{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,25]],"date-time":"2026-10-25T02:28:20Z","timestamp":1792895300980,"version":"4.5.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,9,1]],"date-time":"2025-09-01T00:00:00Z","timestamp":1756684800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,4,9]],"date-time":"2025-04-09T00:00:00Z","timestamp":1744156800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82472323"],"award-info":[{"award-number":["82472323"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82172306"],"award-info":[{"award-number":["82172306"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010035","name":"Outstanding Youth Foundation of Jiangsu Province of China","doi-asserted-by":"publisher","award":["BK20231524"],"award-info":[{"award-number":["BK20231524"]}],"id":[{"id":"10.13039\/501100010035","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Zhejiang Province Natural Science Foundation","doi-asserted-by":"publisher","award":["LR25H200001"],"award-info":[{"award-number":["LR25H200001"]}],"id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007062","name":"Yangzhou University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007062","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012154","name":"Graduate Research and Innovation Projects of Jiangsu Province","doi-asserted-by":"publisher","award":["KYCX24_3820"],"award-info":[{"award-number":["KYCX24_3820"]}],"id":[{"id":"10.13039\/501100012154","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100017238","name":"Sir Run Run Shaw Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100017238","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004835","name":"Zhejiang University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004835","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Lancet Microbe"],"published-print":{"date-parts":[[2025,9]]},"DOI":"10.1016\/j.lanmic.2025.101149","type":"journal-article","created":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T19:00:39Z","timestamp":1752692439000},"page":"101149","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":18,"title":["Global emergence and transmission dynamics of carbapenemase-producing Citrobacter freundii sequence type 22 high-risk international clone: a retrospective, genomic, epidemiological study"],"prefix":"10.1016","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5221-7872","authenticated-orcid":false,"given":"Qiaojun","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Longjie","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoling","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayao","family":"Yao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinran","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyun","family":"Gao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward J","family":"Feil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunsong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8333-9891","authenticated-orcid":false,"given":"Ruichao","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lanmic.2025.101149_bib1","doi-asserted-by":"crossref","first-page":"1199","DOI":"10.1016\/S0140-6736(24)01867-1","article-title":"Global burden of bacterial antimicrobial resistance 1990\u20132021: a systematic analysis with forecasts to 2050","volume":"404","year":"2024","journal-title":"Lancet"},{"key":"10.1016\/j.lanmic.2025.101149_bib2","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aax1946","article-title":"\u03a976: a designed antimicrobial peptide to combat carbapenem- and tigecycline-resistant Acinetobacter baumannii","volume":"5","author":"Nagarajan","year":"2019","journal-title":"Sci Adv"},{"key":"10.1016\/j.lanmic.2025.101149_bib3","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.ijantimicag.2016.10.025","article-title":"Polymyxin B in combination with meropenem against carbapenemase-producing Klebsiella pneumoniae: pharmacodynamics and morphological changes","volume":"49","author":"Sharma","year":"2017","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.lanmic.2025.101149_bib4","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.01346-22","article-title":"Epidemiology and molecular characteristics of mcr-9 in Citrobacter spp from healthy individuals and patients in China","volume":"10","author":"Ju","year":"2022","journal-title":"Microbiol Spectr"},{"key":"10.1016\/j.lanmic.2025.101149_bib5","doi-asserted-by":"crossref","first-page":"2697","DOI":"10.1093\/jac\/dkab209","article-title":"Three clusters of carbapenemase-producing Citrobacter freundii in Finland, 2016\u201320","volume":"76","author":"R\u00e4is\u00e4nen","year":"2021","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.lanmic.2025.101149_bib6","doi-asserted-by":"crossref","DOI":"10.3389\/fcimb.2021.744431","article-title":"Carbapenem-resistant Citrobacter spp as an emerging concern in the hospital-setting: results from a genome-based regional surveillance study","volume":"11","author":"Yao","year":"2021","journal-title":"Front Cell Infect Microbiol"},{"key":"10.1016\/j.lanmic.2025.101149_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijantimicag.2023.107069","article-title":"Emergence and plasmid cointegration-based evolution of NDM-1-producing ST107 Citrobacter freundii high-risk resistant clone in China","volume":"63","author":"Liu","year":"2024","journal-title":"Int J Antimicrob Agents"},{"key":"10.1016\/j.lanmic.2025.101149_bib8","doi-asserted-by":"crossref","first-page":"e846","DOI":"10.1016\/S2666-5247(22)00221-X","article-title":"Distribution and spread of the mobilised RND efflux pump gene cluster tmexCD-toprJ in clinical Gram-negative bacteria: a molecular epidemiological study","volume":"3","author":"Dong","year":"2022","journal-title":"Lancet Microbe"},{"key":"10.1016\/j.lanmic.2025.101149_bib9","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.04144-22","article-title":"Molecular epidemiology of global carbapenemase-producing Citrobacter spp (2015\u20132017)","volume":"11","author":"Nobrega","year":"2023","journal-title":"Microbiol Spectr"},{"key":"10.1016\/j.lanmic.2025.101149_bib10","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1093\/jac\/dkx381","article-title":"Complete nucleotide sequences of two KPC-2-encoding plasmids from the same Citrobacter freundii isolate","volume":"73","author":"Zheng","year":"2018","journal-title":"J Antimicrob Chemother"},{"key":"10.1016\/j.lanmic.2025.101149_bib11","doi-asserted-by":"crossref","DOI":"10.1128\/JCM.00275-20","article-title":"Clinical and genomic epidemiology of carbapenem-nonsusceptible Citrobacter spp at a tertiary health care center over 2 decades","volume":"58","author":"Babiker","year":"2020","journal-title":"J Clin Microbiol"},{"key":"10.1016\/j.lanmic.2025.101149_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e36828","article-title":"First identification and genomic features of multidrug-resistant Citrobacter freundii ST669 strain isolated from a domesticated duck in Bangladesh","volume":"10","author":"Ahmed","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.lanmic.2025.101149_bib13","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.02385-19","article-title":"Comparative genomic analysis of third-generation-cephalosporin-resistant Escherichia coli harboring the blaCMY\u22122-positive IncI1 group, IncB\/O\/K\/Z, and IncC plasmids isolated from healthy broilers in Japan","volume":"64","author":"Shirakawa","year":"2020","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.lanmic.2025.101149_bib14","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1101\/gr.186072.114","article-title":"CheckM: assessing the quality of microbial genomes recovered from isolates, single cells, and metagenomes","volume":"25","author":"Parks","year":"2015","journal-title":"Genome Res"},{"key":"10.1016\/j.lanmic.2025.101149_bib15","series-title":"Performance Standards for Antimicrobial Susceptibility Testing","year":"2020"},{"key":"10.1016\/j.lanmic.2025.101149_bib16","doi-asserted-by":"crossref","first-page":"3691","DOI":"10.1093\/bioinformatics\/btv421","article-title":"Roary: rapid large-scale prokaryote pan genome analysis","volume":"31","author":"Page","year":"2015","journal-title":"Bioinformatics"},{"key":"10.1016\/j.lanmic.2025.101149_bib17","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1093\/molbev\/msp077","article-title":"FastTree: computing large minimum evolution trees with profiles instead of a distance matrix","volume":"26","author":"Price","year":"2009","journal-title":"Mol Biol Evol"},{"key":"10.1016\/j.lanmic.2025.101149_bib18","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.01028-23","article-title":"Molecular characterization and comparison of blaNDM-1-carrying and blaNDM-5-harboring IncX3-type plasmids in carbapenem-resistant Klebsiella pneumoniae","volume":"11","author":"Yang","year":"2023","journal-title":"Microbiol Spectr"},{"key":"10.1016\/j.lanmic.2025.101149_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.drup.2022.100891","article-title":"Opposite evolution of pathogenicity driven by in vivo wzc and wcaJ mutations in ST11-KL64 carbapenem-resistant Klebsiella pneumoniae","volume":"66","author":"He","year":"2023","journal-title":"Drug Resist Updat"},{"key":"10.1016\/j.lanmic.2025.101149_bib20","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1093\/bioinformatics\/btw582","article-title":"PHYLOViZ 2.0: providing scalable data integration and visualization for multiple phylogenetic inference methods","volume":"33","author":"Nascimento","year":"2017","journal-title":"Bioinformatics"},{"key":"10.1016\/j.lanmic.2025.101149_bib21","doi-asserted-by":"crossref","DOI":"10.1128\/aac.01175-23","article-title":"Global genetic diversity and Asian clades evolution: a phylogeographic study of Staphylococcus aureus sequence type 5","volume":"68","author":"Chen","year":"2024","journal-title":"Antimicrob Agents Chemother"},{"key":"10.1016\/j.lanmic.2025.101149_bib22","doi-asserted-by":"crossref","DOI":"10.1093\/ve\/vey016","article-title":"Bayesian phylogenetic and phylodynamic data integration using BEAST 1.10","volume":"4","author":"Suchard","year":"2018","journal-title":"Virus Evol"},{"key":"10.1016\/j.lanmic.2025.101149_bib23","doi-asserted-by":"crossref","first-page":"2938","DOI":"10.1093\/bioinformatics\/btx364","article-title":"UpSetR: an R package for the visualization of intersecting sets and their properties","volume":"33","author":"Conway","year":"2017","journal-title":"Bioinformatics"},{"key":"10.1016\/j.lanmic.2025.101149_bib24","doi-asserted-by":"crossref","DOI":"10.1128\/mSphere.01221-20","article-title":"Widespread prevalence of plasmid-mediated colistin resistance gene mcr-1 in Escherichia coli from P\u00e8re David\u2019s deer in China","volume":"5","author":"Lu","year":"2020","journal-title":"mSphere"},{"key":"10.1016\/j.lanmic.2025.101149_bib25","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.jinf.2023.02.004","article-title":"Population genomic analysis reveals the emergence of high-risk carbapenem-resistant Escherichia coli among ICU patients in China","volume":"86","author":"Zhang","year":"2023","journal-title":"J Infect"},{"key":"10.1016\/j.lanmic.2025.101149_bib26","doi-asserted-by":"crossref","first-page":"2735","DOI":"10.1080\/22221751.2022.2140609","article-title":"Emerging and re-emerging KPC-producing hypervirulent Pseudomonas aeruginosa ST697 and ST463 between 2010 and 2021","volume":"11","author":"Zhang","year":"2022","journal-title":"Emerg Microbes Infect"},{"key":"10.1016\/j.lanmic.2025.101149_bib27","doi-asserted-by":"crossref","DOI":"10.1128\/spectrum.04254-23","article-title":"Investigation of Citrobacter freundii clinical isolates in a Chinese hospital during 2020\u20132022 revealed genomic characterization of an extremely drug-resistant C. freundii ST257 clinical strain GMU8049 co-carrying blaNDM-1 and a novel blaCMY variant","volume":"12","author":"Zhang","year":"2024","journal-title":"Microbiol Spectr"},{"key":"10.1016\/j.lanmic.2025.101149_bib28","doi-asserted-by":"crossref","DOI":"10.1128\/msphere.00366-23","article-title":"Nationwide molecular epidemiology of carbapenemase-producing Citrobacter spp in France in 2019 and 2020","volume":"8","author":"Biez","year":"2023","journal-title":"MSphere"},{"key":"10.1016\/j.lanmic.2025.101149_bib29","doi-asserted-by":"crossref","DOI":"10.2807\/1560-7917.ES.2024.29.49.2400262","article-title":"Persistence of OXA-48-producing ST-22 Citrobacter freundii in patients and the hospital environment, Paris, France, 2016 to 2022","volume":"29","author":"Jolivet","year":"2024","journal-title":"Euro Surveill"}],"container-title":["The Lancet Microbe"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666524725000771?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666524725000771?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T21:50:57Z","timestamp":1762638657000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666524725000771"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":29,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["S2666524725000771"],"URL":"https:\/\/doi.org\/10.1016\/j.lanmic.2025.101149","relation":{},"ISSN":["2666-5247"],"issn-type":[{"value":"2666-5247","type":"print"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Global emergence and transmission dynamics of carbapenemase-producing Citrobacter freundii sequence type 22 high-risk international clone: a retrospective, genomic, epidemiological study","name":"articletitle","label":"Article Title"},{"value":"The Lancet Microbe","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lanmic.2025.101149","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"101149"}}