{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:00:08Z","timestamp":1785456008351,"version":"3.56.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T00:00:00Z","timestamp":1719878400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000865","name":"Bill & Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP11188166"],"award-info":[{"award-number":["OPP11188166"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000865","name":"Bill & Melinda Gates Foundation","doi-asserted-by":"publisher","award":["OPP1204268"],"award-info":[{"award-number":["OPP1204268"]}],"id":[{"id":"10.13039\/100000865","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Lancet Microbe"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.lanmic.2024.07.004","type":"journal-article","created":{"date-parts":[[2024,11,7]],"date-time":"2024-11-07T11:58:06Z","timestamp":1730980686000},"page":"100941","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":10,"title":["Identification of complex Plasmodium falciparum genetic backgrounds circulating in Africa: a multicountry genomic epidemiology analysis"],"prefix":"10.1016","volume":"5","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8060-6771","authenticated-orcid":false,"given":"Olivo","family":"Miotto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfred","family":"Amambua-Ngwa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas N","family":"Amenga-Etego","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muzamil M","family":"Abdel Hamid","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ishag","family":"Adam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6489-167X","authenticated-orcid":false,"given":"Enoch","family":"Aninagyei","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Apinjoh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gordon A","family":"Awandare","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Philip","family":"Bejon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gwladys I","family":"Bertin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marielle","family":"Bouyou-Akotet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoine","family":"Claessens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8711-3037","authenticated-orcid":false,"given":"David J","family":"Conway","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umberto","family":"D'Alessandro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahamadou","family":"Diakite","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdoulaye","family":"Djimd\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5190-2395","authenticated-orcid":false,"given":"Arjen M","family":"Dondorp","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4483-5005","authenticated-orcid":false,"given":"Patrick","family":"Duffy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rick M","family":"Fairhurst","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caterina I","family":"Fanello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Ghansah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deus S","family":"Ishengoma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mara","family":"Lawniczak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oumou","family":"Ma\u00efga-Ascofar\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Auburn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Rosanas-Urgell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Varanya","family":"Wasakul","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7110-7874","authenticated-orcid":false,"given":"Nina F D","family":"White","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandria","family":"Harrott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacob","family":"Almagro-Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard D","family":"Pearson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Goncalves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Ariani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zbynek","family":"Bozdech","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William L","family":"Hamilton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3402-6711","authenticated-orcid":false,"given":"Victoria","family":"Simpson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominic P","family":"Kwiatkowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lanmic.2024.07.004_bib1","series-title":"World Malaria Report 2023","year":"2023"},{"key":"10.1016\/j.lanmic.2024.07.004_bib2","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1186\/1475-2875-9-190","article-title":"Drug coverage in treatment of malaria and the consequences for resistance evolution--evidence from the use of sulphadoxine\/pyrimethamine","volume":"9","author":"Malisa","year":"2010","journal-title":"Malar J"},{"key":"10.1016\/j.lanmic.2024.07.004_bib3","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1016\/S1473-3099(19)30392-5","article-title":"Evolution and expansion of multidrug-resistant malaria in southeast Asia: a genomic epidemiology study","volume":"19","author":"Hamilton","year":"2019","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.lanmic.2024.07.004_bib4","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1056\/NEJMoa2211803","article-title":"Evolution of partial resistance to artemisinins in malaria parasites in Uganda","volume":"389","author":"Conrad","year":"2023","journal-title":"N\u00a0Engl J\u00a0Med"},{"key":"10.1016\/j.lanmic.2024.07.004_bib5","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1016\/S1473-3099(22)00697-1","article-title":"Malaria outbreak in Laos driven by a selective sweep for Plasmodium falciparum kelch13 R539T mutants: a genetic epidemiology analysis","volume":"23","author":"Wasakul","year":"2023","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.lanmic.2024.07.004_bib6","doi-asserted-by":"crossref","first-page":"22","DOI":"10.12688\/wellcomeopenres.18681.1","article-title":"Pf7: an open dataset of Plasmodium falciparum genome variation in 20,000 worldwide samples","volume":"8","author":"Abdel Hamid","year":"2023","journal-title":"Wellcome Open Res"},{"key":"10.1016\/j.lanmic.2024.07.004_bib7","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/ng.2624","article-title":"Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia","volume":"45","author":"Miotto","year":"2013","journal-title":"Nat Genet"},{"key":"10.1016\/j.lanmic.2024.07.004_bib8","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/ng.3189","article-title":"Genetic architecture of artemisinin-resistant Plasmodium falciparum","volume":"47","author":"Miotto","year":"2015","journal-title":"Nat Genet"},{"key":"10.1016\/j.lanmic.2024.07.004_bib9","doi-asserted-by":"crossref","first-page":"1213","DOI":"10.1038\/s41564-023-01377-z","article-title":"Chloroquine resistance evolution in Plasmodium falciparum is mediated by the putative amino acid transporter AAT1","volume":"8","author":"Amambua-Ngwa","year":"2023","journal-title":"Nat Microbiol"},{"key":"10.1016\/j.lanmic.2024.07.004_bib10","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1126\/science.aav5427","article-title":"Major subpopulations of Plasmodium falciparum in sub-Saharan Africa","volume":"365","author":"Amambua-Ngwa","year":"2019","journal-title":"Science"},{"key":"10.1016\/j.lanmic.2024.07.004_bib11","doi-asserted-by":"crossref","first-page":"9687","DOI":"10.1038\/s41598-018-28017-5","article-title":"Consistent signatures of selection from genomic analysis of pairs of temporal and spatial Plasmodium falciparum populations from The Gambia","volume":"8","author":"Amambua-Ngwa","year":"2018","journal-title":"Sci Rep"},{"key":"10.1016\/j.lanmic.2024.07.004_bib12","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1101\/gr.092759.109","article-title":"Circos: an information aesthetic for comparative genomics","volume":"19","author":"Krzywinski","year":"2009","journal-title":"Genome Res"},{"key":"10.1016\/j.lanmic.2024.07.004_bib13","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1186\/s12936-018-2349-7","article-title":"hmmIBD: software to infer pairwise identity by descent between haploid genotypes","volume":"17","author":"Schaffner","year":"2018","journal-title":"Malar J"},{"key":"10.1016\/j.lanmic.2024.07.004_bib14","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1038\/ng.1028","article-title":"De novo assembly and genotyping of variants using colored de Bruijn graphs","volume":"44","author":"Iqbal","year":"2012","journal-title":"Nat Genet"},{"key":"10.1016\/j.lanmic.2024.07.004_bib15","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1101\/gr.093443.109","article-title":"LookSeq: a browser-based viewer for deep sequencing data","volume":"19","author":"Manske","year":"2009","journal-title":"Genome Res"},{"key":"10.1016\/j.lanmic.2024.07.004_bib16","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s13059-023-02914-z","article-title":"JBrowse 2: a modular genome browser with views of synteny and structural variation","volume":"24","author":"Diesh","year":"2023","journal-title":"Genome Biol"},{"key":"10.1016\/j.lanmic.2024.07.004_bib17","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1007\/BF01245622","article-title":"Linkage disequilibrium in finite populations","volume":"38","author":"Hill","year":"1968","journal-title":"Theor Appl Genet"},{"key":"10.1016\/j.lanmic.2024.07.004_bib18","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1186\/s13073-017-0422-4","article-title":"New var reconstruction algorithm exposes high var sequence diversity in a single geographic location in Mali","volume":"9","author":"Dara","year":"2017","journal-title":"Genome Med"},{"key":"10.1016\/j.lanmic.2024.07.004_bib19","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1590\/S0074-02761998000500013","article-title":"Allelic diversity at the merozoite surface protein-1 (MSP-1) locus in natural Plasmodium falciparum populations: a brief overview","volume":"93","author":"Ferreira","year":"1998","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"10.1016\/j.lanmic.2024.07.004_bib20","doi-asserted-by":"crossref","first-page":"7703","DOI":"10.1074\/jbc.M115.698282","article-title":"Multiple Plasmodium falciparum merozoite surface protein 1\u00a0complexes mediate merozoite binding to human erythrocytes","volume":"291","author":"Lin","year":"2016","journal-title":"J\u00a0Biol Chem"},{"key":"10.1016\/j.lanmic.2024.07.004_bib21","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.chom.2015.09.007","article-title":"Processing of Plasmodium falciparum merozoite surface protein msp1 activates a spectrin-binding function enabling parasite egress from RBCs","volume":"18","author":"Das","year":"2015","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.lanmic.2024.07.004_bib22","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/emboj.2009.22","article-title":"A\u00a0multifunctional serine protease primes the malaria parasite for red blood cell invasion","volume":"28","author":"Koussis","year":"2009","journal-title":"EMBO J"},{"key":"10.1016\/j.lanmic.2024.07.004_bib23","doi-asserted-by":"crossref","first-page":"R12","DOI":"10.1186\/gb-2006-7-2-r12","article-title":"Lineage-specific expansion of proteins exported to erythrocytes in malaria parasites","volume":"7","author":"Sargeant","year":"2006","journal-title":"Genome Biol"},{"key":"10.1016\/j.lanmic.2024.07.004_bib24","doi-asserted-by":"crossref","first-page":"1300","DOI":"10.1111\/j.1365-2958.2008.06235.x","article-title":"The Maurer\u2019s cleft protein MAHRP1 is essential for trafficking of PfEMP1 to the surface of Plasmodium falciparum-infected erythrocytes","volume":"68","author":"Spycher","year":"2008","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.lanmic.2024.07.004_bib25","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0046980","article-title":"Plasmodium falciparum antigen 332\u00a0is a resident peripheral membrane protein of Maurer\u2019s clefts","volume":"7","author":"Nilsson","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.lanmic.2024.07.004_bib26","doi-asserted-by":"crossref","first-page":"3613","DOI":"10.1091\/mbc.e06-04-0291","article-title":"A\u00a0cluster of ring stage-specific genes linked to a locus implicated in cytoadherence in Plasmodium falciparum codes for PEXEL-negative and PEXEL-positive proteins exported into the host cell","volume":"17","author":"Spielmann","year":"2006","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.lanmic.2024.07.004_bib27","doi-asserted-by":"crossref","first-page":"982","DOI":"10.1111\/j.1365-2958.2011.07740.x","article-title":"Genetic ablation of a Maurer\u2019s cleft protein prevents assembly of the Plasmodium falciparum virulence complex","volume":"81","author":"Dixon","year":"2011","journal-title":"Mol Microbiol"},{"key":"10.1016\/j.lanmic.2024.07.004_bib28","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003327","article-title":"Hemoglobinopathies: slicing the Gordian knot of Plasmodium falciparum malaria pathogenesis","volume":"9","author":"Taylor","year":"2013","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.lanmic.2024.07.004_bib29","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1126\/science.1213775","article-title":"Hemoglobins S\u00a0and C\u00a0interfere with actin remodeling in Plasmodium falciparum-infected erythrocytes","volume":"334","author":"Cyrklaff","year":"2011","journal-title":"Science"}],"container-title":["The Lancet Microbe"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666524724001940?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666524724001940?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,3,20]],"date-time":"2025-03-20T07:09:26Z","timestamp":1742454566000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666524724001940"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":29,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["S2666524724001940"],"URL":"https:\/\/doi.org\/10.1016\/j.lanmic.2024.07.004","relation":{},"ISSN":["2666-5247"],"issn-type":[{"value":"2666-5247","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of complex Plasmodium falciparum genetic backgrounds circulating in Africa: a multicountry genomic epidemiology analysis","name":"articletitle","label":"Article Title"},{"value":"The Lancet Microbe","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lanmic.2024.07.004","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"100941"}}