{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T21:35:39Z","timestamp":1794605739661,"version":"4.9.1"},"reference-count":30,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T00:00:00Z","timestamp":1748995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002999","name":"Ministerie van Volksgezondheid, Welzijn en Sport","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002999","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013101","name":"National Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013101","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008017","name":"Institut Gustave-Roussy","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008017","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008893","name":"University of Iowa","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008893","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008658","name":"Deutsches Krebsforschungszentrum","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008658","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005010","name":"Associazione Italiana per la Ricerca sul Cancro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005010","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000276","name":"Department of Health and Social Care","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000276","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013342","name":"NIHR Imperial Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013342","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010109","name":"Medizinische Universit\u00e4t Graz","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010109","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010434","name":"&apos;la Caixa&apos; Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010434","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100022011","name":"Cancer Research UK Cambridge Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100022011","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/M012190\/1"],"award-info":[{"award-number":["MR\/M012190\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["CA107333"],"award-info":[{"award-number":["CA107333"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["HHSN261201000032C"],"award-info":[{"award-number":["HHSN261201000032C"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008018","name":"Mutuelle G\u00e9n\u00e9rale de l&apos;Education Nationale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008018","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004099","name":"Ligue Contre le Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004099","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003107","name":"German Federal Ministry of Health","doi-asserted-by":"publisher","award":["ZMVI1-2520DAT111"],"award-info":[{"award-number":["ZMVI1-2520DAT111"]}],"id":[{"id":"10.13039\/501100003107","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000761","name":"Imperial College London","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000761","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004587","name":"Instituto de Salud Carlos III","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004587","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001677","name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001677","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008363","name":"Kr\u00e6ftens Bek\u00e6mpelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008363","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005972","name":"German Cancer Aid","doi-asserted-by":"publisher","award":["70115166"],"award-info":[{"award-number":["70115166"]}],"id":[{"id":"10.13039\/501100005972","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005972","name":"German Cancer Aid","doi-asserted-by":"publisher","award":["70115995"],"award-info":[{"award-number":["70115995"]}],"id":[{"id":"10.13039\/501100005972","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005972","name":"German Cancer Aid","doi-asserted-by":"publisher","award":["70113864"],"award-info":[{"award-number":["70113864"]}],"id":[{"id":"10.13039\/501100005972","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011011","name":"Junta de Andaluc\u00eda","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100011011","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007388","name":"Compagnia di San Paolo","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007388","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002428","name":"Austrian Science Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002428","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000321","name":"World Cancer Research Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000321","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010416","name":"Rollins School of Public Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008700","name":"Centre International de Recherche sur le Cancer","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100024063","name":"National Health Service Corps","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100024063","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004820","name":"Connecticut Department of Energy and Environmental Protection","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004820","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["P30 CA015704"],"award-info":[{"award-number":["P30 CA015704"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014840","name":"Gemeinsame Bundesausschuss","doi-asserted-by":"publisher","award":["01VSF21048"],"award-info":[{"award-number":["01VSF21048"]}],"id":[{"id":"10.13039\/501100014840","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000921","name":"European Cooperation in Science and Technology","doi-asserted-by":"publisher","award":["R01 CA068535"],"award-info":[{"award-number":["R01 CA068535"]}],"id":[{"id":"10.13039\/501100000921","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000921","name":"European Cooperation in Science and Technology","doi-asserted-by":"publisher","award":["BM1206"],"award-info":[{"award-number":["BM1206"]}],"id":[{"id":"10.13039\/501100000921","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["C8221\/A29017"],"award-info":[{"award-number":["C8221\/A29017"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","award":["R01 CA488857"],"award-info":[{"award-number":["R01 CA488857"]}],"id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","award":["P20 CA252733"],"award-info":[{"award-number":["P20 CA252733"]}],"id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000016","name":"U.S. Department of Health and Human Services","doi-asserted-by":"publisher","award":["U01 CA137088"],"award-info":[{"award-number":["U01 CA137088"]}],"id":[{"id":"10.13039\/100000016","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["75N92021D00002"],"award-info":[{"award-number":["75N92021D00002"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["75N92021D00004"],"award-info":[{"award-number":["75N92021D00004"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["75N92021D00005"],"award-info":[{"award-number":["75N92021D00005"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["75N92021D00003"],"award-info":[{"award-number":["75N92021D00003"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["75N92021D00001"],"award-info":[{"award-number":["75N92021D00001"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003494","name":"Herzfelder Family Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003494","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","award":["NIHR213331"],"award-info":[{"award-number":["NIHR213331"]}],"id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004955","name":"Austrian Research Promotion Agency","doi-asserted-by":"publisher","award":["829675"],"award-info":[{"award-number":["829675"]}],"id":[{"id":"10.13039\/501100004955","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001655","name":"German Academic Exchange Service","doi-asserted-by":"publisher","award":["57616814"],"award-info":[{"award-number":["57616814"]}],"id":[{"id":"10.13039\/501100001655","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018693","name":"Horizon Europe","doi-asserted-by":"publisher","award":["101096312"],"award-info":[{"award-number":["101096312"]}],"id":[{"id":"10.13039\/100018693","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016958","name":"Office of Research Infrastructure Programs","doi-asserted-by":"publisher","award":["S10OD028685"],"award-info":[{"award-number":["S10OD028685"]}],"id":[{"id":"10.13039\/100016958","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["504101714"],"award-info":[{"award-number":["504101714"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Federal Ministry of Education and Research Bonn Office","doi-asserted-by":"publisher","award":["01KT2302"],"award-info":[{"award-number":["01KT2302"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Federal Ministry of Education and Research Bonn Office","doi-asserted-by":"publisher","award":["01KD2215C"],"award-info":[{"award-number":["01KD2215C"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Federal Ministry of Education and Research Bonn Office","doi-asserted-by":"publisher","award":["01KD2215A"],"award-info":[{"award-number":["01KD2215A"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Federal Ministry of Education and Research Bonn Office","doi-asserted-by":"publisher","award":["01EO2101"],"award-info":[{"award-number":["01EO2101"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Federal Ministry of Education and Research Bonn Office","doi-asserted-by":"publisher","award":["01KD2104C"],"award-info":[{"award-number":["01KD2104C"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Federal Ministry of Education and Research Bonn Office","doi-asserted-by":"publisher","award":["031L0312A"],"award-info":[{"award-number":["031L0312A"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Lancet Digital Health"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.landig.2025.100891","type":"journal-article","created":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T17:20:55Z","timestamp":1755624055000},"page":"100891","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":16,"title":["Assessing genotype\u2212phenotype correlations in colorectal cancer with deep learning: a multicentre cohort study"],"prefix":"10.1016","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-3598-5720","authenticated-orcid":false,"given":"Marco","family":"Gustav","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marko","family":"van Treeck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0070-3158","authenticated-orcid":false,"given":"Nic G","family":"Reitsam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zunamys I","family":"Carrero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara M L","family":"Loeffler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asier","family":"Rabasco Meneghetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"M\u00e4rkl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa A","family":"Boardman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy J","family":"French","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ellen L","family":"Goode","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Gsur","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefanie","family":"Brezina","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc J","family":"Gunter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neil","family":"Murphy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pia","family":"H\u00f6nscheid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Sperling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Foersch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Steinfelder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tabitha","family":"Harrison","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Peters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Phipps","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jakob Nikolas","family":"Kather","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.landig.2025.100891_bib1","doi-asserted-by":"crossref","DOI":"10.1136\/bmjgh-2020-004415","article-title":"Availability and funding of clinical genomic sequencing globally","volume":"6","author":"Phillips","year":"2021","journal-title":"BMJ Glob Health"},{"key":"10.1016\/j.landig.2025.100891_bib2","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1038\/s41591-019-0462-y","article-title":"Deep learning can predict microsatellite instability directly from histology in gastrointestinal cancer","volume":"25","author":"Kather","year":"2019","journal-title":"Nat Med"},{"key":"10.1016\/j.landig.2025.100891_bib3","doi-asserted-by":"crossref","first-page":"e763","DOI":"10.1016\/S2589-7500(21)00180-1","article-title":"Development and validation of a weakly supervised deep learning framework to predict the status of molecular pathways and key mutations in colorectal cancer from routine histology images: a retrospective study","volume":"3","author":"Bilal","year":"2021","journal-title":"Lancet Digit Health"},{"key":"10.1016\/j.landig.2025.100891_bib4","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1038\/s41591-022-01768-5","article-title":"Swarm learning for decentralized artificial intelligence in cancer histopathology","volume":"28","author":"Saldanha","year":"2022","journal-title":"Nat Med"},{"key":"10.1016\/j.landig.2025.100891_bib5","doi-asserted-by":"crossref","first-page":"1650","DOI":"10.1016\/j.ccell.2023.08.002","article-title":"Transformer-based biomarker prediction from colorectal cancer histology: a large-scale multicentric study","volume":"41","author":"Wagner","year":"2023","journal-title":"Cancer Cell"},{"key":"10.1016\/j.landig.2025.100891_bib6","doi-asserted-by":"crossref","DOI":"10.1016\/j.media.2023.103071","article-title":"Social network analysis of cell networks improves deep learning for prediction of molecular pathways and key mutations in colorectal cancer","volume":"93","author":"Zamanitajeddin","year":"2024","journal-title":"Med Image Anal"},{"key":"10.1016\/j.landig.2025.100891_bib7","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1038\/s43018-020-0087-6","article-title":"Pan-cancer image-based detection of clinically actionable genetic alterations","volume":"1","author":"Kather","year":"2020","journal-title":"Nat Cancer"},{"key":"10.1016\/j.landig.2025.100891_bib8","article-title":"Generalizable biomarker prediction from cancer pathology slides with self-supervised deep learning: a retrospective multi-centric study","volume":"4","author":"Niehues","year":"2023","journal-title":"Cell Rep Med"},{"key":"10.1016\/j.landig.2025.100891_bib9","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1002\/cjp2.312","article-title":"Predicting microsatellite instability and key biomarkers in colorectal cancer from H&E-stained images: achieving state-of-the-art predictive performance with fewer data using Swin Transformer","volume":"9","author":"Guo","year":"2023","journal-title":"J Pathol Clin Res"},{"key":"10.1016\/j.landig.2025.100891_bib10","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1038\/s41698-023-00365-0","article-title":"Self-supervised attention-based deep learning for pan-cancer mutation prediction from histopathology","volume":"7","author":"Saldanha","year":"2023","journal-title":"NPJ Precis Oncol"},{"key":"10.1016\/j.landig.2025.100891_bib11","doi-asserted-by":"crossref","first-page":"e786","DOI":"10.1016\/S2589-7500(23)00148-6","article-title":"Development and validation of artificial intelligence-based prescreening of large-bowel biopsies taken in the UK and Portugal: a retrospective cohort study","volume":"5","author":"Bilal","year":"2023","journal-title":"Lancet Digit Health"},{"key":"10.1016\/j.landig.2025.100891_bib13","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/nature11252","article-title":"Comprehensive molecular characterization of human colon and rectal cancer","volume":"487","year":"2012","journal-title":"Nature"},{"key":"10.1016\/j.landig.2025.100891_bib14","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1016\/j.ccell.2018.03.010","article-title":"Comparative molecular analysis of gastrointestinal adenocarcinomas","volume":"33","author":"Liu","year":"2018","journal-title":"Cancer Cell"},{"key":"10.1016\/j.landig.2025.100891_bib15","doi-asserted-by":"crossref","first-page":"1108","DOI":"10.1158\/2159-8290.CD-13-0219","article-title":"Connecting genomic alterations to cancer biology with proteomics: the NCI Clinical Proteomic Tumor Analysis Consortium","volume":"3","author":"Ellis","year":"2013","journal-title":"Cancer Discov"},{"key":"10.1016\/j.landig.2025.100891_bib17","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1186\/s12885-021-08108-9","article-title":"Multi gene mutation signatures in colorectal cancer patients: predict for the diagnosis, pathological classification, staging and prognosis","volume":"21","author":"Zhuang","year":"2021","journal-title":"BMC Cancer"},{"key":"10.1016\/j.landig.2025.100891_bib18","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1109\/TPAMI.1986.4767851","article-title":"A computational approach to edge detection","volume":"8","author":"Canny","year":"1986","journal-title":"IEEE Trans Pattern Anal Mach Intell"},{"key":"10.1016\/j.landig.2025.100891_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.media.2022.102559","article-title":"Transformer-based unsupervised contrastive learning for histopathological image classification","volume":"81","author":"Wang","year":"2022","journal-title":"Med Image Anal"},{"key":"10.1016\/j.landig.2025.100891_bib20","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1002\/path.5800","article-title":"Weakly supervised annotation-free cancer detection and prediction of genotype in routine histopathology","volume":"256","author":"Schrammen","year":"2022","journal-title":"J Pathol"},{"key":"10.1016\/j.landig.2025.100891_bib21","article-title":"Deep learning identifies morphological patterns of homologous recombination deficiency in luminal breast cancers from whole slide images","volume":"3","author":"Lazard","year":"2022","journal-title":"Cell Rep Med"},{"key":"10.1016\/j.landig.2025.100891_bib22","doi-asserted-by":"crossref","first-page":"4404","DOI":"10.1038\/s41598-023-31284-6","article-title":"Predicting EGFR mutational status from pathology images using a real-world dataset","volume":"13","author":"Pao","year":"2023","journal-title":"Sci Rep"},{"key":"10.1016\/j.landig.2025.100891_bib23","first-page":"233","article-title":"Colorectal cancer statistics, 2023","volume":"73","author":"Siegel","year":"2023","journal-title":"CA Cancer J Clin"},{"key":"10.1016\/j.landig.2025.100891_bib24","first-page":"159","article-title":"Microsatellite instability in colorectal cancer","volume":"17","author":"Nojadeh","year":"2018","journal-title":"EXCLI J"},{"key":"10.1016\/j.landig.2025.100891_bib25","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1097\/PAS.0b013e31817ec2b1","article-title":"Pathologic predictors of microsatellite instability in colorectal cancer","volume":"33","author":"Greenson","year":"2009","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.landig.2025.100891_bib26","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1038\/modpathol.2016.198","article-title":"Morphological characterization of colorectal cancers in The Cancer Genome Atlas reveals distinct morphology-molecular associations: clinical and biological implications","volume":"30","author":"Shia","year":"2017","journal-title":"Mod Pathol"},{"key":"10.1016\/j.landig.2025.100891_bib27","first-page":"1","article-title":"KRAS gene mutations are more common in colorectal villous adenomas and in situ carcinomas than in carcinomas","volume":"4","author":"Zauber","year":"2013","journal-title":"Int J Mol Epidemiol Genet"},{"key":"10.1016\/j.landig.2025.100891_bib28","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1038\/modpathol.2012.240","article-title":"Colorectal carcinomas with KRAS mutation are associated with distinctive morphological and molecular features","volume":"26","author":"Rosty","year":"2013","journal-title":"Mod Pathol"},{"key":"10.1016\/j.landig.2025.100891_bib29","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1097\/PAS.0b013e31824430d7","article-title":"BRAF-mutated, microsatellite-stable adenocarcinoma of the proximal colon: an aggressive adenocarcinoma with poor survival, mucinous differentiation, and adverse morphologic features","volume":"36","author":"Pai","year":"2012","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.landig.2025.100891_bib30","doi-asserted-by":"crossref","first-page":"1244","DOI":"10.1038\/s41416-018-0230-7","article-title":"Tumour budding is associated with the mesenchymal colon cancer subtype and RAS\/RAF mutations: a study of 1320 colorectal cancers with Consensus Molecular Subgroup (CMS) data","volume":"119","author":"Trinh","year":"2018","journal-title":"Br J Cancer"},{"key":"10.1016\/j.landig.2025.100891_bib31","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.1097\/PAS.0000000000000263","article-title":"BRAF V600E immunohistochemistry is reliable in primary and metastatic colorectal carcinoma regardless of treatment status and shows high intratumoral homogeneity","volume":"38","author":"Bledsoe","year":"2014","journal-title":"Am J Surg Pathol"},{"key":"10.1016\/j.landig.2025.100891_bib32","article-title":"Cross-linking breast tumor transcriptomic states and tissue histology","volume":"4","author":"Dawood","year":"2023","journal-title":"Cell Rep Med"}],"container-title":["The Lancet Digital Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589750025000731?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589750025000731?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T04:13:07Z","timestamp":1778904787000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589750025000731"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":30,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["S2589750025000731"],"URL":"https:\/\/doi.org\/10.1016\/j.landig.2025.100891","relation":{},"ISSN":["2589-7500"],"issn-type":[{"value":"2589-7500","type":"print"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Assessing genotype\u2212phenotype correlations in colorectal cancer with deep learning: a multicentre cohort study","name":"articletitle","label":"Article Title"},{"value":"The Lancet Digital Health","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.landig.2025.100891","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"100891"}}