{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T04:56:11Z","timestamp":1789448171007,"version":"build-2803163510"},"reference-count":39,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,6,1]],"date-time":"2025-06-01T00:00:00Z","timestamp":1748736000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,11,14]],"date-time":"2024-11-14T00:00:00Z","timestamp":1731542400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100019018","name":"Chinese Academy of Medical Sciences Innovation Fund for Medical Sciences","doi-asserted-by":"publisher","award":["2018-I2M-2-002"],"award-info":[{"award-number":["2018-I2M-2-002"]}],"id":[{"id":"10.13039\/501100019018","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","award":["MR\/S025308\/1"],"award-info":[{"award-number":["MR\/S025308\/1"]}],"id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005150","name":"Chinese Academy of Medical Sciences","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005150","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014013","name":"UK Research and Innovation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014013","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006149","name":"Oxford University Hospitals NHS Foundation Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006149","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100016580","name":"Kennedy Trust for Rheumatology Research","doi-asserted-by":"publisher","award":["KENN 20 21 02"],"award-info":[{"award-number":["KENN 20 21 02"]}],"id":[{"id":"10.13039\/100016580","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013373","name":"NIHR Oxford Biomedical Research Centre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100013373","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000272","name":"National Institute for Health and Care Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000272","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Lancet Microbe"],"published-print":{"date-parts":[[2025,6]]},"DOI":"10.1016\/j.lanmic.2024.101045","type":"journal-article","created":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T06:50:36Z","timestamp":1745391036000},"page":"101045","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":11,"title":["Immunogenicity of MVA-BN vaccine deployed as mpox prophylaxis: a prospective, single-centre, cohort study and analysis of transcriptomic predictors of response"],"prefix":"10.1016","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3367-3335","authenticated-orcid":false,"given":"Philip G","family":"Drennan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9694-2216","authenticated-orcid":false,"given":"Nicholas M","family":"Provine","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie A","family":"Harris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8317-9194","authenticated-orcid":false,"given":"Ashley","family":"Otter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kate","family":"Hollett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cushla","family":"Cooper","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4041-0867","authenticated-orcid":false,"given":"Roel P H","family":"De Maeyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatrice","family":"Nassanga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberta","family":"Ateere","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Fransiska","family":"Pudjohartono","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanchun","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ji-Li","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nurul Huda Mohamad","family":"Fadzillah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alba","family":"Grifoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Allessandro","family":"Sette","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iman","family":"Satti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sam M","family":"Murray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cathy","family":"Rowe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sema","family":"Mandal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bassam","family":"Hallis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Klenerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Dong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Duncan","family":"Richards","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Fullerton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"McShane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Coles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lanmic.2024.101045_bib1","first-page":"156","article-title":"A pox-like disease in cynomolgus monkeys","volume":"46","author":"Magnus","year":"1959","journal-title":"APMIS"},{"key":"10.1016\/j.lanmic.2024.101045_bib2","series-title":"Multi-country monkeypox outbreak: situation update","year":"2022"},{"key":"10.1016\/j.lanmic.2024.101045_bib3","series-title":"WHO Director-General declares mpox outbreak a public health emergency of international concern","year":"2024"},{"key":"10.1016\/j.lanmic.2024.101045_bib4","doi-asserted-by":"crossref","first-page":"764","DOI":"10.15585\/mmwr.mm7123e1","article-title":"Monkeypox Outbreak\u2014Nine States, May 2022","volume":"71","author":"Minhaj","year":"2022","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"10.1016\/j.lanmic.2024.101045_bib5","doi-asserted-by":"crossref","first-page":"2791","DOI":"10.1038\/s41591-024-03130-3","article-title":"Sustained human outbreak of a new MPXV clade I lineage in the eastern Democratic Republic of the Congo","volume":"30","author":"Vakaniaki","year":"2024","journal-title":"Nat Med"},{"key":"10.1016\/j.lanmic.2024.101045_bib6","doi-asserted-by":"crossref","first-page":"172","DOI":"10.3201\/eid3001.231164","article-title":"Clade I\u2013associated mpox cases associated with sexual contact, the Democratic Republic of the Congo","volume":"30","author":"Kibungu","year":"2024","journal-title":"Emerg Infect Dis"},{"key":"10.1016\/j.lanmic.2024.101045_bib7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0010141","article-title":"The changing epidemiology of human monkeypox\u2014a potential threat? A systematic review","volume":"16","author":"Bunge","year":"2022","journal-title":"PLoS Negl Trop Dis"},{"key":"10.1016\/j.lanmic.2024.101045_bib8","doi-asserted-by":"crossref","first-page":"740","DOI":"10.1038\/nm1261","article-title":"Smallpox vaccine-induced antibodies are necessary and sufficient for protection against monkeypox virus","volume":"11","author":"Edghill-Smith","year":"2005","journal-title":"Nat Med"},{"key":"10.1016\/j.lanmic.2024.101045_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.vaccine.2024.06.021","article-title":"Vaccine effectiveness of 3rd generation mpox vaccines against mpox and disease severity: a systematic review and meta-analysis","volume":"42","author":"Pischel","year":"2024","journal-title":"Vaccine"},{"key":"10.1016\/j.lanmic.2024.101045_bib10","doi-asserted-by":"crossref","first-page":"5225","DOI":"10.1016\/j.vaccine.2015.06.075","article-title":"Comparison of lyophilized versus liquid modified vaccinia Ankara (MVA) formulations and subcutaneous versus intradermal routes of administration in healthy vaccinia-na\u00efve subjects","volume":"33","author":"Frey","year":"2015","journal-title":"Vaccine"},{"key":"10.1016\/j.lanmic.2024.101045_bib11","article-title":"Pan-pox-specific T-cell responses in HIV-1-infected individuals after JYNNEOS vaccination","volume":"96","author":"Sister\u00e9-Or\u00f3","year":"2024","journal-title":"J Med Virol"},{"key":"10.1016\/j.lanmic.2024.101045_bib12","doi-asserted-by":"crossref","first-page":"5948","DOI":"10.1038\/s41467-023-41587-x","article-title":"Monkeypox virus-infected individuals mount comparable humoral immune responses as Smallpox-vaccinated individuals","volume":"14","author":"Otter","year":"2023","journal-title":"Nat Commun"},{"key":"10.1016\/j.lanmic.2024.101045_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.lanmic.2024.100987","article-title":"Assessment of MpoxPlex, a high-throughput and multiplexed immunoassay: a diagnostic accuracy study","author":"Jones","year":"2025","journal-title":"Lancet Microbe"},{"key":"10.1016\/j.lanmic.2024.101045_bib14","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1016\/j.chom.2022.11.003","article-title":"Defining antigen targets to dissect vaccinia virus and monkeypox virus-specific T cell responses in humans","volume":"30","author":"Grifoni","year":"2022","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.lanmic.2024.101045_bib15","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1016\/S1473-3099(14)70845-X","article-title":"Safety and immunogenicity of a candidate tuberculosis vaccine MVA85A delivered by aerosol in BCG-vaccinated healthy adults: a phase 1, double-blind, randomised controlled trial","volume":"14","author":"Satti","year":"2014","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.lanmic.2024.101045_bib16","doi-asserted-by":"crossref","first-page":"50","DOI":"10.4161\/hv.22464","article-title":"Safety and immunogenicity of an FP9-vectored candidate tuberculosis vaccine (FP85A), alone and with candidate vaccine MVA85A in BCG-vaccinated healthy adults: a phase I clinical trial","volume":"9","author":"Rowland","year":"2013","journal-title":"Hum Vaccin Immunother"},{"key":"10.1016\/j.lanmic.2024.101045_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/S2666-5247(24)00074-0","article-title":"Immune responses associated with mpox viral clearance in men with and without HIV in Spain: a multisite, observational, prospective cohort study","volume":"5","author":"Moraes-Cardoso","year":"2024","journal-title":"Lancet Microbe"},{"key":"10.1016\/j.lanmic.2024.101045_bib18","article-title":"Enhanced detection of antigen-specific T cells by a multiplexed AIM assay","volume":"4","author":"Lemieux","year":"2024","journal-title":"Cell Rep Methods"},{"key":"10.1016\/j.lanmic.2024.101045_bib19","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: a Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.lanmic.2024.101045_bib20","article-title":"Fast gene set enrichment analysis","author":"Korotkevich","year":"2021","journal-title":"bioRxiv"},{"key":"10.1016\/j.lanmic.2024.101045_bib21","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1471-2105-14-7","article-title":"GSVA: gene set variation analysis for microarray and RNA-seq data","volume":"14","author":"H\u00e4nzelmann","year":"2013","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.lanmic.2024.101045_bib22","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1038\/ni.2789","article-title":"Molecular signatures of antibody responses derived from a systems biology study of five human vaccines","volume":"15","author":"Li","year":"2014","journal-title":"Nat Immunol"},{"key":"10.1016\/j.lanmic.2024.101045_bib23","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1038\/s41590-022-01329-5","article-title":"Pan-vaccine analysis reveals innate immune endotypes predictive of antibody responses to vaccination","volume":"23","author":"Fourati","year":"2022","journal-title":"Nat Immunol"},{"key":"10.1016\/j.lanmic.2024.101045_bib24","doi-asserted-by":"crossref","first-page":"1160","DOI":"10.1016\/j.immuni.2024.04.009","article-title":"Integrating population and single-cell variations in vaccine responses identifies a naturally adjuvanted human immune setpoint","volume":"57","author":"Mul\u00e8","year":"2024","journal-title":"Immunity"},{"key":"10.1016\/j.lanmic.2024.101045_bib25","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.cell.2014.12.020","article-title":"Variation in the human immune system is largely driven by non-heritable influences","volume":"160","author":"Brodin","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.lanmic.2024.101045_bib26","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1186\/s12859-015-0707-9","article-title":"Quantitative gene set analysis generalized for repeated measures, confounder adjustment, and continuous covariates","volume":"16","author":"Turner","year":"2015","journal-title":"BMC Bioinformatics"},{"key":"10.1016\/j.lanmic.2024.101045_bib27","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1006899","article-title":"Gene set meta-analysis with Quantitative Set Analysis for Gene Expression (QuSAGE)","volume":"15","author":"Meng","year":"2019","journal-title":"PLoS Comput Biol"},{"key":"10.1016\/j.lanmic.2024.101045_bib28","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1016\/j.cell.2020.04.026","article-title":"Imbalanced host response to SARS-CoV-2 drives development of COVID-19","volume":"181","author":"Blanco-Melo","year":"2020","journal-title":"Cell"},{"key":"10.1016\/j.lanmic.2024.101045_bib29","doi-asserted-by":"crossref","first-page":"460","DOI":"10.15585\/mmwr.mm7320a3","article-title":"Monkeypox virus infections after 2 preexposure doses of JYNNEOS vaccine\u2014United States, May 2022\u2013May 2024","volume":"73","author":"Guagliardo","year":"2024","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"10.1016\/j.lanmic.2024.101045_bib30","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/S1473-3099(23)00057-9","article-title":"Effectiveness of one dose of MVA-BN smallpox vaccine against mpox in England using the case-coverage method: an observational study","volume":"23","author":"Bertran","year":"2023","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.lanmic.2024.101045_bib31","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/s41591-022-02090-w","article-title":"Low levels of monkeypox virus-neutralizing antibodies after MVA-BN vaccination in healthy individuals","volume":"29","author":"Zaeck","year":"2023","journal-title":"Nat Med"},{"key":"10.1016\/j.lanmic.2024.101045_bib32","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/j.chom.2023.05.001","article-title":"Complement-dependent mpox-virus-neutralizing antibodies in infected and vaccinated individuals","volume":"31","author":"Hubert","year":"2023","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.lanmic.2024.101045_bib33","doi-asserted-by":"crossref","first-page":"1302","DOI":"10.1016\/S1473-3099(23)00352-3","article-title":"Mpox vaccine and infection-driven human immune signatures: an immunological analysis of an observational study","volume":"23","author":"Cohn","year":"2023","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.lanmic.2024.101045_bib34","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1093\/infdis\/jiae138","article-title":"Mpox-specific immune responses elicited by vaccination or infection in people living with HIV","volume":"230","author":"Gr\u00fcner","year":"2024","journal-title":"J Infect Dis"},{"key":"10.1016\/j.lanmic.2024.101045_bib35","doi-asserted-by":"crossref","first-page":"e455","DOI":"10.1016\/S1473-3099(23)00571-6","article-title":"Mpox neutralising antibodies at 6 months from mpox infection or MVA-BN vaccination: a comparative analysis","volume":"23","author":"Moschetta","year":"2023","journal-title":"Lancet Infect Dis"},{"key":"10.1016\/j.lanmic.2024.101045_bib36","doi-asserted-by":"crossref","first-page":"3856","DOI":"10.1038\/s41467-024-48180-w","article-title":"Predicting vaccine effectiveness for mpox","volume":"15","author":"Berry","year":"2024","journal-title":"Nat Commun"},{"key":"10.1016\/j.lanmic.2024.101045_bib37","doi-asserted-by":"crossref","first-page":"5425","DOI":"10.1016\/j.vaccine.2015.08.032","article-title":"Sex difference in immune response to vaccination: a participant-level meta-analysis of randomized trials of IMVAMUNE smallpox vaccine","volume":"33","author":"Troy","year":"2015","journal-title":"Vaccine"},{"key":"10.1016\/j.lanmic.2024.101045_bib38","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.986840","article-title":"Consequences of sex differences in Type I IFN responses for the regulation of antiviral immunity","volume":"13","author":"Pujantell","year":"2022","journal-title":"Front Immunol"},{"key":"10.1016\/j.lanmic.2024.101045_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2023.102420","article-title":"Immunogenicity and reactogenicity of modified vaccinia Ankara pre-exposure vaccination against mpox according to previous smallpox vaccine exposure and HIV infection: prospective cohort study","volume":"68","author":"Mazzotta","year":"2024","journal-title":"eClinicalMedicine"}],"container-title":["The Lancet Microbe"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666524724003136?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666524724003136?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T08:42:08Z","timestamp":1778920928000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666524724003136"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":39,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["S2666524724003136"],"URL":"https:\/\/doi.org\/10.1016\/j.lanmic.2024.101045","relation":{},"ISSN":["2666-5247"],"issn-type":[{"value":"2666-5247","type":"print"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immunogenicity of MVA-BN vaccine deployed as mpox prophylaxis: a prospective, single-centre, cohort study and analysis of transcriptomic predictors of response","name":"articletitle","label":"Article Title"},{"value":"The Lancet Microbe","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lanmic.2024.101045","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"101045"}}