{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T17:34:47Z","timestamp":1794332087165,"version":"4.9.0"},"reference-count":72,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100007434","name":"Suzuken Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007434","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008673","name":"Yasuda Memorial Medical Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008673","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006062","name":"Foundation for Promotion of Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008886","name":"Princess Takamatsu Cancer Research Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008886","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005865","name":"Mochida Memorial Foundation for Medical and Pharmaceutical Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004420","name":"Wakayama Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004420","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["li.uscap.org","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Laboratory Investigation"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.labinv.2026.106173","type":"journal-article","created":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T15:37:22Z","timestamp":1792769842000},"page":"106173","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Aggregation of Mutant p53 Alters Sialylated and Sulfated Glycan Profiles and Enhances Siglec-9 Ligand Availability in Ovarian Cancer"],"prefix":"10.1016","author":[{"given":"Midori","family":"Ikezaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Noa","family":"Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiko","family":"Takeda-Uchimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoyuki","family":"Iwahashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megumi","family":"Fujino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaho","family":"Nishioka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kazuhiko","family":"Ino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshito","family":"Ihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masakazu","family":"Fujimoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukio","family":"Fujiwara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Komohara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenji","family":"Uchimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3056-8310","authenticated-orcid":false,"given":"Kazuchika","family":"Nishitsuji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.labinv.2026.106173_bib1","first-page":"7","article-title":"Cancer Statistics, 2017","volume":"67","author":"Siegel","year":"2017","journal-title":"CA Cancer J Clin"},{"issue":"1","key":"10.1016\/j.labinv.2026.106173_bib2","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1097\/01.pgp.0000101080.35393.16","article-title":"The histologic type and stage distribution of ovarian carcinomas of surface epithelial origin","volume":"23","author":"Seidman","year":"2004","journal-title":"Int J Gynecol Pathol"},{"issue":"5","key":"10.1016\/j.labinv.2026.106173_bib3","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1586\/eog.12.41","article-title":"Modulating the tumor immune microenvironment as an ovarian cancer treatment strategy","volume":"7","author":"Scarlett","year":"2012","journal-title":"Expert Rev Obstet Gynecol"},{"issue":"1","key":"10.1016\/j.labinv.2026.106173_bib4","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1002\/path.2696","article-title":"Driver mutations in TP53 are ubiquitous in high grade serous carcinoma of the ovary","volume":"221","author":"Ahmed","year":"2010","journal-title":"J Pathol"},{"issue":"6","key":"10.1016\/j.labinv.2026.106173_bib5","doi-asserted-by":"crossref","first-page":"672","DOI":"10.1002\/humu.22552","article-title":"TP53 mutations in human cancer: database reassessment and prospects for the next decade","volume":"35","author":"Leroy","year":"2014","journal-title":"Hum Mutat"},{"issue":"6","key":"10.1016\/j.labinv.2026.106173_bib6","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/j.tig.2022.02.010","article-title":"The p53 network: cellular and systemic DNA damage responses in cancer and aging","volume":"38","author":"Vaddavalli","year":"2022","journal-title":"Trends Genet"},{"issue":"6381","key":"10.1016\/j.labinv.2026.106173_bib7","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/358015a0","article-title":"Cancer. p53, guardian of the genome","volume":"358","author":"Lane","year":"1992","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.labinv.2026.106173_bib8","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a001008","article-title":"TP53 mutations in human cancers: origins, consequences, and clinical use","volume":"2","author":"Olivier","year":"2010","journal-title":"Cold Spring Harb Perspect Biol"},{"issue":"6","key":"10.1016\/j.labinv.2026.106173_bib9","doi-asserted-by":"crossref","first-page":"1027","DOI":"10.1038\/sj.cdd.4401910","article-title":"The P53 pathway: what questions remain to be explored?","volume":"13","author":"Levine","year":"2006","journal-title":"Cell Death Differ"},{"issue":"1","key":"10.1016\/j.labinv.2026.106173_bib10","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1038\/ncb2641","article-title":"p53 mutations in cancer","volume":"15","author":"Muller","year":"2013","journal-title":"Nat Cell Biol"},{"issue":"30","key":"10.1016\/j.labinv.2026.106173_bib11","doi-asserted-by":"crossref","first-page":"9022","DOI":"10.1021\/bi034218k","article-title":"Fibrillar aggregates of the tumor suppressor p53 core domain","volume":"42","author":"Ishimaru","year":"2003","journal-title":"Biochemistry"},{"issue":"52","key":"10.1016\/j.labinv.2026.106173_bib12","doi-asserted-by":"crossref","first-page":"33225","DOI":"10.1073\/pnas.2009931117","article-title":"Sulfated glycosaminoglycans mediate prion-like behavior of p53 aggregates","volume":"117","author":"Iwahashi","year":"2020","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"10","key":"10.1016\/j.labinv.2026.106173_bib13","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.1038\/cdd.2017.105","article-title":"p53 amyloid formation leading to its loss of function: implications in cancer pathogenesis","volume":"24","author":"Ghosh","year":"2017","journal-title":"Cell Death Differ"},{"issue":"33","key":"10.1016\/j.labinv.2026.106173_bib14","doi-asserted-by":"crossref","first-page":"28152","DOI":"10.1074\/jbc.M112.340638","article-title":"Mutant p53 aggregates into prion-like amyloid oligomers and fibrils: implications for cancer","volume":"287","author":"Ano Bom","year":"2012","journal-title":"J Biol Chem"},{"issue":"1","key":"10.1016\/j.labinv.2026.106173_bib15","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.biocel.2010.10.017","article-title":"Co-localization of mutant p53 and amyloid-like protein aggregates in breast tumors","volume":"43","author":"Levy","year":"2011","journal-title":"Int J Biochem Cell Biol"},{"issue":"3","key":"10.1016\/j.labinv.2026.106173_bib16","doi-asserted-by":"crossref","DOI":"10.1093\/pnasnexus\/pgac128","article-title":"Cytoplasmic p53 aggregates accumulated in p53-mutated cancer correlate with poor prognosis","volume":"1","author":"Iwahashi","year":"2022","journal-title":"PNAS Nexus"},{"issue":"17","key":"10.1016\/j.labinv.2026.106173_bib17","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.261017","article-title":"p53 amyloid pathology is correlated with higher cancer grade irrespective of the mutant or wild-type form","volume":"136","author":"Sengupta","year":"2023","journal-title":"J Cell Sci"},{"issue":"33","key":"10.1016\/j.labinv.2026.106173_bib18","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.1038\/s41388-023-02758-8","article-title":"Amyloid-like p53 as prognostic biomarker in serous ovarian cancer-a study of the OVCAD consortium","volume":"42","author":"Heinzl","year":"2023","journal-title":"Oncogene"},{"issue":"9","key":"10.1016\/j.labinv.2026.106173_bib19","doi-asserted-by":"crossref","first-page":"2947","DOI":"10.1111\/cas.16252","article-title":"Impacts of cytoplasmic p53 aggregates on the prognosis and the transcriptome in lung squamous cell carcinoma","volume":"115","author":"Nishitsuji","year":"2024","journal-title":"Cancer Sci"},{"issue":"5","key":"10.1016\/j.labinv.2026.106173_bib20","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/nchembio.546","article-title":"Gain of function of mutant p53 by coaggregation with multiple tumor suppressors","volume":"7","author":"Xu","year":"2011","journal-title":"Nat Chem Biol"},{"issue":"15","key":"10.1016\/j.labinv.2026.106173_bib21","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.259500","article-title":"Oncogenic gain of function due to p53 amyloids occurs through aberrant alteration of cell cycle and proliferation","volume":"135","author":"Navalkar","year":"2022","journal-title":"J Cell Sci"},{"issue":"2","key":"10.1016\/j.labinv.2026.106173_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2020.100820","article-title":"Oncogenic Gain of Function in Glioblastoma Is Linked to Mutant p53 Amyloid Oligomers","volume":"23","author":"Pedrote","year":"2020","journal-title":"iScience"},{"issue":"12","key":"10.1016\/j.labinv.2026.106173_bib23","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1136\/jclinpath-2011-200231","article-title":"Immunohistochemical expression of keratan sulfate: a possible diagnostic marker for carcinomas of the female genital tract","volume":"64","author":"Miyamoto","year":"2011","journal-title":"J Clin Pathol"},{"issue":"6","key":"10.1016\/j.labinv.2026.106173_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.labinv.2024.102057","article-title":"Structural Elucidation and Prognostic Relevance of 297-11A-Sulfated Glycans in Ovarian Carcinoma","volume":"104","author":"Inoue","year":"2024","journal-title":"Lab Invest"},{"issue":"1","key":"10.1016\/j.labinv.2026.106173_bib25","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1016\/j.ajpath.2010.11.009","article-title":"Functional contributions of N- and O-glycans to L-selectin ligands in murine and human lymphoid organs","volume":"178","author":"Arata-Kawai","year":"2011","journal-title":"Am J Pathol"},{"issue":"14","key":"10.1016\/j.labinv.2026.106173_bib26","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27144543","article-title":"Complementary Role of GlcNAc6ST2 and GlcNAc6ST3 in Synthesis of CL40-Reactive Sialylated and Sulfated Glycans in the Mouse Pleural Mesothelium","volume":"27","author":"Takeda-Uchimura","year":"2022","journal-title":"Molecules"},{"issue":"1","key":"10.1016\/j.labinv.2026.106173_bib27","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.ccell.2015.12.002","article-title":"A Designed Inhibitor of p53 Aggregation Rescues p53 Tumor Suppression in Ovarian Carcinomas","volume":"29","author":"Soragni","year":"2016","journal-title":"Cancer Cell"},{"issue":"3","key":"10.1016\/j.labinv.2026.106173_bib28","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1038\/nm0302-282","article-title":"Restoration of the tumor suppressor function to mutant p53 by a low-molecular-weight compound","volume":"8","author":"Bykov","year":"2002","journal-title":"Nat Med"},{"key":"10.1016\/j.labinv.2026.106173_bib29","doi-asserted-by":"crossref","DOI":"10.3389\/fmolb.2023.1165132","article-title":"PRIMA-1 inhibits Y220C p53 amyloid aggregation and synergizes with cisplatin in hepatocellular carcinoma","volume":"10","author":"Paz","year":"2023","journal-title":"Front Mol Biosci"},{"issue":"10","key":"10.1016\/j.labinv.2026.106173_bib30","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1038\/nri3737","article-title":"Siglec-mediated regulation of immune cell function in disease","volume":"14","author":"Macauley","year":"2014","journal-title":"Nat Rev Immunol"},{"issue":"10","key":"10.1016\/j.labinv.2026.106173_bib31","doi-asserted-by":"crossref","first-page":"3670","DOI":"10.1074\/jbc.RA118.004671","article-title":"p53 reactivation with induction of massive apoptosis-1 (PRIMA-1) inhibits amyloid aggregation of mutant p53 in cancer cells","volume":"294","author":"Rangel","year":"2019","journal-title":"J Biol Chem"},{"key":"10.1016\/j.labinv.2026.106173_bib32","article-title":"The glycosyltransferase ST3GAL4 drives immune evasion in acute myeloid leukemia by synthesizing ligands for the glyco-immune checkpoint receptor Siglec-9","author":"Krishnamoorthy","year":"2024","journal-title":"Leukemia"},{"issue":"15","key":"10.1016\/j.labinv.2026.106173_bib33","first-page":"4196","article-title":"Abnormal structure and expression of the p53 gene in human ovarian carcinoma cell lines","volume":"52","author":"Yaginuma","year":"1992","journal-title":"Cancer Res"},{"issue":"6","key":"10.1016\/j.labinv.2026.106173_bib34","doi-asserted-by":"crossref","first-page":"2219","DOI":"10.1084\/jem.180.6.2219","article-title":"Sulfation-dependent recognition of high endothelial venules (HEV)-ligands by L-selectin and MECA 79, and adhesion-blocking monoclonal antibody","volume":"180","author":"Hemmerich","year":"1994","journal-title":"J Exp Med"},{"issue":"11","key":"10.1016\/j.labinv.2026.106173_bib35","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1038\/ni1258","article-title":"A major class of L-selectin ligands is eliminated in mice deficient in two sulfotransferases expressed in high endothelial venules","volume":"6","author":"Uchimura","year":"2005","journal-title":"Nat Immunol"},{"issue":"3","key":"10.1016\/j.labinv.2026.106173_bib36","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.ygyno.2007.02.004","article-title":"Expression of MUC1 in primary and metastatic human epithelial ovarian cancer and its therapeutic significance","volume":"105","author":"Wang","year":"2007","journal-title":"Gynecol Oncol"},{"issue":"6","key":"10.1016\/j.labinv.2026.106173_bib37","doi-asserted-by":"crossref","first-page":"3031","DOI":"10.1111\/jcmm.16345","article-title":"MUC16 promotes EOC proliferation by regulating GLUT1 expression","volume":"25","author":"Wang","year":"2021","journal-title":"J Cell Mol Med"},{"issue":"12","key":"10.1016\/j.labinv.2026.106173_bib38","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.it.2006.10.007","article-title":"Sulfated L-selectin ligands as a therapeutic target in chronic inflammation","volume":"27","author":"Uchimura","year":"2006","journal-title":"Trends Immunol"},{"issue":"11","key":"10.1016\/j.labinv.2026.106173_bib39","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1038\/ni1259","article-title":"N-acetylglucosamine-6-O-sulfotransferases 1 and 2 cooperatively control lymphocyte homing through L-selectin ligand biosynthesis in high endothelial venules","volume":"6","author":"Kawashima","year":"2005","journal-title":"Nat Immunol"},{"issue":"7","key":"10.1016\/j.labinv.2026.106173_bib40","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/S0092-8674(01)00394-4","article-title":"Novel sulfated lymphocyte homing receptors and their control by a Core1 extension beta 1,3-N-acetylglucosaminyltransferase","volume":"105","author":"Yeh","year":"2001","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.labinv.2026.106173_bib41","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.ygyno.2005.07.016","article-title":"Altered mRNA expressions of sialyltransferases in ovarian cancers","volume":"99","author":"Wang","year":"2005","journal-title":"Gynecol Oncol"},{"issue":"4","key":"10.1016\/j.labinv.2026.106173_bib42","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1093\/jb\/mvv010","article-title":"Organelle autoregulation-stress responses in the ER, Golgi, mitochondria and lysosome","volume":"157","author":"Sasaki","year":"2015","journal-title":"J Biochem"},{"issue":"2","key":"10.1016\/j.labinv.2026.106173_bib43","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1247\/csf.19009","article-title":"MGSE Regulates Crosstalk from the Mucin Pathway to the TFE3 Pathway of the Golgi Stress Response","volume":"44","author":"Jamaludin","year":"2019","journal-title":"Cell Struct Funct"},{"issue":"3","key":"10.1016\/j.labinv.2026.106173_bib44","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbagen.2020.129812","article-title":"Mechanisms of productive folding and endoplasmic reticulum-associated degradation of glycoproteins and non-glycoproteins","volume":"1865","author":"Ninagawa","year":"2021","journal-title":"Biochim Biophys Acta Gen Subj"},{"issue":"4","key":"10.1016\/j.labinv.2026.106173_bib45","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/j.bbrc.2006.03.223","article-title":"Carbohydrate microarrays reveal sulphation as a modulator of siglec binding","volume":"344","author":"Campanero-Rhodes","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"issue":"11","key":"10.1016\/j.labinv.2026.106173_bib46","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1021\/acschembio.1c00501","article-title":"Carbohydrate Sulfation As a Mechanism for Fine-Tuning Siglec Ligands","volume":"16","author":"Jung","year":"2021","journal-title":"ACS Chem Biol"},{"issue":"7","key":"10.1016\/j.labinv.2026.106173_bib47","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1093\/glycob\/cwx026","article-title":"Siglec-8 and Siglec-9 binding specificities and endogenous airway ligand distributions and properties","volume":"27","author":"Yu","year":"2017","journal-title":"Glycobiology"},{"issue":"7417","key":"10.1016\/j.labinv.2026.106173_bib48","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nature11404","article-title":"Comprehensive genomic characterization of squamous cell lung cancers","volume":"489","author":"Cancer Genome Atlas Research","year":"2012","journal-title":"Nature"},{"issue":"24","key":"10.1016\/j.labinv.2026.106173_bib49","doi-asserted-by":"crossref","first-page":"9430","DOI":"10.1074\/jbc.RA119.007566","article-title":"Loss of the p53 transactivation domain results in high amyloid aggregation of the Delta40p53 isoform in endometrial carcinoma cells","volume":"294","author":"Melo Dos Santos","year":"2019","journal-title":"J Biol Chem"},{"issue":"27","key":"10.1016\/j.labinv.2026.106173_bib50","doi-asserted-by":"crossref","first-page":"3605","DOI":"10.1038\/onc.2014.296","article-title":"p53 protein aggregation promotes platinum resistance in ovarian cancer","volume":"34","author":"Yang-Hartwich","year":"2015","journal-title":"Oncogene"},{"issue":"2","key":"10.1016\/j.labinv.2026.106173_bib51","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1097\/00000441-194902000-00011","article-title":"Incidence of the blood groups and the secretor factor in patients with pernicious anemia and stomach carcinoma","volume":"217","author":"Ladenson","year":"1949","journal-title":"Am J Med Sci"},{"issue":"1","key":"10.1016\/j.labinv.2026.106173_bib52","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1073\/pnas.59.1.254","article-title":"Glycolipids of hamster fibroblasts and derived malignant-transformed cell lines","volume":"59","author":"Hakomori","year":"1968","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"10.1016\/j.labinv.2026.106173_bib53","first-page":"245","article-title":"Carbohydrate antigens in human cancer","volume":"4","author":"Feizi","year":"1985","journal-title":"Cancer Surv"},{"issue":"2","key":"10.1016\/j.labinv.2026.106173_bib54","first-page":"231","article-title":"Glycosphingolipids as tumor-associated and differentiation markers","volume":"71","author":"Hakomori","year":"1983","journal-title":"J Natl Cancer Inst"},{"issue":"9","key":"10.1016\/j.labinv.2026.106173_bib55","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1038\/nrc3982","article-title":"Glycosylation in cancer: mechanisms and clinical implications","volume":"15","author":"Pinho","year":"2015","journal-title":"Nat Rev Cancer"},{"issue":"2","key":"10.1016\/j.labinv.2026.106173_bib56","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1042\/BST20200763","article-title":"Aberrant protein glycosylation in cancer: implications in targeted therapy","volume":"49","author":"Rodrigues","year":"2021","journal-title":"Biochem Soc Trans"},{"issue":"1","key":"10.1016\/j.labinv.2026.106173_bib57","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.ccell.2019.06.006","article-title":"Glycosylation in the Era of Cancer-Targeted Therapy: Where Are We Heading?","volume":"36","author":"Mereiter","year":"2019","journal-title":"Cancer Cell"},{"issue":"4","key":"10.1016\/j.labinv.2026.106173_bib58","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1038\/nri2056","article-title":"Siglecs and their roles in the immune system","volume":"7","author":"Crocker","year":"2007","journal-title":"Nat Rev Immunol"},{"issue":"11","key":"10.1016\/j.labinv.2026.106173_bib59","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1038\/ni.3552","article-title":"The mucin MUC1 modulates the tumor immunological microenvironment through engagement of the lectin Siglec-9","volume":"17","author":"Beatson","year":"2016","journal-title":"Nat Immunol"},{"issue":"1-2","key":"10.1016\/j.labinv.2026.106173_bib60","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s10555-018-09775-0","article-title":"Cancer-associated mucins: role in immune modulation and metastasis","volume":"38","author":"Bhatia","year":"2019","journal-title":"Cancer Metastasis Rev"},{"issue":"4","key":"10.1016\/j.labinv.2026.106173_bib61","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1172\/JCI65899","article-title":"Interactions between Siglec-7\/9 receptors and ligands influence NK cell-dependent tumor immunosurveillance","volume":"124","author":"Jandus","year":"2014","journal-title":"J Clin Invest"},{"issue":"5","key":"10.1016\/j.labinv.2026.106173_bib62","doi-asserted-by":"crossref","first-page":"1088","DOI":"10.1111\/j.1349-7006.2011.01895.x","article-title":"Ectopic expression of MECA-79 as a novel prognostic indicator in gastric cancer","volume":"102","author":"Okayama","year":"2011","journal-title":"Cancer Sci"},{"key":"10.1016\/j.labinv.2026.106173_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.tranon.2023.101843","article-title":"A comprehensive analysis of the expression, immune infiltration, prognosis and partial experimental validation of CHST family genes in gastric cancer","volume":"40","author":"Zhan","year":"2024","journal-title":"Transl Oncol"},{"issue":"4","key":"10.1016\/j.labinv.2026.106173_bib64","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1038\/s41419-023-05797-x","article-title":"CHST2-mediated sulfation of MECA79 antigens is critical for breast cancer cell migration and metastasis","volume":"14","author":"Zhang","year":"2023","journal-title":"Cell Death Dis"},{"issue":"1","key":"10.1016\/j.labinv.2026.106173_bib65","doi-asserted-by":"crossref","DOI":"10.1093\/jleuko\/qiae190","article-title":"CHST4 associates with high-abundance immune infiltration in hormone receptor-positive breast cancer","volume":"117","author":"Liu","year":"2024","journal-title":"J Leukoc Biol"},{"issue":"6","key":"10.1016\/j.labinv.2026.106173_bib66","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1093\/glycob\/12.6.379","article-title":"Ectopic expression of a GlcNAc 6-O-sulfotransferase, GlcNAc6ST-2, in colonic mucinous adenocarcinoma","volume":"12","author":"Seko","year":"2002","journal-title":"Glycobiology"},{"issue":"12","key":"10.1016\/j.labinv.2026.106173_bib67","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.1038\/labinvest.2016.104","article-title":"Apical membrane expression of distinct sulfated glycans represents a novel marker of cholangiolocellular carcinoma","volume":"96","author":"Hoshino","year":"2016","journal-title":"Lab Invest"},{"issue":"1","key":"10.1016\/j.labinv.2026.106173_bib68","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1093\/glycob\/11.1.75","article-title":"Chromosomal localization and genomic organization for the galactose\/ N-acetylgalactosamine\/N-acetylglucosamine 6-O-sulfotransferase gene family","volume":"11","author":"Hemmerich","year":"2001","journal-title":"Glycobiology"},{"issue":"11","key":"10.1016\/j.labinv.2026.106173_bib69","doi-asserted-by":"crossref","first-page":"6841","DOI":"10.4049\/jimmunol.173.11.6841","article-title":"The membrane-proximal immunoreceptor tyrosine-based inhibitory motif is critical for the inhibitory signaling mediated by Siglecs-7 and -9, CD33-related Siglecs expressed on human monocytes and NK cells","volume":"173","author":"Avril","year":"2004","journal-title":"J Immunol"},{"issue":"11","key":"10.1016\/j.labinv.2026.106173_bib70","doi-asserted-by":"crossref","first-page":"4912","DOI":"10.1172\/JCI120612","article-title":"Self-associated molecular patterns mediate cancer immune evasion by engaging Siglecs on T cells","volume":"128","author":"Stanczak","year":"2018","journal-title":"J Clin Invest"},{"key":"10.1016\/j.labinv.2026.106173_bib71","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/1476-4598-9-118","article-title":"Identification of Siglec-9 as the receptor for MUC16 on human NK cells, B cells, and monocytes","volume":"9","author":"Belisle","year":"2010","journal-title":"Mol Cancer"},{"issue":"44","key":"10.1016\/j.labinv.2026.106173_bib72","doi-asserted-by":"crossref","first-page":"31842","DOI":"10.1074\/jbc.M113.471318","article-title":"Binding of the sialic acid-binding lectin, Siglec-9, to the membrane mucin, MUC1, induces recruitment of beta-catenin and subsequent cell growth","volume":"288","author":"Tanida","year":"2013","journal-title":"J Biol Chem"}],"container-title":["Laboratory Investigation"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683726001030?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0023683726001030?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T16:29:07Z","timestamp":1794328147000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0023683726001030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":72,"alternative-id":["S0023683726001030"],"URL":"https:\/\/doi.org\/10.1016\/j.labinv.2026.106173","relation":{},"ISSN":["0023-6837"],"issn-type":[{"value":"0023-6837","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Aggregation of Mutant p53 Alters Sialylated and Sulfated Glycan Profiles and Enhances Siglec-9 Ligand Availability in Ovarian Cancer","name":"articletitle","label":"Article Title"},{"value":"Laboratory Investigation","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.labinv.2026.106173","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 United States & Canadian Academy of Pathology. Published by Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106173"}}