{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T14:53:11Z","timestamp":1792507991644,"version":"4.5.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,8,28]],"date-time":"2024-08-28T00:00:00Z","timestamp":1724803200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01AI175345"],"award-info":[{"award-number":["R01AI175345"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Lancet Microbe"],"published-print":{"date-parts":[[2025,4]]},"DOI":"10.1016\/j.lanmic.2024.100988","type":"journal-article","created":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T19:59:59Z","timestamp":1739303999000},"page":"100988","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"title":["Antibody responses in Klebsiella pneumoniae bloodstream infection: a prospective cohort study"],"prefix":"10.1016","volume":"6","author":[{"given":"Wontae","family":"Hwang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paeton L","family":"Wantuch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7957-2575","authenticated-orcid":false,"given":"Biana","family":"Bernshtein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia A","family":"Zhiteneva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damien M","family":"Slater","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kian Hutt","family":"Vater","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sushmita","family":"Sridhar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Oliver","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J","family":"Roach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sowmya R","family":"Rao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah E","family":"Turbett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cory J","family":"Knoot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian M","family":"Harding","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Nurul","family":"Amin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan S","family":"Cross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Regina C","family":"LaRocque","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David A","family":"Rosen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3642-5126","authenticated-orcid":false,"given":"Jason B","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lanmic.2024.100988_bib1","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1016\/S0140-6736(22)02185-7","article-title":"Global mortality associated with 33\u00a0bacterial pathogens in 2019: a systematic analysis for the Global Burden of Disease Study 2019","volume":"400","year":"2022","journal-title":"Lancet"},{"key":"10.1016\/j.lanmic.2024.100988_bib2","doi-asserted-by":"crossref","DOI":"10.1128\/JCM.00776-18","article-title":"Identification of biomarkers for differentiation of hypervirulent Klebsiella pneumoniae from classical K\u00a0pneumoniae","volume":"56","author":"Russo","year":"2018","journal-title":"J\u00a0Clin Microbiol"},{"key":"10.1016\/j.lanmic.2024.100988_bib3","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/joim.13007","article-title":"Hypervirulent Klebsiella pneumoniae\u2014clinical and molecular perspectives","volume":"287","author":"Choby","year":"2020","journal-title":"J\u00a0Intern Med"},{"key":"10.1016\/j.lanmic.2024.100988_bib4","doi-asserted-by":"crossref","first-page":"S125","DOI":"10.1016\/j.vaccine.2024.02.072","article-title":"Vaccine value profile for Klebsiella pneumoniae","volume":"42","author":"Dangor","year":"2024","journal-title":"Vaccine"},{"key":"10.1016\/j.lanmic.2024.100988_bib5","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1007\/s40121-021-00533-4","article-title":"Current stage in the development of Klebsiella pneumoniae vaccines","volume":"10","author":"Assoni","year":"2021","journal-title":"Infect Dis Ther"},{"key":"10.1016\/j.lanmic.2024.100988_bib6","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1011367","article-title":"Capsular polysaccharide inhibits vaccine-induced O-antigen antibody binding and function across both classical and hypervirulent K2:O1 strains of Klebsiella pneumoniae","volume":"19","author":"Wantuch","year":"2023","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.lanmic.2024.100988_bib7","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1038\/s41591-020-0825-4","article-title":"Adaptive evolution of virulence and persistence in carbapenem-resistant Klebsiella pneumoniae","volume":"26","author":"Ernst","year":"2020","journal-title":"Nat Med"},{"key":"10.1016\/j.lanmic.2024.100988_bib8","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.mib.2020.01.006","article-title":"The intersection of capsule gene expression, hypermucoviscosity and hypervirulence in Klebsiella pneumoniae","volume":"54","author":"Walker","year":"2020","journal-title":"Curr Opin Microbiol"},{"key":"10.1016\/j.lanmic.2024.100988_bib9","article-title":"The diversity of Klebsiella pneumoniae surface polysaccharides","volume":"2","author":"Follador","year":"2016","journal-title":"Microb Genom"},{"key":"10.1016\/j.lanmic.2024.100988_bib10","article-title":"Identification of Klebsiella capsule synthesis loci from whole genome data","volume":"2","author":"Wyres","year":"2016","journal-title":"Microb Genom"},{"key":"10.1016\/j.lanmic.2024.100988_bib11","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.3389\/fmicb.2020.01249","article-title":"The diversity of lipopolysaccharide (O) and capsular polysaccharide (K) antigens of invasive Klebsiella pneumoniae in a multi-country collection","volume":"11","author":"Choi","year":"2020","journal-title":"Front Microbiol"},{"key":"10.1016\/j.lanmic.2024.100988_bib12","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1080\/14760584.2019.1635460","article-title":"Progress towards the development of Klebsiella vaccines","volume":"18","author":"Choi","year":"2019","journal-title":"Expert Rev Vaccines"},{"key":"10.1016\/j.lanmic.2024.100988_bib13","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.ijmm.2005.04.001","article-title":"Klebsiella pneumoniae type 3 fimbria-mediated immunity to infection in the murine model of respiratory disease","volume":"295","author":"Lavender","year":"2005","journal-title":"Int J\u00a0Med Microbiol"},{"key":"10.1016\/j.lanmic.2024.100988_bib14","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.1093\/infdis\/jiw021","article-title":"Target-agnostic identification of functional monoclonal antibodies against Klebsiella pneumoniae multimeric MrkA fimbrial subunit","volume":"213","author":"Wang","year":"2016","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.lanmic.2024.100988_bib15","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2301302120","article-title":"Identification of\u00a0a\u00a0second glycoform of the clinically prevalent O1 antigen\u00a0from\u00a0Klebsiella pneumoniae","volume":"120","author":"Kelly","year":"2023","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.lanmic.2024.100988_bib16","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1093\/infdis\/jiae097","article-title":"A\u00a0heptavalent O-antigen bioconjugate vaccine exhibits differential functional antibody responses against diverse Klebsiella pneumoniae isolates","volume":"230","author":"Wantuch","year":"2024","journal-title":"J\u00a0Infect Dis"},{"key":"10.1016\/j.lanmic.2024.100988_bib17","doi-asserted-by":"crossref","DOI":"10.1128\/msphere.00680-22","article-title":"The development of immunological assays to evaluate the level and function of antibodies induced by Klebsiella pneumoniae O-antigen vaccines","volume":"8","author":"Wagstaffe","year":"2023","journal-title":"MSphere"},{"key":"10.1016\/j.lanmic.2024.100988_bib18","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1038\/s41467-017-02223-7","article-title":"Immune stealth-driven O2 serotype prevalence and potential for therapeutic antibodies against multidrug resistant Klebsiella pneumoniae","volume":"8","author":"Pennini","year":"2017","journal-title":"Nat Commun"},{"key":"10.1016\/j.lanmic.2024.100988_bib19","doi-asserted-by":"crossref","first-page":"5649","DOI":"10.1016\/j.vaccine.2008.07.100","article-title":"Targeting subcapsular antigens for prevention of Klebsiella pneumoniae infections","volume":"26","author":"Clements","year":"2008","journal-title":"Vaccine"},{"key":"10.1016\/j.lanmic.2024.100988_bib20","article-title":"Production of a promising biosynthetic self-assembled nanoconjugate vaccine against Klebsiella pneumoniae serotype O2 in a general Escherichia Coli host","volume":"8","author":"Peng","year":"2021","journal-title":"Adv Sci (Weinh)"},{"key":"10.1016\/j.lanmic.2024.100988_bib21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0033155","article-title":"Lipopolysaccharide O1 antigen contributes to the virulence in Klebsiella pneumoniae causing pyogenic liver abscess","volume":"7","author":"Hsieh","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.lanmic.2024.100988_bib22","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1186\/s12934-023-02099-x","article-title":"Preparation of a Klebsiella pneumoniae conjugate nanovaccine using glycol-engineered Escherichia coli","volume":"22","author":"Liu","year":"2023","journal-title":"Microb Cell Fact"},{"key":"10.1016\/j.lanmic.2024.100988_bib23","doi-asserted-by":"crossref","DOI":"10.1128\/CMR.00001-19","article-title":"Hypervirulent Klebsiella pneumoniae","volume":"32","author":"Russo","year":"2019","journal-title":"Clin Microbiol Rev"},{"key":"10.1016\/j.lanmic.2024.100988_bib24","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abe0367","article-title":"Persistence and decay of human antibody responses to the receptor binding domain of SARS-CoV-2 spike protein in COVID-19 patients","volume":"5","author":"Iyer","year":"2020","journal-title":"Sci Immunol"},{"key":"10.1016\/j.lanmic.2024.100988_bib25","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0021-9681(87)90171-8","article-title":"A new method\u00a0of\u00a0classifying prognostic comorbidity in longitudinal studies:\u00a0development and validation.","volume":"40","author":"Charlson","year":"1987","journal-title":"J Chronic Dis"},{"key":"10.1016\/j.lanmic.2024.100988_bib26","article-title":"Clinical and genomic characterization of a cohort of patients with Klebsiella pneumoniae bloodstream infection","author":"Roach","year":"2023","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.lanmic.2024.100988_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111216","article-title":"Systems approach to\u00a0define humoral correlates of immunity to Shigella","volume":"40","author":"Bernshtein","year":"2022","journal-title":"Cell Rep"},{"key":"10.1016\/j.lanmic.2024.100988_bib28","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12941-018-0302-9","article-title":"Hypervirulent Klebsiella pneumoniae (hypermucoviscous and aerobactin positive) infection over 6\u00a0years in the elderly in China: antimicrobial resistance patterns, molecular epidemiology and risk factor","volume":"18","author":"Liu","year":"2019","journal-title":"Ann Clin Microbiol Antimicrob"},{"key":"10.1016\/j.lanmic.2024.100988_bib29","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1111\/cmi.12466","article-title":"Klebsiella pneumoniae survives within macrophages by avoiding delivery to lysosomes","volume":"17","author":"Cano","year":"2015","journal-title":"Cell Microbiol"},{"key":"10.1016\/j.lanmic.2024.100988_bib30","doi-asserted-by":"crossref","first-page":"255","DOI":"10.3389\/fcimb.2019.00255","article-title":"The interaction of Klebsiella pneumoniae with lipid rafts-associated cholesterol increases macrophage-mediated phagocytosis due to down regulation of the capsule polysaccharide","volume":"9","author":"Ares","year":"2019","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.lanmic.2024.100988_bib31","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1010693","article-title":"Capsule type defines the capability of Klebsiella pneumoniae in evading Kupffer cell capture in the liver","volume":"18","author":"Huang","year":"2022","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.lanmic.2024.100988_bib32","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1111\/imr.12754","article-title":"The continuing story of T-cell independent antibodies","volume":"288","author":"Allman","year":"2019","journal-title":"Immunol Rev"},{"key":"10.1016\/j.lanmic.2024.100988_bib33","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1011957","article-title":"Unmutated but T\u00a0cell dependent IgM antibodies targeting Streptococcus suis play an essential role in bacterial clearance","volume":"20","author":"Dolbec","year":"2024","journal-title":"PLoS Pathog"},{"key":"10.1016\/j.lanmic.2024.100988_bib34","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1128\/MMBR.00078-15","article-title":"Klebsiella pneumoniae: going on the offense with a strong defense","volume":"80","author":"Paczosa","year":"2016","journal-title":"Microbiol Mol Biol Rev"},{"key":"10.1016\/j.lanmic.2024.100988_bib35","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/s41590-018-0106-2","article-title":"Cross-specificity of protective human antibodies against Klebsiella pneumoniae LPS O-antigen","volume":"19","author":"Rollenske","year":"2018","journal-title":"Nat Immunol"},{"key":"10.1016\/j.lanmic.2024.100988_bib36","doi-asserted-by":"crossref","first-page":"6635","DOI":"10.1038\/s41598-017-06682-2","article-title":"Discovery of monoclonal antibodies cross-reactive to novel subserotypes of K.\u00a0pneumoniae O3","volume":"7","author":"Guachalla","year":"2017","journal-title":"Sci Rep"},{"key":"10.1016\/j.lanmic.2024.100988_bib37","article-title":"Kaptive 2.0: updated capsule and lipopolysaccharide locus typing for the Klebsiella\u00a0pneumoniae species complex","volume":"8","author":"Lam","year":"2022","journal-title":"Microb Genom"},{"key":"10.1016\/j.lanmic.2024.100988_bib38","doi-asserted-by":"crossref","DOI":"10.1128\/mSphere.01335-20","article-title":"Serum antibody responses against carbapenem-resistant Klebsiella pneumoniae in infected patients","volume":"6","author":"Banerjee","year":"2021","journal-title":"MSphere"},{"key":"10.1016\/j.lanmic.2024.100988_bib39","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.00297-18","article-title":"Antibody-mediated killing of carbapenem-resistant ST258 Klebsiella pneumoniae by human neutrophils","volume":"9","author":"Kobayashi","year":"2018","journal-title":"MBio"},{"key":"10.1016\/j.lanmic.2024.100988_bib40","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1038\/s41564-024-01612-1","article-title":"Carbapenem-resistant Klebsiella pneumoniae capsular types, antibiotic resistance and virulence factors in China: a\u00a0longitudinal, multi-centre study","volume":"9","author":"Hu","year":"2024","journal-title":"Nat Microbiol"}],"container-title":["The Lancet Microbe"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666524724002568?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666524724002568?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T18:53:54Z","timestamp":1745002434000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666524724002568"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["S2666524724002568"],"URL":"https:\/\/doi.org\/10.1016\/j.lanmic.2024.100988","relation":{},"ISSN":["2666-5247"],"issn-type":[{"value":"2666-5247","type":"print"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Antibody responses in Klebsiella pneumoniae bloodstream infection: a prospective cohort study","name":"articletitle","label":"Article Title"},{"value":"The Lancet Microbe","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lanmic.2024.100988","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"100988"}}