{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T09:54:08Z","timestamp":1773222848786,"version":"3.50.1"},"reference-count":35,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071166"],"award-info":[{"award-number":["82071166"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020756","name":"Sichuan University West China School of Stomatology","doi-asserted-by":"publisher","award":["RD-03-202306"],"award-info":[{"award-number":["RD-03-202306"]}],"id":[{"id":"10.13039\/100020756","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004912","name":"Sichuan University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004912","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013365","name":"West China Hospital, Sichuan University","doi-asserted-by":"publisher","award":["WCHSIRB-D-2024-452"],"award-info":[{"award-number":["WCHSIRB-D-2024-452"]}],"id":[{"id":"10.13039\/501100013365","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013365","name":"West China Hospital, Sichuan University","doi-asserted-by":"publisher","award":["WCHSIRB-D-2024-266"],"award-info":[{"award-number":["WCHSIRB-D-2024-266"]}],"id":[{"id":"10.13039\/501100013365","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["li.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Laboratory Investigation"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.labinv.2025.104239","type":"journal-article","created":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T09:27:00Z","timestamp":1757755620000},"page":"104239","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Leptin Receptor\u2013Expressing (LepR+) Fibroblasts Activated by BMP Signaling Promote Bone Resorption in Developmental Odontogenic Cysts"],"prefix":"10.1016","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4750-3743","authenticated-orcid":false,"given":"Hetian","family":"Bai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinyong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yeting","family":"Tu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2570-9302","authenticated-orcid":false,"given":"Chongyun","family":"Bao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.labinv.2025.104239_bib1","series-title":"World Health Organization Classification of Head and Neck Tumours","author":"El-Naggar","year":"2017"},{"key":"10.1016\/j.labinv.2025.104239_bib2","series-title":"Head and Neck Tumours. WHO Classification of Tumours","year":"2022"},{"key":"10.1016\/j.labinv.2025.104239_bib3","doi-asserted-by":"crossref","first-page":"1124","DOI":"10.1097\/CM9.0000000000003054","article-title":"Epidemiological analysis of the clinicopathologic characteristics, treatment, and prognosis of 2648 jaw cysts in West China","volume":"137","author":"Li","year":"2024","journal-title":"Chin Med J (Engl)"},{"key":"10.1016\/j.labinv.2025.104239_bib4","doi-asserted-by":"crossref","DOI":"10.1590\/1807-3107bor-2021.vol35.0129","article-title":"Epidemiological evaluation of jaw cysts according to the new WHO classification: a 30-year retrospective analysis","volume":"35","author":"Franklin","year":"2021","journal-title":"Braz Oral Res"},{"key":"10.1016\/j.labinv.2025.104239_bib5","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1186\/s12903-023-03731-3","article-title":"Orthodontic management of a developing dentigerous cyst related to lower second molar: a case report","volume":"23","author":"El-Beialy","year":"2023","journal-title":"BMC Oral Health"},{"key":"10.1016\/j.labinv.2025.104239_bib6","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s00784-024-05612-7","article-title":"Assessment of bone regeneration after maxillary radicular cyst enucleation with or without bone grafting materials: a retrospective cohort study","volume":"28","author":"La Rosa","year":"2024","journal-title":"Clin Oral Investig"},{"key":"10.1016\/j.labinv.2025.104239_bib7","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1111\/iej.14016","article-title":"The IL-1\u03b2-p65 axis stimulates quiescent odontogenic epithelial cell rests via TGF-\u03b2 signalling to promote cell proliferation of the lining epithelia in radicular cysts: a laboratory investigation","volume":"57","author":"Nagano","year":"2024","journal-title":"Int Endod J"},{"key":"10.1016\/j.labinv.2025.104239_bib8","doi-asserted-by":"crossref","first-page":"857","DOI":"10.1016\/j.ajpath.2021.02.010","article-title":"Increased M2 isoform of pyruvate kinase in fibroblasts contributes to the growth, aggressiveness, and osteoclastogenesis of odontogenic keratocysts","volume":"191","author":"Zou","year":"2021","journal-title":"Am J Pathol"},{"key":"10.1016\/j.labinv.2025.104239_bib9","doi-asserted-by":"crossref","first-page":"3420","DOI":"10.1111\/odi.14293","article-title":"Single-cell analysis reveals immune cellular components in odontogenic keratocysts","volume":"29","author":"Man","year":"2023","journal-title":"Oral Dis"},{"key":"10.1016\/j.labinv.2025.104239_bib10","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s00018-022-04183-8","article-title":"Organoids from human tooth showing epithelial stemness phenotype and differentiation potential","volume":"79","author":"Hemeryck","year":"2022","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.labinv.2025.104239_bib11","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nbt.4096","article-title":"Integrating single-cell transcriptomic data across different conditions, technologies, and species","volume":"36","author":"Butler","year":"2018","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.labinv.2025.104239_bib12","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1038\/s41590-018-0276-y","article-title":"Reference-based analysis of lung single-cell sequencing reveals a transitional profibrotic macrophage","volume":"20","author":"Aran","year":"2019","journal-title":"Nat Immunol"},{"key":"10.1016\/j.labinv.2025.104239_bib13","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1038\/nbt.2859","article-title":"The dynamics and regulators of cell fate decisions are revealed by pseudotemporal ordering of single cells","volume":"32","author":"Trapnell","year":"2014","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.labinv.2025.104239_bib14","first-page":"3335","article-title":"Lymphocyte-derived microparticles stimulate osteoclastogenesis by inducing RANKL in fibroblasts of odontogenic keratocysts","volume":"40","author":"Man","year":"2018","journal-title":"Oncol Rep"},{"key":"10.1016\/j.labinv.2025.104239_bib15","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1002\/ajh.26961","article-title":"FKBP12 inhibits hepcidin expression by modulating BMP receptors interaction and ligand responsiveness in hepatocytes","volume":"98","author":"Pettinato","year":"2023","journal-title":"Am J Hematol"},{"key":"10.1016\/j.labinv.2025.104239_bib16","doi-asserted-by":"crossref","first-page":"4533","DOI":"10.1038\/s41467-019-12296-1","article-title":"Transcriptomic profiling of the myeloma bone-lining niche reveals BMP signalling inhibition to improve bone disease","volume":"10","author":"Gooding","year":"2019","journal-title":"Nat Commun"},{"key":"10.1016\/j.labinv.2025.104239_bib17","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1002\/cyto.a.24569","article-title":"Large-scale isolation of functional dermal papilla cells using novel surface marker LEPTIN receptor","volume":"101","author":"Gao","year":"2022","journal-title":"Cytometry A"},{"key":"10.1016\/j.labinv.2025.104239_bib18","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1016\/j.stem.2016.02.015","article-title":"Leptin receptor promotes adipogenesis and reduces osteogenesis by regulating mesenchymal stromal cells in adult bone marrow","volume":"18","author":"Yue","year":"2016","journal-title":"Cell Stem Cell"},{"key":"10.1016\/j.labinv.2025.104239_bib19","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/S0140-6736(69)91422-6","article-title":"Immunoglobulins and immunoglobulin-containing cells in cysts of the jaws","volume":"2","author":"Toller","year":"1969","journal-title":"Lancet"},{"key":"10.1016\/j.labinv.2025.104239_bib20","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a021873","article-title":"TGF-beta and the TGF-beta family: context-dependent roles in cell and tissue physiology","volume":"8","author":"Morikawa","year":"2016","journal-title":"Cold Spring Harb Perspect Biol"},{"key":"10.1016\/j.labinv.2025.104239_bib21","doi-asserted-by":"crossref","first-page":"4085","DOI":"10.1007\/s00018-021-03767-0","article-title":"Morphogens and growth factor signalling in the myeloma bone-lining niche","volume":"78","author":"Morris","year":"2021","journal-title":"Cell Mol Life Sci"},{"key":"10.1016\/j.labinv.2025.104239_bib22","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2017.46","article-title":"Multiple myeloma","volume":"3","author":"Kumar","year":"2017","journal-title":"Nat Rev Dis Primers"},{"key":"10.1016\/j.labinv.2025.104239_bib23","doi-asserted-by":"crossref","first-page":"3866","DOI":"10.1038\/onc.2009.257","article-title":"Bone morphogenic protein 6: a member of a novel class of prognostic factors expressed by normal and malignant plasma cells inhibiting proliferation and angiogenesis","volume":"28","author":"Seckinger","year":"2009","journal-title":"Oncogene"},{"key":"10.1016\/j.labinv.2025.104239_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.labinv.2022.100023","article-title":"IL-6 plays a critical role in stromal fibroblast RANKL induction and consequent osteoclastogenesis in ameloblastoma progression","volume":"103","author":"Yoshimoto","year":"2023","journal-title":"Lab Invest"},{"key":"10.1016\/j.labinv.2025.104239_bib25","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1038\/s41374-021-00671-w","article-title":"\u03b1TAT1-induced tubulin acetylation promotes ameloblastoma migration and invasion","volume":"102","author":"Yoshimoto","year":"2022","journal-title":"Lab Invest"},{"key":"10.1016\/j.labinv.2025.104239_bib26","doi-asserted-by":"crossref","first-page":"1285","DOI":"10.1038\/s41551-024-01238-y","article-title":"Prevention and treatment of peri-implant fibrosis by functionally inhibiting skeletal cells expressing the leptin receptor","volume":"8","author":"Suhardi","year":"2024","journal-title":"Nat Biomed Eng"},{"key":"10.1016\/j.labinv.2025.104239_bib27","article-title":"Lepr-expressing PDLSCs contribute to periodontal homeostasis and respond to mechanical force by Piezo1","volume":"10","author":"Zhang","year":"2023","journal-title":"Adv Sci (Weinh)"},{"key":"10.1016\/j.labinv.2025.104239_bib28","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1177\/00220345241264810","article-title":"Autophagy regulates age-related jawbone loss via LepR+ stromal cells","volume":"103","author":"Sun","year":"2024","journal-title":"J Dent Res"},{"key":"10.1016\/j.labinv.2025.104239_bib29","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1186\/s13287-020-01999-8","article-title":"Activation of mesenchymal stem cells promotes new bone formation within dentigerous cyst","volume":"11","author":"Yu","year":"2020","journal-title":"Stem Cell Res Ther"},{"key":"10.1016\/j.labinv.2025.104239_bib30","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/s41368-024-00281-4","article-title":"Single-cell transcriptomics reveals cell atlas and identifies cycling tumor cells responsible for recurrence in ameloblastoma","volume":"16","author":"Xiong","year":"2024","journal-title":"Int J Oral Sci"},{"key":"10.1016\/j.labinv.2025.104239_bib31","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1177\/002203450208100114","article-title":"Levels of GM-CSF, IL-3, and IL-6 in fluid and tissue from human radicular cysts","volume":"81","author":"Gerv\u00e1sio","year":"2002","journal-title":"J Dent Res"},{"key":"10.1016\/j.labinv.2025.104239_bib32","doi-asserted-by":"crossref","first-page":"20","DOI":"10.14744\/eej.2022.26918","article-title":"The paradigm of the inflammatory radicular cyst: biological aspects to be considered","volume":"8","author":"Osorio","year":"2022","journal-title":"Eur Endod J"},{"key":"10.1016\/j.labinv.2025.104239_bib33","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2020.107682","article-title":"RANKL as a key figure in bridging between the bone and immune system: its physiological functions and potential as a pharmacological target","volume":"218","author":"Honma","year":"2021","journal-title":"Pharmacol Ther"},{"key":"10.1016\/j.labinv.2025.104239_bib34","doi-asserted-by":"crossref","first-page":"499","DOI":"10.3892\/ijo.2016.3548","article-title":"TGF-beta in jaw tumor fluids induces RANKL expression in stromal fibroblasts","volume":"49","author":"Yamada","year":"2016","journal-title":"Int J Oncol"},{"key":"10.1016\/j.labinv.2025.104239_bib35","article-title":"Differential protein expression of osteoclastogenic factors in odontogenic cysts and tumors","volume":"36","author":"Almeida Junior","year":"2022","journal-title":"Braz Oral Res"}],"container-title":["Laboratory Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683725001497?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683725001497?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,10]],"date-time":"2026-03-10T12:38:48Z","timestamp":1773146328000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0023683725001497"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":35,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2025,11]]}},"alternative-id":["S0023683725001497"],"URL":"https:\/\/doi.org\/10.1016\/j.labinv.2025.104239","relation":{},"ISSN":["0023-6837"],"issn-type":[{"value":"0023-6837","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Leptin Receptor\u2013Expressing (LepR+) Fibroblasts Activated by BMP Signaling Promote Bone Resorption in Developmental Odontogenic Cysts","name":"articletitle","label":"Article Title"},{"value":"Laboratory Investigation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.labinv.2025.104239","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 United States & Canadian Academy of Pathology. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"104239"}}