{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T09:14:12Z","timestamp":1777626852175,"version":"3.51.4"},"reference-count":52,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":365,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100011033","name":"State Agency of Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011033","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002924","name":"Federaci\u00f3n Espa\u00f1ola de Enfermedades Raras","doi-asserted-by":"publisher","award":["PI22\/00050"],"award-info":[{"award-number":["PI22\/00050"]}],"id":[{"id":"10.13039\/501100002924","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002924","name":"Federaci\u00f3n Espa\u00f1ola de Enfermedades Raras","doi-asserted-by":"publisher","award":["RD21\/0005\/0001"],"award-info":[{"award-number":["RD21\/0005\/0001"]}],"id":[{"id":"10.13039\/501100002924","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002924","name":"Federaci\u00f3n Espa\u00f1ola de Enfermedades Raras","doi-asserted-by":"publisher","award":["ERA-PerMed-JTC2022"],"award-info":[{"award-number":["ERA-PerMed-JTC2022"]}],"id":[{"id":"10.13039\/501100002924","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002924","name":"Federaci\u00f3n Espa\u00f1ola de Enfermedades Raras","doi-asserted-by":"publisher","award":["AC22\/00027"],"award-info":[{"award-number":["AC22\/00027"]}],"id":[{"id":"10.13039\/501100002924","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000921","name":"European Cooperation in Science and Technology","doi-asserted-by":"publisher","award":["101101220"],"award-info":[{"award-number":["101101220"]}],"id":[{"id":"10.13039\/501100000921","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000921","name":"European Cooperation in Science and Technology","doi-asserted-by":"publisher","award":["PERMEDIK CA21165"],"award-info":[{"award-number":["PERMEDIK CA21165"]}],"id":[{"id":"10.13039\/501100000921","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018412","name":"Sociedad Madrile\u00f1a de Nefrolog\u00eda","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","award":["RYC2018-024461-I"],"award-info":[{"award-number":["RYC2018-024461-I"]}],"id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Carlos III Health Institute","doi-asserted-by":"publisher","award":["PI21\/00251"],"award-info":[{"award-number":["PI21\/00251"]}],"id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100015883","name":"Sociedad Espa\u00f1ola de Nefrolog\u00eda","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100015883","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["li.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Laboratory Investigation"],"published-print":{"date-parts":[[2025,1]]},"DOI":"10.1016\/j.labinv.2024.102182","type":"journal-article","created":{"date-parts":[[2024,11,8]],"date-time":"2024-11-08T16:40:48Z","timestamp":1731084048000},"page":"102182","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cefadroxil Targeting of SLC15A2\/PEPT2 Protects From Colistin Nephrotoxicity"],"prefix":"10.1016","volume":"105","author":[{"given":"Raul","family":"Fernandez-Prado","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lara","family":"Vali\u00f1o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aranzazu","family":"Pintor-Chocano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana B.","family":"Sanz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto","family":"Ortiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7110-6409","authenticated-orcid":false,"given":"Maria Dolores","family":"Sanchez-Ni\u00f1o","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.labinv.2024.102182_bib1","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1093\/ckj\/sfab170","article-title":"RICORS2040: the need for collaborative research in chronic kidney disease","volume":"15","author":"Ortiz","year":"2021","journal-title":"Clin Kidney J"},{"key":"10.1016\/j.labinv.2024.102182_bib2","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1016\/S0140-6736(18)31694-5","article-title":"Forecasting life expectancy, years of life lost, and all-cause and cause-specific mortality for 250 causes of death: reference and alternative scenarios for 2016-40 for 195 countries and territories","volume":"392","author":"Foreman","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.labinv.2024.102182_bib3","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1093\/ndt\/gfac257","article-title":"Chronic kidney disease as cardiovascular risk factor in routine clinical practice: a position statement by the Council of the European Renal Association","volume":"38","author":"Ortiz","year":"2023","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.labinv.2024.102182_bib4","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1093\/ndt\/gfaa314","article-title":"Chronic kidney disease is a key risk factor for severe COVID-19: a call to action by the ERA-EDTA","volume":"36","author":"Ortiz","year":"2021","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.labinv.2024.102182_bib5","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1093\/ckj\/sfad087","article-title":"The ERA registry annual report 2020: a summary","volume":"16","author":"Astley","year":"2023","journal-title":"Clin Kidney J"},{"key":"10.1016\/j.labinv.2024.102182_bib6","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1056\/NEJMra1214243","article-title":"Acute kidney injury and chronic kidney disease as interconnected syndromes","volume":"371","author":"Chawla","year":"2014","journal-title":"N\u00a0Engl J Med"},{"key":"10.1016\/j.labinv.2024.102182_bib7","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1093\/ckj\/sfad082","article-title":"EMPA-KIDNEY: expanding the range of kidney protection by SGLT2 inhibitors","volume":"16","author":"Fern\u00e1ndez-Fernandez","year":"2023","journal-title":"Clin Kidney J"},{"key":"10.1016\/j.labinv.2024.102182_bib8","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.2215\/CJN.00020120","article-title":"Genome-wide association studies of CKD and related traits","volume":"15","author":"Tin","year":"2020","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.labinv.2024.102182_bib9","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1093\/ndt\/gfy367","article-title":"MAGE genes in the kidney: identification of MAGED2 as upregulated during kidney injury and in stressed tubular cells","volume":"34","author":"Vali\u00f1o-Rivas","year":"2019","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.labinv.2024.102182_bib10","doi-asserted-by":"crossref","first-page":"1897","DOI":"10.2215\/CJN.00150118","article-title":"Pharmacology behind common drug nephrotoxicities","volume":"13","author":"Perazella","year":"2018","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.labinv.2024.102182_bib11","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.2215\/CJN.02440314","article-title":"Handling of drugs, metabolites, and uremic toxins by kidney proximal tubule drug transporters","volume":"10","author":"Nigam","year":"2015","journal-title":"Clin J Am Soc Nephrol"},{"key":"10.1016\/j.labinv.2024.102182_bib12","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.abh3355","article-title":"Cryo-EM structure of PepT2 reveals structural basis for proton-coupled peptide and prodrug transport in mammals","volume":"7","author":"Parker","year":"2021","journal-title":"Sci Adv"},{"key":"10.1016\/j.labinv.2024.102182_bib13","doi-asserted-by":"crossref","first-page":"653","DOI":"10.3390\/molecules24030653","article-title":"Molecular mechanisms of colistin-induced nephrotoxicity","volume":"24","author":"Gai","year":"2019","journal-title":"Molecules"},{"key":"10.1016\/j.labinv.2024.102182_bib14","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.3389\/fmicb.2019.01689","article-title":"Polymyxins and their potential next generation as therapeutic antibiotics","volume":"10","author":"Vaara","year":"2019","journal-title":"Front Microbiol"},{"key":"10.1016\/j.labinv.2024.102182_bib15","doi-asserted-by":"crossref","first-page":"1924","DOI":"10.1681\/ASN.2016080918","article-title":"A\u00a0variant of peptide transporter 2 predicts the severity of porphyria-associated kidney disease","volume":"28","author":"Tchernitchko","year":"2017","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.labinv.2024.102182_bib16","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.140750","article-title":"A\u00a0mechanism for matrikine regulation in acute inflammatory lung injury","volume":"6","author":"Robison","year":"2021","journal-title":"JCI Insight"},{"key":"10.1016\/j.labinv.2024.102182_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.105328","article-title":"Polymyxin-induced nephrotoxicity and its predictors: a systematic review and meta-analysis of studies conducted using RIFLE criteria of acute kidney injury","volume":"163","author":"Sisay","year":"2021","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.labinv.2024.102182_bib18","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.jcrc.2017.11.022","article-title":"Chronic kidney disease after acute kidney injury associated with intravenous colistin use in survivors of severe infections: a comparative cohort study","volume":"44","author":"Meraz-Mu\u00f1oz","year":"2018","journal-title":"J\u00a0Crit Care"},{"key":"10.1016\/j.labinv.2024.102182_bib20","doi-asserted-by":"crossref","first-page":"2069","DOI":"10.1681\/ASN.2018020125","article-title":"Single-cell transcriptomics of a human kidney allograft biopsy specimen defines a diverse inflammatory response","volume":"29","author":"Wu","year":"2018","journal-title":"J\u00a0Am Soc Nephrol"},{"key":"10.1016\/j.labinv.2024.102182_bib21","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.01650-19","article-title":"Renal glycosuria as a novel early sign of colistin-induced kidney damage in mice","volume":"63","author":"Samodelov","year":"2019","journal-title":"Antimicrob. Agents Chemother"},{"key":"10.1016\/j.labinv.2024.102182_bib22","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242115853","article-title":"Interaction of fabry disease and diabetes mellitus: suboptimal recruitment of kidney protective factors","volume":"24","author":"Sanchez-Ni\u00f1o","year":"2023","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.labinv.2024.102182_bib23","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.ejpb.2004.07.008","article-title":"Interaction of 31 beta-lactam antibiotics with the H+\/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1","volume":"59","author":"Luckner","year":"2005","journal-title":"Eur J Pharm Biopharm"},{"key":"10.1016\/j.labinv.2024.102182_bib24","article-title":"P-glycoprotein induction ameliorates colistin induced nephrotoxicity in cultured human proximal tubular cells","volume":"10","author":"Lee","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.labinv.2024.102182_bib25","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1083\/jcb.107.4.1359","article-title":"Characterization of a renal tubular epithelial cell line which secretes the autologous target antigen of autoimmune experimental interstitial nephritis","volume":"107","author":"Haverty","year":"1988","journal-title":"J\u00a0Cell Biol"},{"key":"10.1016\/j.labinv.2024.102182_bib26","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1016\/j.kint.2022.11.023","article-title":"The transcription factor Fosl1 preserves Klotho expression and protects from acute kidney injury","volume":"103","author":"Cuarental","year":"2023","journal-title":"Kidney Int"},{"key":"10.1016\/j.labinv.2024.102182_bib27","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1016\/j.kint.2022.02.028","article-title":"Growth differentiation factor-15 preserves Klotho expression in acute kidney injury and kidney fibrosis","volume":"101","author":"Vali\u00f1o-Rivas","year":"2022","journal-title":"Kidney Int"},{"key":"10.1016\/j.labinv.2024.102182_bib28","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1124\/jpet.104.073098","article-title":"Genetic variants of the human H+\/dipeptide transporter PEPT2: analysis of haplotype functions","volume":"311","author":"Pinsonneault","year":"2004","journal-title":"J\u00a0Pharmacol Exp Ther"},{"key":"10.1016\/j.labinv.2024.102182_bib29","doi-asserted-by":"crossref","first-page":"2993","DOI":"10.2337\/db06-0477","article-title":"Modular activation of nuclear factor-kappaB transcriptional programs in human diabetic nephropathy","volume":"55","author":"Schmid","year":"2006","journal-title":"Diabetes"},{"key":"10.1016\/j.labinv.2024.102182_bib30","doi-asserted-by":"crossref","first-page":"988","DOI":"10.4049\/jimmunol.1103031","article-title":"Cross-species transcriptional network analysis defines shared inflammatory responses in murine and human lupus nephritis","volume":"189","author":"Berthier","year":"2012","journal-title":"J\u00a0Immunol"},{"key":"10.1016\/j.labinv.2024.102182_bib31","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aac7071","article-title":"Tissue transcriptome-driven identification of epidermal growth factor as a chronic kidney disease biomarker","volume":"7","author":"Ju","year":"2015","journal-title":"Sci Transl Med"},{"key":"10.1016\/j.labinv.2024.102182_bib32","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0136994","article-title":"Molecular markers of tubulointerstitial fibrosis and tubular cell damage in patients with chronic kidney disease","volume":"10","author":"Nakagawa","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.labinv.2024.102182_bib33","first-page":"1066","article-title":"The effect of different colistin dosing regimens on nephrotoxicity: a cohort study","volume":"11","author":"Samarkos","year":"2022","journal-title":"Antibiot (Basel, Switzerland)"},{"key":"10.1016\/j.labinv.2024.102182_bib34","doi-asserted-by":"crossref","first-page":"5253","DOI":"10.1038\/s41467-022-32972-z","article-title":"Multimodal single cell sequencing implicates chromatin accessibility and genetic background in diabetic kidney disease progression","volume":"13","author":"Wilson","year":"2022","journal-title":"Nat Commun"},{"key":"10.1016\/j.labinv.2024.102182_bib35","doi-asserted-by":"crossref","first-page":"15874","DOI":"10.1073\/pnas.2005477117","article-title":"Cell profiling of mouse acute kidney injury reveals conserved cellular responses to injury","volume":"117","author":"Kirita","year":"2020","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.labinv.2024.102182_bib36","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1080\/0886022X.2020.1795878","article-title":"Evaluation of prognosis and nephrotoxicity in patients treated with colistin in intensive care unit","volume":"42","author":"Gunay","year":"2020","journal-title":"Ren Fail"},{"key":"10.1016\/j.labinv.2024.102182_bib37","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.02329-16","article-title":"Nephrotoxicity in patients with or without cystic fibrosis treated with polymyxin b compared to colistin","volume":"61","author":"Crass","year":"2017","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.labinv.2024.102182_bib38","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1007\/s15010-009-8342-x","article-title":"Effectiveness and safety of colistin for the treatment of multidrug-resistant Pseudomonas aeruginosa infections","volume":"37","author":"Montero","year":"2009","journal-title":"Infection"},{"key":"10.1016\/j.labinv.2024.102182_bib39","article-title":"Spatially resolved human kidney multi-omics single cell atlas highlights the key role of the fibrotic microenvironment in kidney disease progression","author":"Abedini","year":"2022","journal-title":"bioRxiv"},{"key":"10.1016\/j.labinv.2024.102182_bib40","doi-asserted-by":"crossref","first-page":"2444","DOI":"10.1093\/ndt\/gfad112","article-title":"SGLT2i for evidence-based cardiorenal protection in diabetic and non-diabetic chronic kidney disease: a comprehensive review by EURECA-m and ERBP working groups of ERA","volume":"38","author":"Mark","year":"2023","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.labinv.2024.102182_bib41","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/ki.2015.97","article-title":"High prevalence of and potential mechanisms for chronic kidney disease in patients with acute intermittent porphyria","volume":"88","author":"Pallet","year":"2015","journal-title":"Kidney Int"},{"key":"10.1016\/j.labinv.2024.102182_bib42","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1093\/ckj\/sfx146","article-title":"Porphyria and kidney diseases","volume":"11","author":"Pallet","year":"2018","journal-title":"Clin Kidney J"},{"key":"10.1016\/j.labinv.2024.102182_bib43","first-page":"F706","article-title":"Recognition of beta-lactam antibiotics by rat peptide transporters, PEPT1 and PEPT2, in LLC-PK1 cells","volume":"273","author":"Terada","year":"1997","journal-title":"Am J Physiol"},{"key":"10.1016\/j.labinv.2024.102182_bib44","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/S0005-2736(96)00234-9","article-title":"Interaction of anionic cephalosporins with the intestinal and renal peptide transporters PEPT 1 and PEPT 2","volume":"1324","author":"Ganapathy","year":"1997","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.labinv.2024.102182_bib45","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1159\/000092212","article-title":"Renal tubular drug transporters","volume":"103","author":"Launay-Vacher","year":"2006","journal-title":"Nephron. Physiol"},{"key":"10.1016\/j.labinv.2024.102182_bib46","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1007\/s00726-006-0331-0","article-title":"The renal type H+\/peptide symporter PEPT2: structure-affinity relationships","volume":"31","author":"Biegel","year":"2006","journal-title":"Amino Acids"},{"key":"10.1016\/j.labinv.2024.102182_bib47","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1080\/00498250701875254","article-title":"Peptide transporters and their roles in physiological processes and drug disposition","volume":"38","author":"Rubio-Aliaga","year":"2008","journal-title":"Xenobiotica"},{"key":"10.1016\/j.labinv.2024.102182_bib48","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1124\/dmd.107.015263","article-title":"Impact of genetic knockout of PEPT2 on cefadroxil pharmacokinetics, renal tubular reabsorption, and brain penetration in mice","volume":"35","author":"Shen","year":"2007","journal-title":"Drug Metab Dispos"},{"key":"10.1016\/j.labinv.2024.102182_bib49","doi-asserted-by":"crossref","first-page":"236","DOI":"10.2133\/dmpk.23.236","article-title":"Role and relevance of PEPT2 in drug disposition, dynamics, and toxicity","volume":"23","author":"Kamal","year":"2008","journal-title":"Drug Metab Pharmacokinet"},{"issue":"Suppl 6","key":"10.1016\/j.labinv.2024.102182_bib50","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1093\/ndt\/15.suppl_6.11","article-title":"Physiological and pharmacological implications of peptide transporters, PEPT1 and PEPT2","volume":"15","author":"Inui","year":"2000","journal-title":"Nephrol Dial Transplant"},{"key":"10.1016\/j.labinv.2024.102182_bib51","doi-asserted-by":"crossref","first-page":"2761","DOI":"10.1172\/JCI1909","article-title":"Delta-aminolevulinic acid transport by intestinal and renal peptide transporters and its physiological and clinical implications","volume":"101","author":"D\u00f6ring","year":"1998","journal-title":"J\u00a0Clin Invest"},{"key":"10.1016\/j.labinv.2024.102182_bib52","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1093\/jac\/dkv340","article-title":"Human oligopeptide transporter 2 (PEPT2) mediates cellular uptake of polymyxins","volume":"71","author":"Lu","year":"2016","journal-title":"J\u00a0Antimicrob Chemother"},{"key":"10.1016\/j.labinv.2024.102182_bib53","doi-asserted-by":"crossref","first-page":"207","DOI":"10.5582\/bst.2015.01078","article-title":"Substrates of the human oligopeptide transporter hPEPT2","volume":"9","author":"Zhao","year":"2015","journal-title":"Biosci Trends"}],"container-title":["Laboratory Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683724018609?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683724018609?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:41:46Z","timestamp":1777423306000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0023683724018609"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,1]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["S0023683724018609"],"URL":"https:\/\/doi.org\/10.1016\/j.labinv.2024.102182","relation":{},"ISSN":["0023-6837"],"issn-type":[{"value":"0023-6837","type":"print"}],"subject":[],"published":{"date-parts":[[2025,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cefadroxil Targeting of SLC15A2\/PEPT2 Protects From Colistin Nephrotoxicity","name":"articletitle","label":"Article Title"},{"value":"Laboratory Investigation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.labinv.2024.102182","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 United States & Canadian Academy of Pathology. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"102182"}}