{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T23:12:47Z","timestamp":1791673967484,"version":"4.3.4"},"reference-count":50,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T00:00:00Z","timestamp":1744675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["742927"],"award-info":[{"award-number":["742927"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018693","name":"Horizon Europe","doi-asserted-by":"publisher","award":["101053962"],"award-info":[{"award-number":["101053962"]}],"id":[{"id":"10.13039\/100018693","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008599","name":"Alzheimerfonden","doi-asserted-by":"publisher","award":["FO2024-0048-HK-24"],"award-info":[{"award-number":["FO2024-0048-HK-24"]}],"id":[{"id":"10.13039\/501100008599","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008599","name":"Alzheimerfonden","doi-asserted-by":"publisher","award":["AF-968270"],"award-info":[{"award-number":["AF-968270"]}],"id":[{"id":"10.13039\/501100008599","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008599","name":"Alzheimerfonden","doi-asserted-by":"publisher","award":["FO2024-0048-TK-130"],"award-info":[{"award-number":["FO2024-0048-TK-130"]}],"id":[{"id":"10.13039\/501100008599","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008599","name":"Alzheimerfonden","doi-asserted-by":"publisher","award":["AF-994551"],"award-info":[{"award-number":["AF-994551"]}],"id":[{"id":"10.13039\/501100008599","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008599","name":"Alzheimerfonden","doi-asserted-by":"publisher","award":["ALZ2022-0006"],"award-info":[{"award-number":["ALZ2022-0006"]}],"id":[{"id":"10.13039\/501100008599","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008599","name":"Alzheimerfonden","doi-asserted-by":"publisher","award":["AF-939721"],"award-info":[{"award-number":["AF-939721"]}],"id":[{"id":"10.13039\/501100008599","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008599","name":"Alzheimerfonden","doi-asserted-by":"publisher","award":["AF-930351"],"award-info":[{"award-number":["AF-930351"]}],"id":[{"id":"10.13039\/501100008599","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006306","name":"Sigrid Jus\u00e9lius Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006306","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["ADSF-21-831376-C"],"award-info":[{"award-number":["ADSF-21-831376-C"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["ZEN-21-848495"],"award-info":[{"award-number":["ZEN-21-848495"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["SG-23-1038904 QC"],"award-info":[{"award-number":["SG-23-1038904 QC"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["ADSF-24-1284328-C"],"award-info":[{"award-number":["ADSF-24-1284328-C"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["ADSF-21-831381-C"],"award-info":[{"award-number":["ADSF-21-831381-C"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000957","name":"Alzheimer's Association","doi-asserted-by":"publisher","award":["ADSF-21-831377-C"],"award-info":[{"award-number":["ADSF-21-831377-C"]}],"id":[{"id":"10.13039\/100000957","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100019599","name":"European Partnership on Metrology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100019599","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007436","name":"Erling Persson Family Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007436","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008484","name":"Paavo Nurmi Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008484","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006706","name":"Tampere Tuberculosis Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006706","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010815","name":"Foundation for Old Maids","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010815","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013278","name":"EU Joint Programme Neurodegenerative Disease Research","doi-asserted-by":"publisher","award":["JPND2021-00694"],"award-info":[{"award-number":["JPND2021-00694"]}],"id":[{"id":"10.13039\/100013278","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017510","name":"UK Dementia Research Institute","doi-asserted-by":"publisher","award":["2017-00915"],"award-info":[{"award-number":["2017-00915"]}],"id":[{"id":"10.13039\/501100017510","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017510","name":"UK Dementia Research Institute","doi-asserted-by":"publisher","award":["2022-00732"],"award-info":[{"award-number":["2022-00732"]}],"id":[{"id":"10.13039\/501100017510","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017510","name":"UK Dementia Research Institute","doi-asserted-by":"publisher","award":["UKDRI-1003"],"award-info":[{"award-number":["UKDRI-1003"]}],"id":[{"id":"10.13039\/501100017510","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100002565","name":"Alzheimer's Drug Discovery Foundation","doi-asserted-by":"publisher","award":["201809-2016862"],"award-info":[{"award-number":["201809-2016862"]}],"id":[{"id":"10.13039\/100002565","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["2022-01018"],"award-info":[{"award-number":["2022-01018"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["2019-02397"],"award-info":[{"award-number":["2019-02397"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["2023-00356"],"award-info":[{"award-number":["2023-00356"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011797","name":"Turun Yliopistollinen Keskussairaala","doi-asserted-by":"publisher","award":["X51001"],"award-info":[{"award-number":["X51001"]}],"id":[{"id":"10.13039\/501100011797","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","award":["848146"],"award-info":[{"award-number":["848146"]}],"id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","award":["755320"],"award-info":[{"award-number":["755320"]}],"id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007601","name":"Horizon 2020","doi-asserted-by":"publisher","award":["860197"],"award-info":[{"award-number":["860197"]}],"id":[{"id":"10.13039\/501100007601","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003125","name":"Finnish Cultural Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003125","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002327","name":"The Social Insurance Institution of Finland","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002327","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100022340","name":"Finnish Society of Clinical Chemistry","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100022340","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012317","name":"UCLH Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012317","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008320","name":"Finnish Brain Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008320","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004037","name":"Juho Vainio Fundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004037","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Research Council of Finland","doi-asserted-by":"publisher","award":["117787"],"award-info":[{"award-number":["117787"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Research Council of Finland","doi-asserted-by":"publisher","award":["322112"],"award-info":[{"award-number":["322112"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Research Council of Finland","doi-asserted-by":"publisher","award":["129378"],"award-info":[{"award-number":["129378"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Research Council of Finland","doi-asserted-by":"publisher","award":["121584"],"award-info":[{"award-number":["121584"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Research Council of Finland","doi-asserted-by":"publisher","award":["134309"],"award-info":[{"award-number":["134309"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Research Council of Finland","doi-asserted-by":"publisher","award":["286284"],"award-info":[{"award-number":["286284"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Research Council of Finland","doi-asserted-by":"publisher","award":["41071"],"award-info":[{"award-number":["41071"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Research Council of Finland","doi-asserted-by":"publisher","award":["124282"],"award-info":[{"award-number":["124282"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Research Council of Finland","doi-asserted-by":"publisher","award":["126925"],"award-info":[{"award-number":["126925"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002341","name":"Research Council of Finland","doi-asserted-by":"publisher","award":["347850"],"award-info":[{"award-number":["347850"]}],"id":[{"id":"10.13039\/501100002341","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004325","name":"Signe and Ane Gyllenberg Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004325","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004022","name":"Jenny and Antti Wihuri Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004022","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021720","name":"Olav Thon Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021720","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003792","name":"Brain Foundation","doi-asserted-by":"publisher","award":["FO2022-0270"],"award-info":[{"award-number":["FO2022-0270"]}],"id":[{"id":"10.13039\/501100003792","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013500","name":"Diabetes Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013500","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007625","name":"Cure Alzheimer's Fund","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007625","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010711","name":"Sy\u00f6p\u00e4s\u00e4\u00e4ti\u00f6","doi-asserted-by":"publisher","award":["101080117"],"award-info":[{"award-number":["101080117"]}],"id":[{"id":"10.13039\/501100010711","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005633","name":"Heart Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005633","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010600","name":"Tays","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100010600","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010114","name":"Yrj\u00f6 Jahnsson Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010114","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004012","name":"Jane and Aatos Erkko Fundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004012","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["22HLT07"],"award-info":[{"award-number":["22HLT07"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010661","name":"Horizon 2020 Framework Programme","doi-asserted-by":"publisher","award":["ALFGBG-71320"],"award-info":[{"award-number":["ALFGBG-71320"]}],"id":[{"id":"10.13039\/100010661","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007505","name":"Kirsten og Freddy Johansens Fond","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007505","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100008415","name":"Diabetesliitto","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008415","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004756","name":"Emil Aaltonen Fundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004756","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Lancet Healthy Longevity"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.lanhl.2025.100717","type":"journal-article","created":{"date-parts":[[2025,7,15]],"date-time":"2025-07-15T22:44:15Z","timestamp":1752619455000},"page":"100717","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Factors related to blood-based biomarkers for neurodegenerative diseases and their intergenerational associations in the Young Finns Study: a cohort study"],"prefix":"10.1016","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3817-0043","authenticated-orcid":false,"given":"Marja A","family":"Heiskanen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juha","family":"Mykk\u00e4nen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katja","family":"Pahkala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9498-364X","authenticated-orcid":false,"given":"Markus","family":"Juonala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mika","family":"K\u00e4h\u00f6nen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Terho","family":"Lehtim\u00e4ki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomi P","family":"Laitinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eero","family":"Jokinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P\u00e4ivi","family":"Tossavainen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Linko-Parvinen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanna-Mari","family":"Pallari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kaj","family":"Blennow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henrik","family":"Zetterberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorma","family":"Viikari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olli","family":"Raitakari","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0911-7478","authenticated-orcid":false,"given":"Suvi P","family":"Rovio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lanhl.2025.100717_bib1","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1038\/s43587-023-00403-3","article-title":"Blood biomarkers for Alzheimer\u2019s disease in clinical practice and trials","volume":"3","author":"Hansson","year":"2023","journal-title":"Nat Aging"},{"key":"10.1016\/j.lanhl.2025.100717_bib2","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1212\/WNL.0000000000207193","article-title":"Blood biomarkers in neurodegenerative diseases","volume":"101","author":"Alcolea","year":"2023","journal-title":"Neurology"},{"key":"10.1016\/j.lanhl.2025.100717_bib3","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1038\/s41380-024-02709-z","article-title":"Alzheimer\u2019s disease biomarkers and their current use in clinical research and practice","volume":"30","author":"Hunter","year":"2025","journal-title":"Mol Psychiatry"},{"key":"10.1016\/j.lanhl.2025.100717_bib4","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1038\/s43587-023-00400-6","article-title":"The role of cerebrospinal fluid and other biomarker modalities in the Alzheimer\u2019s disease diagnostic revolution","volume":"3","author":"Schindler","year":"2023","journal-title":"Nat Aging"},{"key":"10.1016\/j.lanhl.2025.100717_bib5","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.jalz.2013.01.002","article-title":"Appropriate use criteria for amyloid PET: a report of the Amyloid Imaging Task Force, the Society of Nuclear Medicine and Molecular Imaging, and the Alzheimer\u2019s Association","volume":"9","author":"Johnson","year":"2013","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.lanhl.2025.100717_bib6","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1016\/j.jalz.2018.07.220","article-title":"Appropriate use criteria for lumbar puncture and cerebrospinal fluid testing in the diagnosis of Alzheimer\u2019s disease","volume":"14","author":"Shaw","year":"2018","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.lanhl.2025.100717_bib7","doi-asserted-by":"crossref","first-page":"5143","DOI":"10.1002\/alz.13859","article-title":"Revised criteria for diagnosis and staging of Alzheimer\u2019s disease: Alzheimer\u2019s Association Workgroup","volume":"20","author":"Jack","year":"2024","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.lanhl.2025.100717_bib8","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/nature25456","article-title":"High-performance plasma amyloid-\u03b2 biomarkers for Alzheimer\u2019s disease","volume":"554","author":"Nakamura","year":"2018","journal-title":"Nature"},{"key":"10.1016\/j.lanhl.2025.100717_bib9","first-page":"e688","article-title":"Validation of plasma amyloid-\u03b2 42\/40 for detecting Alzheimer disease amyloid plaques","volume":"98","author":"Li","year":"2022","journal-title":"Neurology"},{"key":"10.1016\/j.lanhl.2025.100717_bib10","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1001\/jamaneurol.2019.1632","article-title":"Performance of fully automated plasma assays as screening tests for Alzheimer disease-related \u03b2-amyloid status","volume":"76","author":"Palmqvist","year":"2019","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.lanhl.2025.100717_bib11","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1038\/s41591-024-02869-z","article-title":"Highly accurate blood test for Alzheimer\u2019s disease is similar or superior to clinical cerebrospinal fluid tests","volume":"30","author":"Barth\u00e9lemy","year":"2024","journal-title":"Nat Med"},{"key":"10.1016\/j.lanhl.2025.100717_bib12","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1001\/jama.2020.12134","article-title":"Discriminative accuracy of plasma phospho-tau217 for Alzheimer disease vs other neurodegenerative disorders","volume":"324","author":"Palmqvist","year":"2020","journal-title":"JAMA"},{"key":"10.1016\/j.lanhl.2025.100717_bib13","doi-asserted-by":"crossref","first-page":"1592","DOI":"10.1093\/brain\/awac333","article-title":"Head-to-head comparison of 10 plasma phospho-tau assays in prodromal Alzheimer\u2019s disease","volume":"146","author":"Janelidze","year":"2023","journal-title":"Brain"},{"key":"10.1016\/j.lanhl.2025.100717_bib14","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1001\/jamaneurol.2022.5272","article-title":"Prediction of longitudinal cognitive decline in preclinical Alzheimer disease using plasma biomarkers","volume":"80","author":"Mattsson-Carlgren","year":"2023","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.lanhl.2025.100717_bib15","doi-asserted-by":"crossref","DOI":"10.1002\/alz.14100","article-title":"Longitudinal plasma phosphorylated-tau217 and other related biomarkers in a non-demented Alzheimer\u2019s risk-enhanced sample","author":"Du","year":"2024","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.lanhl.2025.100717_bib16","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1001\/jamaneurol.2023.5319","article-title":"Diagnostic accuracy of a plasma phosphorylated tau 217 immunoassay for Alzheimer disease pathology","volume":"81","author":"Ashton","year":"2024","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.lanhl.2025.100717_bib17","doi-asserted-by":"crossref","first-page":"e87","DOI":"10.1016\/S2666-7568(20)30061-1","article-title":"Serum markers glial fibrillary acidic protein and neurofilament light for prognosis and monitoring in cognitively normal older people: a prospective memory clinic-based cohort study","volume":"2","author":"Verberk","year":"2021","journal-title":"Lancet Healthy Longev"},{"key":"10.1016\/j.lanhl.2025.100717_bib18","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1001\/jamaneurol.2021.3671","article-title":"Differences between plasma and cerebrospinal fluid glial fibrillary acidic protein levels across the Alzheimer disease continuum","volume":"78","author":"Benedet","year":"2021","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.lanhl.2025.100717_bib19","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1186\/s13195-020-00682-7","article-title":"Combination of plasma amyloid \u03b2(1-42\/1-40) and glial fibrillary acidic protein strongly associates with cerebral amyloid pathology","volume":"12","author":"Verberk","year":"2020","journal-title":"Alzheimers Res Ther"},{"key":"10.1016\/j.lanhl.2025.100717_bib20","doi-asserted-by":"crossref","first-page":"4667","DOI":"10.1007\/s12035-020-02035-9","article-title":"Different clinical contexts of use of blood neurofilament light chain protein in the spectrum of neurodegenerative diseases","volume":"57","author":"Palermo","year":"2020","journal-title":"Mol Neurobiol"},{"key":"10.1016\/j.lanhl.2025.100717_bib21","doi-asserted-by":"crossref","first-page":"3479","DOI":"10.1021\/acschemneuro.9b00095","article-title":"Potential value of plasma amyloid-\u03b2, total tau, and neurofilament light for identification of early Alzheimer\u2019s disease","volume":"10","author":"Shi","year":"2019","journal-title":"ACS Chem Neurosci"},{"key":"10.1016\/j.lanhl.2025.100717_bib22","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.4155\/bio-2019-0163","article-title":"Establishment of neurofilament light chain Simoa assay in cerebrospinal fluid and blood","volume":"11","author":"Hendricks","year":"2019","journal-title":"Bioanalysis"},{"key":"10.1016\/j.lanhl.2025.100717_bib23","first-page":"1","article-title":"Association between modifiable risk factors and levels of blood-based biomarkers of Alzheimer\u2019s and related dementias in the look AHEAD cohort","volume":"13","author":"Hayden","year":"2024","journal-title":"JAR Life"},{"key":"10.1016\/j.lanhl.2025.100717_bib24","doi-asserted-by":"crossref","first-page":"25729","DOI":"10.18632\/aging.203790","article-title":"Factors influencing serum neurofilament light chain levels in normal aging","volume":"13","author":"Koini","year":"2021","journal-title":"Aging"},{"key":"10.1016\/j.lanhl.2025.100717_bib25","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1002\/alz.12787","article-title":"Confounding factors of Alzheimer\u2019s disease plasma biomarkers and their impact on clinical performance","volume":"19","author":"Pichet Binette","year":"2023","journal-title":"Alzheimer Dement"},{"key":"10.1016\/j.lanhl.2025.100717_bib26","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2022.35068","article-title":"Association of plasma and cerebrospinal fluid Alzheimer disease biomarkers with race and the role of genetic ancestry, vascular comorbidities, and neighborhood factors","volume":"5","author":"Hajjar","year":"2022","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.lanhl.2025.100717_bib27","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/alz.12647","article-title":"Team for the H-HS. Medical comorbidities and ethnicity impact plasma Alzheimer\u2019s disease biomarkers: important considerations for clinical trials and practice","volume":"19","author":"O\u2019Bryant","year":"2023","journal-title":"Alzheimer Dement"},{"key":"10.1016\/j.lanhl.2025.100717_bib28","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1002\/alz.12466","article-title":"Associations of amyloid and neurodegeneration plasma biomarkers with comorbidities","volume":"18","author":"Syrjanen","year":"2022","journal-title":"Alzheimer Dement"},{"key":"10.1016\/j.lanhl.2025.100717_bib29","doi-asserted-by":"crossref","first-page":"e1745","DOI":"10.1212\/WNL.0000000000007231","article-title":"Relative risk for Alzheimer disease based on complete family history","volume":"92","author":"Cannon-Albright","year":"2019","journal-title":"Neurology"},{"key":"10.1016\/j.lanhl.2025.100717_bib30","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1007\/s11065-012-9193-2","article-title":"Family history and APOE-4 genetic risk in Alzheimer\u2019s disease","volume":"22","author":"Donix","year":"2012","journal-title":"Neuropsychol Rev"},{"key":"10.1016\/j.lanhl.2025.100717_bib31","doi-asserted-by":"crossref","DOI":"10.1093\/braincomms\/fcab308","article-title":"Measuring heritable contributions to Alzheimer\u2019s disease: polygenic risk score analysis with twins","volume":"4","author":"Karlsson","year":"2022","journal-title":"Brain Commun"},{"key":"10.1016\/j.lanhl.2025.100717_bib32","doi-asserted-by":"crossref","first-page":"798","DOI":"10.1001\/jamaneurol.2024.1763","article-title":"Parental history of memory impairment and \u03b2-amyloid in cognitively unimpaired older adults","volume":"81","author":"Seto","year":"2024","journal-title":"JAMA Neurology"},{"key":"10.1016\/j.lanhl.2025.100717_bib33","doi-asserted-by":"crossref","first-page":"659","DOI":"10.3233\/JAD-2012-120676","article-title":"Alzheimer\u2019s Disease Neuroimaging Initiative. Maternal family history is associated with Alzheimer\u2019s disease biomarkers","volume":"31","author":"Honea","year":"2012","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.lanhl.2025.100717_bib34","doi-asserted-by":"crossref","first-page":"5949","DOI":"10.1073\/pnas.0914141107","article-title":"Increased fibrillar amyloid-\u03b2 burden in normal individuals with a family history of late-onset Alzheimer\u2019s","volume":"107","author":"Mosconi","year":"2010","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.lanhl.2025.100717_bib35","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.neurobiolaging.2015.12.013","article-title":"Maternal dementia age at onset in relation to amyloid burden in non-demented elderly offspring","volume":"40","author":"Maye","year":"2016","journal-title":"Neurobiol Aging"},{"key":"10.1016\/j.lanhl.2025.100717_bib36","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1002\/alz.13407","article-title":"The heritability of blood-based biomarkers related to risk of Alzheimer\u2019s disease in a population-based sample of early old-age men","volume":"20","author":"Gillespie","year":"2023","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.lanhl.2025.100717_bib37","doi-asserted-by":"crossref","first-page":"1220","DOI":"10.1093\/ije\/dym225","article-title":"Cohort profile: The cardiovascular risk in young Finns study","volume":"37","author":"Raitakari","year":"2008","journal-title":"International Journal of Epidemiology"},{"key":"10.1016\/j.lanhl.2025.100717_bib38","doi-asserted-by":"crossref","first-page":"6506","DOI":"10.1002\/alz.14140","article-title":"Optimizing cutpoints for clinical interpretation of brain amyloid status using plasma p-tau217 immunoassays","volume":"20","author":"Figdore","year":"2024","journal-title":"Alzheimer Dement"},{"key":"10.1016\/j.lanhl.2025.100717_bib39","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1002\/alz.13518","article-title":"Biological variation estimates of Alzheimer\u2019s disease plasma biomarkers in healthy individuals","volume":"20","author":"Brum","year":"2023","journal-title":"Alzheimer Dement"},{"key":"10.1016\/j.lanhl.2025.100717_bib40","doi-asserted-by":"crossref","DOI":"10.1093\/braincomms\/fcac174","article-title":"Establishment of reference values for plasma neurofilament light based on healthy individuals aged 5\u201390 years","volume":"4","author":"Simr\u00e9n","year":"2022","journal-title":"Brain Commun"},{"key":"10.1016\/j.lanhl.2025.100717_bib41","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1080\/00365513.2020.1730434","article-title":"Reference interval and preanalytical properties of serum neurofilament light chain in Scandinavian adults","volume":"80","author":"Hviid","year":"2020","journal-title":"Scandinavian J Clin Lab Investigation"},{"key":"10.1016\/j.lanhl.2025.100717_bib42","doi-asserted-by":"crossref","first-page":"1398","DOI":"10.1038\/s41591-022-01822-2","article-title":"Performance of plasma phosphorylated tau 181 and 217 in the community","volume":"28","author":"Mielke","year":"2022","journal-title":"Nat Med"},{"key":"10.1016\/j.lanhl.2025.100717_bib43","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1126\/science.8346443","article-title":"Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer\u2019s disease in late onset families","volume":"261","author":"Corder","year":"1993","journal-title":"Science"},{"key":"10.1016\/j.lanhl.2025.100717_bib44","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.0000000000210287","article-title":"Quantitative assessment of the effect of chronic kidney disease on plasma p-tau217 concentrations","volume":"104","author":"Bornhorst","year":"2025","journal-title":"Neurology"},{"key":"10.1016\/j.lanhl.2025.100717_bib45","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.1002\/alz.12949","article-title":"Plasma amyloid \u03b242\/amyloid \u03b240 ratio is independent of renal function","volume":"19","author":"Lehmann","year":"2023","journal-title":"Alzheimer Dement"},{"key":"10.1016\/j.lanhl.2025.100717_bib46","doi-asserted-by":"crossref","first-page":"2625","DOI":"10.1007\/s10072-023-07284-9","article-title":"Associations of liver function with plasma biomarkers for Alzheimer\u2019s disease","volume":"45","author":"Zhang","year":"2024","journal-title":"Neurol Sci"},{"key":"10.1016\/j.lanhl.2025.100717_bib47","article-title":"Hepatic and renal function impact concentrations of plasma biomarkers of neuropathology","volume":"14","author":"Berry","year":"2022","journal-title":"Alzheimer Dement"},{"key":"10.1016\/j.lanhl.2025.100717_bib48","doi-asserted-by":"crossref","first-page":"2626","DOI":"10.1002\/ehf2.13986","article-title":"Serum glial fibrillary acidic protein indicates memory impairment in patients with chronic heart failure","volume":"9","author":"Traub","year":"2022","journal-title":"ESC Heart Fail"},{"key":"10.1016\/j.lanhl.2025.100717_bib49","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1016\/j.jalz.2017.09.016","article-title":"Body mass index and risk of dementia: analysis of individual-level data from 1.3 million individuals","volume":"14","author":"Kivim\u00e4ki","year":"2018","journal-title":"Alzheimer Dement"},{"key":"10.1016\/j.lanhl.2025.100717_bib50","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1001\/jamaneurol.2024.1748","article-title":"\u03b2-amyloid in cognitively unimpaired individuals\u2014blame mom?","volume":"81","author":"Dubal","year":"2024","journal-title":"JAMA Neurology"}],"container-title":["The Lancet Healthy Longevity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666756825000364?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666756825000364?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T09:16:41Z","timestamp":1778923001000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666756825000364"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":50,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["S2666756825000364"],"URL":"https:\/\/doi.org\/10.1016\/j.lanhl.2025.100717","relation":{},"ISSN":["2666-7568"],"issn-type":[{"value":"2666-7568","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Factors related to blood-based biomarkers for neurodegenerative diseases and their intergenerational associations in the Young Finns Study: a cohort study","name":"articletitle","label":"Article Title"},{"value":"The Lancet Healthy Longevity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lanhl.2025.100717","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"100717"}}