{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T13:58:44Z","timestamp":1781272724547,"version":"3.54.1"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,8,1]],"date-time":"2022-08-01T00:00:00Z","timestamp":1659312000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,5,12]],"date-time":"2022-05-12T00:00:00Z","timestamp":1652313600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2018\/20468-0"],"award-info":[{"award-number":["2018\/20468-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2019\/12068-5"],"award-info":[{"award-number":["2019\/12068-5"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001807","name":"Funda\u00e7\u00e3o de Amparo \u00e0 Pesquisa do Estado de S\u00e3o Paulo","doi-asserted-by":"publisher","award":["2016\/13465-0"],"award-info":[{"award-number":["2016\/13465-0"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["142306\/2020-7"],"award-info":[{"award-number":["142306\/2020-7"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["304033\/2021-9"],"award-info":[{"award-number":["304033\/2021-9"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["409216\/2018-6"],"award-info":[{"award-number":["409216\/2018-6"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["302917\/2019-5"],"award-info":[{"award-number":["302917\/2019-5"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["408636\/2018-1"],"award-info":[{"award-number":["408636\/2018-1"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Lancet Regional Health - Americas"],"published-print":{"date-parts":[[2022,8]]},"DOI":"10.1016\/j.lana.2022.100285","type":"journal-article","created":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T14:21:33Z","timestamp":1653661293000},"page":"100285","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Mapping and characterizing areas with high levels of malaria in pregnancy in Brazil: A spatiotemporal analysis"],"prefix":"10.1016","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1863-1914","authenticated-orcid":false,"given":"Jamille Greg\u00f3rio","family":"Dombrowski","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura Cordeiro","family":"Gomes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2121-9063","authenticated-orcid":false,"given":"Camila","family":"Lorenz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1564-0871","authenticated-orcid":false,"given":"Raquel Gardini Sanches","family":"Palasio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Marchesini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina","family":"Epiphanio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio Romero Farias","family":"Marinho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lana.2022.100285_bib0001","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1053\/j.semperi.2019.03.018","article-title":"An overview of malaria in pregnancy","volume":"43","author":"Bauserman","year":"2019","journal-title":"Semin Perinatol"},{"key":"10.1016\/j.lana.2022.100285_bib0002","series-title":"World Malaria Report 2020: 20 Years of Global Progress and Challenges Licence: CC BY-NC-SA 3.0 IGO","year":"2020"},{"key":"10.1016\/j.lana.2022.100285_bib0003","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a025551","article-title":"Malaria during pregnancy","volume":"7","author":"Fried","year":"2017","journal-title":"Cold Spring Harb Perspect Med"},{"key":"10.1016\/j.lana.2022.100285_bib0004","doi-asserted-by":"crossref","first-page":"e1101","DOI":"10.1016\/S2214-109X(17)30340-6","article-title":"Quantification of the association between malaria in pregnancy and stillbirth: a systematic review and meta-analysis","volume":"5","author":"Moore","year":"2017","journal-title":"Lancet Glob Heal"},{"key":"10.1016\/j.lana.2022.100285_bib0005","series-title":"Secretaria de Vigil\u00e2ncia em Sa\u00fade (SIVEP)\/Minist\u00e9rio da Sa\u00fade","year":"2020"},{"key":"10.1016\/j.lana.2022.100285_bib0006","unstructured":"BRASIL. Minist\u00e9rio da Sa\u00fade. Secretaria de Vigil\u00e2ncia em Sa\u00fade. Situa\u00e7\u00e3o Epidemiol\u00f3gica da Mal\u00e1ria no Brasil. Bras\u00edlia\/DF, 2019 https:\/\/portalarquivos.saude.gov.br\/images\/pdf\/2019\/dezembro\/03\/3.a-Situa\u00e7\u00e3o Epidemiol\u00f3gica da Mal\u00e1ria_Brasil_CIT_28.11.2018.pdf."},{"key":"10.1016\/j.lana.2022.100285_bib0007","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1186\/s12936-016-1335-1","article-title":"Challenges for malaria elimination in Brazil","volume":"15","author":"Ferreira","year":"2016","journal-title":"Malar J"},{"key":"10.1016\/j.lana.2022.100285_bib0008","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1590\/0074-0276140047","article-title":"A decade of malaria during pregnancy in Brazil: what has been done concerning prevention and management","volume":"109","author":"Marchesini","year":"2014","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"10.1016\/j.lana.2022.100285_bib0009","first-page":"1","article-title":"Impact of malaria in pregnancy as latin america approaches elimination","volume":"xx","author":"Yanow","year":"2016","journal-title":"Trends Parasitol"},{"key":"10.1016\/j.lana.2022.100285_bib0010","series-title":"Exploring Spatial Data with GeoDaTM: a Workbook","author":"Anselin","year":"2005"},{"key":"10.1016\/j.lana.2022.100285_bib0011","series-title":"Applied Spatial Statistics for Public Health Data","author":"Waller","year":"2004"},{"key":"10.1016\/j.lana.2022.100285_bib0012","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/j.0016-7363.2005.00671.x","article-title":"GeoDa: An Introduction to Spatial Data Analysis","volume":"38","author":"Anselin","year":"2006","journal-title":"Geogr Anal"},{"key":"10.1016\/j.lana.2022.100285_bib0013","unstructured":"Talbot, T, S. Kumar and M K. SaTScan Tutorial No. 1: Purely Spatial Poisson Scan Statistic for Cancer Incidence [Software Tutorial]. 2014. www.satscan.org."},{"key":"10.1016\/j.lana.2022.100285_bib0014","unstructured":"IBGE. Instituto Brasileiro de Geografia e Estat\u00edstica. Amaz\u00f4nia Legal. 2022. https:\/\/www.ibge.gov.br\/geociencias\/cartas-e-mapas\/mapasregionais\/15819-amazonia-legal.html?=&t=o-que-e. Accessed 20 February 2022."},{"key":"10.1016\/j.lana.2022.100285_bib0015","series-title":"Funda\u00e7\u00e3o Nacional da Sa\u00fade. Manual de Terap\u00eautica da Mal\u00e1ria","year":"2001"},{"key":"10.1016\/j.lana.2022.100285_bib0016","series-title":"Guia pr\u00e1tico de Tratamento da Mal\u00e1ria no Brasil","year":"2010"},{"key":"10.1016\/j.lana.2022.100285_bib0017","doi-asserted-by":"crossref","first-page":"e107","DOI":"10.1016\/S1473-3099(18)30066-5","article-title":"Burden, pathology, and costs of malaria in pregnancy: new developments for an old problem","volume":"18","author":"Rogerson","year":"2018","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.lana.2022.100285_bib0018","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0004494","article-title":"Costs associated with malaria in pregnancy in the brazilian amazon, a low endemic area where plasmodium Vivax predominates","volume":"10","author":"B\u00f4tto-Menezes","year":"2016","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.lana.2022.100285_bib0019","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0005606","article-title":"Burden and impact of Plasmodium vivax in pregnancy: A multi-centre prospective observational study","volume":"11","author":"Bardaj\u00ed","year":"2017","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.lana.2022.100285_bib0020","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1186\/1475-2875-13-506","article-title":"Pregnant women are a reservoir of malaria transmission in Blantyre, Malawi","volume":"13","author":"Boudov\u00e1","year":"2014","journal-title":"Malar J"},{"key":"10.1016\/j.lana.2022.100285_bib0021","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1186\/s12916-017-0877-6","article-title":"Influence of the number and timing of malaria episodes during pregnancy on prematurity and small-for-gestational-age in an area of low transmission","volume":"15","author":"Moore","year":"2017","journal-title":"BMC Med"},{"key":"10.1016\/j.lana.2022.100285_bib0022","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/S1473-3099(07)70021-X","article-title":"Epidemiology and burden of malaria in pregnancy","volume":"7","author":"Desai","year":"2007","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.lana.2022.100285_bib0023","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.pt.2004.06.007","article-title":"Malaria in pregnancy and the endemicity spectrum: what can we learn?","volume":"20","author":"Nosten","year":"2004","journal-title":"Trends Parasitol"},{"key":"10.1016\/j.lana.2022.100285_bib0024","doi-asserted-by":"crossref","first-page":"73","DOI":"10.4269\/ajtmh.18-0135","article-title":"The hidden burden of plasmodium vivax malaria in pregnancy in the amazon: an observational study in northwestern Brazil","volume":"99","author":"Pincelli","year":"2018","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.lana.2022.100285_bib0025","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0009390","article-title":"Adverse pregnancy outcomes are associated with Plasmodium vivax malaria in a prospective cohort of women from the Brazilian Amazon","volume":"15","author":"Dombrowski","year":"2021","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.lana.2022.100285_bib0026","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2019.3300","article-title":"Association of malaria infection during pregnancy with head circumference of newborns in the Brazilian amazon","volume":"2","author":"Dombrowski","year":"2019","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.lana.2022.100285_bib0027","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0079966","article-title":"Malaria infection has spatial, temporal, and spatiotemporal heterogeneity in unstable malaria transmission areas in northwest ethiopia","volume":"8","author":"Alemu","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.lana.2022.100285_bib0028","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/s12936-021-03614-4","article-title":"The top 1%: quantifying the unequal distribution of malaria in Brazil","volume":"20","author":"Lana","year":"2021","journal-title":"Malar J"},{"key":"10.1016\/j.lana.2022.100285_bib0029","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1590\/S1020-49892009000900003","article-title":"Mal\u00e1ria durante a gravidez: efeito sobre o curso da gesta\u00e7\u00e3o na regi\u00e3o amaz\u00f4nica","volume":"26","author":"Chagas","year":"2009","journal-title":"Rev Panam Salud P\u00fablica"},{"key":"10.1016\/j.lana.2022.100285_bib0030","first-page":"149","article-title":"Mal\u00e1ria em gr\u00e1vidas de uma maternidade p\u00fablica de Rio Branco (Acre, Brasil)","volume":"25","author":"Jarude","year":"2003","journal-title":"Rev Bras Ginecol e Obs"},{"key":"10.1016\/j.lana.2022.100285_bib0031","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0144399","article-title":"Plasmodium vivax malaria in pregnant women in the Brazilian amazon and the risk factors associated with prematurity and low birth weight: a descriptive study","volume":"10","author":"B\u00f4tto-Menezes","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.lana.2022.100285_bib0032","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.pt.2011.01.007","article-title":"Malaria in pregnancy: small babies, big problem","volume":"27","author":"Umbers","year":"2011","journal-title":"Trends Parasitol"},{"key":"10.1016\/j.lana.2022.100285_bib0033","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1016\/S1473-3099(12)70222-0","article-title":"Malaria prevention in pregnancy, birthweight, and neonatal mortality: a meta-analysis of 32 national cross-sectional datasets in Africa","volume":"12","author":"Eisele","year":"2012","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.lana.2022.100285_bib0034","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12936-017-1889-6","article-title":"G6PD deficiency alleles in a malaria-endemic region in the Western Brazilian Amazon","volume":"16","author":"Dombrowski","year":"2017","journal-title":"Malar J"},{"key":"10.1016\/j.lana.2022.100285_bib0035","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1093\/trstmh\/trt015","article-title":"Glucose-6-phosphate dehydrogenase deficient variants are associated with reduced susceptibility to malaria in the Brazilian Amazon","volume":"107","author":"Santana","year":"2013","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"10.1016\/j.lana.2022.100285_bib0036","series-title":"Secretaria de Vigil\u00e2ncia em Sa\u00fade. Guia de Tratamento Da Mal\u00e1ria no Brasil","year":"2020"},{"key":"10.1016\/j.lana.2022.100285_bib0037","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.1590\/0074-0276140229","article-title":"Malaria in pregnant women living in areas of low transmission on the southeast Brazilian Coast: molecular diagnosis and humoural immunity profile","volume":"109","author":"Hristov","year":"2014","journal-title":"Mem Inst Oswaldo Cruz"}],"container-title":["The Lancet Regional Health - Americas"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667193X22001028?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2667193X22001028?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T11:15:55Z","timestamp":1778930155000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2667193X22001028"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,8]]},"references-count":37,"alternative-id":["S2667193X22001028"],"URL":"https:\/\/doi.org\/10.1016\/j.lana.2022.100285","relation":{},"ISSN":["2667-193X"],"issn-type":[{"value":"2667-193X","type":"print"}],"subject":[],"published":{"date-parts":[[2022,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Mapping and characterizing areas with high levels of malaria in pregnancy in Brazil: A spatiotemporal analysis","name":"articletitle","label":"Article Title"},{"value":"The Lancet Regional Health - Americas","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lana.2022.100285","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"100285"}}