{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T23:17:46Z","timestamp":1783552666344,"version":"3.55.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T00:00:00Z","timestamp":1769558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Beijing Natural Science Foundation","doi-asserted-by":"publisher","award":["JQ24041"],"award-info":[{"award-number":["JQ24041"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100018537","name":"National Science and Technology Major Project","doi-asserted-by":"publisher","award":["2023ZD0505403"],"award-info":[{"award-number":["2023ZD0505403"]}],"id":[{"id":"10.13039\/501100018537","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271507"],"award-info":[{"award-number":["82271507"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Lancet Digital Health"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.landig.2026.100989","type":"journal-article","created":{"date-parts":[[2026,4,21]],"date-time":"2026-04-21T19:19:09Z","timestamp":1776799149000},"page":"100989","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"title":["Ischaemic stroke recurrence in patients with symptomatic intracranial atherosclerotic stenosis in China (PROMISE): a multivariable prediction model development and validation study"],"prefix":"10.1016","volume":"8","author":[{"given":"Chengbei","family":"Hou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuhai","family":"Guo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunxiu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuehong","family":"Chu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqi","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanwan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erlan","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanhui","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9705-4237","authenticated-orcid":false,"given":"Chen","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xunming","family":"Ji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0494-416X","authenticated-orcid":false,"given":"Chuanjie","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.landig.2026.100989_bib1","doi-asserted-by":"crossref","DOI":"10.1016\/j.jstrokecerebrovasdis.2020.105504","article-title":"Infarct recurrence in intracranial atherosclerosis: results from the MyRIAD study","volume":"30","author":"Romano","year":"2021","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"10.1016\/j.landig.2026.100989_bib2","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/S0140-6736(13)62038-3","article-title":"Aggressive medical treatment with or without stenting in high-risk patients with intracranial artery stenosis (SAMMPRIS): the final results of a randomised trial","volume":"383","author":"Derdeyn","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.landig.2026.100989_bib3","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1056\/NEJMoa043033","article-title":"Comparison of warfarin and aspirin for symptomatic intracranial arterial stenosis","volume":"352","author":"Chimowitz","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.landig.2026.100989_bib4","doi-asserted-by":"crossref","first-page":"67","DOI":"10.4103\/2394-8108.186260","article-title":"Rationale for ischemic conditioning to prevent stroke in patients with intracranial arterial stenosis","volume":"2","author":"Al Kasab","year":"2016","journal-title":"Brain Circ"},{"key":"10.1016\/j.landig.2026.100989_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.jstrokecerebrovasdis.2023.107086","article-title":"Recurrence risk in symptomatic intracranial stenosis treated medically in the real world","volume":"32","author":"Yaghi","year":"2023","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"10.1016\/j.landig.2026.100989_bib6","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1016\/S1474-4422(20)30079-X","article-title":"Prevalence, predictors, and prognosis of symptomatic intracranial stenosis in patients with transient ischaemic attack or minor stroke: a population-based cohort study","volume":"19","author":"Hurford","year":"2020","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.landig.2026.100989_bib7","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1001\/jamaneurol.2020.1326","article-title":"Prognosis of asymptomatic intracranial stenosis in patients with transient ischemic attack and minor stroke","volume":"77","author":"Hurford","year":"2020","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.landig.2026.100989_bib8","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1517\/14656566.6.5.755","article-title":"Clopidogrel for the secondary prevention of stroke","volume":"6","author":"Diener","year":"2005","journal-title":"Expert Opin Pharmacother"},{"key":"10.1016\/j.landig.2026.100989_bib9","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/S0140-6736(07)60150-0","article-title":"Validation and refinement of scores to predict very early stroke risk after transient ischaemic attack","volume":"369","author":"Johnston","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.landig.2026.100989_bib10","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1136\/svn-2022-001606","article-title":"Risk stratification in symptomatic intracranial atherosclerotic disease with conventional vascular risk factors and cerebral haemodynamics","volume":"8","author":"Tian","year":"2023","journal-title":"Stroke Vasc Neurol"},{"key":"10.1016\/j.landig.2026.100989_bib11","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2022.851353","article-title":"Radiomics nomogram for predicting stroke recurrence in symptomatic intracranial atherosclerotic stenosis","volume":"16","author":"Tang","year":"2022","journal-title":"Front Neurosci"},{"key":"10.1016\/j.landig.2026.100989_bib12","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2023.1323270","article-title":"An interpretable machine learning model for stroke recurrence in patients with symptomatic intracranial atherosclerotic arterial stenosis","volume":"17","author":"Gao","year":"2024","journal-title":"Front Neurosci"},{"key":"10.1016\/j.landig.2026.100989_bib13","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1177\/1747493017694391","article-title":"2014 Chinese guidelines for secondary prevention of ischemic stroke and transient ischemic attack","volume":"12","author":"Wang","year":"2017","journal-title":"Int J Stroke"},{"key":"10.1016\/j.landig.2026.100989_bib14","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1177\/1747493016654489","article-title":"Remote limb ischemic conditioning treatment for intracranial atherosclerotic stenosis patients","volume":"11","author":"Hou","year":"2016","journal-title":"Int J Stroke"},{"key":"10.1016\/j.landig.2026.100989_bib15","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/S1474-4422(22)00335-0","article-title":"Chronic remote ischaemic conditioning in patients with symptomatic intracranial atherosclerotic stenosis (the RICA trial): a multicentre, randomised, double-blind sham-controlled trial in China","volume":"21","author":"Hou","year":"2022","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.landig.2026.100989_bib16","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1080\/01621459.1957.10501411","article-title":"Note on grouping","volume":"52","author":"Cox","year":"1957","journal-title":"J Am Stat Assoc"},{"key":"10.1016\/j.landig.2026.100989_bib17","doi-asserted-by":"crossref","first-page":"1534","DOI":"10.1177\/2047487319846715","volume":"26","author":"Rossello","year":"2019","journal-title":"Eur J Prev Cardiol"},{"key":"10.1016\/j.landig.2026.100989_bib18","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1212\/WNL.0000000000003534","article-title":"Relationship between risk factor control and vascular events in the SAMMPRIS trial","volume":"88","author":"Turan","year":"2017","journal-title":"Neurology"},{"key":"10.1016\/j.landig.2026.100989_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.jstrokecerebrovasdis.2021.106141","article-title":"Lipid levels and short-term risk of recurrent brain infarcts in symptomatic intracranial stenosis","volume":"31","author":"Prabhakaran","year":"2022","journal-title":"J Stroke Cerebrovasc Dis"},{"key":"10.1016\/j.landig.2026.100989_bib20","doi-asserted-by":"crossref","first-page":"2063","DOI":"10.1212\/01.wnl.0000279338.18776.26","article-title":"Risk factor status and vascular events in patients with symptomatic intracranial stenosis","volume":"69","author":"Chaturvedi","year":"2007","journal-title":"Neurology"},{"key":"10.1016\/j.landig.2026.100989_bib21","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1161\/CIRCULATIONAHA.114.011147","article-title":"Cause and mechanisms of intracranial atherosclerosis","volume":"130","author":"Ritz","year":"2014","journal-title":"Circulation"},{"key":"10.1016\/j.landig.2026.100989_bib22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.numecd.2011.09.007","article-title":"Retention of atherogenic lipoproteins in the artery wall and its role in atherogenesis","volume":"22","author":"Fogelstrand","year":"2012","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"10.1016\/j.landig.2026.100989_bib23","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1016\/j.jacc.2018.06.046","article-title":"Impact of lipids on cardiovascular health: JACC health promotion series","volume":"72","author":"Ference","year":"2018","journal-title":"J Am Coll Cardiol"},{"key":"10.1016\/j.landig.2026.100989_bib24","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1212\/WNL.45.8.1488","article-title":"The warfarin-aspirin symptomatic intracranial disease study","volume":"45","author":"Chimowitz","year":"1995","journal-title":"Neurology"},{"key":"10.1016\/j.landig.2026.100989_bib25","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1159\/000534822","article-title":"Patterns and implications of intracranial atherosclerosis in anterior and posterior circulation identified by high-resolution vessel wall imaging","volume":"53","author":"Zheng","year":"2024","journal-title":"Cerebrovasc Dis"},{"key":"10.1016\/j.landig.2026.100989_bib26","doi-asserted-by":"crossref","DOI":"10.1177\/1756286420909991","article-title":"Different risk factors in identical features of intracranial atherosclerosis plaques in the posterior and anterior circulation in high-resolution MRI","volume":"13","author":"Xu","year":"2020","journal-title":"Ther Adv Neurol Disord"},{"key":"10.1016\/j.landig.2026.100989_bib27","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1016\/S1474-4422(21)00376-8","article-title":"Intracranial atherosclerotic stenosis: risk factors, diagnosis, and treatment","volume":"21","author":"Gutierrez","year":"2022","journal-title":"Lancet Neurol"},{"key":"10.1016\/j.landig.2026.100989_bib28","doi-asserted-by":"crossref","first-page":"e364","DOI":"10.1161\/STR.0000000000000375","article-title":"2021 guideline for the prevention of stroke in patients with stroke and transient ischemic attack: a guideline from the American Heart Association\/American Stroke Association","volume":"52","author":"Kleindorfer","year":"2021","journal-title":"Stroke"},{"key":"10.1016\/j.landig.2026.100989_bib29","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1001\/jama.2024.12829","article-title":"Balloon angioplasty vs medical management for intracranial artery stenosis: the BASIS randomized clinical trial","volume":"332","author":"Sun","year":"2024","journal-title":"JAMA"},{"key":"10.1016\/j.landig.2026.100989_bib30","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.recesp.2021.06.027","article-title":"Survival analyses in cardiovascular research, part 2: statistical methods in challenging situations","volume":"75","author":"Rossello","year":"2022","journal-title":"Rev Esp Cardiol (Engl Ed)"}],"container-title":["The Lancet Digital Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589750026000129?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2589750026000129?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T22:47:47Z","timestamp":1783550867000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2589750026000129"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":30,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S2589750026000129"],"URL":"https:\/\/doi.org\/10.1016\/j.landig.2026.100989","relation":{},"ISSN":["2589-7500"],"issn-type":[{"value":"2589-7500","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ischaemic stroke recurrence in patients with symptomatic intracranial atherosclerotic stenosis in China (PROMISE): a multivariable prediction model development and validation study","name":"articletitle","label":"Article Title"},{"value":"The Lancet Digital Health","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.landig.2026.100989","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"100989"}}