{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T07:59:29Z","timestamp":1780732769354,"version":"3.54.1"},"reference-count":34,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100007836","name":"Fudan University Shanghai Key Laboratory of Intelligent Information Processing","doi-asserted-by":"publisher","award":["2018ZHYL0213"],"award-info":[{"award-number":["2018ZHYL0213"]}],"id":[{"id":"10.13039\/100007836","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017950","name":"Shanghai Municipal Health Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017950","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82372669"],"award-info":[{"award-number":["82372669"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["li.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Laboratory Investigation"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.labinv.2025.104252","type":"journal-article","created":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T06:14:17Z","timestamp":1760336057000},"page":"104252","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Artificial Intelligence\u2013Powered Spatial Analysis of the Tumor Microenvironment in Pulmonary Lymphoepithelial Carcinoma"],"prefix":"10.1016","volume":"105","author":[{"given":"Haohua","family":"Teng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yueyuxiao","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chan","family":"Xiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jikai","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhanxian","family":"Shang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianying","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiushun","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2548-5492","authenticated-orcid":false,"given":"Yuchen","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.labinv.2025.104252_bib1","article-title":"Tumours","volume":"Volume 5","year":"2021"},{"issue":"4","key":"10.1016\/j.labinv.2025.104252_bib2","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1002\/jso.27309","article-title":"Clinicopathological features and survival of rare primary pulmonary lymphoepithelial carcinoma: a cohort from a single center","volume":"128","author":"Nie","year":"2023","journal-title":"J Surg Oncol"},{"issue":"19","key":"10.1016\/j.labinv.2025.104252_bib3","doi-asserted-by":"crossref","first-page":"4748","DOI":"10.1002\/cncr.27452","article-title":"Primary pulmonary lymphoepithelioma-like carcinoma: fifty-two patients with long-term follow-up","volume":"118","author":"Liang","year":"2012","journal-title":"Cancer"},{"issue":"1","key":"10.1016\/j.labinv.2025.104252_bib4","doi-asserted-by":"crossref","first-page":"3108","DOI":"10.1038\/s41467-019-10902-w","article-title":"The genomic landscape of Epstein-Barr virus-associated pulmonary lymphoepithelioma-like carcinoma","volume":"10","author":"Hong","year":"2019","journal-title":"Nat Commun"},{"issue":"6","key":"10.1016\/j.labinv.2025.104252_bib5","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1097\/00000478-200206000-00004","article-title":"New aspects in clinicopathologic and oncogene studies of 23 pulmonary lymphoepithelioma-like carcinomas","volume":"26","author":"Chang","year":"2002","journal-title":"Am J Surg Pathol"},{"issue":"4","key":"10.1016\/j.labinv.2025.104252_bib6","doi-asserted-by":"crossref","DOI":"10.1128\/jvi.01693-21","article-title":"Genomic landscapes of Epstein-Barr virus in pulmonary lymphoepithelioma-like carcinoma","volume":"96","author":"Wu","year":"2022","journal-title":"J Virol"},{"issue":"8","key":"10.1016\/j.labinv.2025.104252_bib7","doi-asserted-by":"crossref","first-page":"2065","DOI":"10.3390\/cancers12082065","article-title":"Distinct molecular landscape of Epstein-Barr virus associated pulmonary lymphoepithelioma-like carcinoma revealed by genomic sequencing","volume":"12","author":"Chau","year":"2020","journal-title":"Cancers (Basel)"},{"issue":"1","key":"10.1016\/j.labinv.2025.104252_bib8","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1038\/s41467-021-21795-z","article-title":"Comprehensive single-cell sequencing reveals the stromal dynamics and tumor-specific characteristics in the microenvironment of nasopharyngeal carcinoma","volume":"12","author":"Gong","year":"2021","journal-title":"Nat Commun"},{"key":"10.1016\/j.labinv.2025.104252_bib9","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.canlet.2020.02.010","article-title":"Single cell RNA-seq reveals the landscape of tumor and infiltrating immune cells in nasopharyngeal carcinoma","volume":"477","author":"Zhao","year":"2020","journal-title":"Cancer Lett"},{"key":"10.1016\/j.labinv.2025.104252_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.744889","article-title":"The stromal and immune landscape of nasopharyngeal carcinoma and its implications for precision medicine targeting the tumor microenvironment","volume":"11","author":"Gong","year":"2021","journal-title":"Front Oncol"},{"key":"10.1016\/j.labinv.2025.104252_bib11","article-title":"Epstein-Barr virus DNA seropositivity links distinct tumoralheterogeneity and immune landscape in nasopharyngeal carcinoma","volume":"14","author":"Li","year":"2023","journal-title":"Front Immunol"},{"issue":"6","key":"10.1016\/j.labinv.2025.104252_bib12","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.1315","article-title":"Single-cell analysis reveals the multiple patterns of immune escape in the nasopharyngeal carcinoma microenvironment","volume":"13","author":"Lin","year":"2023","journal-title":"Clin Transl Med"},{"key":"10.1016\/j.labinv.2025.104252_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.lungcan.2023.107178","article-title":"Clinicopathologic features, tumor immune microenvironment and genomic landscape of EBV-related and EBV-unrelated poorly differentiated nonkeratinizing squamous cell carcinoma of the thymus","volume":"179","author":"Zhang","year":"2023","journal-title":"Lung Cancer"},{"issue":"4","key":"10.1016\/j.labinv.2025.104252_bib14","doi-asserted-by":"crossref","first-page":"323","DOI":"10.2169\/internalmedicine.43.323","article-title":"Pulmonary lymphoepithelioma-like carcinoma: predominant infiltration of tumor-associated cytotoxic T lymphocytes might represent the enhanced tumor immunity","volume":"43","author":"Kobayashi","year":"2004","journal-title":"Intern Med"},{"issue":"4","key":"10.1016\/j.labinv.2025.104252_bib15","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.4103\/jcrt.jcrt_2711_22","article-title":"Comparison of first-line immunotherapy efficacy between advanced lung squamous cell carcinoma and pulmonary lymphoepithelioma-like carcinoma: a propensity score matching multicenter study","volume":"19","author":"Zhou","year":"2023","journal-title":"J Cancer Res Ther"},{"issue":"1","key":"10.1016\/j.labinv.2025.104252_bib16","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1038\/s41379-021-00919-2","article-title":"Digital pathology and artificial intelligence in translational medicine and clinical practice","volume":"35","author":"Baxi","year":"2022","journal-title":"Mod Pathol"},{"issue":"1","key":"10.1016\/j.labinv.2025.104252_bib17","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.celrep.2018.03.086","article-title":"Spatial organization and molecular correlation of tumor- infiltrating lymphocytes using deep learning on pathology images","volume":"23","author":"Saltz","year":"2018","journal-title":"Cell Rep"},{"issue":"1","key":"10.1016\/j.labinv.2025.104252_bib18","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/s41392-021-00729-7","article-title":"Technological advances in cancer immunity: from immunogenomics to single-cell analysis and artificial intelligence","volume":"6","author":"Xu","year":"2021","journal-title":"Signal Transduct Target Ther"},{"issue":"17","key":"10.1016\/j.labinv.2025.104252_bib19","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1200\/JCO.21.02010","article-title":"Artificial intelligence-powered spatial analysis of tumor- infiltrating lymphocytes as complementary biomarker for immune checkpoint inhibition in non-small-cell lung cancer","volume":"40","author":"Park","year":"2022","journal-title":"J Clin Oncol"},{"issue":"7894","key":"10.1016\/j.labinv.2025.104252_bib20","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1038\/s41586-021-04278-5","article-title":"Multi-omic machine learning predictor of breast cancer therapy response","volume":"601","author":"Sammut","year":"2022","journal-title":"Nature"},{"key":"10.1016\/j.labinv.2025.104252_bib21","series-title":"Momentum contrast for unsupervised visual representation learning","author":"He","year":"2020"},{"issue":"12","key":"10.1016\/j.labinv.2025.104252_bib22","doi-asserted-by":"crossref","first-page":"1226","DOI":"10.1038\/s41592-019-0582-9","article-title":"ilastik: interactive machine learning for (bio)image analysis","volume":"16","author":"Berg","year":"2019","journal-title":"Nat Methods"},{"issue":"2","key":"10.1016\/j.labinv.2025.104252_bib23","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1158\/2767-9764.CRC-21-0146","article-title":"Resolving the heterogeneous tumor-centric cellular neighborhood through multiplexed, spatial paracrine interactions in the setting of immune checkpoint blockade","volume":"2","author":"Maus","year":"2022","journal-title":"Cancer Res Commun"},{"issue":"19","key":"10.1016\/j.labinv.2025.104252_bib24","first-page":"2343","article-title":"Spatial and molecular profiling of the mononuclear phagocyte network in classic Hodgkin lymphoma","volume":"141","author":"Stewart","year":"2023","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.labinv.2025.104252_bib25","doi-asserted-by":"crossref","first-page":"6726","DOI":"10.1038\/s41467-021-26974-6","article-title":"Immune cell topography predicts response to PD-1 blockade in cutaneous T cell lymphoma","volume":"12","author":"Phillips","year":"2021","journal-title":"Nat Commun"},{"issue":"6","key":"10.1016\/j.labinv.2025.104252_bib26","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1038\/s41571-019-0175-7","article-title":"Regulatory T cells in cancer immunosuppression-implications for anticancer therapy","volume":"16","author":"Togashi","year":"2019","journal-title":"Nat Rev Clin Oncol"},{"key":"10.1016\/j.labinv.2025.104252_bib27","article-title":"Comparison of immunotherapy, chemotherapy, and chemoimmunotherapy in advanced pulmonary lymphoepithelioma-like carcinoma: a retrospective study","volume":"12","author":"Xiao","year":"2022","journal-title":"Front Oncol"},{"issue":"3","key":"10.1016\/j.labinv.2025.104252_bib28","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.lungcan.2015.03.017","article-title":"PD-L1 is highly expressed in lung lymphoepithelioma-like carcinoma: a potential rationale for immunotherapy","volume":"88","author":"Chang","year":"2015","journal-title":"Lung Cancer"},{"issue":"3","key":"10.1016\/j.labinv.2025.104252_bib29","doi-asserted-by":"crossref","first-page":"e329","DOI":"10.1016\/j.cllc.2018.12.014","article-title":"Clinical features and prognosis of pulmonary lymphoepithelioma- like carcinoma: summary of eighty-five cases","volume":"20","author":"Qin","year":"2019","journal-title":"Clin Lung Cancer"},{"issue":"11","key":"10.1016\/j.labinv.2025.104252_bib30","doi-asserted-by":"crossref","first-page":"3081","DOI":"10.1016\/j.cell.2025.03.018","article-title":"A single-cell atlas reveals immune heterogeneity in anti- PD-1-treated non-small cell lung cancer","volume":"188","author":"Liu","year":"2025","journal-title":"Cell"},{"issue":"14","key":"10.1016\/j.labinv.2025.104252_bib31","doi-asserted-by":"crossref","DOI":"10.1172\/JCI180080","article-title":"Spatial and functional targeting of intratumoral Tregs reverses CD8+ T cell exhaustion and promotes cancer immunotherapy","volume":"134","author":"Zhou","year":"2024","journal-title":"J Clin Invest"},{"issue":"32","key":"10.1016\/j.labinv.2025.104252_bib32","doi-asserted-by":"crossref","first-page":"33019","DOI":"10.18632\/oncotarget.5028","article-title":"PD-L1 is remarkably over-expressed in EBV-associated pulmonary lymphoepithelioma-like carcinoma and related to poor disease-free survival","volume":"6","author":"Fang","year":"2015","journal-title":"Oncotarget"},{"issue":"3","key":"10.1016\/j.labinv.2025.104252_bib33","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.21037\/jtd.2018.03.14","article-title":"Correlation and prognostic significance of PD-L1 and P53 expression in resected primary pulmonary lymphoepithelioma-like carcinoma","volume":"10","author":"Yu","year":"2018","journal-title":"J Thorac Dis"},{"key":"10.1016\/j.labinv.2025.104252_bib34","first-page":"1451","article-title":"Positive expression of programmed death ligand-1 correlates with superior outcomes and might be a therapeutic target in primary pulmonary lymphoepithelioma-like carcinoma","volume":"8","author":"Jiang","year":"2015","journal-title":"Onco Targets Ther"}],"container-title":["Laboratory Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002368372500162X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S002368372500162X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T07:05:58Z","timestamp":1780729558000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S002368372500162X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":34,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["S002368372500162X"],"URL":"https:\/\/doi.org\/10.1016\/j.labinv.2025.104252","relation":{},"ISSN":["0023-6837"],"issn-type":[{"value":"0023-6837","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Artificial Intelligence\u2013Powered Spatial Analysis of the Tumor Microenvironment in Pulmonary Lymphoepithelial Carcinoma","name":"articletitle","label":"Article Title"},{"value":"Laboratory Investigation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.labinv.2025.104252","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 United States & Canadian Academy of Pathology. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"104252"}}