{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T22:02:06Z","timestamp":1762639326958,"version":"build-2065373602"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T00:00:00Z","timestamp":1750118400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003646","name":"National Health Insurance Service","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003646","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003625","name":"Korea Ministry of Health and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003625","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Lancet Regional Health - Western Pacific"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.lanwpc.2025.101619","type":"journal-article","created":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T07:45:29Z","timestamp":1751615129000},"page":"101619","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Temporal trends in ischemic stroke and female sex as a risk modifier in atrial fibrillation: insights from non-anticoagulated Asian patients in a nationwide cohort study"],"prefix":"10.1016","volume":"60","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9468-7517","authenticated-orcid":false,"given":"Dong-Seon","family":"Kang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pil-Sung","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinseob","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daehoon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6991-4765","authenticated-orcid":false,"given":"Eunsun","family":"Jang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hee Tae","family":"Yu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tae-Hoon","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung Hoon","family":"Sung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui-Nam","family":"Pak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7566-1626","authenticated-orcid":false,"given":"Gregory Y.H.","family":"Lip","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9036-7225","authenticated-orcid":false,"given":"Boyoung","family":"Joung","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.lanwpc.2025.101619_bib1","article-title":"Atrial fibrillation: epidemiology, screening and digital health","volume":"37","author":"Linz","year":"2024","journal-title":"Lancet Reg Health Eur"},{"key":"10.1016\/j.lanwpc.2025.101619_bib2","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1093\/eurheartj\/ehz386","article-title":"Risk of dementia in stroke-free patients diagnosed with atrial fibrillation: data from a population-based cohort","volume":"40","author":"Kim","year":"2019","journal-title":"Eur Heart J"},{"key":"10.1016\/j.lanwpc.2025.101619_bib3","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1161\/CIRCULATIONAHA.121.055018","article-title":"Atrial fibrillation and dementia: a report from the AF-SCREEN international collaboration","volume":"145","author":"Rivard","year":"2022","journal-title":"Circulation"},{"key":"10.1016\/j.lanwpc.2025.101619_bib4","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1055\/s-0043-1776394","article-title":"Sex as a risk factor for atrial fibrillation-related stroke","volume":"124","author":"Corica","year":"2024","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.lanwpc.2025.101619_bib5","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1055\/a-2325-5923","volume":"124","author":"Wang","year":"2024","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.lanwpc.2025.101619_bib6","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1055\/s-0041-1739411","article-title":"2021 Focused update consensus guidelines of the Asia pacific heart rhythm society on stroke prevention in atrial fibrillation: executive summary","volume":"122","author":"Chao","year":"2022","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.lanwpc.2025.101619_bib7","doi-asserted-by":"crossref","first-page":"832","DOI":"10.1161\/CIRCULATIONAHA.117.029081","article-title":"Female sex is a risk modifier rather than a risk factor for stroke in atrial fibrillation: should we use a CHA(2)DS(2)-VA score rather than CHA(2)DS(2)-VASc?","volume":"137","author":"Nielsen","year":"2018","journal-title":"Circulation"},{"key":"10.1016\/j.lanwpc.2025.101619_bib8","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1093\/eurheartj\/ehad508","article-title":"Stroke risk in women with atrial fibrillation","volume":"45","author":"Buhari","year":"2024","journal-title":"Eur Heart J"},{"key":"10.1016\/j.lanwpc.2025.101619_bib9","doi-asserted-by":"crossref","first-page":"6728","DOI":"10.1038\/s41467-024-51193-0","article-title":"Risk of stroke in male and female patients with atrial fibrillation in a nationwide cohort","volume":"15","author":"Nielsen","year":"2024","journal-title":"Nat Commun"},{"key":"10.1016\/j.lanwpc.2025.101619_bib10","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1093\/eurheartj\/ehae198","article-title":"Ischaemic stroke in women with atrial fibrillation: temporal trends and clinical implications","volume":"45","author":"Teppo","year":"2024","journal-title":"Eur Heart J"},{"key":"10.1016\/j.lanwpc.2025.101619_bib11","article-title":"Comparing CHA(2)DS(2)-VA and CHA(2)DS(2)-VASc scores for stroke risk stratification in patients with atrial fibrillation: a temporal trends analysis from the retrospective Finnish AntiCoagulation in Atrial Fibrillation (FinACAF) cohort","volume":"43","author":"Teppo","year":"2024","journal-title":"Lancet Reg Health Eur"},{"key":"10.1016\/j.lanwpc.2025.101619_bib12","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1055\/a-2269-1123","article-title":"Racial differences in bleeding risk: an ecological Epidemiological study comparing Korea and United Kingdom subjects","volume":"124","author":"Kang","year":"2024","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.lanwpc.2025.101619_bib13","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1055\/a-2278-8769","article-title":"Racial differences in ischemic and hemorrhagic stroke: an ecological epidemiological study","volume":"124","author":"Kang","year":"2024","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.lanwpc.2025.101619_bib14","article-title":"Treatment timing and the effects of rhythm control strategy in patients with atrial fibrillation: nationwide cohort study","volume":"373","author":"Kim","year":"2021","journal-title":"BMJ"},{"key":"10.1016\/j.lanwpc.2025.101619_bib15","doi-asserted-by":"crossref","DOI":"10.1038\/srep27410","article-title":"Stroke and thromboembolic event rates in atrial fibrillation according to different guideline treatment thresholds: a nationwide cohort study","volume":"6","author":"Nielsen","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.lanwpc.2025.101619_bib16","doi-asserted-by":"crossref","first-page":"3083","DOI":"10.1002\/sim.3697","article-title":"Balance diagnostics for comparing the distribution of baseline covariates between treatment groups in propensity-score matched samples","volume":"28","author":"Austin","year":"2009","journal-title":"Stat Med"},{"key":"10.1016\/j.lanwpc.2025.101619_bib17","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1093\/biomet\/81.3.515","article-title":"Proportional hazards tests and diagnostics based on weighted residuals","volume":"81","author":"Grambsch","year":"1994","journal-title":"Biometrika"},{"key":"10.1016\/j.lanwpc.2025.101619_bib18","doi-asserted-by":"crossref","first-page":"3718","DOI":"10.1093\/eurheartj\/ehae540","article-title":"CHA2DS2-VASc or a non-sex score (CHA2DS2-VA) for stroke risk prediction in atrial fibrillation: contemporary insights and clinical implications","volume":"45","author":"Lip","year":"2024","journal-title":"Eur Heart J"},{"key":"10.1016\/j.lanwpc.2025.101619_bib19","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1093\/qjmed\/hcu054","article-title":"Is female sex a risk factor for stroke and thromboembolism in patients with atrial fibrillation? A systematic review and meta-analysis","volume":"107","author":"Wagstaff","year":"2014","journal-title":"QJM"},{"key":"10.1016\/j.lanwpc.2025.101619_bib20","doi-asserted-by":"crossref","first-page":"1528","DOI":"10.1093\/europace\/euab087","article-title":"A meta-analysis of clinical risk factors for stroke in anticoagulant-na\u00efve patients with atrial fibrillation","volume":"23","author":"Noubiap","year":"2021","journal-title":"Europace"},{"key":"10.1016\/j.lanwpc.2025.101619_bib21","first-page":"2880","article-title":"Withdrawn as duplicate: the CHA2DS2-VASc score for stroke risk stratification in patients with atrial fibrillation: a brief history","volume":"36","author":"Lip","year":"2015","journal-title":"Eur Heart J"},{"key":"10.1016\/j.lanwpc.2025.101619_bib22","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1055\/s-0038-1675400","article-title":"Predicting thromboembolic and bleeding event risk in patients with non-valvular atrial fibrillation: a systematic review","volume":"118","author":"Borre","year":"2018","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.lanwpc.2025.101619_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2022.101757","article-title":"Adherence to the Atrial Fibrillation Better Care (ABC) pathway and the risk of major outcomes in patients with atrial fibrillation: a post-hoc analysis from the prospective GLORIA-AF registry","volume":"55","author":"Romiti","year":"2023","journal-title":"eClinicalMedicine"},{"key":"10.1016\/j.lanwpc.2025.101619_bib24","doi-asserted-by":"crossref","first-page":"327","DOI":"10.3390\/ijerph18010327","article-title":"Have policies tackled gender inequalities in health? A scoping review","volume":"18","author":"Cresp\u00ed-Llor\u00e9ns","year":"2021","journal-title":"Int J Environ Res Public Health"},{"key":"10.1016\/j.lanwpc.2025.101619_bib25","doi-asserted-by":"crossref","DOI":"10.1136\/bmj.e3522","article-title":"Assessment of female sex as a risk factor in atrial fibrillation in Sweden: nationwide retrospective cohort study","volume":"344","author":"Friberg","year":"2012","journal-title":"BMJ"},{"key":"10.1016\/j.lanwpc.2025.101619_bib26","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1177\/1060028020904969","article-title":"The Tasmanian Atrial Fibrillation Study (TAFS): differences in stroke prevention according to sex","volume":"54","author":"Pilcher","year":"2020","journal-title":"Ann Pharmacother"},{"key":"10.1016\/j.lanwpc.2025.101619_bib27","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1161\/STROKEAHA.116.015900","article-title":"Do women with atrial fibrillation experience more severe strokes? Results from the Austrian stroke unit registry","volume":"48","author":"Lang","year":"2017","journal-title":"Stroke"},{"key":"10.1016\/j.lanwpc.2025.101619_bib28","doi-asserted-by":"crossref","first-page":"3314","DOI":"10.1093\/eurheartj\/ehae176","article-title":"2024 ESC guidelines for the management of atrial fibrillation developed in collaboration with the European Association for Cardio-Thoracic Surgery (EACTS)","volume":"45","author":"Van Gelder","year":"2024","journal-title":"Eur Heart J"},{"key":"10.1016\/j.lanwpc.2025.101619_bib29","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1055\/a-2434-9244","article-title":"The 2024 European society of cardiology guidelines for diagnosis and management of atrial fibrillation: a viewpoint from a practicing clinician's perspective","volume":"124","author":"Potpara","year":"2024","journal-title":"Thromb Haemost"}],"container-title":["The Lancet Regional Health - Western Pacific"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666606525001567?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666606525001567?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T21:58:59Z","timestamp":1762639139000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666606525001567"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":29,"alternative-id":["S2666606525001567"],"URL":"https:\/\/doi.org\/10.1016\/j.lanwpc.2025.101619","relation":{},"ISSN":["2666-6065"],"issn-type":[{"type":"print","value":"2666-6065"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Temporal trends in ischemic stroke and female sex as a risk modifier in atrial fibrillation: insights from non-anticoagulated Asian patients in a nationwide cohort study","name":"articletitle","label":"Article Title"},{"value":"The Lancet Regional Health - Western Pacific","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lanwpc.2025.101619","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"101619"}}