.2023.100308_bib35","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1016\/j.jcmgh.2022.06.007","article-title":"Cell-specific deletion of NLRP3 inflammasome identifies myeloid cells as key drivers of liver inflammation and fibrosis in murine steatohepatitis","volume":"14","author":"Kaufmann","year":"2022","journal-title":"Cell Mol Gastroenterol Hepatol"},{"issue":"2","key":"10.1016\/j.labinv.2023.100308_bib36","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1007\/s10753-017-0718-y","article-title":"Inhibitory effects of toll-like receptor 4, NLRP3 inflammasome, and interleukin-1beta on white adipocyte browning","volume":"41","author":"Okla","year":"2018","journal-title":"Inflammation"},{"issue":"5","key":"10.1016\/j.labinv.2023.100308_bib37","doi-asserted-by":"crossref","first-page":"E751","DOI":"10.1152\/ajpendo.00180.2019","article-title":"NLRP3 inflammasome mediates white adipose tissue browning after burn","volume":"317","author":"Vinaik","year":"2019","journal-title":"Am J Physiol Endocrinol Metab"},{"issue":"1","key":"10.1016\/j.labinv.2023.100308_bib38","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-70765-w","article-title":"C57BL\/6J substrain differences in response to high-fat diet intervention","volume":"10","author":"Siersbaek","year":"2020","journal-title":"Sci Rep"}],"container-title":["Laboratory Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683723002519?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683723002519?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T20:00:24Z","timestamp":1758398424000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0023683723002519"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2]]},"references-count":38,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,2]]}},"alternative-id":["S0023683723002519"],"URL":"https:\/\/doi.org\/10.1016\/j.labinv.2023.100308","relation":{},"ISSN":["0023-6837"],"issn-type":[{"value":"0023-6837","type":"print"}],"subject":[],"published":{"date-parts":[[2024,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"NLRP3 Deficiency in Nonimmune Cells Averts Obesity-Induced Fatty Liver Disease","name":"articletitle","label":"Article Title"},{"value":"Laboratory Investigation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.labinv.2023.100308","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 United States & Canadian Academy of Pathology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100308"}}