{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T16:43:51Z","timestamp":1784133831983,"version":"3.55.0"},"reference-count":119,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T00:00:00Z","timestamp":1773705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000654","name":"Marie Curie","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000654","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/X008290\/1"],"award-info":[{"award-number":["BB\/X008290\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014688","name":"Scottish Rock Garden Club","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014688","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004440","name":"Wellcome","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000837","name":"University of Nottingham","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["225221\/Z\/22\/Z"],"award-info":[{"award-number":["225221\/Z\/22\/Z"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Lancet Healthy Longevity"],"published-print":{"date-parts":[[2026,4]]},"DOI":"10.1016\/j.lanhl.2026.100842","type":"journal-article","created":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T19:19:57Z","timestamp":1777058397000},"page":"100842","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"title":["The crucial role of normative ageing in respiratory pathogenesis"],"prefix":"10.1016","volume":"7","author":[{"given":"Caroline M","family":"Weight","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda L","family":"Tatler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4410-3397","authenticated-orcid":false,"given":"Robert T R","family":"Huckstepp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian M","family":"Adcock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J","family":"Barnes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2777-5071","authenticated-orcid":false,"given":"Edwin J R","family":"van Beek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Christopher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachel L","family":"Clifford","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devesh J","family":"Dhasmana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon P","family":"Hart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arshad","family":"Hashmat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Simon","family":"Noble","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian","family":"Sayers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emma","family":"Short","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1128-8831","authenticated-orcid":false,"given":"Rebecca","family":"Stinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart R G","family":"Calimport","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4360-5902","authenticated-orcid":false,"given":"Barry L","family":"Bentley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lanhl.2026.100842_bib2","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1183\/09031936.99.14614549","article-title":"Physiological changes in respiratory function associated with ageing","volume":"13","author":"Janssens","year":"1999","journal-title":"Eur Respir J"},{"key":"10.1016\/j.lanhl.2026.100842_bib3","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1183\/13993003.00347-2016","article-title":"Exercise, ageing and the lung","volume":"48","author":"Roman","year":"2016","journal-title":"Eur Respir J"},{"key":"10.1016\/j.lanhl.2026.100842_bib4","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1126\/science.aay7319","article-title":"To help aging populations, classify organismal senescence","volume":"366","author":"Calimport","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.lanhl.2026.100842_bib5","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1007\/s11357-024-01315-9","article-title":"Defining an ageing-related pathology, disease or syndrome: international consensus statement","volume":"47","author":"Short","year":"2025","journal-title":"GeroScience"},{"key":"10.1016\/j.lanhl.2026.100842_bib6","doi-asserted-by":"crossref","first-page":"6789","DOI":"10.1007\/s11357-025-01509-9","article-title":"International Consortium to Classify Ageing-related Pathologies (ICCARP) senescence definitions: achieving international consensus","volume":"47","author":"Short","year":"2025","journal-title":"GeroScience"},{"key":"10.1016\/j.lanhl.2026.100842_bib7","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.resp.2013.03.012","article-title":"The aging respiratory system--pulmonary structure, function and neural control","volume":"187","author":"Lalley","year":"2013","journal-title":"Respir Physiol Neurobiol"},{"key":"10.1016\/j.lanhl.2026.100842_bib8","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1007\/s12603-021-1587-5","article-title":"Respiratory sarcopenia and sarcopenic respiratory disability: concepts, diagnosis, and treatment","volume":"25","author":"Nagano","year":"2021","journal-title":"J Nutr Health Aging"},{"key":"10.1016\/j.lanhl.2026.100842_bib9","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1513\/pats.201201-003AW","article-title":"TGF-\u03b2 activation and lung fibrosis","volume":"9","author":"Tatler","year":"2012","journal-title":"Proc Am Thorac Soc"},{"issue":"1","key":"10.1016\/j.lanhl.2026.100842_bib10","doi-asserted-by":"crossref","first-page":"e9","DOI":"10.1016\/j.amjmed.2005.01.077","article-title":"Aging influences on pharyngeal anatomy and physiology: the predisposition to pharyngeal collapse","volume":"119","author":"Malhotra","year":"2006","journal-title":"Am J Med"},{"key":"10.1016\/j.lanhl.2026.100842_bib11","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1044\/1092-4388(2008\/07-0092)","article-title":"Effects of age, gender, bolus condition, viscosity, and volume on pharyngeal and upper esophageal sphincter pressure and temporal measurements during swallowing","volume":"52","author":"Butler","year":"2009","journal-title":"J Speech Lang Hear Res"},{"key":"10.1016\/j.lanhl.2026.100842_bib12","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1164\/rccm.201503-0463OC","article-title":"Phenotype of normal spirometry in an aging population","volume":"192","author":"Vaz Fragoso","year":"2015","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.lanhl.2026.100842_bib13","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.822437","article-title":"Age-related differences in structure and function of nasal epithelial cultures from healthy children and elderly people","volume":"13","author":"Bal\u00e1zs","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.lanhl.2026.100842_bib14","first-page":"307","article-title":"Influence of age on bronchial mucociliary transport","volume":"60","author":"Puchelle","year":"1979","journal-title":"Scand J Respir Dis"},{"key":"10.1016\/j.lanhl.2026.100842_bib15","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1164\/ajrccm.163.4.9909121","article-title":"The effect of aging on nasal mucociliary clearance, beat frequency, and ultrastructure of respiratory cilia","volume":"163","author":"Ho","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.lanhl.2026.100842_bib16","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1016\/S2213-2600(21)00079-5","article-title":"Airway mucin MUC5AC and MUC5B concentrations and the initiation and progression of chronic obstructive pulmonary disease: an analysis of the SPIROMICS cohort","volume":"9","author":"Radicioni","year":"2021","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.lanhl.2026.100842_bib17","doi-asserted-by":"crossref","first-page":"7450","DOI":"10.1007\/s00330-024-10800-w","article-title":"Assessment of pulmonary physiological changes caused by aging, cigarette smoking, and COPD with hyperpolarized 129Xe magnetic resonance","volume":"34","author":"Rao","year":"2024","journal-title":"Eur Radiol"},{"key":"10.1016\/j.lanhl.2026.100842_bib18","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1093\/brain\/awy078","article-title":"The ventrolateral medulla and medullary raphe in sudden unexpected death in epilepsy","volume":"141","author":"Patodia","year":"2018","journal-title":"Brain"},{"key":"10.1016\/j.lanhl.2026.100842_bib19","doi-asserted-by":"crossref","first-page":"373","DOI":"10.5665\/sleep.3418","article-title":"Degeneration of brainstem respiratory neurons in dementia with Lewy bodies","volume":"37","author":"Presti","year":"2014","journal-title":"Sleep"},{"key":"10.1016\/j.lanhl.2026.100842_bib20","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1093\/brain\/awg220","article-title":"Depletion of ventromedullary NK-1 receptor-immunoreactive neurons in multiple system atrophy","volume":"126","author":"Benarroch","year":"2003","journal-title":"Brain"},{"key":"10.1016\/j.lanhl.2026.100842_bib21","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1111\/j.1469-7793.1998.00963.x","article-title":"The effect of rapid eye movement (REM) sleep on upper airway mechanics in normal human subjects","volume":"510","author":"Rowley","year":"1998","journal-title":"J Physiol"},{"key":"10.1016\/j.lanhl.2026.100842_bib22","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/S0140-6736(02)09464-3","article-title":"Obstructive sleep apnoea","volume":"360","author":"Malhotra","year":"2002","journal-title":"Lancet"},{"key":"10.1016\/j.lanhl.2026.100842_bib23","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/S2213-2600(15)00043-0","article-title":"Prevalence of sleep-disordered breathing in the general population: the HypnoLaus study","volume":"3","author":"Heinzer","year":"2015","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.lanhl.2026.100842_bib24","first-page":"1064","article-title":"Obstructive sleep apnea: women's perspective","volume":"3","author":"Jehan","year":"2016","journal-title":"J Sleep Med Disord"},{"key":"10.1016\/j.lanhl.2026.100842_bib25","doi-asserted-by":"crossref","first-page":"710","DOI":"10.1007\/s13311-012-0141-x","article-title":"Surgical therapy of obstructive sleep apnea: a review","volume":"9","author":"Carvalho","year":"2012","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.lanhl.2026.100842_bib26","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1152\/japplphysiol.00423.2013","article-title":"Electrical stimulation of the hypoglossal nerve: a potential therapy","volume":"116","author":"Schwartz","year":"2014","journal-title":"J Appl Physiol (1985)"},{"key":"10.1016\/j.lanhl.2026.100842_bib27","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1038\/s41576-024-00695-0","article-title":"Genetics of chronic respiratory disease","volume":"25","author":"Sayers","year":"2024","journal-title":"Nat Rev Genet"},{"key":"10.1016\/j.lanhl.2026.100842_bib28","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1038\/s41588-023-01314-0","article-title":"Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk","volume":"55","author":"Shrine","year":"2023","journal-title":"Nat Genet"},{"key":"10.1016\/j.lanhl.2026.100842_bib29","doi-asserted-by":"crossref","first-page":"1020","DOI":"10.1038\/s43587-023-00455-5","article-title":"Multivariate genome-wide analysis of aging-related traits identifies novel loci and new drug targets for healthy aging","volume":"3","author":"Rosoff","year":"2023","journal-title":"Nat Aging"},{"key":"10.1016\/j.lanhl.2026.100842_bib30","article-title":"Leveraging global multi-ancestry meta-analysis in the study of idiopathic pulmonary fibrosis genetics","volume":"2","author":"Partanen","year":"2022","journal-title":"Cell Genom"},{"key":"10.1016\/j.lanhl.2026.100842_bib31","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1007\/s40572-021-00328-2","article-title":"Environmental exposures and lung aging: molecular mechanisms and implications for improving respiratory health","volume":"8","author":"Eckhardt","year":"2021","journal-title":"Curr Environ Health Rep"},{"key":"10.1016\/j.lanhl.2026.100842_bib32","doi-asserted-by":"crossref","DOI":"10.1177\/2633105520942221","article-title":"DNA methylation clocks and their predictive capacity for aging phenotypes and healthspan","volume":"15","author":"Bergsma","year":"2020","journal-title":"Neurosci Insights"},{"key":"10.1016\/j.lanhl.2026.100842_bib33","doi-asserted-by":"crossref","first-page":"13452","DOI":"10.18632\/aging.206184","article-title":"Cell-type specific epigenetic clocks to quantify biological age at cell-type resolution","volume":"16","author":"Tong","year":"2024","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.lanhl.2026.100842_bib34","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1038\/s42003-024-06609-4","article-title":"Development of an epigenetic clock resistant to changes in immune cell composition","volume":"7","author":"Tomusiak","year":"2024","journal-title":"Commun Biol"},{"key":"10.1016\/j.lanhl.2026.100842_bib35","doi-asserted-by":"crossref","first-page":"16539","DOI":"10.18632\/aging.103784","article-title":"Accelerated epigenetic aging as a risk factor for chronic obstructive pulmonary disease and decreased lung function in two prospective cohort studies","volume":"12","author":"Breen","year":"2020","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.lanhl.2026.100842_bib36","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1164\/rccm.202407-1504OC","article-title":"Epigenome-wide analysis identifies pollution-sensitive loci in fibrotic interstitial lung disease","volume":"211","author":"Goobie","year":"2025","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.lanhl.2026.100842_bib37","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.01257-2024","article-title":"ERJ advances: epigenetic ageing and leveraging DNA methylation in chronic respiratory diseases","volume":"64","author":"Hernandez Cordero","year":"2024","journal-title":"Eur Respir J"},{"key":"10.1016\/j.lanhl.2026.100842_bib38","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1186\/s13148-023-01577-8","article-title":"Accelerated epigenetic age, inflammation, and gene expression in lung: comparisons of smokers and vapers with non-smokers","volume":"15","author":"Song","year":"2023","journal-title":"Clin Epigenetics"},{"key":"10.1016\/j.lanhl.2026.100842_bib39","doi-asserted-by":"crossref","first-page":"L456","DOI":"10.1152\/ajplung.00171.2024","article-title":"Epigenetic age acceleration in idiopathic pulmonary fibrosis revealed by DNA methylation clocks","volume":"328","author":"Kurbanov","year":"2025","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.lanhl.2026.100842_bib40","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1164\/rccm.201408-1452OC","article-title":"Relationship of DNA methylation and gene expression in idiopathic pulmonary fibrosis","volume":"190","author":"Yang","year":"2014","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.lanhl.2026.100842_bib41","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s13148-018-0464-5","article-title":"Altered DNA methylation is associated with aberrant gene expression in parenchymal but not airway fibroblasts isolated from individuals with COPD","volume":"10","author":"Clifford","year":"2018","journal-title":"Clin Epigenetics"},{"key":"10.1016\/j.lanhl.2026.100842_bib42","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1165\/rcmb.2013-0304OC","article-title":"DNA methylation is globally disrupted and associated with expression changes in chronic obstructive pulmonary disease small airways","volume":"50","author":"Vucic","year":"2014","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.lanhl.2026.100842_bib43","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1164\/rccm.201108-1382OC","article-title":"Variable DNA methylation is associated with chronic obstructive pulmonary disease and lung function","volume":"185","author":"Qiu","year":"2012","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.lanhl.2026.100842_bib44","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004898","article-title":"Integrative analysis of DNA methylation and gene expression data identifies EPAS1 as a key regulator of COPD","volume":"11","author":"Yoo","year":"2015","journal-title":"PLoS Genet"},{"key":"10.1016\/j.lanhl.2026.100842_bib45","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.3390\/biom15101452","article-title":"Inflammaging and senescence-driven extracellular matrix remodeling in age-associated cardiovascular disease","volume":"15","author":"M\u0142ynarska","year":"2025","journal-title":"Biomolecules"},{"key":"10.1016\/j.lanhl.2026.100842_bib46","doi-asserted-by":"crossref","DOI":"10.3389\/fcvm.2024.1384996","article-title":"Inflammaging, immunosenescence, and cardiovascular aging: insights into long COVID implications","volume":"11","author":"M\u00fcller","year":"2024","journal-title":"Front Cardiovasc Med"},{"key":"10.1016\/j.lanhl.2026.100842_bib47","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1038\/s41392-023-01502-8","article-title":"Inflammation and aging: signaling pathways and intervention therapies","volume":"8","author":"Li","year":"2023","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.lanhl.2026.100842_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101494","article-title":"Triple jeopardy in ageing: COVID-19, co-morbidities and inflamm-ageing","volume":"73","author":"Rea","year":"2022","journal-title":"Ageing Res Rev"},{"key":"10.1016\/j.lanhl.2026.100842_bib49","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.molimm.2015.01.015","article-title":"Circulating TNF and mitochondrial DNA are major determinants of neutrophil phenotype in the advanced-age, frail elderly","volume":"65","author":"Verschoor","year":"2015","journal-title":"Mol Immunol"},{"key":"10.1016\/j.lanhl.2026.100842_bib50","doi-asserted-by":"crossref","first-page":"1929","DOI":"10.1016\/j.vaccine.2010.12.121","article-title":"Aging reduces the functionality of anti-pneumococcal antibodies and the killing of Streptococcus pneumoniae by neutrophil phagocytosis","volume":"29","author":"Simell","year":"2011","journal-title":"Vaccine"},{"key":"10.1016\/j.lanhl.2026.100842_bib51","doi-asserted-by":"crossref","first-page":"L826","DOI":"10.1152\/ajplung.00424.2018","article-title":"Cellular senescence in the lung across the age spectrum","volume":"316","author":"Parikh","year":"2019","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.lanhl.2026.100842_bib52","doi-asserted-by":"crossref","DOI":"10.1038\/srep35871","article-title":"Oxidative stress dependent microRNA-34a activation via PI3K\u03b1 reduces the expression of sirtuin-1 and sirtuin-6 in epithelial cells","volume":"6","author":"Baker","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.lanhl.2026.100842_bib53","doi-asserted-by":"crossref","first-page":"L372","DOI":"10.1152\/ajplung.00393.2017","article-title":"NLRP3 inflammasome activation in aged macrophages is diminished during Streptococcus pneumoniae infection","volume":"314","author":"Cho","year":"2018","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.lanhl.2026.100842_bib54","doi-asserted-by":"crossref","DOI":"10.1183\/16000617.0106-2021","article-title":"Extracellular vesicle-mediated cellular crosstalk in lung repair, remodelling and regeneration","volume":"31","author":"Kadota","year":"2022","journal-title":"Eur Respir Rev"},{"key":"10.1016\/j.lanhl.2026.100842_bib55","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1165\/rcmb.2019-0341ED","article-title":"PAI-1: a new target for controlling lung-cell senescence and fibrosis?","volume":"62","author":"Adnot","year":"2020","journal-title":"Am J Respir Cell Mol Biol"},{"key":"10.1016\/j.lanhl.2026.100842_bib56","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.ebiom.2018.06.032","article-title":"TGF-\u03b23 promotes MUC5AC hyper-expression by modulating autophagy pathway in airway epithelium","volume":"33","author":"Zhang","year":"2018","journal-title":"EBioMedicine"},{"key":"10.1016\/j.lanhl.2026.100842_bib57","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1007\/s00441-011-1189-3","article-title":"Transforming growth factor-\u03b2 and atherosclerosis: interwoven atherogenic and atheroprotective aspects","volume":"347","author":"Toma","year":"2012","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.lanhl.2026.100842_bib58","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.3390\/biom12101456","article-title":"Immunosenescence, inflammaging, and lung senescence in asthma in the elderly","volume":"12","author":"Soma","year":"2022","journal-title":"Biomolecules"},{"key":"10.1016\/j.lanhl.2026.100842_bib59","doi-asserted-by":"crossref","first-page":"874","DOI":"10.1016\/j.jaci.2015.05.044","article-title":"The airway microbiome in patients with severe asthma: associations with disease features and severity","volume":"136","author":"Huang","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.lanhl.2026.100842_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.114573","article-title":"The role of sirtuin 1 and its activators in age-related lung disease","volume":"162","author":"Sun","year":"2023","journal-title":"Biomed Pharmacother"},{"key":"10.1016\/j.lanhl.2026.100842_bib61","doi-asserted-by":"crossref","first-page":"L230","DOI":"10.1152\/ajplung.00382.2016","article-title":"Decreased phosphatase PTEN amplifies PI3K signaling and enhances proinflammatory cytokine release in COPD","volume":"313","author":"Yanagisawa","year":"2017","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.lanhl.2026.100842_bib62","doi-asserted-by":"crossref","first-page":"958","DOI":"10.4049\/jimmunol.1302341","article-title":"Autophagy induction by SIRT6 through attenuation of insulin-like growth factor signaling is involved in the regulation of human bronchial epithelial cell senescence","volume":"192","author":"Takasaka","year":"2014","journal-title":"J Immunol"},{"key":"10.1016\/j.lanhl.2026.100842_bib63","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1378\/chest.12-2381","article-title":"Sputum plasminogen activator inhibitor-1 elevation by oxidative stress-dependent nuclear factor-\u03baB activation in COPD","volume":"144","author":"To","year":"2013","journal-title":"Chest"},{"key":"10.1016\/j.lanhl.2026.100842_bib64","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1164\/rccm.200708-1269OC","article-title":"SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease","volume":"177","author":"Rajendrasozhan","year":"2008","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.lanhl.2026.100842_bib65","doi-asserted-by":"crossref","first-page":"556","DOI":"10.1164\/rccm.201810-1975TR","article-title":"Cellular senescence as a mechanism and target in chronic lung diseases","volume":"200","author":"Barnes","year":"2019","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.lanhl.2026.100842_bib66","doi-asserted-by":"crossref","first-page":"886","DOI":"10.1164\/rccm.200509-1374OC","article-title":"Alveolar cell senescence in patients with pulmonary emphysema","volume":"174","author":"Tsuji","year":"2006","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.lanhl.2026.100842_bib67","doi-asserted-by":"crossref","first-page":"L266","DOI":"10.1152\/ajplung.00419.2022","article-title":"Small airway fibroblasts from patients with chronic obstructive pulmonary disease exhibit cellular senescence","volume":"326","author":"Wrench","year":"2024","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.lanhl.2026.100842_bib68","doi-asserted-by":"crossref","first-page":"L799","DOI":"10.1152\/ajplung.00334.2022","article-title":"Age-associated differences in the human lung extracellular matrix","volume":"324","author":"Koloko Ngassie","year":"2023","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.lanhl.2026.100842_bib69","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1183\/13993003.01125-2016","article-title":"Age-dependent elastin degradation is enhanced in chronic obstructive pulmonary disease","volume":"48","author":"Huang","year":"2016","journal-title":"Eur Respir J"},{"key":"10.1016\/j.lanhl.2026.100842_bib70","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0311760","article-title":"Age-related lung changes linked to altered lysosomal protease profile, histology, and ultrastructure","volume":"19","author":"Aufy","year":"2024","journal-title":"PLoS One"},{"key":"10.1016\/j.lanhl.2026.100842_bib71","doi-asserted-by":"crossref","first-page":"2636","DOI":"10.1111\/febs.15282","article-title":"The ECM path of senescence in aging: components and modifiers","volume":"287","author":"Levi","year":"2020","journal-title":"FEBS J"},{"key":"10.1016\/j.lanhl.2026.100842_bib72","first-page":"683","article-title":"Exponential analysis of elastic recoil and aging in healthy males and females","volume":"47","author":"Colebatch","year":"1979","journal-title":"J Appl Physiol Respir Environ Exerc Physiol"},{"key":"10.1016\/j.lanhl.2026.100842_bib73","doi-asserted-by":"crossref","first-page":"L946","DOI":"10.1152\/ajplung.00415.2017","article-title":"Aging and anatomical variations in lung tissue stiffness","volume":"314","author":"Sicard","year":"2018","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.lanhl.2026.100842_bib74","doi-asserted-by":"crossref","first-page":"10694","DOI":"10.18632\/aging.205994","article-title":"Modulating in vitro lung fibroblast activation via senolysis of senescent human alveolar epithelial cells","volume":"16","author":"Spina","year":"2024","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.lanhl.2026.100842_bib75","doi-asserted-by":"crossref","first-page":"389","DOI":"10.3390\/pharmaceutics12040389","article-title":"Senescence of IPF lung fibroblasts disrupt alveolar epithelial cell proliferation and promote migration in wound healing","volume":"12","author":"Blokland","year":"2020","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.lanhl.2026.100842_bib76","doi-asserted-by":"crossref","first-page":"L1164","DOI":"10.1152\/ajplung.00220.2017","article-title":"IPF lung fibroblasts have a senescent phenotype","volume":"313","author":"\u00c1lvarez","year":"2017","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"key":"10.1016\/j.lanhl.2026.100842_bib77","doi-asserted-by":"crossref","DOI":"10.1083\/jcb.202002120","article-title":"Telomerase treatment prevents lung profibrotic pathologies associated with physiological aging","volume":"219","author":"Pi\u00f1eiro-Hermida","year":"2020","journal-title":"J Cell Biol"},{"key":"10.1016\/j.lanhl.2026.100842_bib78","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1097\/MCP.0000000000000475","article-title":"Pulmonary phenotypes associated with genetic variation in telomere-related genes","volume":"24","author":"Hoffman","year":"2018","journal-title":"Curr Opin Pulm Med"},{"key":"10.1016\/j.lanhl.2026.100842_bib79","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/s41586-020-2882-8","article-title":"Inhibition of LT\u03b2R signalling activates WNT-induced regeneration in lung","volume":"588","author":"Conlon","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.lanhl.2026.100842_bib80","doi-asserted-by":"crossref","DOI":"10.1155\/2021\/6241600","article-title":"PRMT7: a pivotal arginine methyltransferase in stem cells and development","volume":"2021","author":"Wang","year":"2021","journal-title":"Stem Cells Int"},{"key":"10.1016\/j.lanhl.2026.100842_bib81","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.1038\/s41467-022-28809-4","article-title":"The arginine methyltransferase PRMT7 promotes extravasation of monocytes resulting in tissue injury in COPD","volume":"13","author":"G\u00fcnes G\u00fcnsel","year":"2022","journal-title":"Nat Commun"},{"key":"10.1016\/j.lanhl.2026.100842_bib82","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1042\/CS20210900","article-title":"Autophagy in asthma and chronic obstructive pulmonary disease","volume":"136","author":"Barnes","year":"2022","journal-title":"Clin Sci (Lond)"},{"key":"10.1016\/j.lanhl.2026.100842_bib83","doi-asserted-by":"crossref","first-page":"769","DOI":"10.1016\/j.jaci.2015.01.046","article-title":"Oxidative stress-induced mitochondrial dysfunction drives inflammation and airway smooth muscle remodeling in patients with chronic obstructive pulmonary disease","volume":"136","author":"Wiegman","year":"2015","journal-title":"J Allergy Clin Immunol"},{"key":"10.1016\/j.lanhl.2026.100842_bib84","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1186\/1465-9921-14-97","article-title":"Prolonged cigarette smoke exposure alters mitochondrial structure and function in airway epithelial cells","volume":"14","author":"Hoffmann","year":"2013","journal-title":"Respir Res"},{"key":"10.1016\/j.lanhl.2026.100842_bib85","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1007\/s00441-016-2511-x","article-title":"Mechanisms of lung aging","volume":"367","author":"Brandenberger","year":"2017","journal-title":"Cell Tissue Res"},{"key":"10.1016\/j.lanhl.2026.100842_bib86","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.651474","article-title":"Insights into the effects of mucosal epithelial and innate immune dysfunction in older people on host interactions with Streptococcus pneumoniae","volume":"11","author":"Weight","year":"2021","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.lanhl.2026.100842_bib87","doi-asserted-by":"crossref","first-page":"07","DOI":"10.1111\/ggi.13839","article-title":"Association between sarcopenia and pneumonia in older people","volume":"20","author":"Okazaki","year":"2020","journal-title":"Geriatr Gerontol Int"},{"key":"10.1016\/j.lanhl.2026.100842_bib88","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1186\/s12979-023-00383-3","article-title":"Toll-like receptor 4 (TLR4): new insight immune and aging","volume":"20","author":"Kim","year":"2023","journal-title":"Immun Ageing"},{"key":"10.1016\/j.lanhl.2026.100842_bib89","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.3389\/fimmu.2018.01366","article-title":"Streptococcus pneumoniae\u2019s virulence and host immunity: aging, diagnostics, and prevention","volume":"9","author":"Brooks","year":"2018","journal-title":"Front Immunol"},{"key":"10.1016\/j.lanhl.2026.100842_bib90","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1164\/rccm.202004-1483OC","article-title":"Experimental human pneumococcal colonization in older adults is feasible and safe, not immunogenic","volume":"203","author":"Adler","year":"2021","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.lanhl.2026.100842_bib91","first-page":"0720","article-title":"Meta-transcriptomics reveals dysbiosis of the respiratory microbiome in older adults with long COVID","volume":"8","author":"Liao","year":"2025","journal-title":"Research (Wash D C)"},{"key":"10.1016\/j.lanhl.2026.100842_bib92","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1038\/s41392-023-01722-y","article-title":"Lung microbiome: new insights into the pathogenesis of respiratory diseases","volume":"9","author":"Li","year":"2024","journal-title":"Signal Transduct Target Ther"},{"key":"10.1016\/j.lanhl.2026.100842_bib93","doi-asserted-by":"crossref","DOI":"10.1183\/13993003.00428-2024","article-title":"Host-microbial interactions differ with age of asthma onset","volume":"64","author":"Versi","year":"2024","journal-title":"Eur Respir J"},{"key":"10.1016\/j.lanhl.2026.100842_bib94","doi-asserted-by":"crossref","first-page":"191","DOI":"10.3389\/fmed.2020.00191","article-title":"Airway remodeling in asthma","volume":"7","author":"Hough","year":"2020","journal-title":"Front Med (Lausanne)"},{"key":"10.1016\/j.lanhl.2026.100842_bib95","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1111\/all.15977","article-title":"Metabolic pathways in immune senescence and inflammaging: novel therapeutic strategy for chronic inflammatory lung diseases. An EAACI position paper from the Task Force for Immunopharmacology","volume":"79","author":"Roth-Walter","year":"2024","journal-title":"Allergy"},{"key":"10.1016\/j.lanhl.2026.100842_bib96","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/1465-9921-15-72","article-title":"Impaired macrophage phagocytosis of bacteria in severe asthma","volume":"15","author":"Liang","year":"2014","journal-title":"Respir Res"},{"key":"10.1016\/j.lanhl.2026.100842_bib97","doi-asserted-by":"crossref","DOI":"10.1172\/JCI186889","article-title":"Cellular and molecular features of asthma mucus plugs provide clues about their formation and persistence","volume":"135","author":"Liegeois","year":"2025","journal-title":"J Clin Invest"},{"key":"10.1016\/j.lanhl.2026.100842_bib98","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.18632\/aging.202527","article-title":"Shorter telomeres in children with severe asthma, an indicative of accelerated aging","volume":"13","author":"Barb\u00e9-Tuana","year":"2021","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.lanhl.2026.100842_bib99","doi-asserted-by":"crossref","first-page":"805","DOI":"10.3390\/jof8080805","article-title":"A fun-guide to innate immune responses to fungal infections","volume":"8","author":"Burgess","year":"2022","journal-title":"J Fungi (Basel)"},{"key":"10.1016\/j.lanhl.2026.100842_bib100","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1055\/s-0041-1739472","article-title":"Invasive pulmonary aspergillosis in hospital and ventilator-associated pneumonias","volume":"43","author":"Chen","year":"2022","journal-title":"Semin Respir Crit Care Med"},{"key":"10.1016\/j.lanhl.2026.100842_bib101","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-75888-8","article-title":"Polypharmacy, hospitalization, and mortality risk: a nationwide cohort study","volume":"10","author":"Chang","year":"2020","journal-title":"Sci Rep"},{"key":"10.1016\/j.lanhl.2026.100842_bib102","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/S2213-2600(14)70088-8","article-title":"Respiratory microbiome in IPF: cause, effect, or biomarker?","volume":"2","author":"Molyneaux","year":"2014","journal-title":"Lancet Respir Med"},{"key":"10.1016\/j.lanhl.2026.100842_bib103","doi-asserted-by":"crossref","DOI":"10.1183\/23120541.00720-2022","article-title":"Azithromycin alters spatial and temporal dynamics of airway microbiota in idiopathic pulmonary fibrosis","volume":"9","author":"Gijs","year":"2023","journal-title":"ERJ Open Res"},{"key":"10.1016\/j.lanhl.2026.100842_bib104","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.imlet.2021.11.001","article-title":"Mechanisms underpinning poor antibody responses to vaccines in ageing","volume":"241","author":"Lee","year":"2022","journal-title":"Immunol Lett"},{"key":"10.1016\/j.lanhl.2026.100842_bib105","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/s41541-024-00874-4","article-title":"Insights into vaccines for elderly individuals: from the impacts of immunosenescence to delivery strategies","volume":"9","author":"Hou","year":"2024","journal-title":"NPJ Vaccines"},{"key":"10.1016\/j.lanhl.2026.100842_bib106","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1164\/rccm.201211-1969OC","article-title":"Heat-related emergency hospitalizations for respiratory diseases in the Medicare population","volume":"187","author":"Anderson","year":"2013","journal-title":"Am J Respir Crit Care Med"},{"issue":"suppl 2","key":"10.1016\/j.lanhl.2026.100842_bib107","doi-asserted-by":"crossref","first-page":"S174","DOI":"10.1093\/infdis\/jiab105","article-title":"Pneumococcal meningitis outbreaks in Africa, 2000\u20132018: systematic literature review and meningitis surveillance database analyses","volume":"224","author":"Franklin","year":"2021","journal-title":"J Infect Dis"},{"key":"10.1016\/j.lanhl.2026.100842_bib108","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1146\/annurev-virology-012420-022445","article-title":"Seasonality of respiratory viral infections","volume":"7","author":"Moriyama","year":"2020","journal-title":"Annu Rev Virol"},{"key":"10.1016\/j.lanhl.2026.100842_bib109","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2021-051519","article-title":"Impact of electronic cigarette ever use on lung function in adults aged 45-85: a cross-sectional analysis from the Canadian Longitudinal Study on Aging","volume":"11","author":"Joshi","year":"2021","journal-title":"BMJ Open"},{"key":"10.1016\/j.lanhl.2026.100842_bib110","doi-asserted-by":"crossref","DOI":"10.1016\/j.envint.2024.109019","article-title":"Ambient fine particulate matter and its constituents may exacerbate the acceleration of aging in adults","volume":"192","author":"Guo","year":"2024","journal-title":"Environ Int"},{"key":"10.1016\/j.lanhl.2026.100842_bib111","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1136\/thoraxjnl-2016-208910","article-title":"Association between exposure to ambient particulate matter and chronic obstructive pulmonary disease: results from a cross-sectional study in China","volume":"72","author":"Liu","year":"2017","journal-title":"Thorax"},{"key":"10.1016\/j.lanhl.2026.100842_bib112","doi-asserted-by":"crossref","first-page":"13","DOI":"10.3390\/epigenomes8020013","article-title":"Pathogenesis of PM2.5-related disorders in different age groups: children, adults, and the elderly","volume":"8","author":"Amnuaylojaroen","year":"2024","journal-title":"Epigenomes"},{"key":"10.1016\/j.lanhl.2026.100842_bib113","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.a3110","article-title":"Lung cancer deaths from indoor radon and the cost effectiveness and potential of policies to reduce them","volume":"338","author":"Gray","year":"2009","journal-title":"BMJ"},{"key":"10.1016\/j.lanhl.2026.100842_bib114","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmr.2025.100069","article-title":"Senotherapy for chronic lung disease","volume":"77","author":"Barnes","year":"2025","journal-title":"Pharmacol Rev"},{"key":"10.1016\/j.lanhl.2026.100842_bib115","doi-asserted-by":"crossref","first-page":"9687","DOI":"10.3390\/ijms26199687","article-title":"Heterogeneity of cellular senescence, senotyping, and targeting by senolytics and senomorphics in lung diseases","volume":"26","author":"Ozdemir","year":"2025","journal-title":"Int J Mol Sci"},{"key":"10.1016\/j.lanhl.2026.100842_bib116","doi-asserted-by":"crossref","first-page":"3591","DOI":"10.2147\/DDDT.S148868","article-title":"Resveratrol as a potential therapeutic drug for respiratory system diseases","volume":"11","author":"Zhu","year":"2017","journal-title":"Drug Des Devel Ther"},{"key":"10.1016\/j.lanhl.2026.100842_bib117","doi-asserted-by":"crossref","first-page":"1772","DOI":"10.1038\/s43587-024-00758-1","article-title":"Effect of nicotinamide riboside on airway inflammation in COPD: a randomized, placebo-controlled trial","volume":"4","author":"Norheim","year":"2024","journal-title":"Nat Aging"},{"issue":"suppl 1","key":"10.1016\/j.lanhl.2026.100842_bib118","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1111\/ggi.14653","article-title":"Targeting cellular senescence: a promising approach in respiratory diseases","volume":"24","author":"Sugimoto","year":"2024","journal-title":"Geriatr Gerontol Int"},{"key":"10.1016\/j.lanhl.2026.100842_bib119","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2023.104481","article-title":"Senolytics dasatinib and quercetin in idiopathic pulmonary fibrosis: results of a phase I, single-blind, single-center, randomized, placebo-controlled pilot trial on feasibility and tolerability","volume":"90","author":"Nambiar","year":"2023","journal-title":"EBioMedicine"},{"key":"10.1016\/j.lanhl.2026.100842_bib120","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1164\/rccm.202004-1274OC","article-title":"Senescence of alveolar type 2 cells drives progressive pulmonary fibrosis","volume":"203","author":"Yao","year":"2021","journal-title":"Am J Respir Crit Care Med"}],"container-title":["The Lancet Healthy Longevity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666756826000267?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666756826000267?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T20:28:19Z","timestamp":1783110499000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666756826000267"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":119,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["S2666756826000267"],"URL":"https:\/\/doi.org\/10.1016\/j.lanhl.2026.100842","relation":{},"ISSN":["2666-7568"],"issn-type":[{"value":"2666-7568","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The crucial role of normative ageing in respiratory pathogenesis","name":"articletitle","label":"Article Title"},{"value":"The Lancet Healthy Longevity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lanhl.2026.100842","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"100842"}}