{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:59:09Z","timestamp":1790423949799,"version":"4.1.0"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T00:00:00Z","timestamp":1784764800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["U19AI129387"],"award-info":[{"award-number":["U19AI129387"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006492","name":"National Institute of Allergy and Infectious Diseases Division of Intramural Research","doi-asserted-by":"publisher","award":["U19AI089696"],"award-info":[{"award-number":["U19AI089696"]}],"id":[{"id":"10.13039\/100006492","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Lancet Regional Health - Africa"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.lanafr.2026.100122","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T19:44:04Z","timestamp":1786650244000},"page":"100122","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Extending seasonal malaria chemoprevention to older children: a non-inferiority randomized controlled trial of Dihydroartemisinin\u2013piperaquine as a policy alternative in Mali"],"prefix":"10.1016","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6238-5063","authenticated-orcid":false,"given":"Mahamoudou","family":"Toure","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soumba","family":"Keita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fousseyni","family":"Kane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daouda","family":"Sanogo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim","family":"Sanogo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moussa","family":"Keita","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ibrahim M.","family":"Sissoko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3543-7451","authenticated-orcid":false,"given":"Mountaga","family":"Diallo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hamady","family":"Coulibaly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bourema","family":"Cisse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Drissa","family":"Konate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Issaka","family":"Guindo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9847-3353","authenticated-orcid":false,"given":"Mossa Ag","family":"Malle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheick Oumar","family":"Tangara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sory I","family":"Diawara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mady","family":"Cissoko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Sanogo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aissata","family":"Kone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sidi","family":"Niare","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aissatou","family":"Maiga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nafomon","family":"Sogoba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helle Holm","family":"Hansonn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Alifrangis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4268-8857","authenticated-orcid":false,"given":"Mahamadou","family":"Diakite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey G.","family":"Shaffer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seydou","family":"Doumbia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lanafr.2026.100122_bib1","series-title":"World Malaria Report 2025: Addressing the Threat of Antimalarial Drug Resistance","year":"2025"},{"key":"10.1016\/j.lanafr.2026.100122_bib2","author":"Fronti\u00e8res"},{"key":"10.1016\/j.lanafr.2026.100122_bib3","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1186\/s12936-018-2573-1","article-title":"Impact evaluation of malaria control interventions on morbidity and all-cause child mortality in Mali, 2000-2012","volume":"17","author":"Kayentao","year":"2018","journal-title":"Malar J"},{"key":"10.1016\/j.lanafr.2026.100122_bib5","article-title":"Sub-national targeting of seasonal malaria chemoprevention in the Sahelian countries of the nouakchott initiative","volume":"10","author":"Noor","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.lanafr.2026.100122_bib6","first-page":"185","article-title":"[Seasonal transmission of malaria in the Senegal River Valley: case study of the city of Kaedi-Mauritanie]","volume":"34","author":"Ba","year":"2019","journal-title":"Pan Afr Med J"},{"key":"10.1016\/j.lanafr.2026.100122_bib7","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.tracli.2017.03.002","article-title":"Falciparum malaria prevalence among blood donors in Bamako, Mali","volume":"24","author":"Kouriba","year":"2017","journal-title":"Transfus Clin Biol"},{"key":"10.1016\/j.lanafr.2026.100122_bib8","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1186\/s12936-021-03650-0","article-title":"Indoor and outdoor malaria transmission in two ecological settings in rural Mali: implications for vector control","volume":"20","author":"Keita","year":"2021","journal-title":"Malar J"},{"key":"10.1016\/j.lanafr.2026.100122_bib10","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1186\/s12936-017-1974-x","article-title":"Measuring the impact of seasonal malaria chemoprevention as part of routine malaria control in Kita, Mali","volume":"16","author":"Diawara","year":"2017","journal-title":"Malar J"},{"key":"10.1016\/j.lanafr.2026.100122_bib11","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1186\/s12889-025-22461-5","article-title":"Seasonal malaria chemoprevention in children aged 3-59 months in Mali: parents' perceptions, attitudes and beliefs regarding drug administration","volume":"25","author":"Diarra","year":"2025","journal-title":"BMC Public Health"},{"key":"10.1016\/j.lanafr.2026.100122_bib12","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1186\/s12936-016-1251-4","article-title":"Seasonality and shift in age-specific malaria prevalence and incidence in Binko and Carriere villages close to the lake in Selingue, Mali","volume":"15","author":"Toure","year":"2016","journal-title":"Malar J"},{"key":"10.1016\/j.lanafr.2026.100122_bib13","doi-asserted-by":"crossref","DOI":"10.1128\/aac.01806-24","article-title":"Frequencies of molecular markers of drug resistance in the context of two different Seasonal Malaria Chemoprevention (SMC) treatment regimens in the Koulikoro health district, Mali","volume":"69","author":"Traore","year":"2025","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.lanafr.2026.100122_bib14","doi-asserted-by":"crossref","first-page":"4387","DOI":"10.1128\/AAC.04923-14","article-title":"Randomized noninferiority trial of Dihydroartemisinin-piperaquine compared with sulfadoxine-pyrimethamine plus amodiaquine for seasonal malaria chemoprevention in Burkina Faso","volume":"59","author":"Zongo","year":"2015","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.lanafr.2026.100122_bib15","doi-asserted-by":"crossref","DOI":"10.2196\/51660","article-title":"Seasonal malaria chemoprevention therapy in children up to 9 years of age: protocol for a cluster-randomized trial study","volume":"13","author":"Toure","year":"2024","journal-title":"JMIR Res Protoc"},{"key":"10.1016\/j.lanafr.2026.100122_bib16","doi-asserted-by":"crossref","first-page":"499","DOI":"10.2307\/2531021","article-title":"Sample-size formula for the proportional-hazards regression model","volume":"39","author":"Schoenfeld","year":"1983","journal-title":"Biometrics"},{"key":"10.1016\/j.lanafr.2026.100122_bib17","series-title":"WHO Policy Recommendation: Seasonal Malaria Chemoprevention (SMC) for Plasmodium falciparum Malaria Control in Highly Seasonal Transmission areas of the Sahel Sub-Region in Africa","year":"2012"},{"key":"10.1016\/j.lanafr.2026.100122_bib18","doi-asserted-by":"crossref","first-page":"928","DOI":"10.1056\/NEJMoa1509150","article-title":"Dihydroartemisinin-Piperaquine for the prevention of malaria in pregnancy","volume":"374","author":"Kakuru","year":"2016","journal-title":"N Engl J Med"},{"key":"10.1016\/j.lanafr.2026.100122_bib19","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1186\/1475-2875-12-249","article-title":"Spatiotemporal mathematical modelling of mutations of the dhps gene in African Plasmodium falciparum","volume":"12","author":"Flegg","year":"2013","journal-title":"Malar J"},{"key":"10.1016\/j.lanafr.2026.100122_bib20","doi-asserted-by":"crossref","first-page":"6905","DOI":"10.1038\/s41598-021-86450-5","article-title":"School-based screening and treatment may reduce P. falciparum transmission","volume":"11","author":"Cohee","year":"2021","journal-title":"Sci Rep"},{"key":"10.1016\/j.lanafr.2026.100122_bib21","doi-asserted-by":"crossref","first-page":"5127","DOI":"10.1128\/AAC.49.12.5127-5128.2005","article-title":"Pitfalls in estimating piperaquine elimination","volume":"49","author":"Tarning","year":"2005","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.lanafr.2026.100122_bib22","article-title":"The effect of dosing regimens on the antimalarial efficacy of Dihydroartemisinin-piperaquine: a pooled analysis of individual patient data","volume":"10","year":"2013","journal-title":"PLoS Med"},{"key":"10.1016\/j.lanafr.2026.100122_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0011225","article-title":"A randomised trial to compare the safety, tolerability and efficacy of three drug combinations for intermittent preventive treatment in children","volume":"5","author":"Bojang","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.lanafr.2026.100122_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0007164","article-title":"Randomized trial of piperaquine with sulfadoxine-pyrimethamine or dihydroartemisinin for malaria intermittent preventive treatment in children","volume":"4","author":"Cisse","year":"2009","journal-title":"PLoS One"},{"key":"10.1016\/j.lanafr.2026.100122_bib25","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1128\/AAC.05877-11","article-title":"Randomized, double-blind, placebo-controlled trial of monthly versus bimonthly dihydroartemisinin-piperaquine chemoprevention in adults at high risk of malaria","volume":"56","author":"Lwin","year":"2012","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.lanafr.2026.100122_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1000407","article-title":"Intermittent preventive treatment of malaria provides substantial protection against malaria in children already protected by an insecticide-treated bednet in Mali: a randomised, double-blind, placebo-controlled trial","volume":"8","author":"Dicko","year":"2011","journal-title":"PLoS Med"},{"key":"10.1016\/j.lanafr.2026.100122_bib27","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1000408","article-title":"Intermittent preventive treatment of malaria provides substantial protection against malaria in children already protected by an insecticide-treated bednet in Burkina Faso: a randomised, double-blind, placebo-controlled trial","volume":"8","author":"Konate","year":"2011","journal-title":"PLoS Med"},{"key":"10.1016\/j.lanafr.2026.100122_bib28","doi-asserted-by":"crossref","first-page":"524","DOI":"10.4269\/ajtmh.17-0599","article-title":"Impact evaluation of seasonal malaria chemoprevention under routine program implementation: a quasi-experimental study in Burkina Faso","volume":"98","author":"Druetz","year":"2018","journal-title":"Am J Trop Med Hyg"},{"key":"10.1016\/j.lanafr.2026.100122_bib29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001689","article-title":"Protective efficacy and safety of three antimalarial regimens for the prevention of malaria in young Ugandan children: a randomized controlled trial","volume":"11","author":"Bigira","year":"2014","journal-title":"PLoS Med"},{"key":"10.1016\/j.lanafr.2026.100122_bib30","doi-asserted-by":"crossref","first-page":"293","DOI":"10.4097\/kja.21165","article-title":"Considerations for crossover design in clinical study","volume":"74","author":"Lim","year":"2021","journal-title":"Korean J Anesthesiol"},{"key":"10.1016\/j.lanafr.2026.100122_bib31","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1016\/S1473-3099(24)00746-1","article-title":"Effectiveness of sulfadoxine\u2013pyrimethamine plus amodiaquine and dihydroartemisinin\u2013piperaquine for seasonal malaria chemoprevention in Uganda: a three-arm, open-label, non-inferiority and superiority, cluster-randomised, controlled trial","volume":"25","author":"Nuwa","year":"2025","journal-title":"Lancet Infect Dis"}],"container-title":["The Lancet Regional Health - Africa"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S3050501126001033?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S3050501126001033?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T11:17:29Z","timestamp":1790421449000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S3050501126001033"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":29,"alternative-id":["S3050501126001033"],"URL":"https:\/\/doi.org\/10.1016\/j.lanafr.2026.100122","relation":{},"ISSN":["3050-5011"],"issn-type":[{"value":"3050-5011","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Extending seasonal malaria chemoprevention to older children: a non-inferiority randomized controlled trial of Dihydroartemisinin\u2013piperaquine as a policy alternative in Mali","name":"articletitle","label":"Article Title"},{"value":"The Lancet Regional Health - Africa","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lanafr.2026.100122","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"100122"}}