{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T21:08:05Z","timestamp":1793826485044,"version":"4.6.1"},"reference-count":29,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T00:00:00Z","timestamp":1777939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Lancet Healthy Longevity"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.lanhl.2026.100861","type":"journal-article","created":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T20:02:41Z","timestamp":1786564961000},"page":"100861","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cognitive behavioural therapy for insomnia and epigenetic ageing: secondary analysis from a randomised controlled trial"],"prefix":"10.1016","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5516-0819","authenticated-orcid":false,"given":"Judith E","family":"Carroll","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cynthia D","family":"Kusters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3056-8878","authenticated-orcid":false,"given":"Hash Brown","family":"Taha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Olmstead","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth C","family":"Breen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael R","family":"Irwin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lanhl.2026.100861_bib1","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.jsmc.2022.03.003","article-title":"Epidemiology of insomnia: prevalence, course, risk factors, and public health burden","volume":"17","author":"Morin","year":"2022","journal-title":"Sleep Med Clin"},{"key":"10.1016\/j.lanhl.2026.100861_bib2","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.jamda.2015.12.009","article-title":"The effect of age in the association between frailty and poor sleep quality: a population-based study in community-dwellers (The Atahualpa Project)","volume":"17","author":"Del Brutto","year":"2016","journal-title":"J Am Med Dir Assoc"},{"key":"10.1016\/j.lanhl.2026.100861_bib3","first-page":"877","article-title":"Racial\/ethnic differences in sleep disturbances: the multi-ethnic study of atherosclerosis (MESA)","volume":"38","author":"Chen","year":"2015","journal-title":"Sleep"},{"key":"10.1016\/j.lanhl.2026.100861_bib4","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.smrv.2019.06.003","article-title":"Prevalence of sleep disturbances among head and neck cancer patients: a systematic review and meta-analysis","volume":"47","author":"Santoso","year":"2019","journal-title":"Sleep Med Rev"},{"key":"10.1016\/j.lanhl.2026.100861_bib5","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1001\/archpsyc.59.2.131","article-title":"Mortality associated with sleep duration and insomnia","volume":"59","author":"Kripke","year":"2002","journal-title":"Arch Gen Psychiatry"},{"key":"10.1016\/j.lanhl.2026.100861_bib6","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/nri2471","article-title":"The ageing immune system: is it ever too old to become young again?","volume":"9","author":"Dorshkind","year":"2009","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.lanhl.2026.100861_bib7","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1111\/acel.12601","article-title":"Molecular and physiological manifestations and measurement of aging in humans","volume":"16","author":"Khan","year":"2017","journal-title":"Aging Cell"},{"key":"10.1016\/j.lanhl.2026.100861_bib8","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1097\/PSY.0000000000001320","article-title":"New directions in geroscience: integrating social and behavioral drivers of biological aging","volume":"86","author":"Nielsen","year":"2024","journal-title":"Psychosom Med"},{"key":"10.1016\/j.lanhl.2026.100861_bib9","doi-asserted-by":"crossref","first-page":"303","DOI":"10.18632\/aging.101684","article-title":"DNA methylation GrimAge strongly predicts lifespan and healthspan","volume":"11","author":"Lu","year":"2019","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.lanhl.2026.100861_bib10","doi-asserted-by":"crossref","first-page":"573","DOI":"10.18632\/aging.101414","article-title":"An epigenetic biomarker of aging for lifespan and healthspan","volume":"10","author":"Levine","year":"2018","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.lanhl.2026.100861_bib11","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.73420","article-title":"DunedinPACE, a DNA methylation biomarker of the pace of aging","volume":"11","author":"Belsky","year":"2022","journal-title":"Elife"},{"issue":"suppl 1","key":"10.1016\/j.lanhl.2026.100861_bib12","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1093\/geroni\/igab046.015","article-title":"A computational solution to bolster epigenetic clock reliability for clinical trials and longitudinal tracking","volume":"5","author":"Higgins-Chen","year":"2021","journal-title":"Innov Aging"},{"key":"10.1016\/j.lanhl.2026.100861_bib13","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.biopsych.2016.07.008","article-title":"Epigenetic aging and immune senescence in women with insomnia symptoms: findings from the Women\u2019s Health Initiative study","volume":"81","author":"Carroll","year":"2017","journal-title":"Biol Psychiatry"},{"key":"10.1016\/j.lanhl.2026.100861_bib14","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1097\/PSY.0000000000001243","article-title":"Short sleep and insomnia are associated with accelerated epigenetic age","volume":"86","author":"Kusters","year":"2024","journal-title":"Psychosom Med"},{"key":"10.1016\/j.lanhl.2026.100861_bib15","doi-asserted-by":"crossref","first-page":"6777","DOI":"10.1007\/s11357-025-01608-7","article-title":"Insomnia accelerates the epigenetic clocks in older adults","volume":"47","author":"Rivero-Segura","year":"2025","journal-title":"GeroScience"},{"key":"10.1016\/j.lanhl.2026.100861_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.jad.2025.120381","article-title":"Accelerated epigenetic aging in males with mood disorders accompanied by insomnia","volume":"393","author":"Ma","year":"2026","journal-title":"J Affect Disord"},{"key":"10.1016\/j.lanhl.2026.100861_bib17","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1186\/s13148-025-01898-w","article-title":"Sleep patterns and DNA methylation age acceleration in middle-aged and older Chinese adults","volume":"17","author":"Diao","year":"2025","journal-title":"Clin Epigenet"},{"key":"10.1016\/j.lanhl.2026.100861_bib18","doi-asserted-by":"crossref","first-page":"125","DOI":"10.7326\/M15-2175","article-title":"Management of chronic insomnia disorder in adults: a clinical practice guideline from the American College of Physicians","volume":"165","author":"Qaseem","year":"2016","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.lanhl.2026.100861_bib19","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1001\/jamapsychiatry.2021.3422","article-title":"Prevention of incident and recurrent major depression in older adults with insomnia: a randomized clinical trial","volume":"79","author":"Irwin","year":"2022","journal-title":"JAMA Psychiatry"},{"key":"10.1016\/j.lanhl.2026.100861_bib20","doi-asserted-by":"crossref","first-page":"2325","DOI":"10.1007\/s11357-023-00741-5","article-title":"Remission of insomnia in older adults treated with cognitive behavioral therapy for insomnia (CBT-I) reduces p16INK4a gene expression in peripheral blood: secondary outcome analysis from a randomized clinical trial","volume":"45","author":"Carroll","year":"2023","journal-title":"GeroScience"},{"key":"10.1016\/j.lanhl.2026.100861_bib21","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1111\/jgs.19246","article-title":"Stress tests and biomarkers of resilience: proceedings of the second state of resilience science conference","volume":"73","author":"Col\u00f3n-Emeric","year":"2025","journal-title":"J Am Geriatr Soc"},{"key":"10.1016\/j.lanhl.2026.100861_bib22","doi-asserted-by":"crossref","DOI":"10.1111\/jsr.12759","article-title":"Sleep and subjective cognitive decline in cognitively healthy elderly: results from two cohorts","volume":"28","author":"Tsapanou","year":"2019","journal-title":"J Sleep Res"},{"key":"10.1016\/j.lanhl.2026.100861_bib23","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.psyneuen.2015.02.010","article-title":"Improved sleep quality in older adults with insomnia reduces biomarkers of disease risk: pilot results from a randomized controlled comparative efficacy trial","volume":"55","author":"Carroll","year":"2015","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.lanhl.2026.100861_bib24","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1016\/j.coemr.2021.03.021","article-title":"Sleep and biological aging: a short review","volume":"18","author":"Carroll","year":"2021","journal-title":"Curr Opin Endocr Metab Res"},{"key":"10.1016\/j.lanhl.2026.100861_bib25","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/nri3042","article-title":"Reciprocal regulation of the neural and innate immune systems","volume":"11","author":"Irwin","year":"2011","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.lanhl.2026.100861_bib26","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.bbi.2022.05.016","article-title":"Stress-induced biological aging: a review and guide for research priorities","volume":"104","author":"Polsky","year":"2022","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.lanhl.2026.100861_bib27","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.bbi.2018.06.019","article-title":"Associations between chronic caregiving stress and T cell markers implicated in immunosenescence","volume":"73","author":"Prather","year":"2018","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.lanhl.2026.100861_bib28","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1016\/S0889-1591(03)00031-X","article-title":"Nocturnal catecholamines and immune function in insomniacs, depressed patients, and control subjects","volume":"17","author":"Irwin","year":"2003","journal-title":"Brain Behav Immun"},{"key":"10.1016\/j.lanhl.2026.100861_bib29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbi.2015.06.012","article-title":"Mind-body therapies and control of inflammatory biology: a descriptive review","volume":"51","author":"Bower","year":"2016","journal-title":"Brain Behav Immun"}],"container-title":["The Lancet Healthy Longevity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666756826000450?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666756826000450?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,24]],"date-time":"2026-08-24T20:26:54Z","timestamp":1787603214000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666756826000450"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":29,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["S2666756826000450"],"URL":"https:\/\/doi.org\/10.1016\/j.lanhl.2026.100861","relation":{},"ISSN":["2666-7568"],"issn-type":[{"value":"2666-7568","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cognitive behavioural therapy for insomnia and epigenetic ageing: secondary analysis from a randomised controlled trial","name":"articletitle","label":"Article Title"},{"value":"The Lancet Healthy Longevity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lanhl.2026.100861","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"100861"}}