{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T01:49:38Z","timestamp":1785894578996,"version":"3.56.0"},"reference-count":28,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003569","name":"Korea Ministry of Food and Drug Safety","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003569","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012621","name":"NIHR University College London Hospitals Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003452","name":"Innovation and Technology Commission","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003452","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Lancet Healthy Longevity"],"published-print":{"date-parts":[[2026,6]]},"DOI":"10.1016\/j.lanhl.2026.100868","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T19:40:45Z","timestamp":1784230845000},"page":"100868","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"title":["Risk of fracture with gabapentinoid treatment in older adults: a multinational population-based study"],"prefix":"10.1016","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-4850-566X","authenticated-orcid":false,"given":"Andrew S C","family":"Yuen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2372-5181","authenticated-orcid":false,"given":"Boqing","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adrienne Y L","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Hong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju Hwan","family":"Kim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph F","family":"Hayes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David P J","family":"Osborn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank M C","family":"Besag","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Howard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5001-0253","authenticated-orcid":false,"given":"Matthew G","family":"Wilson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wallis C Y","family":"Lau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8242-0014","authenticated-orcid":false,"given":"Ian C K","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8840-7267","authenticated-orcid":false,"given":"Li","family":"Wei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju-Young","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8645-1942","authenticated-orcid":false,"given":"Kenneth K C","family":"Man","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lanhl.2026.100868_bib2","doi-asserted-by":"crossref","first-page":"1624","DOI":"10.1001\/jama.2016.1464","article-title":"CDC guideline for prescribing opioids for chronic pain--United States, 2016","volume":"315","author":"Dowell","year":"2016","journal-title":"JAMA"},{"key":"10.1016\/j.lanhl.2026.100868_bib3","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1056\/NEJMp1704633","article-title":"Gabapentin and pregabalin for pain - is increased prescribing a cause for concern?","volume":"377","author":"Goodman","year":"2017","journal-title":"N Engl J Med"},{"key":"10.1016\/j.lanhl.2026.100868_bib4","doi-asserted-by":"crossref","first-page":"5005","DOI":"10.1038\/s41467-023-40637-8","article-title":"Gabapentinoid consumption in 65 countries and regions from 2008 to 2018: a longitudinal trend study","volume":"14","author":"Chan","year":"2023","journal-title":"Nat Commun"},{"key":"10.1016\/j.lanhl.2026.100868_bib5","doi-asserted-by":"crossref","first-page":"1263","DOI":"10.1080\/14737175.2016.1202764","article-title":"Alpha2delta ligands, gabapentin, pregabalin and mirogabalin: a review of their clinical pharmacology and therapeutic use","volume":"16","author":"Calandre","year":"2016","journal-title":"Expert Rev Neurother"},{"key":"10.1016\/j.lanhl.2026.100868_bib6","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.coph.2005.11.003","article-title":"The mechanisms of action of gabapentin and pregabalin","volume":"6","author":"Sills","year":"2006","journal-title":"Curr Opin Pharmacol"},{"key":"10.1016\/j.lanhl.2026.100868_bib7","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0028-3908(01)00172-1","article-title":"Inhibition of neuronal Ca(2+) influx by gabapentin and pregabalin in the human neocortex","volume":"42","author":"Fink","year":"2002","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.lanhl.2026.100868_bib8","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1007\/s11914-022-00750-x","article-title":"Effects of gabapentin and pregabalin on calcium homeostasis: implications for physical rehabilitation of musculoskeletal tissues","volume":"20","author":"Reyes Fernandez","year":"2022","journal-title":"Curr Osteoporos Rep"},{"key":"10.1016\/j.lanhl.2026.100868_bib9","doi-asserted-by":"crossref","first-page":"496","DOI":"10.3390\/life12040496","article-title":"Osteogenic effect of pregabalin in human primary mesenchymal stem cells, osteoblasts, and osteosarcoma cells","volume":"12","author":"Wagener","year":"2022","journal-title":"Life"},{"key":"10.1016\/j.lanhl.2026.100868_bib12","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1093\/gerona\/glab102","article-title":"Mortality, falls, and fracture risk are positively associated with frailty: a SIDIAP cohort study of 890\u2009000 patients","volume":"77","author":"Middleton","year":"2022","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"10.1016\/j.lanhl.2026.100868_bib13","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2024.44488","article-title":"Gabapentinoids and risk of hip fracture","volume":"7","author":"Leung","year":"2024","journal-title":"JAMA Netw Open"},{"key":"10.1016\/j.lanhl.2026.100868_bib14","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1186\/s12916-024-03774-5","article-title":"Gabapentinoid use and the risk of fractures in patients with inflammatory arthritis: nested case-control study in the Clinical Practice Research Datalink Aurum","volume":"22","author":"Scott","year":"2024","journal-title":"BMC Med"},{"key":"10.1016\/j.lanhl.2026.100868_bib15","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1681\/ASN.2019090904","article-title":"Hip fracture risk among hemodialysis-dependent patients prescribed opioids and gabapentinoids","volume":"31","author":"Vangala","year":"2020","journal-title":"J Am Soc Nephrol"},{"key":"10.1016\/j.lanhl.2026.100868_bib17","doi-asserted-by":"crossref","first-page":"04","DOI":"10.1111\/j.1365-2125.2009.03537.x","article-title":"Validation and validity of diagnoses in the General Practice Research Database: a systematic review","volume":"69","author":"Herrett","year":"2010","journal-title":"Br J Clinic Pharmacol"},{"key":"10.1016\/j.lanhl.2026.100868_bib19","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2017-016640","article-title":"Cohort profile: the National Health Insurance Service-National Health Screening Cohort (NHIS-HEALS) in Korea","volume":"7","author":"Seong","year":"2017","journal-title":"BMJ Open"},{"key":"10.1016\/j.lanhl.2026.100868_bib20","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1002\/sim.2302","article-title":"Tutorial in biostatistics: the self-controlled case series method","volume":"25","author":"Whitaker","year":"2006","journal-title":"Stat Med"},{"key":"10.1016\/j.lanhl.2026.100868_bib21","article-title":"Use of antipsychotic drugs and cholinesterase inhibitors and risk of falls and fractures: self-controlled case series","volume":"374","author":"Wang","year":"2021","journal-title":"BMJ"},{"key":"10.1016\/j.lanhl.2026.100868_bib22","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2024-081627","article-title":"Use of gabapentinoid treatment and the risk of self-harm: population based self-controlled case series study","volume":"389","author":"Yuen","year":"2025","journal-title":"BMJ"},{"key":"10.1016\/j.lanhl.2026.100868_bib23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1005035","article-title":"Association between gabapentinoid treatment, concurrent use with opioid or benzodiazepine and the risk of drug poisoning: a self-controlled case series study","volume":"23","author":"Yuen","year":"2026","journal-title":"PLoS Med"},{"key":"10.1016\/j.lanhl.2026.100868_bib24","doi-asserted-by":"crossref","DOI":"10.1002\/pds.70071","article-title":"Core concepts: self-controlled designs in pharmacoepidemiology","volume":"34","author":"Bots","year":"2025","journal-title":"Pharmacoepidemiol Drug Saf"},{"key":"10.1016\/j.lanhl.2026.100868_bib25","doi-asserted-by":"crossref","first-page":"e194","DOI":"10.1016\/S2666-7568(23)00285-4","article-title":"Risk of fractures in half a million survivors of 20 cancers: a population-based matched cohort study using linked English electronic health records","volume":"5","author":"Buzasi","year":"2024","journal-title":"Lancet Healthy Longev"},{"key":"10.1016\/j.lanhl.2026.100868_bib26","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1002\/epi4.12776","article-title":"Fractures in people with epilepsy: a nationwide population-based cohort study","volume":"8","author":"Babunovska","year":"2023","journal-title":"Epilepsia Open"},{"key":"10.1016\/j.lanhl.2026.100868_bib28","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1198\/jasa.2011.ap10108","article-title":"Self-controlled case series analysis with event-dependent observation periods","volume":"106","author":"Farrington","year":"2011","journal-title":"J Am Stat Assoc"},{"key":"10.1016\/j.lanhl.2026.100868_bib29","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1093\/biostatistics\/kxn013","article-title":"Case series analysis for censored, perturbed, or curtailed post-event exposures","volume":"10","author":"Farrington","year":"2009","journal-title":"Biostatistics"},{"key":"10.1016\/j.lanhl.2026.100868_bib30","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1097\/EDE.0b013e31821d09cd","article-title":"Future cases as present controls to adjust for exposure trend bias in case-only studies","volume":"22","author":"Wang","year":"2011","journal-title":"Epidemiology"},{"key":"10.1016\/j.lanhl.2026.100868_bib31","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0197-2456(86)90046-2","article-title":"Meta-analysis in clinical trials","volume":"7","author":"DerSimonian","year":"1986","journal-title":"Control Clin Trials"},{"key":"10.1016\/j.lanhl.2026.100868_bib32","author":"Bell"},{"key":"10.1016\/j.lanhl.2026.100868_bib34","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1136\/bmj.39335.541782.AD","article-title":"Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies","volume":"335","author":"von Elm","year":"2007","journal-title":"BMJ"},{"key":"10.1016\/j.lanhl.2026.100868_bib35","doi-asserted-by":"crossref","first-page":"2214","DOI":"10.1001\/jama.2009.1738","article-title":"Chronic musculoskeletal pain and the occurrence of falls in an older population","volume":"302","author":"Leveille","year":"2009","journal-title":"JAMA"}],"container-title":["The Lancet Healthy Longevity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666756826000528?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666756826000528?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T01:15:47Z","timestamp":1785892547000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666756826000528"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6]]},"references-count":28,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["S2666756826000528"],"URL":"https:\/\/doi.org\/10.1016\/j.lanhl.2026.100868","relation":{},"ISSN":["2666-7568"],"issn-type":[{"value":"2666-7568","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Risk of fracture with gabapentinoid treatment in older adults: a multinational population-based study","name":"articletitle","label":"Article Title"},{"value":"The Lancet Healthy Longevity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lanhl.2026.100868","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"100868"}}