{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:28:12Z","timestamp":1787315292530,"version":"build-2736575974"},"reference-count":35,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1137853"],"award-info":[{"award-number":["APP1137853"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005416","name":"Norges Forskningsr\u00e5d","doi-asserted-by":"publisher","award":["311628"],"award-info":[{"award-number":["311628"]}],"id":[{"id":"10.13039\/501100005416","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013278","name":"EU Joint Programme Neurodegenerative Disease Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100013278","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Forschung, Technologie und Raumfahrt","doi-asserted-by":"publisher","award":["01ED2011"],"award-info":[{"award-number":["01ED2011"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004410","name":"T\u00fcrkiye Bilimsel ve Teknolojik Ara\u015ft\u0131rma Kurumu","doi-asserted-by":"publisher","award":["119N125"],"award-info":[{"award-number":["119N125"]}],"id":[{"id":"10.13039\/501100004410","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014013","name":"UK Research and Innovation","doi-asserted-by":"publisher","award":["MR\/T046740\/1"],"award-info":[{"award-number":["MR\/T046740\/1"]}],"id":[{"id":"10.13039\/100014013","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"ZonMw","doi-asserted-by":"publisher","award":["733051108"],"award-info":[{"award-number":["733051108"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Lancet Healthy Longevity"],"published-print":{"date-parts":[[2025,12]]},"DOI":"10.1016\/j.lanhl.2025.100783","type":"journal-article","created":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T23:46:00Z","timestamp":1765237560000},"page":"100783","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"title":["Clinical effectiveness of music interventions for dementia and depression in older people (MIDDEL): a multinational, cluster-randomised controlled trial"],"prefix":"10.1016","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9776-4925","authenticated-orcid":false,"given":"Vigdis","family":"Sveinsdottir","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1688-8556","authenticated-orcid":false,"given":"J\u00f6rg","family":"Assmus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justine","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2213-4467","authenticated-orcid":false,"given":"Felicity A","family":"Baker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bur\u00e7in","family":"U\u00e7aner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9586-241X","authenticated-orcid":false,"given":"Gunter","family":"Kreutz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Geretsegger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9761-3705","authenticated-orcid":false,"given":"Naomi","family":"Rasing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9647-1437","authenticated-orcid":false,"given":"Jodie","family":"Bloska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4463-1181","authenticated-orcid":false,"given":"Phoebe A","family":"Stretton-Smith","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young-Eun C","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo Dugstad","family":"Wake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Odell-Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3623-033X","authenticated-orcid":false,"given":"Jeanette","family":"Tamplin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemieke C","family":"Vink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joanne","family":"Ablewhite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna","family":"Neuser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrike","family":"Frischen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antje","family":"Timmer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Wosch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Janus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian","family":"Gold","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lanhl.2025.100783_bib1","doi-asserted-by":"crossref","first-page":"2204","DOI":"10.1016\/S0140-6736(24)00685-8","article-title":"Burden of disease scenarios for 204 countries and territories, 2022\u20132050: a forecasting analysis for the Global Burden of Disease Study 2021","volume":"403","author":"Vollset","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.lanhl.2025.100783_bib2","article-title":"Music-based therapeutic interventions for people with dementia","volume":"7","author":"van der Steen","year":"2018","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.lanhl.2025.100783_bib3","article-title":"Music-based therapeutic interventions for people with dementia","volume":"3","author":"van der Steen","year":"2025","journal-title":"Cochrane Database Syst Rev"},{"key":"10.1016\/j.lanhl.2025.100783_bib4","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1038\/nrn3666","article-title":"Brain correlates of music-evoked emotions","volume":"15","author":"Koelsch","year":"2014","journal-title":"Nat Rev Neurosci"},{"key":"10.1016\/j.lanhl.2025.100783_bib5","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2018-023436","article-title":"Music Interventions for Dementia and Depression in ELderly care (MIDDEL): protocol and statistical analysis plan for a multinational cluster-randomised trial","volume":"9","author":"Gold","year":"2019","journal-title":"BMJ Open"},{"key":"10.1016\/j.lanhl.2025.100783_bib6","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.1093\/brain\/awv135","article-title":"Why musical memory can be preserved in advanced Alzheimer\u2019s disease","volume":"138","author":"Jacobsen","year":"2015","journal-title":"Brain"},{"key":"10.1016\/j.lanhl.2025.100783_bib7","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1080\/13607863.2015.1093599","article-title":"Effectiveness of group music therapy versus recreational group singing for depressive symptoms of elderly nursing home residents: pragmatic trial","volume":"21","author":"Werner","year":"2017","journal-title":"Aging Ment Health"},{"key":"10.1016\/j.lanhl.2025.100783_bib8","doi-asserted-by":"crossref","first-page":"e153","DOI":"10.1016\/S2666-7568(22)00027-7","article-title":"Clinical effectiveness of music interventions for dementia and depression in elderly care (MIDDEL): Australian cohort of an international pragmatic cluster-randomised controlled trial","volume":"3","author":"Baker","year":"2022","journal-title":"Lancet Healthy Longev"},{"key":"10.1016\/j.lanhl.2025.100783_bib9","series-title":"The ICD-10 classification of mental and behavioural disorders: diagnostic criteria for research","year":"1993"},{"key":"10.1016\/j.lanhl.2025.100783_bib10","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1080\/08098131.2020.1779790","article-title":"Developing consensus description of group music therapy characteristics for persons with dementia","volume":"30","author":"Janus","year":"2021","journal-title":"Nord J Music Ther"},{"key":"10.1016\/j.lanhl.2025.100783_bib11","series-title":"Voicework in Music Therapy: Research and Practice","first-page":"130","article-title":"How can singing in music therapy influence social engagement for people with dementia: insights from polyvagal theory","author":"Ridder","year":"2011"},{"key":"10.1016\/j.lanhl.2025.100783_bib12","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s12877-015-0082-4","article-title":"Individual music therapy for managing neuropsychiatric symptoms for people with dementia and their carers: a cluster randomised controlled feasibility study","volume":"15","author":"Hsu","year":"2015","journal-title":"BMC Geriatr"},{"key":"10.1016\/j.lanhl.2025.100783_bib13","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1186\/s12889-015-2395-9","article-title":"Study protocol for a cluster randomized trial of the Community of Voices choir intervention to promote the health and well-being of diverse older adults","volume":"15","author":"Johnson","year":"2015","journal-title":"BMC Public Health"},{"key":"10.1016\/j.lanhl.2025.100783_bib14","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1212\/WNL.43.11.2412-a","article-title":"The Clinical Dementia Rating (CDR): current version and scoring rules","volume":"43","author":"Morris","year":"1993","journal-title":"Neurology"},{"key":"10.1016\/j.lanhl.2025.100783_bib15","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0022-3956(75)90026-6","article-title":"\u201cMini-mental state\u201d. A practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"Folstein","year":"1975","journal-title":"J Psychiatr Res"},{"key":"10.1016\/j.lanhl.2025.100783_bib16","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1192\/bjp.134.4.382","article-title":"A new depression scale designed to be sensitive to change","volume":"134","author":"Montgomery","year":"1979","journal-title":"Br J Psychiatry"},{"key":"10.1016\/j.lanhl.2025.100783_bib17","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1192\/bjp.bp.110.085431","article-title":"Individual music therapy for depression: randomised controlled trial","volume":"199","author":"Erkkil\u00e4","year":"2011","journal-title":"Br J Psychiatry"},{"key":"10.1016\/j.lanhl.2025.100783_bib18","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1111\/ijcp.12188","article-title":"Evaluation of an 8-item Severe Impairment Battery (SIB-8) vs the full SIB in moderate to severe Alzheimer\u2019s disease patients participating in a donepezil study","volume":"67","author":"Schmitt","year":"2013","journal-title":"Int J Clin Pract"},{"key":"10.1016\/j.lanhl.2025.100783_bib19","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1176\/jnp.12.2.233","article-title":"Validation of the NPI-Q, a brief clinical form of the Neuropsychiatric Inventory","volume":"12","author":"Kaufer","year":"2000","journal-title":"J Neuropsychiatry Clin Neurosci"},{"key":"10.1016\/j.lanhl.2025.100783_bib21","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1097\/00006842-200205000-00016","article-title":"Assessing quality of life in older adults with cognitive impairment","volume":"64","author":"Logsdon","year":"2002","journal-title":"Psychosom Med"},{"key":"10.1016\/j.lanhl.2025.100783_bib22","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/s12955-014-0199-8","article-title":"Professional Care Team Burden (PCTB) scale\u2014reliability, validity and factor analysis","volume":"13","author":"Auer","year":"2015","journal-title":"Health Qual Life Outcomes"},{"key":"10.1016\/j.lanhl.2025.100783_bib23","series-title":"Applied Longitudinal Data Analysis for Medical Science: A Practical Guide","author":"Twisk","year":"2023"},{"key":"10.1016\/j.lanhl.2025.100783_bib24","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2023.102224","article-title":"Home-based family caregiver-delivered music and reading interventions for people living with dementia (HOMESIDE trial): an international randomised controlled trial","volume":"65","author":"Baker","year":"2023","journal-title":"EClinicalMedicine"},{"key":"10.1016\/j.lanhl.2025.100783_bib25","doi-asserted-by":"crossref","first-page":"2470","DOI":"10.1001\/jama.2017.7423","article-title":"Sound Health: an NIH-Kennedy Center initiative to explore music and the mind","volume":"317","author":"Collins","year":"2017","journal-title":"JAMA"},{"key":"10.1016\/j.lanhl.2025.100783_bib26","article-title":"Comparative efficacy of interventions for reducing symptoms of depression in people with dementia: systematic review and network meta-analysis","volume":"372","author":"Watt","year":"2021","journal-title":"BMJ"},{"key":"10.1016\/j.lanhl.2025.100783_bib27","article-title":"Cognitive impairment, depressive symptoms, and demographic characteristics of care home residents living with dementia in six countries","author":"Sveinsdottir","year":"2025","journal-title":"Aging Ment Health"},{"key":"10.1016\/j.lanhl.2025.100783_bib28","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/S0140-6736(24)01296-0","article-title":"Dementia prevention, intervention, and care: 2024 report of the Lancet standing Commission","volume":"404","author":"Livingston","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.lanhl.2025.100783_bib29","doi-asserted-by":"crossref","first-page":"663","DOI":"10.3233\/JAD-170410","article-title":"Can musical or painting interventions improve chronic pain, mood, quality of life, and cognition in patients with mild Alzheimer\u2019s disease? Evidence from a randomized controlled trial","volume":"60","author":"Pongan","year":"2017","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.lanhl.2025.100783_bib30","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.gerinurse.2024.02.021","article-title":"The impact of group music therapy in ameliorating the depression among patients with dementia in care homes: a randomized control trial","volume":"56","author":"Xu","year":"2024","journal-title":"Geriatr Nurs"},{"key":"10.1016\/j.lanhl.2025.100783_bib31","doi-asserted-by":"crossref","first-page":"960","DOI":"10.1037\/pag0000861","article-title":"Effects of one-to-one music therapy in older adults with cognitive impairment: a randomized controlled trial","volume":"39","author":"Mangiacotti","year":"2024","journal-title":"Psychol Aging"},{"key":"10.1016\/j.lanhl.2025.100783_bib32","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1159\/000515317","article-title":"Quality of life assessment in older adults with dementia: a systematic review","volume":"50","author":"Burks","year":"2021","journal-title":"Dement Geriatr Cogn Disord"},{"key":"10.1016\/j.lanhl.2025.100783_bib33","doi-asserted-by":"crossref","first-page":"485","DOI":"10.3390\/brainsci12040485","article-title":"The impact of music on stress biomarkers: protocol of a substudy of the cluster-randomized controlled trial Music Interventions for Dementia and Depression in ELderly Care (MIDDEL)","volume":"12","author":"Rasing","year":"2022","journal-title":"Brain Sci"},{"key":"10.1016\/j.lanhl.2025.100783_bib34","doi-asserted-by":"crossref","DOI":"10.31389\/jltc.294","article-title":"Music in care home settings: guidelines for implementation and evaluation based on the Music Interventions for Depression and Dementia in ELderly Care (MIDDEL) study in the UK","author":"Schneider","year":"2024","journal-title":"J Long Term Care"},{"key":"10.1016\/j.lanhl.2025.100783_bib35","series-title":"Music interventions for care home residents with dementia: evaluation and implementation in the context of the multinational cluster-randomized Music Interventions for Dementia and Depression in ELderly care (MIDDEL) trial. PhD thesis","author":"Rasing","year":"2024"},{"key":"10.1016\/j.lanhl.2025.100783_bib36","article-title":"Memory for Music (M4M) protocol for an international randomized controlled trial: effects of individual intensive musical training based on singing in non-musicians with Alzheimer\u2019s disease","author":"Lichtensztejn","year":"2024","journal-title":"medRxiv"}],"container-title":["The Lancet Healthy Longevity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666756825001023?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666756825001023?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T12:30:11Z","timestamp":1776429011000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666756825001023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":35,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["S2666756825001023"],"URL":"https:\/\/doi.org\/10.1016\/j.lanhl.2025.100783","relation":{},"ISSN":["2666-7568"],"issn-type":[{"value":"2666-7568","type":"print"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Clinical effectiveness of music interventions for dementia and depression in older people (MIDDEL): a multinational, cluster-randomised controlled trial","name":"articletitle","label":"Article Title"},{"value":"The Lancet Healthy Longevity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lanhl.2025.100783","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"100783"}}